[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mental-imagery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mental-imagery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,69,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100625527","tele-supported-motor-imagery-exercise-in-high-risk-pregnancy-100625527",false,"NCT07423793","Tele-Supported Motor Imagery Exercise in High-Risk Pregnancy","Maternal and Fetal Effects of Tele-Rehabilitation-Supported Motor Imagery-Based Exercise in High-Risk Pregnancy: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Pregnant women who have completed the 12th week of gestation, are hospitalized for inpatient care, and have at least one of the following risk factors:\n\n   * Obstetric conditions associated with adverse outcomes and physical activity restriction, such as cervical insufficiency, multiple pregnancy, or uncontrolled gestational diabetes, for which exercise is contraindicated;\n   * Maternal body mass index (BMI) greater than 30 kg\u002Fm² leading to physical inactivity.\n2. Ability to read and write in Turkish.\n3. Willingness to participate voluntarily in the study.\n\nExclusion Criteria:\n\n1. Pregnant women with conditions such as gestational diabetes mellitus or pregnancy-induced hypertension for whom physical activity is recommended.\n2. Presence of severe cardiovascular, pulmonary, or systemic disorders.\n3. Presence of seizure disorders or significant psychiatric conditions.\n4. Any cognitive impairment that interferes with cooperation or understanding.\n5. Any medical condition that prevents safe and effective implementation of the interventions.\n6. Other high-risk obstetric conditions requiring early medical intervention (e.g., premature rupture of membranes, placenta previa, preeclampsia).\n\nLack of digital literacy required to participate in tele-rehabilitation.\n\n\\-","FEMALE","18 Years","45 Years",{"count":20,"type":21},38,"ESTIMATED","INTERVENTIONAL",[24],"NA","High-risk pregnancy is defined as a pregnancy in which there is an increased likelihood of adverse maternal and\u002For fetal outcomes due to maternal or fetal conditions. The global prevalence of high-risk pregnancies ranges between 10% and 60%. In cases where pregnancy complications occur, bed rest is frequently recommended to prevent further deterioration. However, prolonged inactivity may lead to unfavorable maternal outcomes, and appropriately prescribed exercise may help reduce the negative consequences of immobility.\n\nLong-term maternal exercise has been shown to promote vascular remodeling and angiogenesis in the uterine and umbilical arteries, increase vessel diameter, and reduce vascular resistance. Previous studies have demonstrated that exercise reduces the risk of gestational diabetes, preeclampsia, gestational hypertension, and macrosomia without increasing the risk of preterm birth, low birth weight, or perinatal mortality. Despite these benefits, women with high-risk pregnancies may have different perceptions and concerns regarding physical activity compared to healthy pregnant women.\n\nMotor imagery is a mental process in which an individual cognitively rehearses a movement without performing it physically. Neuroimaging studies have demonstrated activation of similar brain regions during motor imagery and actual movement. Mental imagery-guided relaxation exercises have been shown to improve maternal anxiety, stress levels, fetal attachment, and blood pressure in both healthy and hypertensive pregnancies. Recent findings also indicate that motor imagery-based exercise combined with diaphragmatic breathing does not adversely affect the fetus in high-risk pregnancies and may improve maternal well-being and oxygen saturation without inducing uterine contractions.\n\nThis randomized controlled trial aims to investigate the maternal and fetal effects of an 8-week tele-rehabilitation-supported motor imagery-based exercise program in high-risk pregnant women who are prescribed hospital- or home-based bed rest.",[27,28,29],"High Risk Pregnancy","Tele-rehabilitation","Mental Imagery","NOT_YET_RECRUITING","2026-02-15",{"date":33,"type":34},"2026-02-20","ACTUAL",{"date":33,"type":21},{"date":37,"type":21},"2027-02-28",{"name":39,"class":40},"Izmir University of Economics","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100607803","mental-imagery-on-upper-extremity-skills-100607803","NCT07193303","Mental Imagery on Upper Extremity Skills","The Immediate Effect of Mental Imagery on Upper Extremity Skills With the Patients of Parkinson's Disease","Inclusion Criteria:\n\n* Healthy individuals aged 40-75 years, diagnosed with idiopathic PD according to the UK Parkinson's Disease Association Brain Bank criteria by a specialist neurologist, with a Modified Hoehn \\& Yahr (m-HY) scale stage ≤4, and with a Mini Mental State Examination score of ≥24 for those with training and ≥18 for those without training, and with no known disease, volunteered to participate in the study.\n* PD individuals with no other known neurological and\u002For systemic disease\n* PD individuals without any upper extremity contractures\n\nExclusion Criteria:\n\n* Individuals with diagnosed and\u002For treated psychiatric illnesses who are considered unable to complete the tests.\n* Individuals who is taking neuroleptic medications or antidepressants.\n* Individuals with orthopedic conditions that interfere with manual dexterity tests, such as severe dyskinesia, carpal tunnel syndrome, tendon injuries, or finger amputations; rheumatological conditions such as rheumatoid arthritis and osteoarthritis; and individuals with any neurological condition other than PD.","ALL","40 Years","75 Years",{"count":53,"type":21},30,[24],"Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized pathologically by the progressive loss of dopaminergic neurons in the substantia nigra and clinically by the presence of motor symptoms such as bradykinesia, resting tremor, and\u002For rigidity. Among the motor deficits frequently observed in PD, patients are known to frequently report difficulties with manual dexterity. Many upper extremity and manual dexterity deficits are present in PD. Motor imagery (MI) is the imaginal execution of motor activities or the activation of specific muscles in the absence of any explicit feedback. This area of rehabilitation has been shown to be effective in improving and developing motor skills in many neurological conditions where patients exhibit motor recognition and execution impairments. MI can be applied at all stages of recovery from PD, is highly effective in movement-related pathologies, and can be performed independently.There is sufficient evidence that MI improves motor performance and learning in individuals with neurological disorders such as multiple sclerosis, stroke, and spinal cord injury. The study was designed to investigate the immediate effects of mental imagery, which is thought to be effective in controlling difficulties in planning and initiating movements in PD, on upper extremity skills. Therefore, the aim of this study was to determine the effect of mental imagery on upper extremity skills in PD.",[57,29,58],"PARKINSON DISEASE (Disorder)","Motor Imagery","RECRUITING","2025-12-18",{"date":62,"type":34},"2025-12-19",{"date":64,"type":34},"2025-07-01",{"date":66,"type":21},"2026-01-30",{"name":68,"class":40},"Kahramanmaras Sutcu Imam University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":86,"leadSponsor":88,"locationsCount":41},"100607807","effects-of-motor-imagery-training-100607807","NCT07193355","Effects of Motor Imagery Training","Effects of Motor Imagery Training on Kinesiophobia, Gait, and Balance in Parkinson's Disease Patients","Inclusion Criteria:\n\n* Individuals aged 40-75 diagnosed with idiopathic PD, with a Modified Hoehn \\& Yahr (m-HY) scale stage ≤4, and a score of ≥22 on the Mini Mental State Examination for those with formal training and ≥18 for those without formal training;\n* Individuals with no other known neurological and\u002For systemic disease;\n* Individuals without any upper extremity contractures;\n\nExclusion Criteria:\n\n* Individuals with diagnosed and\u002For treated psychiatric illnesses;\n* Individuals who are taking neuroleptic medications or antidepressants;\n* Individuals with orthopedic conditions such as severe dyskinesia, carpal tunnel syndrome, tendon injuries, and finger amputations that interfere with manual dexterity tests; rheumatological conditions such as rheumatoid arthritis and osteoarthritis; and individuals with any neurological disease other than PD.",{"count":77,"type":21},50,[24],"Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized pathologically by the progressive loss of dopaminergic neurons in the substantia nigra and clinically by the presence of motor symptoms such as bradykinesia, resting tremor, and\u002For rigidity. Among the motor deficits frequently observed in PD, patients are known to frequently report difficulties with manual dexterity.Typical features of balance deficits in PD include decreased sway, decreased base of support, rigidity, abnormal intersegmental coordination, and postural misalignment. Related somatosensory deficits in PD include problems orienting to and processing sensory and somatosensory information.Motor imagery (MI) is the imaginal execution of motor activities or the activation of specific muscles in the absence of any explicit feedback. This area of rehabilitation has been shown to be effective in improving and developing motor skills in many neurological conditions where patients exhibit motor recognition and execution impairments. MI can be applied at all stages of recovery from PD, is highly effective in movement-related pathologies, and can be performed independently.Studies evaluating the effect of mental imagery training on balance measures in PD are limited. One study evaluating the effect of combined MI-physical therapy versus physical therapy alone group treatment noted positive trends toward balance improvements in the combined group. In a case study of a single participant with PD, a 3-month neurocognitive rehabilitation program incorporating mental imagery over 20 sessions resulted in balance improvements and a reduced risk of falls in both the \"OFF\" and \"ON\" phases, as measured by the Tinetti Balance and Gait Assessment Scale.The aim of this study is to investigate the effects of motor imagery training on kinesiophobia, walking and balance in patients with Parkinson's disease.",[57,29,81],"Gait Balance","2025-09-18",{"date":84,"type":34},"2025-09-25",{"date":64,"type":34},{"date":87,"type":21},"2026-07-30",{"name":68,"class":40},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":41},"100551023","improving-treatment-of-major-depressive-disorder-by-reducing-negative-future-oriented-mental-imagery-100551023","NCT06454695","Improving Treatment of Major Depressive Disorder by Reducing Negative Future-Oriented Mental Imagery","Improving Treatment of Severe Major Depressive Disorder by Reducing Negative Future-Oriented Mental Imagery","PROFIT","Inclusion Criteria:\n\n* Aged 18 years or older;\n* Meet DSM-5 criteria for major depressive disorder;\n* Presence of 1-3 negative future-oriented mental images, which cause distress;\n* Be able to understand questionnaires and study information letter;\n* In case of medication use: are stable on medication for six weeks or longer.\n\nExclusion Criteria:\n\n* Current or history of psychotic disorder;\n* Current or history of bipolar disorder;\n* Severe cognitive impairment (e.g., mental retardation) as evidenced by educational records, parental report and\u002For clinical impression;\n* Current EMDR or imagery rescripting therapy;\n* Other circumstances that might affect participation (e.g., severe medical disorder, relocation).",{"count":77,"type":21},[24],"Patients with major depressive disorder (MDD) often do not sufficiently benefit from treatment. That is, around 50% of patients with MDD do not respond to treatment and 20-30% only achieve partial remission. Future-oriented negative mental imagery (e.g., mental images of suicide or own funeral) is likely an important maintaining factor of depression and initial studies in depression indicate that targeting mental imagery with 'imagery rescripting' could be a promising therapeutic technique to reduces depressive symptomatology by targeting these images directly that elicits strong affects\u002Femotions and depressive symptomatology.\n\nBefore testing the (cost)effectiveness of future-oriented imagery rescripting to treatment as usual (TAU), a pilot study is needed to examine 1) the acceptability of the intervention, 2) the feasibility of the study, and 3) the variance of effect on reducing depressive symptomatology that can serve as estimate of the sample size for a follow-up randomized controlled trial (RCT).\n\nA multicenter pilot RCT with a mixed factorial design with three time points (i.e., baseline, post-treatment, and follow-up of 3 months) will test 50 patients with MDD who will be randomly allocated to future-oriented imagery rescripting plus TAU or TAU only.\n\nThe sample consists of adult patients of 18 years or older with an MDD diagnosis.\n\nAll patients in this pilot study receive TAU, which involves a combination of pharmacological and psychological interventions. Half of the patients will also receive 3-5 sessions of future-oriented imagery rescripting (ImRes). In each ImRes session, patients identify an image of a autobiographic catastrophic future event (e.g., catastrophic images of future suicide or the loss of work or a loved one). They are subsequently asked to \"rescript\" this image into a more benign one.\n\nThe primary aim of this pilot study is to determine the acceptability of the intervention. The secondary aims are to elucidate factors that may facilitate or hinder the feasibility of the follow-up RCT (e.g., recruitment process) and to estimate the variance of the effect on reduction of depressive symptomatology, which informs the sample size calculation of the follow-up RCT. To study acceptability, the investigators assess depressive symptoms (BDI-II and BADS) and treatment satisfaction (SRS and CSQ-8). To measure feasibility, the investigators will assess recruitment\u002Fadmission ratio, dropout and (serious) adverse events. Finally, to estimate the variance of effects, group effects on the BDI-II will be tested at post-treatment and follow-up (corrected for baseline).\n\nImagery rescripting on negative memories has already proven effective and safe in MDD patients. There is no known major risk associated with study participation. Patient burden comprises an online or phone-based screening interview of maximum 60 minutes and several questionnaires. Participants receive a reimbursement of €25,- after study completion (i.e., after follow-up assessment). The project will contribute to improving the care for patients with MDD. If the results show that the intervention is feasible and acceptable, this pilot study will inform the setup of the main RCT on the (cost)effectiveness of the intervention (ZonMW).",[101,29,102],"Major Depressive Disorder","Cognitive Behavioral Therapy",[104,105,106],"Imagery rescripting","Prospective negative mental images","Depression","2024-08-22",{"date":109,"type":34},"2024-08-23",{"date":111,"type":34},"2024-06-01",{"date":113,"type":21},"2025-11-01",{"name":115,"class":40},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)"]