[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mental-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mental-stress":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,81,110,135,177,217],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100627815","cranberry-polyphenols-and-stress-resilience-during-multitasking-in-healthy-adults-100627815",false,"NCT07453537","Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults","Cranberry Polyphenols and Human Stress Resilience: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Integrating Cognitive, Physiological, and Microbiome Adaptations Underlying Nutritional Neuroprotection and Multitasking Performance in Healthy Adults.","CRAN-MULTI","Inclusion Criteria:\n\n* At least 110 pounds\n* Between 30 and 55 years\n* BMI between 18.9 and 29.9 kg\u002Fm²\n* A minimum education level of high school or above\n\nExclusion Criteria:\n\n* Heavy caffeine users (consuming more than 300 mg\u002Fday or more than two cups of coffee per day)\n* Alcohol consumption exceeding three drinks per week\n* A smoking history of 10 years or more, or current use of cannabis products\n* Uncontrolled hypertension\n* Clinically diagnosed illnesses such as diabetes, cardiovascular disease, neurological disorders, or mental health conditions\n* Participants currently taking prescribed anti-inflammatory medications, antibiotics, or antidepressants that may affect study outcomes, particularly those related to blood and fecal sample analysis\n* Individuals who regularly take vitamin or mineral supplements and are unwilling to discontinue them for the duration of the study will not qualify.\n* Participants must be willing to maintain their current daily routine and lifestyle, undergo body weight and height measurements, and notify study coordinators of any illnesses or significant adverse life events during the study period\n* Those with specific dietary restrictions that prevent them from consuming the standardized breakfast sandwich required in the study protocol\n* Participants must successfully complete the on-site multitasking task as a screening measure prior to signing consent.\n* Beck's Depression Inventory score of 21 or higher\n* Beck's Anxiety Inventory score of 21 or higher\n* A history of severe suicidal tendencies, or seasonal depression\n* Pregnancy and breastfeeding (Female participants must complete four pregnancy tests throughout the study and track their menstrual cycle. Those unwilling to comply with these requirements will not be eligible.)\n* Potential participants must not have taken any anti-inflammatory medications, antibiotics, or antidepressants within the past three months prior to the start of the study\n* Individuals who were previously enrolled in IRB#202300950 will be excluded due to the learning effect of cognitive tests, ensuring accurate data collection for this study",true,"ALL","30 Years","55 Years",{"count":22,"type":23},84,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1). It is further hypothesized that cranberry juice will mitigate multitasking-related fatigue, mood fluctuations, and cognitive impairment, accompanied by favorable changes in circulating stress biomarkers and stress-regulatory neurochemical pathways (Aim 2\u002FHypothesis 2). Finally, the study incorporates gut analysis to determine whether cranberry juice induces beneficial shifts in the gut microbiota and microbial metabolites (e.g., SCFAs) and whether these changes are associated with improved cognitive and stress-related outcomes, consistent with a microbiome-gut-brain axis mechanism (Aim 3\u002FHypothesis 3).",[29,30,31,32,33,34],"Stress Response","Mental Stress","Multitasking Behavior and Multitasking Ability","Physiological Stress","Cognitive Symptoms","Motor Activity","RECRUITING","2026-06-29",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":23},"2026-08-01",{"date":43,"type":23},"2029-08-01",{"name":45,"class":46},"University of Florida","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100601350","tan-for-first-responders-100601350","NCT07109349","tAN for First Responders","Effect of Transcutaneous Auricular Neurostimulation on Mental Wellness and Resiliency for First Responders: A Pilot Trial","Inclusion Criteria:\n\n1. Participant is currently employed in a first responder position\n2. Age ≥ 18 years\n3. Reliable access to an internet-enabled device to complete required questionnaires\n4. GAD-7 score ≥ 5\n\nExclusion Criteria:\n\n1. Participant has a history of epileptic seizures\n2. Participant has a history of neurologic diseases or traumatic brain injury\n3. Participant has presence of devices (e.g., pacemakers, cochlear prostheses or implants, neurostimulators)\n4. Participant has abnormal left ear anatomy or ear infection present\n5. Participant has auditory impairment of the left ear (ruptured eardrum, deafness, tinnitus, etc.)\n6. Participant is currently enrolled in another interventional trial\n7. Women of childbearing potential, not using adequate contraception as per the investigator's judgement\n8. Females who are pregnant or lactating\n9. Participant has any other significant disease or disorder which, in the opinion of the Investigator, may either put the participant at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial","18 Years",{"count":57,"type":23},30,[26],"This study is designed as an open label, single arm, decentralized clinical study in which first responders will receive transcutaneous auricular neurostimulation (tAN), which targets the auricular branch of the vagus nerve (ABVN) via the mastoid and the auriculotemporal nerve (ATN) anterior to the tragus. Participants will be enrolled in the study over the course of eight weeks (56 days).\n\nParticipants will respond to daily and weekly questionnaires regarding mood, stress, sleep, energy\u002Ffatigue, and burnout. Each week, participants will complete consolidated online questionnaires (intended to last no longer than 15 minutes) comprised of the Perceived Stress Short-Form (PSS-4), Well-Being Index (WHO-5), Mini-Z Burnout (5-item), PROMS Sleep Disturbance (PROMIS-SD), GAD-7 (every 2 weeks), and Perceived Stress (PSS-10; monthly). The PSS-10 will replace the PSS-4 on Days 0, 28, and 56.\n\nNo tAN treatment will be delivered during the Baseline Period (days between Study Introduction and Day 0). Participants will complete the weekly set of questionnaires (\"Weekly Questionnaires\") on Day 0. Participants will be recommended to complete the daily set of questionnaires (\"Daily Questionnaires \") on the other days of the Baseline Period.\n\nOn Days 1 - 28, participants will self-administer one session of one to two hours of tAN therapy each day. Participants will be recommended to complete the daily tAN session post-shift prior to sleep. Weekly Questionnaires will be completed by participants on Study Days 0, 7, 14, 21, 28, 35, 42, 49, and 56. Participants will be recommended to complete Daily Questionnaires on all other study days, up to Day 28. Daily Questionnaires will not be required to be completed by participants. Daily tAN sessions and Daily Questionnaires will cease after Day 28. Participants will complete a Study Satisfaction Questionnaire with the Weekly Questionnaires on Day 56.\n\nFollowing Day 56, participants will schedule a Study Exit Interview with the Research Coordinator.",[61,30],"Mental Fatigue",[63,64,65,66,67,68,69,70],"Mental resilience","tAN","Transcutaneous Auricular Neurostimulation","Vagus nerve stimulation","Neurostimulation","First responders","taVNS","Police officer","2026-06-01",{"date":73,"type":39},"2026-06-02",{"date":75,"type":39},"2025-09-10",{"date":77,"type":23},"2026-07-20",{"name":79,"class":80},"Spark Biomedical, Inc.","INDUSTRY",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":47},"100603586","influence-of-melatonin-on-cardiovascular-and-thermoregulatory-responses-to-stress-100603586","NCT07138443","Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress","Influence of Melatonin on Cardiovascular and Skin Temperature Responses to Stress: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Must be between the ages of 18-70 years old.\n* All subjects will be required to abstain from exercise and caffeine for 12 h, and alcohol for 24 h prior to the experiment.\n* BMI must be \\\u003C30 kg\u002Fm2.\n* Menstruating women will initially be tested during their early follicular phase (2-5 days after initiating menstruation) or during low hormone phase (2-5 days after initiating menstruation) if on oral contraceptives to control for potential impact of sex steroids. Post-menopausal females (\\>5 years) will also be included. Females must have an intact uterus and at least one ovary. Use of hormonal replacement therapy will be allowed.\n\nExclusion Criteria:\n\n* Circadian rhythm sleep disorders\n* High obstructive sleep apnea diagnosis determined by STOP-BANG.\n* History of meeting Diagnostic and Statistical Manual of Mental health (DSM-V) criteria of major psychiatric disorder\n* Unstable or serious medical conditions (heart failure, diabetes, cardiovascular disease, etc.)\n* Current, or use within past month, of psychoactive (other than stable treatment with antidepressant), hypnotic, stimulant or analgesic medication (except occasional non-narcotic analgesics), beta blockers, or alpha blockers\n* Shift work or other types of self-imposed irregular sleep schedules\n* Habitual smoking (6 or more cigarettes per week)\n* Habitual alcohol consumption (more than 2 alcoholic drinks per day)\n* Pregnancy or breast feeding","70 Years",{"count":90,"type":23},20,[26],"This study aims to evaluate the influence of acute oral melatonin supplementation on cardiovascular and skin temperature responses to mental stress. The hypothesis is that acute melatonin will lead to reduced cardiovascular and skin temperature responsiveness to acute mental stress.",[94,30],"Stress",[96,97,98,99,100],"Melatonin","Mental stress","Trier Social Stress Test","Cardiovascular","Skin temperature","2025-08-21",{"date":103,"type":39},"2025-08-22",{"date":105,"type":23},"2025-08",{"date":107,"type":23},"2026-08",{"name":109,"class":46},"Baylor University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":17,"sex":18,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":24,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":47},"100582822","the-effectiveness-of-mental-wellness-youth-hubs-in-hong-kong-100582822","NCT06868303","The Effectiveness of Mental Wellness Youth Hubs in Hong Kong","A Quasi-controlled Study on the Effectiveness of Mental Wellness Youth Hubs in Hong Kong","Inclusion Criteria:\n\n* For hub user group: 12- to 24-year-old hub users who receive community-based mental wellness youth hub services for young people.\n* For community control group: 12- to 24-year-old community youths who do not receive any youth services in the community.\n* For eClinic user group: 12- to 24-year-old eClinic service users.\n\nExclusion Criteria:\n\n* Youths with known diagnosis of psychiatric disorders (including Depression, Generalized Anxiety Disorder, Panic Disorder, Phobia, Obsessive Compulsive Disorder, Bipolar Disorder, Eating Disorder, Personality Disorder, Post-Traumatic Stress Disorder and Psychotic Disorder)\n* Youths who receive psychiatric medication (including antidepressants, antipsychotics and antiepileptic drugs)","12 Years","24 Years",{"count":120,"type":23},1300,[26],"This study sets out to evaluate (i) whether the model in phase two can improve symptoms, quality of life, functioning, and psychological outcomes in young people utilising the hub services (n = 600) compared to those in the community controls (n = 600), (ii) the mechanisms that may drive these improvements, and (iii) whether any particular subgroup(s) of youths (e.g., gender, socio-economic status, migrant status) may benefit more from this service model. The experiment group will include 600 hub users who are not currently using psychiatric medications and do not have a formal diagnosis at the time of enrolling in the hub activity. The control group will also comprise of 600 young people, recruited from a community cohort managed by the research team. The community cohort is accessible via the Youth Epidemiological Study Online platform (YES online), which recruits young people aged 12 to 24 years. Only YES online participants who are not using the service of LevelMind@JC and psychiatric medications will be recruited for this study. The two groups will be matched in age, gender, and baseline distress level measured by the 6-item Kessler Psychological Distress Scale (K6). There will also be a substudy assessing the effect of four service models: NLPRA eClinic, Integrated Community Centre for Mental Wellness (ICCMW) step-up care, general practitioners, and hub casework support service on symptom-based mental health outcome, comparing a cohort of young people receiving these four services respectively. A total of 252 participants will be recrruited. Another substudy will be conducted to investigate the extent to which participation in Tier 1 activities contributes to improvements in targeted outcome areas, assessing young people (n = 675) before and after their participation of Tier 1 activities. A consecutive sampling will be used, where a subject who meets the criteria of inclusion will be selected until this required sample size is achieved.",[30],[125],"Youth Mental Health","2025-06-03",{"date":128,"type":39},"2025-06-06",{"date":130,"type":39},"2025-05-06",{"date":132,"type":23},"2028-04-01",{"name":134,"class":46},"The University of Hong Kong",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":24,"phases":144,"briefSummary":145,"conditions":146,"keywords":155,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":176},"100576742","co-occurence-of-mental-illness-and-problematic-alcohol-use-an-internet-based-cognitive-behavior-therapy-intervention-100576742","NCT06789250","Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention","CoMiT","Inclusion Criteria:\n\n* Age ≥18 years\n* AUDIT ≥ 6 points for women and ≥ 8 points for men\n* Symptoms of depression, anxiety disorder and\u002For stress-related illness\n* Adequate ability to speak, read and write Swedish\n* Having access to the internet and a smartphone, computer or other device.\n\nExclusion Criteria:\n\n* Ongoing psychological treatment.\n* Ongoing medication for AUD\n* Recent changes (within the past three months) in psychiatric medication or planned changes during the treatment period. New medication prescribed during the study shall be reported but will not lead to exclusion\n* Severe psychiatric disorders based on a Mini-International Neuropsychiatric Interview (MINI) interview and reported medical history\n* Severe medical conditions that may impede participation in the study\n* Severe cognitive impairment\n* Current suicidality\n* Severe alcohol addiction where specialized treatment is more appropriate\n* Risk for severe alcohol withdrawal symptoms with a need for medical treatment. Participation is possible after completing alcohol withdrawal treatment within the ordinary health-care system, accessible to the Swedish population.\n* Substance use disorder, other than alcohol or nicotine, within the past six months.",{"count":143,"type":23},240,[26],"The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression, anxiety, stress or disturbed sleep.\n\nThe main questions the study aims to answer are:\n\n* Does the ICBT program lower the self-rated suffering from mental illness?\n* Does the ICBT program lower the self-reported alcohol intake? Researchers will compare the ICBT program to the participants who are rancomized to a control grout that receives weekly attention from the research team, to see if the treatment works. In both groups, the participants will have the opportunity to ask for support from a therapist during the week days.\n\nParticipants are adults living in Sweden. They will:\n\n* Receive an ICBT program supported by a trained therapist. It consists of modules that the participants will work with on their computer for 10 weeks. Some modules will be compulsory and other optional for the participants.\n* Fill out forms to rate their mental illness and alcohol intake at the start and the end of the study as well as once every week during treatment.\n\nPrimary outcome measures are depression, anxiety and stress symptoms (measured with Depression Anxiety and Stress Scale 21 (DASS-21)) and alcohol intake measured with self-reported amounts. Other, secondary, outcome measures used will for example be about insomnia symptoms and disability assessment. Pre-treatment measurement, post-treatment measurement and 6-months and 12-months follow up is planned to be collected through an online survey.",[147,148,149,150,30,151,152,153,154],"Alcohol Drinking Related Problems","Alcohol Use Disorders","Depressive Disorders","Mental Illness","Mental and Behavioral Disorders","Sleep Problems","Stress Disorders","Anxiety Disorder\u002FAnxiety State",[156,157,158,159,160,161,94,162,163,164,165],"Internet intervention","Depression","Anxiety","Individually tailored","Transdiagnostic","Internet-based cognitive behavioral therapy (ICBT)","Sleeping disorders","Mental illness","Harmful alcohol use","Alcohol addiction","2025-02-21",{"date":168,"type":39},"2025-02-24",{"date":170,"type":39},"2025-01-05",{"date":172,"type":23},"2026-05",{"name":174,"class":175},"Linkoeping University","OTHER_GOV",2,{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":184,"enrollmentInfo":185,"targetDuration":187,"studyType":188,"phases":4,"briefSummary":189,"conditions":190,"keywords":195,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":176},"100555716","mental-health-of-the-polycrisis-generation-100555716","NCT06515704","Mental Health of the Polycrisis Generation","The Mental Health of Young Adults in Times of Polycrisis","Inclusion Criteria:\n\n* Age between 18 and 29 years\n* Standard educational opportunities\n* Polish fluent\n* Polish nationality\n\nExclusion Criteria:\n\n* Intellectual disability\n* Inability to self-complete the research questionnaires","29 Years",{"count":186,"type":23},600,"12 Months","OBSERVATIONAL","The goal of this observational, longitudinal study is to identify risk and protective factors that buffer the effects of individual daily stress and adaptation to global crises on the quality of life and mental health conditions of young people entering adulthood (aged 18-29, fluent in Polish, and living in Poland). Moderators such as factors related to development, personality variables compatible with the domains according to ICD-11, psychological resilience, closeness in relationships with a partner\u002Ffriends\u002Fparents, and the level of postformal thinking will also be considered.\n\nThe main hypotheses it aims to consider are:\n\nH1: Poorer adaptation to individual and global crises is associated with higher levels of perceived stress, leading to worse indicators of mental health and quality of life.\n\nH2: A higher level of implementation of developmental tasks, including more fulfilled criteria of adulthood and a mature identity, mitigates the relationship between stress\u002F crisis adaptation and health and quality of life indicators.\n\nH3: Resilience and better relationships (closeness with a partner\u002F friends\u002F parents) buffer the negative effect of stress on health and quality of life.\n\nH4: A higher level of postformal thinking mitigates the relationship between stress\u002F crisis adaptation and health and quality of life indicators.\n\nH5: A higher intensity of psychopathological personality traits is a risk factor that amplifies the negative effect of stress on health and quality of life.\n\nResearchers will analyze measurements taken from the same group (a representative sample of Polish young adults) at two time points - now and in 12 months. The aim is to observe the extent to which the effects of current daily stressors and adaptation to the crisis, as well as the effects of potential moderators, are relatively stable.",[94,191,192,193,30,194],"Stress-related Problem","Cumulative Trauma","Mental Health Issue","Quality of Life",[196,197,198,199,200,201,202,203,204,205,206,207],"cumulative stress","quality of life","mental health","young adults","stress syndrome","resilience","closeness relationships","postformal thinking","personality","development","risk factors","protective factors","2025-02-18",{"date":210,"type":39},"2025-02-19",{"date":212,"type":39},"2024-09-01",{"date":214,"type":23},"2025-10-31",{"name":216,"class":46},"Jagiellonian University",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":24,"phases":227,"briefSummary":228,"conditions":229,"keywords":232,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":47},"100445012","virtual-agents-based-digital-interventions-to-improve-health-100445012","NCT05074901","Virtual Agents-based Digital Interventions to Improve Health","Acceptance and Efficacy of a Smartphone-based App Using a Conversational Agent to Monitor Health Status and\u002For Deliver Behavioral Intervention to Reduce Psycho-social Stress","KANOPEE","Inclusion Criteria:\n\n* Being aged 18 years old and over (the app is available for younger users but their data will not be analyzed)\n* having downloaded the app\n* having a smartphone Android or Iphone\n* being located in France\n* having accepted the electronic informed consent\n\nExclusion Criteria:\n\n* having clicked on the \"emergency button\" (in the app, there is a warning message : this app is not for emergency situations. If you need an urgent psychological support, click here\")\n* having downloaded the app but without answering any questionnaire",{"count":226,"type":23},20000,[26],"KANOPEE is a free smartphone application providing screening, follow-up tools and autonomous digital interventions to lower psycho-social stress and its repercussions on sleep and behaviors in the general population.\n\nAdditionally, KANOPEE permits an adaptation of the intervention to the subject (i.e., an adapted waiting period, frequency, and content), enabling to perform innovative trial conditions.\n\nThe objective of this long-term study is to evaluate the efficacy of KANOPEE on users among the French general population exposed to psycho-social stress.",[230,30,231,157,158],"Mental Disorder","Insomnia",[233,234,235,236],"e-health","embodied conversational agent","ecological momentary assessment","ecological momentary intervention","2021-09-29",{"date":239,"type":39},"2021-10-12",{"date":241,"type":39},"2020-04-22",{"date":243,"type":23},"2027-12-31",{"name":245,"class":46},"University of Bordeaux"]