[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolic-inflexibility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolic-inflexibility":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100387094","metabolic-inflexibility-is-related-to-elevated-muscle-anaerobic-glycolysis-100387094",false,"NCT04320264","Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis","Inclusion Criteria:\n\n* 18-50 years old\n* BMI of 25 - 30 kg\u002Fm2\n* BMI \\> 40kg\u002Fm2\n* Lactate levels in top and lower 25%\n\nExclusion Criteria:\n\n* Pregnant women\n* Mentally disabled\n* Prisoners\n* Smokers\n* Subjects with heart disease\n* Type 1 and 2 diabetes\n* Endocrine disease\n* Hypertension\n* Musculoskeletal disease\n* Peripheral occlusion\n* Hepatic disease\n* Have had weight fluctuations exceeding + 3% in the previous 12 months\n* On medications which alter carbohydrate metabolism will not be studied","ALL","18 Years","50 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","The focus of this proposal is on overweight (25\\>BMI\\\u003C30 kg\u002Fm2) subjects, as these individuals exhibit a high risk of becoming obese and\u002For developing metabolic diseases. We hypothesize that in some overweight individuals there is a \"metabolic program\" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.",[24],"Metabolic Inflexibility",[24,26,27],"Obesity","Anaerobic glycolysis","RECRUITING","2025-08-04",{"date":31,"type":32},"2025-08-07","ACTUAL",{"date":34,"type":32},"2020-03-03",{"date":36,"type":20},"2025-12",{"name":38,"class":39},"East Carolina University","OTHER"]