[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolic-syndrome-protection-against\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolic-syndrome-protection-against":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,82,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100362068","animal-and-plant-proteins-and-glucose-metabolism-100362068",false,"NCT03994367","Animal and Plant Proteins and Glucose Metabolism","HP","Inclusion Criteria:\n\n* age: ≥21 and ≤70 years;\n* BMI: \\>24.5 and \\\u003C32.5 kg\u002Fm2;\n* habitual protein intake \\\u003C0.9 g\u002Fkg\u002Fday (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and\n* weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise\u002Fweek) for at least 2 months before entering the study.\n\nExclusion Criteria:\n\n* prediabetes or type 2 diabetes;\n* evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \\\u003C60 ml\u002Fmin\u002F1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg\u002Fg);\n* vegetarians or vegans;\n* intolerance or allergies to ingredients in the metabolic meal or intervention diet;\n* take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;\n* received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;\n* consume tobacco products or excessive alcohol (women: \\>14 drinks\u002Fweek; men: \\>21 drinks\u002Fweek);\n* evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and\n* unwilling or unable to provide informed consent.",true,"ALL","21 Years","70 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.",[28,29,30],"Metabolic Syndrome","Metabolic Syndrome, Protection Against","Glucose Metabolism Disorders",[32,33,34],"High Protein","Metabolism","Diet","RECRUITING","2026-05-05",{"date":38,"type":39},"2026-05-08","ACTUAL",{"date":41,"type":39},"2019-07-12",{"date":43,"type":22},"2028-04-25",{"name":45,"class":46},"University of Missouri-Columbia","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100523714","strong-families-start-at-homefamilias-fuertes-comienzan-en-casa-100523714","NCT06099288","Strong Families Start at Home\u002FFamilias Fuertes Comienzan en Casa","Strong Families Start at Home\u002FFamilias Fuertes Comienzan en Casa: A Novel Video and Motivational Interviewing Intervention to Improve Diet Quality of Low-income, Ethnically Diverse Children","Inclusion Criteria:\n\n* At least 18 years old\n* Self-identity as Latinx\u002FHispanic\n* Speak English or Spanish\n* Be the primary caregiver of a child between 2- 5 years of age\n* Live with the child most of the time\n* Eat a minimum of three evening meals per week with the child\n* Not have participated in the R34 study\n* Have a smart phone\n* Be willing to have a meal video recorded in the home\n\nExclusion Criteria:\n\n* A doctor or WIC provider has told them that their child was underweight in the past 6 months\n* The child has a diagnosed feeding disorder or dietary restriction that impacts how they eat","18 Years",{"count":57,"type":22},257,[25],"The goal of this clinical trial is to test the ability of a home-based parental nutrition intervention to improve diet quality in preschool aged children within low-income, Latinx\u002FHispanic families. The main questions it aims to answer are:\n\n* Does this enhanced intervention change children's diet quality?\n* Does this enhanced intervention change parental feeding practices?\n* Does this enhanced intervention change the availability of healthy foods in the home?\n\nParticipants will:\n\n* Work with a support coach\n* Have a home visit with a support coach once a month, for three months\n* Have a phone call with a support coach once a month, for three months\n* Receive written materials and text messages over the six months\n\nResearchers will compare a control group receiving different written materials and messages to see if the enhanced intervention changes diet quality in children.",[29,61],"Diet, Healthy",[63,64,65,66,67,68,69,70,71,72],"Motivational Interview","Home-Based","Intervention","Latinx","Families","Nutrition","Cultural Tailoring","Social Cognitive Theory","Self-Determination Theory","Self-Perception Theory","2025-05-06",{"date":75,"type":39},"2025-05-07",{"date":77,"type":39},"2024-01-01",{"date":79,"type":22},"2027-11-01",{"name":81,"class":46},"Brown University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":16,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":47},"100562648","optimized-tailored-interventions-in-metabolic-and-lifestyle-outcomes-optimal-100562648","NCT06605898","Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)","Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes: Examining the Effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay(MIND) on Cognitive Performance, Metabolic Health and Lifestyle Outcomes Using Advanced Machine Learning Strategies","Inclusion Criteria:\n\n* 45-64 years of age\n* 20\u002F20 or corrected vision\n* No food allergies or intolerances\n* Not pregnant, lactating, or have given birth in the past 12 months\n* Do not smoke, use tobacco, or abuse drugs\n* Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer\n* Not currently taking oral hypoglycemic agents, or insulin\n* No history of malabsorptive or bariatric surgery\n* Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Able to consume the study meals\n* Not enrolled in another dietary, exercise, or medication study during the study.\n\nExclusion Criteria:\n\n* Non-consent of participant\n* Above 64 or below 45 years of age\n* Vision not 20\u002F20 or corrected\n* Food allergies or intolerances\n* Pregnant, lactating, or have given birth in the past 12 months\n* Smoke, use tobacco, or abuse drugs\n* Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer\n* Currently taking oral hypoglycemic agents or insulin\n* History of malabsorptive or bariatric surgery\n* Cognitively impaired and\u002For prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Unable to consume the study meals\n* Concurrent enrollment in another dietary, exercise, or medication study","45 Years","64 Years",{"count":92,"type":22},72,[25],"The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults. Our research team will evaluate three different groups: the first group will be chosen using a predictive analytics model that predicts who will benefit most from the MIND diet, the second group will follow the MIND diet without being pre-selected, and the third group will eat a standard healthy diet to serve as a comparison.\n\nThe main questions it aims to answer are:\n\nDoes the MIND diet improve cognitive performance and heart health relative to a control diet? How does the health impact of the MIND diet in participants pre-identified through predictive analytics compare to those without such pre-selection? Which of the three groups - predictive analytics selected MIND diet group, standard MIND diet group, or healthy control - demonstrate the most significant improvements in cognitive and cardiovascular health over the course of the trial?\n\nParticipants will:\n\nConsume one meal that follows the MIND diet or a control meal every day for 3 months. Visit the lab before and after the 3 months of meals for tests. Keep a record of the food they eat during the study.",[96,61,29],"Cognitive Change",[98,99,100],"Executive function","MIND","Dietary Pattern","2024-09-18",{"date":103,"type":39},"2024-09-20",{"date":105,"type":39},"2024-07-03",{"date":107,"type":22},"2027-12-31",{"name":109,"class":46},"University of Illinois at Urbana-Champaign",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":16,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":130,"locationsCount":4},"100549732","nutritional-intervention-for-sustaining-health-nurish-trial-100549732","NCT06437860","Nutritional Intervention for Sustaining Health (NURISH) Trial","Nutritional Intervention for Sustaining Health (NURISH) Trial: Examining the Effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) on Cognitive Performance, Metabolic Health, and Nutrient Status.","Inclusion Criteria:\n\n* 45-64 years of age\n* 20\u002F20 or corrected vision\n* No food allergies or intolerances\n* Not pregnant, lactating, or have given birth in the past 12 months\n* Do not smoke, use tobacco, or abuse drugs\n* Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer\n* Not currently taking oral hypoglycemic agents, or insulin\n* No history of malabsorptive or bariatric surgery\n* Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Able to consume the study meals\n* Not enrolled in another dietary, exercise, or medication study during the study\n\nExclusion Criteria:\n\n* Non-consent of participant\n* Above 64 or below 45 years of age\n* Vision not 20\u002F20 or corrected\n* Food allergies or intolerances\n* Pregnant, lactating, or have given birth in the past 12 months\n* Smoke, use tobacco, or abuse drugs\n* Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer\n* Currently taking oral hypoglycemic agents or insulin\n* History of malabsorptive or bariatric surgery\n* Cognitively impaired and\u002For prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Unable to consume the study meals\n* Concurrent enrollment in another dietary, exercise, or medication study",{"count":92,"type":22},[25],"The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults.The main questions it aims to answer are:\n\nDoes the MIND diet improve cognitive performance and heart health relative to a control diet?\n\nResearchers will compare the MIND diet group to a control (a healthy diet that does not match the MIND diet) to see if the MIND provides more benefit to health.\n\nParticipants will:\n\nConsume one meal that follows the MIND diet or a control meal every day for 3 months Visit the lab before and after the 3 months of meals for tests. Keep a record of the food they eat during the study.",[96,29,61],[98,99,122],"Dietary pattern","NOT_YET_RECRUITING","2024-05-24",{"date":126,"type":39},"2024-05-31",{"date":128,"type":22},"2024-06-03",{"date":107,"type":22},{"name":109,"class":46}]