[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolism-lipids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolism-lipids":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100591039","phase-4-observing-metabolism-of-epa-with-consideration-of-genetics-and-sex-100591039",false,"NCT06975241","Observing Metabolism of EPA With Consideration of Genetics And Sex","Determining Contribution of Sex and Genetics to DHA Synthesis Rates Over 12 Weeks of EPA Supplementation in Healthy Individuals","OMEGA","Inclusion Criteria:\n\n* BMI between 18.5- 30 kg\u002Fm2\n* healthy\n\nExclusion Criteria:\n\n* Consumption of fish\u002Fseafood or EPA\u002FDHA-enriched foods currently or within the previous 6 months\n* Consumption of any supplements containing ALA\u002FEPA\u002FDHA currently or within the previous 6 months\n* Allergies to any component of the study supplement (fish, gelatin etc.)\n* BMI \\\u003C18.5 kg\u002Fm² or \\>30 kg\u002Fm²\n* Women who are pregnant, breastfeeding or planning on becoming pregnant\n* Diagnosis with chronic or communicable diseases\n* Prescription of chronic pharmacological medications (except for oral contraceptives)\n* High blood pressure (systolic or diastolic blood pressure above 130 or 80mmHg, respectively)\n* Hypertriglyceridemia (serum \\> or = 1.69 mmol\u002Fl)\n* Hypercholesterolemia (serum LDL-C \\> or =5 mmol\u002Fl)\n* Anticipated changes in lifestyle within the next 4 months\n* Smoking\n* Heavy alcohol use (\\>3 drinks\u002Fday)\n* Major surgery in the last six months",true,"ALL","18 Years","35 Years",{"count":22,"type":23},64,"ESTIMATED","INTERVENTIONAL",[26],"PHASE4","The goal of this clinical study is to learn how fast EPA is converted to other molecules, including DHA, with consideration of biological sex and genetics in healthy humans.\n\nThe main questions it aims to answer are:\n\n* How fast is EPA converted to DHA in blood, and is the conversion rate affected by sex and a specific genotype we previously identified?\n* How do sex and the specific genotypes affect blood DHA levels and other products of DHA in response to dietary EPA?\n* How fast does dietary EPA replace blood EPA and other omega-3 fatty acids, and is the rate affected by sex and genotype?\n\nParticipants will be asked to take EPA supplements for 12 weeks and provide a series of venous blood samples over the study duration.",[29,30,31],"Healthy","Omega 3","Metabolism, Lipids",[33,34,35,36,37,38,39],"eicosapentaenoic acid","omega-3 polyunsaturated fatty acids","lipid metabolism","healthy adults","docosahexaenoic acid","single nucleotide polymorphism","elongation of very long-chain 2","RECRUITING","2026-02-25",{"date":43,"type":44},"2026-02-27","ACTUAL",{"date":46,"type":44},"2025-07-29",{"date":48,"type":23},"2026-09",{"name":50,"class":51},"University of Toronto","OTHER"]