[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolism-medication-toxicity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolism-medication-toxicity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100580459","methadone-dose-monitoring-with-a-remote-medication-monitor-100580459",false,"NCT06837571","Methadone Dose Monitoring With a Remote Medication Monitor","Assessment of Methadone Dose Taken","Inclusion Criteria:\n\n* Age 18-70\n* A prescription for methadone at a dose of 10mg or more for at least one week.\n* Taking methadone as prescribed during the last 4 days before consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70\n* A condition preventing or complicating ISF collection\n* dermatological (skin) condition\n* immunodeficiency\n* recent blood donation\n* anemia\n* end stage renal disease\n* liver cirrhosis\n* cancer\n* congestive heart failure\n* bleeding diathesis\n* tuberculosis (TB)\n* Any active severe depression\n* suicidal ideation\n* mania symptoms\n* Pregnancy\n* Intending to become pregnant during the course of the study\n* Enrolled in a substance use disorder treatment program\n* Under a conservatorship.","ALL","18 Years","70 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","Proof of concept: Pilot Study\n\nA Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication adherence monitor and would allow for the physician, counselor, patient, or family member to remotely verify that a physician-prescribed dose has been taken.",[25,26,27,28,29],"Methadone Toxicity","Methadone Overdose","Pain, Chronic","Drug Metabolism, Poor, CYP2D6-Related","Metabolism Medication Toxicity",[31],"Pharmacokinetics","NOT_YET_RECRUITING","2025-02-15",{"date":35,"type":36},"2025-02-20","ACTUAL",{"date":38,"type":21},"2025-04-26",{"date":40,"type":21},"2025-06",{"name":42,"class":43},"Cari Health Inc.","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":51,"keywords":52,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":44},"100514674","assessment-of-methadone-dose-taken-100514674","NCT05981573","Inclusion Criteria:\n\n* Age 18-70\n* A prescription for methadone for chronic pain at a dose of 10mg or more for at least one week.\n* Taking methadone as prescribed during the last 4 days before consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70\n* A condition preventing or complicating ISF collection\n* dermatological (skin) condition\n* immunodeficiency\n* recent blood donation\n* anemia\n* end stage renal disease\n* liver cirrhosis\n* cancer\n* congestive heart failure\n* bleeding diathesis\n* tuberculosis (TB)\n* Any active severe depression\n* suicidal ideation\n* mania symptoms\n* Pregnancy\n* Intending to become pregnant during the course of the study\n* Enrolled in a substance use disorder treatment program\n* Under a conservatorship.",{"count":20,"type":21},[25,26,27,28,29],[31],"RECRUITING","2025-02-11",{"date":56,"type":36},"2025-02-13",{"date":58,"type":36},"2024-08-26",{"date":60,"type":21},"2026-04",{"name":42,"class":43}]