[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolome":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,100,133,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100633895","microbiome-and-metabolome-profiles-in-couples-undergoing-ivf-and-reproductive-outcomes-100633895",false,"NCT07532629","Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes","Microbiome and Metabolome Profiles in Couples Undergoing IVF and Their Association With Reproductive Outcomes in a Prospective Longitudinal Cohort Study","Mi IVF","Inclusion Criteria:\n\n* Women aged 18 to 40 years at enrolment.\n* Men aged between 18 to 56 years at enrolment.\n* Couples planning to undergo IVF treatment at a participating centre.\n* Sufficient understanding of spoken and written Swedish or English to provide informed consent and complete the web-based questionnaire.\n\nExclusion Criteria:\n\n* Pregnancy at the time of enrolment (confirmed or suspected).\n* Recent systemic antibiotic use within the past 4 weeks\n* Active vaginal or genital tract infection at the time of sampling",true,"ALL","18 Years","40 Years",{"count":22,"type":23},1000,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization. Biological samples will be collected from both female and male partners, including semen, vaginal, and blood samples, to characterize microbial composition and metabolic profiles. The study aims to examine how these biological profiles are associated with reproductive outcomes such as fertilization, pregnancy, miscarriage, and live birth. Participants will be followed longitudinally, and reproductive and obstetric outcomes will be obtained through linkage with national health registers.",[27,28,29,30,31,32],"Infertility","Assisted Reproductive Technology","Pregnancy Complications","Pregnancy Loss, Early","Metabolome","Microbiome",[34,32,31,35,36],"IVF","Male fertility","Pregnancy outcome","RECRUITING","2026-04-13",{"date":40,"type":41},"2026-04-16","ACTUAL",{"date":43,"type":41},"2022-06-10",{"date":45,"type":23},"2029-03-01",{"name":47,"class":48},"Karolinska Institutet","OTHER",3,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":74,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100628100","probiotic-research-open-label-functional-intervention-and-longitudinal-evaluation-in-healthy-adults-100628100","NCT07457242","Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults","PROFILE","Inclusion Criteria:\n\n* Aged 18 years or older at the time of providing informed consent.\n* In generally good health, with no known medical conditions that could interfere with the aims of the study or participant safety, as judged by self-report and screening questionnaire.\n* No history of significant psychiatric or neurological illness\n* Ability to complete study specific tasks, including:\n* Daily oral intake of a probiotic capsule\n* Self-collection of stool samples\n* Completion of online questionnaires and simple cognitive tasks\n* Able to read, understand, and communicate in English, in order to give informed consent and follow study instructions.\n* Access to the internet and a suitable device (e.g., smartphone, tablet, or computer) for completing online aspects of the study.\n\nExclusion Criteria:\n\n* Participants will be excluded from the study if any of the following criteria apply:\n* Use of any systemic antibiotic or systemic immunosuppressive medication within the past 8 weeks, including but not limited to:\n* β-lactam antibiotics, macrolides, tetracyclines, fluoroquinolones, aminoglycosides, glycopeptides, sulfonamides, antimycobacterial agents, systemic antifungals or antivirals\n* Use of any systemic immunosuppressants within the past 16 weeks, including, but not limited to:\n* Systemic corticosteroids, conventional immunosuppressants, biologic immunomodulators, targeted synthetic immunosuppressants, cytotoxic chemotherapy, or transplant-related immunosuppression.\n* A longer exclusion window is applied for systemic immunosuppressive therapies due to their prolonged and potentially lasting effects on immune function and gut microbial composition compared with systemic antibiotics.\n* Participants who commence systemic antibiotics or immunosuppressive therapy after enrolment will not be withdrawn from safety monitoring but will stop the supplement and will not continue the intervention phase of the study. With participant consent, data collected may still be used.\n* Major gastrointestinal disease or surgery:\n* Any history of significant gastrointestinal disease or surgery that may alter gut microbiome composition, immune function, or nutrient absorption, including but not limited to inflammatory bowel disease (Crohn's disease, ulcerative colitis, indeterminate colitis); coeliac disease or other chronic malabsorptive disorders; chronic liver, biliary, or pancreatic disease; moderate-to-severe or unstable irritable bowel syndrome; gastrointestinal malignancy; chronic gastrointestinal motility disorders; recurrent Clostridioides difficile infection; or any major gastrointestinal surgery such as bowel resection, bariatric surgery, colectomy, ileostomy or colostomy. Prior appendectomy or cholecystectomy alone is not exclusionary.\n* Current pregnancy or development of pregnancy, breastfeeding\n* Known allergy to probiotic or compounding ingredients:\n* Vitamin D3\n* Isomaltooligosaccharide\n* Yeast extract",{"count":58,"type":23},180,"INTERVENTIONAL",[61],"NA","This study is a pre-post, open-label cohort study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults. Participants will take one capsule daily for either 1 month or 6 months.\n\nDuring the study, participants will complete online cognitive tasks and provide blood and stool samples collected during home visits by trained staff. The samples will be analysed to explore changes in gut bacteria and other biological markers.\n\nThis study aims to understand whether the supplement is well tolerated and whether measurable biological changes occur. The study does not involve any experimental drugs or invasive procedures beyond blood sampling and stool collection, and participants will not be asked to change any current prescribed medications or treatments; with eligibility exclusions applying for recent antibiotics or immunosuppressants. The supplement is being studied for research purposes only and is not intended to diagnose, treat, or prevent disease. Participants will be invited to participate in a follow-up visit to assess long-term effects.",[64,65,66,31,67,68,69,70,71,72,73],"Cognition","Multiomics","Microbiome Analysis","Proteome","Metagenome","Probiotics Supplement","Gut-brain Axis","Pilot Study","Adult","Sleep",[75,76,32,77,78,79,80,81,82,83,84,85,86,87,88],"Probiotics","Dietary Supplements","Multi-omics","Metabolomics","Proteomics","Mitochondrial Function","Cellular Metabolism","Short-Chain Fatty Acids","Bioinformatics","Healthy volunteers","Pilot study","feasibility study","cognitive function","mental health","NOT_YET_RECRUITING","2026-03-03",{"date":92,"type":41},"2026-03-09",{"date":94,"type":23},"2026-07-01",{"date":96,"type":23},"2027-07-01",{"name":98,"class":99},"OneCarbon","INDUSTRY",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":18,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":59,"phases":112,"briefSummary":113,"conditions":114,"keywords":120,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100593652","lifestyle-interventions-to-prevent-cognitive-deficits-in-subjects-with-depressive-symptoms-from-mechanisms-to-clinical-practice-100593652","NCT07009223","Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice","Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice","POWER","Inclusion Criteria:\n\n* Aged between 50 and 80 years;\n* Diagnosis of DDM according to DSM-5 or depressive symptoms (PHQ-9 or GDS-15 ≥ 5, the choice of test will be justified by the participant's age);\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Active gastrointestinal disorders;\n* Autoimmune disorders;\n* Chronic inflammatory disorders;\n* Diagnosis of dementia; cognitive impairment or mild functional impairment.\n* Use of antibiotics and\u002For anti-inflammatory drugs in the 8 weeks prior to the screening visit.","50 Years","80 Years",{"count":111,"type":23},120,[61],"The goal of this clinical study is to investigate if lifestyle changes can help prevent cognitive decline and reduce depressive symptoms in people between the ages of 50 and 80 with depressive symptoms or a diagnosis of major depression, but without signs of cognitive decline.\n\nThe main questions it aims to answer are:\n\n* Does regular physical activity improve mood and memory in people who are depressed or have depressive symptoms?\n* Does cognitive training help prevent mental difficulties in people at risk of cognitive decline?\n* Do changes in diet and lifestyle alter the composition of the gut microbiota and immuno-related infiammatory factors?\n\nResearchers will compare three different treatment groups to see which intervention is most effective in improving mental and cognitive health.\n\nThe participants:\n\n* Will take part to online sessions on healthy eating based on the Mediterranean diet\n* Some will do regular exercise, supervised by a personal trainer\n* Others will do weekly cognitive training in small groups at the hospital\n* They will provide blood and fecal samples and complete cognitive tests and clinical questionnaires at the beginning, at the end of the treatment (12 weeks), and after 3 months.",[115,116,117,31,118,119],"Major Depressive Disorder (MDD)","Physical Activity","Inflammation","Gut Microbiota","Depressive Symptoms",[121,64,122],"Depression","nutrition","2026-02-09",{"date":125,"type":41},"2026-02-11",{"date":127,"type":41},"2025-10-01",{"date":129,"type":23},"2028-03",{"name":131,"class":48},"IRCCS Centro San Giovanni di Dio Fatebenefratelli",1,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":17,"sex":141,"minAge":142,"maxAge":20,"enrollmentInfo":143,"targetDuration":4,"studyType":59,"phases":145,"briefSummary":146,"conditions":147,"keywords":154,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":132},"100569196","how-a-single-workout-affects-gut-bugs-in-women-with-different-fitness-levels-and-body-types-100569196","NCT06691100","How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types","The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes","FITGut-W","Inclusion Criteria:\n\n* Biological sex: female\n* BMI 19 to 24.99 kg\u002Fm2 or BMI 30-40 kg\u002Fm2\n* Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)\n* Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).\n\nExclusion Criteria:\n\n* Biological sex: male\n* BMI \\\u003C 19 kg\u002Fm2 or \\> 40 kg\u002Fm2\n* Currently pregnant, \\\u003C 2 years postpartum, lactating\n* Currently taking any herbal, fiber, or prebiotic supplement\n* Current or 1-month before the study, taking oral or vaginal antibiotics\n* Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.","FEMALE","21 Years",{"count":144,"type":23},40,[61],"This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w\u002Fo obesity). The specific aims are as follows:\n\n* Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity.\n* Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.",[148,149,150,151,152,31,153,118],"Weight Management","Obesity","Exercise","Women","Gut Microbiome","Health",[118,155,150,148,149],"Womens Health","2025-07-22",{"date":158,"type":41},"2025-07-24",{"date":160,"type":41},"2024-10-16",{"date":162,"type":23},"2027-10-16",{"name":164,"class":48},"George Washington University",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":17,"sex":141,"minAge":19,"maxAge":20,"enrollmentInfo":172,"targetDuration":174,"studyType":24,"phases":4,"briefSummary":175,"conditions":176,"keywords":181,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":194},"100449036","impact-of-the-microbiome-on-time-to-pregnancy-and-pregnancy-outcomes-in-fertile-women-attempting-to-conceive-100449036","NCT05127252","Impact of the Microbiome on Time to Pregnancy and Pregnancy Outcomes in Fertile Women Attempting to Conceive","SweBioFertil","Inclusion Criteria:\n\n* Women with a previous live birth in the past 5 years and planning a new pregnancy with the same male partner.\n* 18-40 years of age\n* Swedish personal identity number and a Swedish address (to send a sampling self-kit)\n* Sufficient understanding of spoken and written Swedish or English to provide informed consent and complete the web-based questionnaire.\n\nExclusion Criteria:\n\n* Women who do not have a child yet and plan to cease their contraception.",{"count":173,"type":23},500,"2 Years","This study aims to investigate the microbiome of women with previously proven fertility who plan to become pregnant.",[29,177,178,179,180,31],"Contraception","Pregnancy Loss","Fertility","Microbial Colonization",[182,183,184,185],"cohort","fertility","microbiome","microbiota","2023-05-26",{"date":188,"type":41},"2023-05-30",{"date":190,"type":41},"2023-04-10",{"date":192,"type":23},"2026-12-30",{"name":47,"class":48},2]