[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metastases-to-brain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metastases-to-brain":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100624902","motor-eloquent-navigated-transcranial-magnetic-stimulation-for-radiosurgery-planning-100624902",false,"NCT07415668","Motor Eloquent Navigated Transcranial Magnetic Stimulation for Radiosurgery Planning","MENTOR","Inclusion Criteria:\n\n1. Informed consent\n2. Age ≥ 18 years\n3. Cerebral metastasis within or adjacent to the primary motor cortex (≤10 mm)\n4. Resection of tumor\n5. Eligible for and planned to undergo postresection radiosurgery at Inselspital Bern\n\nExclusion Criteria:\n\n1. Contraindication to TMS (e.g. Cochlear Implant, other metallic or electrical implants, excluding teeth and post craniotomy, Meniere's disease, pacemaker, deep brain stimulation electrodes, refractory convulsion, symptomatic tinnitus, depression diagnosed by a specialist, psychosis)\n2. Prior cerebral radiation therapy within the affected precentral gyrus\u002Faffecting the planned SRS plan\n3. Planned whole brain radiotherapy\n4. Second lesion within 2 cm ipsilateral in the primary motor cortex\n5. Infection or difficulties in wound healing within the last two weeks prior inclusion\n6. Pregnancy","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","With this project, the study group wants to investigate whether a postoperative navigated transcranial magnetic stimulation (nTMS) motor map can improve stereotactic radiosurgery (SRS) planning in patients who underwent resection for a brain metastasis near the primary motor cortex. Specifically, the map could allow for more precise location of motor eloquent tissue, thereby minimizing the radiation dose on these areas while preserving high radiation dose on target tissue (i.e. tumor cells).",[26],"Metastases to Brain",[28,29,30],"metastasis","Navigated Transcranial Magnetic Stimulation (nTMS)","Stereotactic Radiosurgery (SRS)","RECRUITING","2026-04-23",{"date":34,"type":35},"2026-04-29","ACTUAL",{"date":37,"type":20},"2026-05-08",{"date":39,"type":20},"2029-10-31",{"name":41,"class":42},"Insel Gruppe AG, University Hospital Bern","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100475718","concurrent-fluorescence-and-sonographically-guided-eradication-of-contrast-enhancing-gliomas-and-metastases-100475718","NCT05474573","Concurrent Fluorescence and Sonographically Guided Eradication of Contrast-enhancing Gliomas and Metastases","Concurrent Fluorescence and Sonographically Guided Eradication of Gliomas and Metastases Enhancing Contrast Agent in Magnetic Resonance Imaging: a Randomised, Controlled Trial","CONFLUENSE","Inclusion Criteria:\n\n* single gliomas with contrast enhancement in preoperative magnetic resonance imaging (presumed high-grade gliomas)\n* one or several brain metastases from any cancer\n* newly diagnosed\n* Karnofsky Performance Status 60-100%\n* age 18-79 years\n* performed magnetic resonance imaging with contrast enhancement\n\nExclusion Criteria:\n\n* tumor spreading to corpus callosum or brainstem\n* previously performed brain radiotherapy\n* planned supratotal tumor resection until neurophysiologically revealed eloquent areas\n* known hypersensibility to 5-aminolevulinic or to porphyrin\n* hepatic or renal insufficiency\n* porphyria\n* pregnancy\n* breast feeding","79 Years",{"count":54,"type":20},52,[23],"Objective of the study is to determine whether combined use of intraoperative fluorescence with 5-aminolevulinic acid (5-ALA) and sonography can achieve higher rate of gross total resection of contrast-enhancing gliomas and brain metastases compared to intraoperative fluorescence with 5-ALA alone.",[58,26],"Glioma, Malignant",[60,61,62,63,64,65,66],"contrast-enhancing glioma","brain metastasis","sonography","ultrasound","fluorescence","5-aminolevulinic acid","5-ALA","2025-05-13",{"date":69,"type":35},"2025-05-16",{"date":71,"type":35},"2022-09-01",{"date":73,"type":20},"2027-08-31",{"name":75,"class":76},"Sklifosovsky Institute of Emergency Care","OTHER_GOV"]