[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microbiomeimmune-function-critically-ill\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microbiomeimmune-function-critically-ill":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100573684","the-gut-microbiome---source-of-sepsis-and-novel-target-in-intensive-care-units-100573684",false,"NCT06749483","The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?","The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units? Research on Human Tissue, Body Fluids, Neuropsychological Assessment and Brain Imaging","MS-ICU","Inclusion Criteria:\n\n* Age ≥ 18 years\n* One of the following criteria\n\n  1. Critically ill patients treated with meropenem or piperacillin\u002Ftazobactam started within the last 72 h\n  2. Critically ill patients without systemic antimicrobial therapy within the last 72 hours and an expected ICU length of stay of more than 3 days\n  3. Long-term survivors of sepsis, e.g. from pre-existing sepsis cohorts\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Major bowel resection\n* Selective decontamination of the oral and digestive tract\n* Oral vancomycin therapy\n* Immunocompromised patients\n* History of chemotherapy during the last 6 months.\n* Known travel history to countries to areas of high antimicrobial resistance (\\>5% according to the report of the European Centre for Disease Prevention and Control and all countries except USA and Canada) within the last 4 weeks\n* Acute neurological diseases (e.g., brain ischemia, hemorrhage, meningoencephalitis, tumor)\n* Manifest dementia, pre-existing psychiatric diseases (schizophrenia, psychosis)\n* Acute brain surgery\n* MRI contraindications: pacemakers, hearing aids, neurostimulation, insulin pumps, other potentially ferromagnetic implants, screws, clips, prostheses, metal splinters, etc., pregnancy, claustrophobia, extensive tattoos.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.",[25,26,27,28,29,30],"Critical Illness","Intensive Care Unit Delirium","Neurocognitive Deficit","Microbiome,immune Function, Critically Ill","Infection in ICU","Sepsis",[32,33,34,35,36,37,38],"sepsis","broad-spectrum antibiotics","stool","neuropsychological assessment","delirium","neurocognitive impairment","microbiome","RECRUITING","2024-12-27",{"date":42,"type":43},"2024-12-30","ACTUAL",{"date":40,"type":43},{"date":46,"type":21},"2026-12-31",{"name":48,"class":49},"Jena University Hospital","OTHER","Microbiome,Immune Function, Critically Ill"]