[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microcirculation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microcirculation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,51,79,102,134,157,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100530991","icu-combined-assessment-of-cardio-respiratory-exercise-100530991",false,"NCT06193980","ICU Combined Assessment of Cardio-Respiratory Exercise","Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness","ICU-CARE","Inclusion Criteria:\n\n* Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Trajectory of health expected to be significantly limited in the upcoming 12 months\n* those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity\n* have significant orthopedic or musculoskeletal impairment affecting mobility\n* have a medical history of neuromuscular disease\n* ongoing respiratory limitations (i.e., supplemental oxygen)\n* significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)\n* a body mass index (BMI) of ≥ 40 kg\u002Fm2 (impacting NIRS signal due to adipose tissue thickness)\n* if participant's primary residence is a significant distance from the participating study site","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness\u002Fdysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.",[25,26,27,28,29],"ICU Acquired Weakness","Sepsis","Shock","Critical Illness","Microcirculation",[31,32,29,33,34,35,36,37],"ICU Survivors","Oxygen Delivery","skeletal muscle","Exercise","near-infrared spectroscopy","cardiopulmonary exercise test","cardiovascular physiology","RECRUITING","2026-06-11",{"date":41,"type":42},"2026-06-15","ACTUAL",{"date":44,"type":42},"2023-12-15",{"date":46,"type":21},"2029-12",{"name":48,"class":49},"University of Manitoba","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":50},"100635619","correlation-between-capillary-refill-time-and-perfusion-index-in-critically-ill-patients-100635619","NCT07555041","Correlation Between Capillary Refill Time and Perfusion Index in Critically Ill Patients","Correlation Between Capillary Refilling tIme and Perfusion Index in Critically Ill Patients","CRIPI","Inclusion criteria :\n\n* Adult patient.\n* Admission within the previous 24 hours, or within 24 hours of the onset of a hemodynamic instability criterion (requirement for vasopressors or fluid resuscitation).\n* Absence of patient objection.\n\nExclusion criteria :\n\n* Legal guardianship, curatorship, or judicial protection.\n* No social security coverage.\n* Morphological abnormalities preventing CRT and IP measurements.",{"count":60,"type":21},250,"Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients.\n\nCRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. CRT is defined as the time, in seconds, required for the skin surface to return to its initial color after release of pressure.\n\nAlthough CRT is a monitoring tool used on a daily basis in emergency departments and critical care units, its practical measurement modalities remain poorly standardized and time-consuming. Consequently, there is no consensus regarding the most reproducible bedside method for CRT assessment. Moreover, repeated CRT measurements during patient management are resource-intensive in terms of medical time and may raise issues related to healthcare staff availability.\n\nThe perfusion index (PI) is a marker of tissue perfusion derived from a pulse oximetry sensor. This monitoring device is routinely used in all critically ill patients. It is placed on the finger and worn continuously, including during patient transport.\n\nBecause PI measurement is automatic and continuous, establishing its correlation with CRT could allow for more precise tissue perfusion monitoring while reducing the time burden associated with bedside assessments in critically ill patients.",[63,64,29,65],"Shock State","Hemodynamics Instability","Monitoring",[67,68,29,69],"Capillary refill time","Perfusion index","Intensive care","2026-04-30",{"date":72,"type":42},"2026-05-01",{"date":74,"type":42},"2026-04-29",{"date":76,"type":21},"2027-05-29",{"name":78,"class":49},"Hospices Civils de Lyon",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100631340","evaluation-of-the-microcirculatory-response-to-fluids-in-critically-ill-patients-with-venous-congestion-a-prospective-observational-study-100631340","NCT07499401","Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study","MICRO-CONGEST","Inclusion Criteria:\n\n* Critically ill patients admitted to the intensive care unit\n* Invasive or minimally invasive hemodynamic monitoring\n\nExclusion Criteria:\n\n* Suspected or confirmed pregnancy\n* Inability to access the oral cavity (e.g., facial trauma, oral bleeding)",{"count":87,"type":21},30,"The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion",[90,29,91],"Venous Congestion","Volume Expansion","2026-03-28",{"date":94,"type":42},"2026-04-02",{"date":96,"type":42},"2024-12-15",{"date":98,"type":21},"2026-06",{"name":100,"class":49},"Università Politecnica delle Marche",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100586093","hemodynamic-evaluation-using-microcirculation-for-early-treatment-of-septic-patients-100586093","NCT06910891","Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients","HEMOCAP","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Admitted to the Emergency Department for suspected Sepsis for less than 6 hours according to international Sepsis-3 definitions (high probability of infection defined by a fever greater than or equal tol to 38.3°C with a suspected infectious source + Score NEWS 2 greater than or equal to 2)\n3. Affiliated to a social security system\n4. Having agreed to participate in this study\n\nExclusion Criteria:\n\n1. Patient with arterial hypotension (SBP ≤ 100 mmHg) on admission\n2. Patient having already received a 500mL filling test over 30 minutes\n3. Patients moribund according to the investigator\n4. Pregnancy or breastfeeding\n5. Patient under guardianship, curatorship or safeguard of justice",{"count":110,"type":21},556,"INTERVENTIONAL",[113],"NA","Despite early treatment, the deterioration and mortality of sepsis patients remains high. A possible explanation could be persistent tissue hypoperfusion, or undetected in the early phase despite the normalization of macro-hemodynamic parameters. This interventional study evaluates the impact of measuring microcirculation parameters by nurses on patient prognosis through early initiation of vascular filling.",[26,116,29],"Emergency Care",[118,119,120,121,122,123],"microcirculation","septic patient","organ dysfunction","sepsis","peripheral perfusion index","emergency unit","2025-11-18",{"date":126,"type":42},"2025-11-21",{"date":128,"type":42},"2025-09-20",{"date":130,"type":21},"2027-03-28",{"name":132,"class":49},"University Hospital, Limoges",6,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":111,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":101},"100485858","the-impact-of-intra-operative-fluid-infusion-rate-on-microcirculation-100485858","NCT05606536","The Impact of Intra-operative Fluid Infusion Rate on Microcirculation","The Impact of Intra-operative Fluid Infusion Rate on Hemodilution and Microcirculation Prospective Observational Pilot Study","Inclusion Criteria:\n\n* elective recumbent and laparoscopic surgery\n* informed consent\n\nExclusion Criteria:\n\n* blood loss over 250 ml\n* hemodynamic instability requiring noradrenaline infusion",{"count":142,"type":21},80,[113],"Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. For elective surgery that is not associated with higher blood loss and a long period of preoperative fasting, including fluids IFT is dosed to cover the basal daily need for fluids. However, it is not clear whether this fluid dose is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG). EG binds a significant amount of plasma, which is released during EG destruction and causes relative hemodilution.\n\nIsovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected. However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome.",[146,29,147],"Fluid Therapy","Hemodilution","2025-03-24",{"date":150,"type":42},"2025-03-27",{"date":152,"type":42},"2022-10-01",{"date":154,"type":21},"2025-12-31",{"name":156,"class":49},"University Hospital Hradec Kralove",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":164,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":111,"phases":167,"briefSummary":168,"conditions":169,"keywords":172,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":50},"100577556","urethral-perfusion-index-guided-hemodynamic-management-in-patients-having-major-abdominal-surgery-the-upright-randomized-feasibility-trial-100577556","NCT06799832","Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial","UPRIGHT","Inclusion Criteria:\n\n* at least 45 years old\n* scheduled for elective major abdominal surgery (involving visceral organs with an expected duration of at least 120 minutes)\n* indication for an arterial catheter\n* indication for an urinary catheter\n\nExclusion Criteria:\n\n* Pregnancy\n* Planned surgery: nephrectomy, liver or kidney transplantation surgery\n* Patients who previously had surgery on the urethra or bladder\n* Patients without clinical indication for continuous blood pressure monitoring with an intraarterial catheter","45 Years",{"count":166,"type":21},116,[113],"We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to routine care (with blinded urethral perfusion index monitoring). As pre-planned substudies, we will also assess the agreement between a) urethral perfusion index-derived pulse rate and heart rate measured with an electrocardiogram and b) between the urethral perfusion index and the peripheral perfusion index.",[170,171,29],"Urethral Perfusion Index","Tissue Perfusion",[173,174,118],"urethral perfusion index","tissue perfusion","2025-02-19",{"date":177,"type":42},"2025-02-21",{"date":179,"type":42},"2025-01-21",{"date":181,"type":21},"2025-07-31",{"name":183,"class":49},"Universitätsklinikum Hamburg-Eppendorf",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":191,"sex":17,"minAge":18,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":111,"phases":195,"briefSummary":198,"conditions":199,"keywords":202,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":4},"100564269","phase-1-investigation-of-novel-and-established-therapies-in-a-human-intravenous-lipopolysaccharide-model-of-sepsis-100564269","NCT06626984","Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis","INITIALISE","Inclusion Criteria:\n\n1. Healthy adult volunteers aged between 18 and 40 years of age\n2. Informed consent to participate\n\nExclusion Criteria:\n\n1. Current participation in a clinical trial\n2. Pregnant or breastfeeding\n3. Current history of smoking\n4. Alcohol intake \\> 21 units per week\n5. Regular intake of any relevant prescription or over-the-counter medication. Any regular medication use will be reviewed on a case-by-case basis as to (a) risk and (b) potential confounding effect.\n6. Oxygen saturation \\\u003C95% breathing room air\n7. Abnormal findings on history, examination or laboratory tests suggestive of underlying illness (in the opinion of the clinician undertaking screening)\n8. History of recurrent vaso-vagal episodes\n9. Allergy to Imatinib\n10. Positive or equivocal hepatitis B or C serology result",true,"40 Years",{"count":194,"type":21},65,[196,197],"PHASE1","PHASE2","Sepsis is a common and life-threatening condition caused by a dysregulated host immune response to infection. Given the prominent role of endothelial breakdown and dysfunction in sepsis, therefore, there is an urgent need to establish strategies to protect the endothelium and preserve microcirculatory function.\n\nThis study is a randomised clinical study investigating intravenous fluid therapy and oral imatinib therapy in healthy human volunteers exposed to intravenous lipopolysaccharide (LPS).\n\nThe objective of the study is to investigate the biological effects of fluid and imatinib therapy on LPS-induced microcirculatory dysfunction.",[26,200,201,29],"Fluid Overload","Endothelial Dysfunction",[203,204],"Intravenous Fluid Therapy","Imatinib","NOT_YET_RECRUITING","2024-10-02",{"date":208,"type":42},"2024-10-04",{"date":210,"type":21},"2024-12-01",{"date":212,"type":21},"2026-07-01",{"name":214,"class":49},"Belfast Health and Social Care Trust"]