[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microfractures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microfractures":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100470148","phase-1-amic-compared-with-microfracture-for-focal-articular-cartilage-damage-of-the-hip-100470148",false,"NCT05402072","AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip","Autologous MatRix-Induced ChondrogenEsis ComPared With Microfracture for Focal ArtIcular CaRtilage Damage of the Hip (REPAIR): A Pilot Randomized Controlled Trial","REPAIR","Inclusion Criteria:\n\n1. All patients aged 18-55 years\n2. Hip pain lasting 6 months or more with no relief from documented non-operative modalities\n3. Focal articular cartilage defects of the acetabulum on MRI, confirmed to be full thickness (International Cartilage Regeneration and Joint Preservation Society (ICRS) grade 3 or 4) during arthroscopic examination\n4. Focal acetabular articular cartilage lesions measuring between 3 cm2 and 25 cm2 on MRI and confirmed on arthroscopic examination\n5. Patient agrees to participate in the study-specific postoperative rehabilitation protocol\n6. Patient can speak, read, and understand the language of the site\n7. Patient has provided informed consent\n\nExclusion Criteria:\n\n1. Cartilage defects of the femoral head\n2. Previous surgery on the study hip\n3. Traumatic chondral injury of the hip from a single event\n4. Presence of advanced osteoarthritis (Tonnis grade 3) or any other acute or chronic inflammatory joint disease\n5. Known hypersensitivity or allergy to porcine collagen\n6. Acute or chronic infection at the surgical site\n7. Evidence of hip dysplasia (i.e., lateral centre edge angle \\\u003C 20˚)\n8. Evidence of acetabular over coverage such as coxa profunda or coxa protrusion\n9. Immunosuppressive or anti-proliferative medication use\n10. Chronic pain syndromes\n11. Significant medical co-morbidities (requiring assistance for activities of daily living (ADLs))\n12. History of paediatric hip disease\n13. Uncontrolled diabetes\n14. Contraindications to MRI imaging (e.g. claustrophobia)\n15. Patient is involved in ongoing legal or workplace claims\n16. Patient is incarcerated\n17. Patient is pregnant or breastfeeding\n18. Patient who will likely have problems, in the judgement of the investigator, with maintaining follow-up\n19. Any other reason(s) the investigator feels is relevant for excluding the patient","ALL","18 Years","55 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced chondrogenesis (AMIC) in comparison to microfracture on hip function, health-related quality of life, hip pain, cartilage regeneration, health utility, and any adverse events at 2 years. Follow-up will occur at 6 weeks, 6 months, 12 months, 18 months, and 24 months post-surgery.",[28,29,30],"Hip Arthroscopy","Articular Cartilage Defect","Microfractures","RECRUITING","2025-09-22",{"date":34,"type":35},"2025-09-24","ACTUAL",{"date":37,"type":35},"2023-03-13",{"date":39,"type":22},"2027-01-01",{"name":41,"class":42},"McMaster University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100543664","microfracture-with-platelet-rich-plasma-gel-injection-for-osteochondral-lesion-of-the-talus-100543664","NCT06358807","Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus","Clinical Efficacy of Arthroscopic Microfracture Combined With Local Injection of Platelet Rich Plasma Gel in Treatment of Osteochondral Lesion of the Talus: A Randomized Control Trial","Inclusion Criteria:\n\n* Chronic ankle pain, diagnosed as osteochondral lesion of the talus;\n* Lesion size ≤ 1.5 cm2 or the diameter of the lesion ≤ 1.5 cm;\n* Conservative treatment of at least 3 months fails to relieve symptoms;\n* Willingness to voluntarily participate in the trial and to sign informed consent.\n\nExclusion Criteria:\n\n* Varus or valgus deformity of the ankle of more than 5 degrees;\n* Grade III injury of the lateral collateral ligament of ankle;\n* Chronic synovitis (rheumatoid arthritis, pigmented villous nodular synovitis, etc.);\n* Joint fibrosis, stiffness, and significantly restricted range of motion;\n* Evidence of moderate to severe knee osteoarthritis on plain radiographs;\n* Failure to complete the rehabilitation protocol as required;\n* Patient medically not fit for surgery, radiographs or MRI;\n* For women, pregnant, planning to be pregnant or lactating.","60 Years",{"count":53,"type":22},70,[55],"NA","The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral lesion of the talus (OLT). The interface integration of the injured area will also be assessed via radiographic follow-up. The main questions it aims to answer are:\n\n* Does arthroscopic microfracture combined with PRP gel injection improve ankle function of participants based on American Orthopedic Foot and Ankle Society (AOFAS) Score?\n* Does arthroscopic microfracture combined with PRP gel injection improve interface integration of the injured cartilage on magnetic resonance imaging (MRI)? Researchers will compare arthroscopic microfracture with concomitant local injection of PRP gel to isolated microfracture to see if intraoperative PRP gel injection adds clinical efficacy to isolated arthroscopic microfracture in treatment of OLT.\n\nParticipants will:\n\n* Undergo either isolated arthroscopic microfracture or microfracture with intraoperative injection of PRP gel\n* Receive clinical follow-up 3, 6, 12, and 24 months after surgery and answer scales of ankle function assessment\n* Take MRI preoperatively and 6, 12 and 24 months after surgery",[58,30,59],"Osteochondral Lesion of Talus","Platelet Rich Plasma",[58,30,59,61,62],"Arthroscopic Techniques","Clinical Efficacy","2024-05-17",{"date":65,"type":35},"2024-05-20",{"date":67,"type":35},"2024-01-01",{"date":69,"type":22},"2026-12-31",{"name":71,"class":42},"Peking University Third Hospital"]