[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"micropulse-laser\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:micropulse-laser":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100615676","micropulse-laser-in-treatment-of-initial-and-refractory-cases-of-center-involved-diabetic-macular-edema-100615676",false,"NCT07295704","Micropulse Laser in Treatment of Initial and Refractory Cases of Center-Involved Diabetic Macular Edema","Comparative Evaluation of Micropulse Laser in Treatment of Initial and Refractory Cases of Center-Involved Diabetic Macular Edema","Inclusion Criteria:\n\n* Age ≥18 years.\n* Both sexes.\n* Patients with type 1 or 2 diabetes mellitus (DM), best-corrected visual acuity (BCVA) of 20\u002F400 or better, and center-involved DME \\[defined as a central macular thickness (CMT) of \\>250 but \\\u003C700µm measured by spectral-domain optical coherence tomography\\].\n* Patients with any level of non-proliferative diabetic retinopathy or proliferative diabetic retinopathy with adequate panretinal photocoagulation (PRP) and no signs of disease activity determined by fluorescein angiography (FA).\n\nExclusion Criteria:\n\n* Monocular eyes.\n* Chronic renal failure or renal transplant because of diabetic nephropathy.\n* Glycated hemoglobin (HbA1c) of more than 10%.\n* Vitreomacular traction syndrome.\n* Epiretinal membrane.\n* PRP within 4months before the treatment.\n* Intraocular surgery within 6months, including cataract or vitreoretinal operation.\n* Rubeosis iridis.\n* Severe glaucoma.\n* High-risk proliferative diabetic retinopathy.\n* Poor dilation.\n* Increased foveal avascular zone.\n* Any condition that could interfere with optical coherence tomography (OCT) measurement or visual acuity.","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the effect of subthreshold 577 nm micropulse laser photocoagulation in the treatment of initial and refractory cases of Center-Involved Diabetic Macular Edema.",[24,25,26,27,28],"Micropulse Laser","Treatment","Initial","Refractory","Center-Involved Diabetic Macular Edema","RECRUITING","2025-12-06",{"date":32,"type":33},"2025-12-22","ACTUAL",{"date":35,"type":33},"2025-10-15",{"date":37,"type":20},"2026-03-30",{"name":39,"class":40},"The General Authority for Teaching Hospitals and Institutes","NETWORK",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":61,"leadSponsor":63,"locationsCount":4},"100552088","combination-of-micropulse-laser-with-or-without-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy-100552088","NCT06468540","Combination of Micropulse Laser With or Without Photodynamic Therapy for Chronic Central Serous Chorioretinopathy","Comparative Study on the Efficacy of the Combination of Micropulse Laser With or Without Photodynamic Therapy in the Treatment of Chronic Central Serous Chorioretinal Disease","Inclusion Criteria:\n\n* Age \\>18 years old.\n* The patient diagnosed with chronic central serous chorioretinopathy with a history of more than 6 months. The diagnostic criteria for chronic CSC were as follows: FFA examination showed leakage of strong fluorescent spots with the extension of angiography time, and late fluorescence accumulation, accompanied by decreased central vision, darkening of vision, and deformable microopia. Fundus examination showed superficial detachment of retinal neuroepithelium in macula.\n* Patients received single micropulse laser therapy or micropulse laser combined with drug-free photodynamic therapy, and had not received other laser or surgical treatment in the six months prior to treatment.\n* Patients had follow-up data before and after treatment for 1 month and at least 6 months.\n\nExclusion Criteria:\n\n* Patients with other fundus diseases or refractive interstitial opacity.\n* During treatment, other treatments other than micropulse laser or drug-free photodynamic therapy were received.\n* Various reasons led to incomplete patient data.","70 Years",{"count":51,"type":20},60,"In this study, patients with chronic central serous chorioretinopathy who were treated by micropulse laser alone or micropulse laser combined with photodynamic therapy without drugs are retrospectively included. The visual acuity changes, subretinal fluid absorption and choroidal characteristics of the two groups are compared 1 to 6 months after treatment. We will also analyze baseline characteristics that influence post-treatment outcomes to identify potential predictors of poor treatment outcomes.",[54,24,55],"Central Serous Chorioretinopathy","Photodynamic Therapy","NOT_YET_RECRUITING","2024-06-15",{"date":59,"type":33},"2024-06-21",{"date":57,"type":20},{"date":62,"type":20},"2025-12-15",{"name":64,"class":65},"Beijing Hospital","OTHER_GOV"]