[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microsatellite-stable-endometrial-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microsatellite-stable-endometrial-carcinoma":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100556176","translational-study-of-mss-tp53-mutation-and-chromosome-instability-relationship-in-endometrial-carcinoma-100556176",false,"NCT06521684","Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma","Inclusion Criteria:\n\n* willing to participate in the study and sign the informed consent\n* age ≥18 years old\n* researchers evaluated that it was suitable to participate in this translational study\n* Endometrial cancer was confirmed histologically\n* histopathological molecular classification was consistent with pMMR type and POLE wild type\n* The tumor tissue obtained by operation was the primary lesion\n\nExclusion Criteria:\n\n* Received chemotherapy within 14 days prior to sample collection, or received anti-tumor drug therapy such as radiotherapy, biotherapy, endocrine therapy, targeted therapy, immunotherapy, within 21 days prior to sample collection\n* previously treated with KIF18A inhibitors\n* researchers believed that the subjects were not suitable for the translational study for other reasons","FEMALE","18 Years",{"count":18,"type":19},110,"ESTIMATED","OBSERVATIONAL","The objective is to understand the relationship between TP53 mutation, MSS and chromosome instability in endometrial cancer and the effect on clinical prognosis.We will collect a small amount of tumor tissue samples. NGS panel detection and WGD\u002FAS analysis were performed on the tissue. Paracancer tissue was used as a negative control and relevant information in medical records during the operation. Then we will collect clinical diagnosis and disease information through telephone follow-up after the completion of the operation.",[23,24,25,26],"Endometrial Neoplasms","TP53 Gene Mutation","Chromosomal Instability","Microsatellite Stable Endometrial Carcinoma",[28,25,29,24,30],"Endometrial Cancer","microsatellite stability","Whole genome duplication","NOT_YET_RECRUITING","2024-07-22",{"date":34,"type":35},"2024-07-26","ACTUAL",{"date":37,"type":19},"2024-09-01",{"date":39,"type":19},"2025-06-01",{"name":41,"class":42},"Peking Union Medical College Hospital","OTHER"]