[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microtia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microtia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,56,84,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100604834","evaluation-of-the-auryzon-ear-20-system-in-ear-reconstruction-100604834",false,"NCT07154667","Evaluation of the Auryzon™ EAR 2.0 System in Ear Reconstruction","Enhancing Cartilaginous Ear Reconstruction - An Institutional Outcomes Study","Inclusion Criteria:\n\n* Patients aged 5-20 years seeking to undergo surgical ear reconstruction or microtia repair under general anesthesia through NCH-FL\n* Pre-existing physical deformity of the ear necessitating surgical reconstruction\n* Patient of sufficient health to undergo surgery under general anesthesia\n* Parental or legally acceptable representative (LAR) permission obtained for inclusion in the study; patient assent obtained where age-appropriate\n* Sufficient fluency in English or Spanish to complete patient\u002Fparent surveys\n\nExclusion Criteria:\n\n* Patients who will be ≤4 years old, or ≥21 years old at time of surgery\n* Patients with ear deformities do not require surgical correction\n* Patient's whose ear reconstruction surgery will be performed somewhere other than Nemours Children's Hospital - Florida\n* Patients determined to be in poor health to undergo surgery under general anesthesia\n* Parental or LAR permission cannot be obtained, and\u002For patient of sufficient age and cognitive capacity declines to assent\n* Lack of fluency in English or Spanish to complete patient\u002Fparent surveys","ALL","5 Years","20 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to improve surgical outcomes for children and young adults with ear differences severe secondary to congenital conditions (like microtia, a condition where the ear is underdeveloped), trauma (such as dog bites), or surgical resections secondary to skin cancer. The investigators have developed a novel medical device to shape cartilage into pre-determined shapes that, once assembled, assists the surgeon in creating an anatomically accurate cartilaginous ear framework, reduce surgery time, and minimize wire need. Other factors that might affect the quality of surgical outcomes will be examined in clinical trial participants.",[27,28,29,30,31,32,33],"Microtia, Congenital","Microtia","Microtia-Anotia","Ear Deformities, Acquired","Ear Deformity External","Ear Malformation","Ear Cartilage",[35,36,37,38,39,40,41,42],"microtia","ear reconstruction","craniofacial difference","anotia","plastic surgery","ear defect","ear trauma","ear deficit","RECRUITING","2025-12-19",{"date":46,"type":47},"2025-12-29","ACTUAL",{"date":49,"type":47},"2025-10-01",{"date":51,"type":21},"2030-12-31",{"name":53,"class":54},"Nemours Children's Clinic","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100510710","international-childhood-leukemia-microbiomemetabolome-cohort-100510710","NCT05929976","InterNatIonal CHildhood Leukemia Microbiome\u002FMEtabolome Cohort","Multi-National Nutritional Biobanking Program in Pediatric Oncology InterNatIonal CHildhood Leukemia Microbiome\u002FMEtabolome Cohort","NICHE","Inclusion Criteria:\n\n* Patients must be between 3 years and 18 years of age at time of assent\u002Fconsent.\n* Patients must have newly diagnosed B- or T-cell ALL, or mixed phenotype acute leukemia confirmed by pathology report.\n* Patients must be receiving treatment at one of the participating centers.\n\nExclusion Criteria:\n\n\\- Patients receiving hematopoietic cell transplant.","3 Years","18 Years",{"count":67,"type":21},4900,"OBSERVATIONAL","Nutritional status is a measurable and modifiable factor that is often not considered during treatment and its clinical impact undervalued due in part to the heavy demands on clinicians in low and middle income countries to deliver therapy to large numbers of patients. The proposed study will create a biobank of clinical data and biological specimens which will foster future studies on cancer progression and prognosis as well as toxicities during treatment which may impact survivorship and late-effects. Eligible patients must be between 3 years and 18 years of age at time of assent\u002Fconsent, have newly diagnosed B- or T-cell acute lymphoblastic leukemia or mixed phenotype acute leukemia confirmed by pathology report, and must be receiving treatment at one of the participating centers. Patients receiving hematopoietic cell transplant will be excluded. Institutions were selected to ensure representation of several global health indicators related to nutritional status and wealth classification according to the World Bank. Data related to demographic variables (socioeconomic status, food security), lifestyle habits (diet, physical activity), nutritional anthropometrics (height, weight and arm anthropometry), and nutritional biological indices (stool and blood) will be collected at designated timepoints throughout treatment and one year after the end of treatment.",[71,72,28,73],"Acute Lymphoblastic Leukemia","Nutrition Aspect of Cancer","Genetic Predisposition","2025-07-17",{"date":76,"type":47},"2025-07-22",{"date":78,"type":47},"2022-10-26",{"date":80,"type":21},"2029-10-01",{"name":82,"class":54},"Columbia University",8,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":65,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":55},"100461449","phase-2-microbiome-metabolites-and-alcohol-in-hiv-to-reduce-cvd-rct-100461449","NCT05288790","Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT","META HIV CVD","Inclusion Criteria:\n\n* HIV infected\n\nExclusion Criteria:\n\n* Not fluent in English","89 Years",{"count":93,"type":21},250,[95],"PHASE2","Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and death. This randomized controlled trial will determine whether a pill containing healthy gut bacteria can increase the number good bacteria in the gut, lower levels of inflammation, and lower the risk of heart disease and death.",[28,98,99,100,101],"Dysbiosis","Alcohol Drinking","HIV Infections","Cardiovascular Diseases","2025-06-18",{"date":104,"type":47},"2025-06-24",{"date":106,"type":47},"2023-09-18",{"date":108,"type":21},"2027-02-28",{"name":110,"class":54},"Vanderbilt University Medical Center",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":55},"100574800","safety-and-efficacy-of-connecting-the-residual-ear-to-the-cartilage-scaffold-in-first--vs-second-stage-surgery-100574800","NCT06763991","Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery","Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery : a Protocl of a Randomized Controlled Trial in Non-expanded Auricular Reconstruction for Concha-type Microtia","Inclusion Criteria:\n\nAll consecutive patients between 6 and 30 years with a congenital concha-microtia8, admitted to our hospital are potentially eligible, and enrollment in the study will be based on the following criteria.\n\n1. Patients were fully informed about the purpose, modalities and risks associated with this study, signed an informed consent form and were willing to be followed up.\n2. Contrast-enhanced computed tomography (CT) scan shows he or she has 3.Patients can tolerate general anesthesia without severe chronic organic or mental illness.\n\nExclusion Criteria:\n\n1. Patients combined with other ear diseases such as ear fistula, titis media, etc.\n2. Patients receive other unrelated ear surgeries during the study\n3. Skin in the surgical area with infection, ulceration, and scarring.","6 Years","30 Years",{"count":121,"type":21},78,[24],"Eligible patients will be admitted from the outpatient clinic to complete the relevant examinations after admission（Preoperative routine examination and chest CT）. The baseline parameters will be registered when admitted to hospital, including case number, diagnosis, sex, age, height, weight, and underlying medical conditions. Patients have at least 12 hours to consider participation in the study and will be given the opportunity to ask questions about the study. Written informed consent will be obtained by the surgical resident or the surgeon after admission to the hospital.\n\nRandomization will be done by relevant member . After inclusion, patients will be allocated to one of the two study groups (First-stage Connection or Second-stage Connection) using an online randomization program. The perioperative care will be the same for all included patients.Surgery will be performed by experienced surgeons, with non-expanded ear reconstruction using autologous rib cartilage. The surgery normally comprises two stages. After each surgery, details and duration of the surgery will be documented. For each stage of surgery, patients are scheduled for visits about 3-6 months. In addition, after the total surgery, patients are to fill out 'Glasgow Benefit Inventory' and 'Patient and Observer Scar Assessment Scale'.",[28,125,126,127,128,129],"Outcome Assessment","RCT","Surgery Related Complications Rate","Treatment Outcome","Reconstruction","NOT_YET_RECRUITING","2025-05-15",{"date":133,"type":47},"2025-05-16",{"date":135,"type":21},"2025-06-01",{"date":137,"type":21},"2027-02-20",{"name":139,"class":54},"Sichuan Provincial People's Hospital"]