[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microvascular-changes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microvascular-changes":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100642745","microvasculature-ultrasound-super-resolution-in-transplant-delayed-graft-function-100642745",false,"NCT07645599","Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function","MUST-D","Inclusion Criteria:\n\nFor stage 1 of the study:\n\n1. We will enroll patients ≥18 years of age\n2. Patients who received a kidney transplant 2a. Patients requiring dialysis in the first 14 days after transplant 2b. Patients with working allografts not requiring dialysis (control group)\n\nFor stage 2 of the study\n\n1. We will enroll patients at least 18 years of age or older\n2. Patients who received a kidney transplant 2a. Patients who received kidney transplants from low KDPI kidneys (KDPI \\\u003C 35) 2b. Patients who received kidney transplants from high KDPI kidneys (KDPI \\> 75)\n\nExclusion Criteria:\n\n1. BMI \\> 40\n2. Inability to provide informed consent\n3. Pregnant woman\n4. Breastfeeding women\n5. Hypersensitivity to perfluten lipid microsphere and components including polyethylene glycol (PEG)\n6. Unstable cardiopulmonary condition (acute myocardial infarction, acute coronary artery symptoms, worsening or unstable congestive heart failure, serious ventricular arrhythmias).\n7. Known history of cardiac shunts\n8. Patients who have known sickle cell disease or trait","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","3 Years","OBSERVATIONAL","This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery. The goal is to see whether changes in the kidney's small blood vessels can help predict how well the transplanted kidney will work early after transplant, including whether delayed graft function may occur.\n\nInvestigators hope this technique can become a safe, noninvasive way to evaluate transplanted kidneys without needing as many invasive biopsies. It may also help doctors better assess donor kidneys at higher-risk of suboptimal functioning.",[25,26,27,28],"End Stage Chronic Renal Failure","Renal Transplant","Microvascular Changes","Microvascular Circulation",[30,31,32,33,34,35,36,37,38,39],"renal allograft","kidney allograft","kidney transplant","super-resolution ultrasound","lipid microspheres","renal microvasculature","kidney microvasculature","delayed graft function","Kidney Donor Profile Index","deceased donor kidney transplant","NOT_YET_RECRUITING","2026-06-08",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":20},"2026-06-01",{"date":48,"type":20},"2028-06-30",{"name":50,"class":51},"Roderick Tan","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":52},"100415252","diabetic-neuropathy-in-spinal-cord-stimulator-patients-100415252","NCT04687215","Diabetic Neuropathy in Spinal Cord Stimulator Patients","Spinal Cord Stimulation Improves Pain, Arterial Stiffness and Vascular Flow in Lower Extremities in Patients With Diabetes Mellitus Type II A Multidisciplinary Collaborative Prospective Study","Inclusion Criteria:\n\n1. Patients with DM type 2 of more than 1-year duration\n2. DM stage 3 or less\n3. Patients ≥18 years of age\n4. Refractory painful diabetic peripheral neuropathy of the lower extremities\n5. ABI index \\\u003C0.9\n\nExclusion Criteria:\n\n1. Patients on anticoagulants\n2. Patients with active infections\n3. Patients with HbA1\\>10\n4. Psychiatric disorders and cognitive dysfunctions\n5. Illicit Drug Usage\n6. Patients on dialysis\n7. BMI\\>35.0\n8. Surgery within the last 30 days\n9. Ulcer of the lower extremities\n10. Calcification of the peripheral arteries",{"count":61,"type":20},25,"The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, improving micro-circulatory changes induced by Diabetes Mellitus (DM), improving macro-circulatory changes induced by DM and improving arterial stiffness of the vessels of the lower extremity.",[64,65,66,67,68,27,69],"Diabetes Mellitus","Neuropathy","Neuropathic Pain","Vascular Diseases","Vascular Stiffness","Pain, Chronic","RECRUITING","2026-02-03",{"date":73,"type":44},"2026-02-05",{"date":75,"type":44},"2022-01-27",{"date":77,"type":20},"2026-12-01",{"name":79,"class":51},"University of Chicago"]