[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microvascular-circulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microvascular-circulation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100642745","microvasculature-ultrasound-super-resolution-in-transplant-delayed-graft-function-100642745",false,"NCT07645599","Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function","MUST-D","Inclusion Criteria:\n\nFor stage 1 of the study:\n\n1. We will enroll patients ≥18 years of age\n2. Patients who received a kidney transplant 2a. Patients requiring dialysis in the first 14 days after transplant 2b. Patients with working allografts not requiring dialysis (control group)\n\nFor stage 2 of the study\n\n1. We will enroll patients at least 18 years of age or older\n2. Patients who received a kidney transplant 2a. Patients who received kidney transplants from low KDPI kidneys (KDPI \\\u003C 35) 2b. Patients who received kidney transplants from high KDPI kidneys (KDPI \\> 75)\n\nExclusion Criteria:\n\n1. BMI \\> 40\n2. Inability to provide informed consent\n3. Pregnant woman\n4. Breastfeeding women\n5. Hypersensitivity to perfluten lipid microsphere and components including polyethylene glycol (PEG)\n6. Unstable cardiopulmonary condition (acute myocardial infarction, acute coronary artery symptoms, worsening or unstable congestive heart failure, serious ventricular arrhythmias).\n7. Known history of cardiac shunts\n8. Patients who have known sickle cell disease or trait","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","3 Years","OBSERVATIONAL","This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery. The goal is to see whether changes in the kidney's small blood vessels can help predict how well the transplanted kidney will work early after transplant, including whether delayed graft function may occur.\n\nInvestigators hope this technique can become a safe, noninvasive way to evaluate transplanted kidneys without needing as many invasive biopsies. It may also help doctors better assess donor kidneys at higher-risk of suboptimal functioning.",[25,26,27,28],"End Stage Chronic Renal Failure","Renal Transplant","Microvascular Changes","Microvascular Circulation",[30,31,32,33,34,35,36,37,38,39],"renal allograft","kidney allograft","kidney transplant","super-resolution ultrasound","lipid microspheres","renal microvasculature","kidney microvasculature","delayed graft function","Kidney Donor Profile Index","deceased donor kidney transplant","NOT_YET_RECRUITING","2026-06-08",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":20},"2026-06-01",{"date":48,"type":20},"2028-06-30",{"name":50,"class":51},"Roderick Tan","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":63,"conditions":64,"keywords":72,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":52},"100623641","submental-tissue-oxygenation-and-arterial-lactate-in-major-surgery-100623641","NCT07399275","Submental Tissue Oxygenation and Arterial Lactate in Major Surgery","Relationship Between Submental Tissue Oxygenation, Microvascular Reactivity, and Arterial Lactate During Major Surgical Procedures","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Scheduled for major surgical procedures under general anesthesia\n* Major surgery defined as procedures associated with a risk of significant blood loss and\u002For impaired tissue perfusion, requiring invasive arterial blood pressure monitoring and hourly arterial blood gas analysis\n* Planned intraoperative arterial catheter placement as part of routine clinical care\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Refusal or inability to provide informed consent\n* Absence of invasive arterial blood pressure monitoring\n* Known pregnancy\n* Severe peripheral vascular disease affecting upper extremities\n* Anatomical abnormalities or skin conditions preventing placement of NIRS sensors on the submental or thenar regions\n* Emergency surgery requiring immediate intervention\n* Preoperative severe metabolic acidosis (arterial pH \\\u003C 7.20)",true,{"count":62,"type":20},150,"During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects. These changes can lead to impaired tissue perfusion, which is commonly reflected by increased arterial lactate levels. However, lactate measurements are intermittent and may not detect early perfusion abnormalities.\n\nThis prospective observational study aims to investigate the relationship between submental tissue oxygenation measured by near-infrared spectroscopy (NIRS), microvascular reactivity assessed by the vascular occlusion test, and arterial lactate levels during major surgery. Adult patients undergoing major abdominal, neurosurgical, or orthopedic procedures will be monitored intraoperatively using non-invasive NIRS techniques, while arterial blood gas analyses will be performed as part of routine clinical care.\n\nThe study does not involve any changes to standard anesthesia or surgical management. All treatments and clinical decisions will be made by the responsible care team according to routine practice. By evaluating non-invasive indicators of tissue oxygenation and microvascular function, this study aims to improve the understanding of early intraoperative tissue perfusion changes and their association with metabolic markers.",[65,66,67,28,68,69,70,71],"Microcirculatory Dysfunction","Tissue Hypoperfusion","Microcirculatory Status","Near Infrared Spectroscopy","Vascular Occlusion Test","Lactate Blood Increase","Major Surgery",[73,74,75,76,77,78],"tissue hypoperfusion","microvascular circulation","Near infrared spectroscopy","vascular occlusion","lactate blood increase","Major surgery","2026-02-03",{"date":81,"type":44},"2026-02-10",{"date":83,"type":20},"2026-02-15",{"date":85,"type":20},"2027-02-15",{"name":87,"class":88},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":60,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":52},"100582509","phase-4-effect-of-beta-blockers-on-coronary-flow-and-resistance-in-patients-with-anoca-100582509","NCT06864234","Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA","Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study","BEACON","Inclusion Criteria:\n\n* Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR \\>0.80 and no diameter stenosis \\>50%\n* Normal, TIMI 3 flow at angiography\n* Stable haemodynamics\n\nExclusion Criteria:\n\n* Clinical signs or symptoms of congestive heart failure\n* Severe valvular heart disease requiring either surgical or percutaneous intervention\n* History of coronary artery bypass grafting\n* Tortuous coronary anatomy in which wire manipulation could be complex\n* Heart rate \\\u003C60 beats per minute\n* Systolic blood pressure \\\u003C100 mmHg\n* Unable to give consent\n* LVEF\\\u003C40%",{"count":98,"type":20},46,"INTERVENTIONAL",[101],"PHASE4","The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).\n\nThe main questions it aims to answer are:\n\n* Do beta-blockers improve coronary blood flow in patients with ANOCA?\n* Do beta-blockers reduce coronary microvascular resistance in these patients?\n\nResearchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation.\n\nParticipants will:\n\n* Receive a beta-blocker or a placebo\n* Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.",[104,105,28],"Coronary Arterial Disease (CAD)","Angina (Stable)",[107,108,109,110,111],"angina","coronary artery disease","absolute coronary flow","continuous intracoronary thermodilution","Beta-blockers","RECRUITING","2025-07-08",{"date":115,"type":44},"2025-07-14",{"date":117,"type":44},"2025-07-03",{"date":119,"type":20},"2025-12-31",{"name":121,"class":51},"VZW Cardiovascular Research Center Aalst"]