[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microvasculature\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microvasculature":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100568615","phase-2-palmitic-acid-and-human-microvascular-function-100568615",false,"NCT06683534","Palmitic Acid and Human Microvascular Function","Use of Quercetin to Increase Resiliency to Palmitic Acid in the Human Microvasculature","Inclusion Criteria:\n\n* Obesity (BMI\\>30)\n* Aged 18-40 years\n* English Speaking\n\nExclusion Criteria:\n\n* BMI\\>60\n* Resting SBP ≥180 mmHg or DBP ≥ 110mmHg\n* Pregnancy or breastfeeding.\n* Prior history of myocardial infarction\n* Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension)\n* Active mouth sores that affect the buccal mucosa.","ALL","18 Years","40 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this study is to learn how a supplement Quercetin can affect microvascular function.\n\nParticipants will:\n\n* give two blood draws of 5 mL each\n* have a camera placed under the tongue to take pictures of blood vessels\n* have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion\n\nResearchers will compare blood vessel function of those who take estrogen supplements to those who do not.",[27,28,29,30,31,32],"Microvascular Dysfunction","Microvasculature","Cardiovascular Diseases","Cardiovascular Diseases (CVD)","Microvascular Health","Obesity and Overweight",[34,35],"Obesity","Supplement","NOT_YET_RECRUITING","2026-04-28",{"date":39,"type":40},"2026-04-29","ACTUAL",{"date":42,"type":21},"2026-07",{"date":44,"type":21},"2030-12",{"name":46,"class":47},"Medical College of Wisconsin","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100574389","characterizing-the-retinal-microvasculature-in-patients-with-fabry-disease-a-prospective-observational-study-100574389","NCT06758648","Characterizing the Retinal Microvasculature in Patients with Fabry Disease: a Prospective Observational Study","VASCinFABRY","Inclusion Criteria:\n\n* Age \\> 18 years\n* Diagnosis of Fabry disease by genetic testing or GB3 activity in leukocytes.\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Active infection or cancer\n* Surgery less than 2 weeks prior to inclusion in the study\n* Known glaucoma\n* Lack of capacity to give consent; lack of informed consent.\n* Known epilepsy",{"count":57,"type":21},63,"OBSERVATIONAL","This study aims to gain a deeper understanding of endothelial dysfunction in patients with Fabry disease through a prospective study of the retinal microvasculature and to identify an objective, non-invasive marker to assess disease severity and cardiovascular risk in patients.\n\nThe main questions addressed are: Do dynamic and static retinal vessel analysis parameters differ from those in healthy individuals? Can these parameters predict cardiovascular and\u002For Fabry-related events during follow-up? Do these parameters change during follow-up in patients with a non-stable disease?",[61,62,28],"Fabry Disease","Endothelial Dysfunction",[64,65,66,67],"Chronic inflammation","retinal microvasculature","retinal vessel analysis","vasculopathy","RECRUITING","2024-12-30",{"date":71,"type":40},"2025-01-06",{"date":73,"type":40},"2020-06-25",{"date":75,"type":21},"2025-11-01",{"name":77,"class":47},"Technical University of Munich"]