[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"middle-aged\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:middle-aged":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100619459","mbsr-effects-on-aging-anxiety-and-body-image-100619459",false,"NCT07344896","MBSR Effects on Aging Anxiety and Body Image","Effects of a Mindfulness-Based Stress Reduction Program on Aging Anxiety and Body Image in Middle-Aged Women: A Randomized Controlled Trial","Inclusion Criteria:\n\n* At least primary school graduate,\n* Being between 40-59 years old,\n* Living in Çumra district center,\n* Being open to communication and cooperation\n\nExclusion Criteria:\n\n* Those with chronic illnesses (self-report)\n* Foreign nationals Those with psychiatric illnesses (self-report) Those with physical disabilities and limited mobility",true,"FEMALE","40 Years","59 Years",{"count":21,"type":22},58,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study was designed to determine the effect of a mindfulness-based stress reduction (MBSR) program on aging anxiety and body image among middle-aged women. The primary hypotheses to be tested are as follows:\n\nH0a: There is no difference in the mean scores of the Aging Anxiety Scale between the women in the experimental group who receive the mindfulness-based stress reduction program and the women in the control group.\n\nH0b: There is no difference in the mean scores of the Body Image Scale between the women in the experimental group who receive the mindfulness-based stress reduction program and the women in the control group.\n\nH0c: There is no difference between the pre-intervention and post-intervention mean scores of the Aging Anxiety Scale among the women in the experimental group who receive the mindfulness-based stress reduction program.\n\nH0d: There is no difference between the pre-intervention and post-intervention mean scores of the Body Image Scale among the women in the experimental group who receive the mindfulness-based stress reduction program.\n\nThe researchers will compare the experimental group with the control group in order to assess the effect of the mindfulness-based stress reduction program on aging anxiety and body image among middle-aged women.\n\nParticipants:\n\n* They will attend an 8-session mindfulness-based stress reduction program.\n* They will participate in one silent mindfulness retreat session.",[28,29,30],"Body Image","Mindfulness Based Stress Reduction","Middle Aged",[32,33,34,35],"aging anxiety","middle age woman","mindfulness","body image","NOT_YET_RECRUITING","2026-05-18",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":22},"2026-06-01",{"date":44,"type":22},"2027-05-30",{"name":46,"class":47},"KTO Karatay University","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100575170","web-app-based-lifestyle-physical-activity-promotion-program-wpapp-for-middle-aged-latinas-100575170","NCT06768801","Web-app Based Lifestyle Physical Activity Promotion Program (WPAPP) for Middle Aged Latinas","Pilot RCT of the Web-app Based Lifestyle Physical Activity Promotion Program (WPAPP) for Middle Aged Latinas","WPAPP-Latina","Inclusion Criteria: women aged 40-60 who self-identify as Latina or Hispanic women, are able to read and write in English or Spanish, live in the United States, and can use the app and complete online data collection using a smart phone, tablet, or computer.\n\n\\-\n\nExclusion Criteria: pregnancy within 3 months of starting the study, having or being of high risk for cardiovascular or musculoskeletal illnesses or injuries\n\n\\-","60 Years",{"count":58,"type":22},40,[25],"The purpose of the proposed project is to conduct a pilot randomized controlled trial (RCT) of the Web-App based Lifestyle Physical Activity Promotion Program (WPAPP) for middle-aged Latinas. The WPAPP is a web application (app) to promote lifestyle physical activity that was developed and tested with Korean American middle aged women. It shows promise for effectiveness with Latinas. The specific aims are:\n\n1. To test the feasibility and satisfaction of the WPAPP modified for Latinas.\n2. To examine preliminary effectiveness of the WPAPP-Latina on increasing physical activity and decreasing depressive symptoms.",[30,62,63,64,65],"Women","Depressive Symptoms","Physical Activity","Hispanic or Latino",[67],"Web-based App","2025-01-06",{"date":70,"type":40},"2025-01-10",{"date":72,"type":22},"2025-03",{"date":74,"type":22},"2025-09",{"name":76,"class":47},"University of Texas at Austin",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100503930","impact-of-ces1-genotype-on-remimazolam-100503930","NCT05841667","Impact of CES1 Genotype on Remimazolam","A Clinical Study to Explore the Effect of Carboxylesterase 1 (CES1) Genotype on Pharmacokinetics, Safety, and Efficacy of Remimazolam","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status 1 or 2\n* Age 19-70 years\n* Elective surgery\n\nExclusion Criteria:\n\n* Concomitant regional anesthesia\n* Uncontrolled hypertension (systolic blood pressure \\>180 mmHg)\n* Uncontrolled diabetes mellitus (HbA1c \\>9.0%)\n* Aspartate transaminase (AST), Alanine transferase (ALT), Total bilirubin \\> more than 2 times the normal upper limit\n* Estimated glomerular filtration rate \\\u003C60 ml\u002Fmin\u002F1.73m2\n* Moderate to severe chronic pulmonary obstructive disease or respiratory failure\n* Emergency\n* Hepatectomy, Liver transplantation\n* Cardiopulmonary bypass use\n* Craniotomy due to head trauma, unstable intracranial pressure, or brain disease\n* Use of benzodiazepine medications (if tolerance is present)\n* Anxiety, alcohol\u002Fdrug dependence, or addiction to tricyclic antidepressants\n* Reported hypersensitivity and adverse reactions to benzodiazepines, flumazenil, and other agents used during anesthesia\n* Lactose-related genetic disorders\n* Myasthenia gravis or myasthenia gravis syndrome\n* Newly diagnosed myocardial infarction\u002Fclinically significant coronary artery disease, cerebral ischemic attack\u002Fstroke within 6 months, or significant untreated coronary artery disease\n* Implanted rate-responsive cardiac pacemaker with a bioelectrical impedance sensor.\n* Intrinsic brain disorders or other conditions that make it difficult to determine the depth of anesthesia through EEG measurements (e.g., epilepsy)\n* History of severe allergies\n* Cognitive impairment that prevents comprehension of the instructions and consent form of this study, in case of sedation\n* Expected intraoperative blood loss of 1000 ml or more\n* Judged by the investigator to be unsuitable for participation in this study due to other reasons","ALL","19 Years","70 Years",{"count":88,"type":22},120,"OBSERVATIONAL","Remimazolam is primarily metabolized via CES1, and other drugs that are commonly metabolized by CES1 are known to have their pharmacokinetics and clinical effects affected by genetic polymorphisms in CES1.\n\nThe goal of this observational study is to investigate the impact of the CES1 genotype on the pharmacokinetics, safety, and efficacy of remimazolam in patients undergoing elective surgery.",[92,30,93],"Adult","Elective Surgical Procedures","RECRUITING","2024-10-09",{"date":97,"type":40},"2024-10-15",{"date":99,"type":40},"2023-09-06",{"date":101,"type":22},"2025-12-31",{"name":103,"class":47},"Korea University Guro Hospital",1]