[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"migraine-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:migraine-disorder":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,80,114,164,191,217],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100619758","yogabased-movements-for-primary-headaches-migraine-andor-cluster-headache---yourhead-100619758",false,"NCT07348783","Yogabased Movements for Primary Headaches (Migraine and\u002For Cluster Headache) - YOURHEAD","Yogabased Movements Weekly (Online Live or Face to Face) for Primary Headaches","Inclusion Criteria:\n\n* Diagnosed chronic migraine and\u002For cluster (Hortons) headache\n* Men and women 18-65 years\n* Diagnosed with chronic\u002Fhigh frequency migraine (≥15 headache days\u002Fmonth with at least ≥8 with migraine)\n* Diagnosed with chronic cluster head ache (i.e shorter remission than 3 months per year), diagnosed according to ICHD-III criteria.\n* Ability to perform yoga based moments and to give consent.\n* Internet connection with computer\u002Fipad\u002Fmobile to perform digitally\u002Ftele-health instructions\n* Willing to use wristwatch for actigraphy\n* Willing to leave blood samples in laboratory\n\nExclusion Criteria:\n\n* Recent or planned operations during the last 6 weeks\n* Drug dependence, alcohol dependence, mental disorders as psychosis, bipolar disorder, anxiety as PTSD etc)\n* Parallel enrollment in other clinical trails\n* Unmedicated high blood pressure, heart disease as heart failure\n* Non Swedish speaking\n* Not able to perform low intensity exercise at home or FTF (face to face) - both online or live.\n* Participants unsure to participate due to drug addiction or other causes\n* Disorientation and not able to inform regarding other serious conditions","ALL","18 Years","65 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Brief Summary:\n\nMigraine and\u002For Cluster Headache: Study Overview\n\n\\*\\*Background:\\*\\* Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected. According to the WHO's recurring burden of disease reports, migraine is among the neurological conditions responsible for the highest number of years lost due to illness. The headaches associated with migraine and cluster headache range from moderate to severe and cause great suffering. Available treatments do not work for everyone and are often associated with adverse side effects. Physical activity has been shown in several studies to have a positive effect on headache. Given the high prevalence of mental health issues, stress, and sleep problems within this patient group, relaxation and low-intensity exercise such as yoga-based movements (YB) could potentially help individuals improve sleep and well-being, while also providing some preventive effect on headaches.\n\n\\*\\*Hypothesis:\\*\\*\n\nIndividuals with severe migraine or cluster headache have a strong need for new treatment options. Alternative therapies such as yoga-based exercises, when combined with standard medical treatment as per clinical guidelines, may positively impact:\n\nHeadache symptoms, Sleep quality and Overall life quality\n\n* Purpose and Goals:\\*\\* This randomized controlled study aims to evaluate the effect of a web-based yoga (YB) or live face to face (FTF) intervention in individuals suffering of primary headaches-mainly chronic migraine and\u002For cluster headache. The study will assess the effect of YB on health-related changes in headache frequency, intensity, and duration associated with primary headache conditions, with a focus headache frequency. A secondary objective is to analyze quality of life, sleep quality, mental health as depression and anxiety. The RCT will also measure objective sleep and biomarkers. We are now summarizing the effects after a pilot study.\n* Relevance for the Patient Group:\\*\\* The core objective of the project is to determine whether yoga-based exercises can serve as a complementary treatment to enhance quality of life and health in patients with severe primary headache. To ensure equal healthcare access, this intervention will be delivered in digital format and\u002For FTF to optimize availability and expand care for individuals with primary headache disorders. These efforts aim to improve life quality and well-being in a vulnerable patient population. Headache conditions often affect individuals in their most productive years, and many live with symptoms for decades. Both work and private life are frequently disrupted, resulting in sick leave and social isolation. Close relatives are also affected, as those suffering from headaches require more recovery time to cope with daily life. With this proposed project, we aim to use physical yoga, rooted in holistic traditional medicine, to help individuals with severe primary headache achieve better physical and mental health-particularly improved sleep quality, which in turn enhances overall life quality.",[27,28,29,30,31,32],"Cluster Headache - Episodic and Chronic","Migraine Headache","Migraine Headache, With or Without Aura","Migraine in Adults","Cluster Headaches and Other Trigeminal Autonomic Cephalgias","Migraine Disorder","RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":37},"2026-05-01",{"date":41,"type":21},"2027-12-30",{"name":43,"class":44},"Karolinska Institutet","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100642094","self-hypnosis-training-for-migraine-management-hylami-a-pilot-and-proof-of-concept-study-100642094","NCT07644299","Self-Hypnosis Training for Migraine Management (HYlaMI): A Pilot and Proof-of-Concept Study","Self-Hypnosis Training for Migraine Management (HYlaMI): A Pilot and Proof-of-Concept Study of the Intervention Program (ORBIT Phase IIa-IIb)","HYlaMI","Inclusion Criteria:\n\n* Formal diagnosis of migraine for more than one year (physician-issued; self-reported diagnosis accepted)\n* French-speaking\n* No consumption of alcohol or recreational drugs on the morning before group hypnosis sessions (migraine rescue medication is accepted but must be reported if taken before a session)\n* Reliable internet connection\n* Available to follow the 2.5-month self-hypnosis training program\n\nExclusion Criteria:\n\n* Sensory or cognitive impairments that would interfere with comprehension (e.g., deafness)\n* Severe, unstabilized neurological or psychiatric disorder that impairs communication\n* Previous psychological treatment using hypnosis techniques for pain management\n* Current participation in another psychological intervention (potential confounder for anxiety\u002Fdepression outcomes)",{"count":55,"type":21},40,[24],"Migraine is one of the most common and disabling neurological conditions worldwide, affecting approximately 1 billion people. Available pharmacological treatments have significant limitations (side effects, contraindications, medication overuse), highlighting the need for effective non-pharmacological alternatives.\n\nThe HYlaMI program (Self-Hypnosis Training for Migraine Management) is an 8-session group-based telehealth intervention adapted from HYlaDO, a self-hypnosis program developed for chronic pain management at the Hôpital Maisonneuve-Rosemont Pain Clinic (Montréal, Canada). Building on a refinement study conducted in autumn 2025 (CER: 2026-4061), HYlaMI combines heterohypnosis (guided by a trained clinician) and self-hypnosis (practiced autonomously at home using audio recordings) through weekly one-hour video sessions (Zoom\u002FCIUSSS EMTL platform).\n\nThis study combines ORBIT Phase IIa (proof of concept) and Phase IIb (pilot study) objectives. The primary aims are to evaluate the feasibility of the HYlaMI program (retention and adherence rates) and to assess whether it can generate a clinically significant change in migraine-related disability compared to a waitlist control group. Secondary aims include evaluating effects on anxiety and depressive symptoms, pain self-efficacy, situational pain\u002Fanxiety\u002Frelaxation, migraine frequency, intensity and duration, medication intake, work absenteeism, quality of life, and the economic burden of migraine.\n\nA mixed-methods design will be used. Forty adults with a diagnosis of migraine for more than one year will be randomized to either the HYlaMI intervention group (n=20) or a waitlist control group (n=20). Participants will complete validated questionnaires at multiple time points (pre-intervention, mid-intervention, post-intervention, and 4-week follow-up), a weekly migraine diary, and self-hypnosis practice logs. Two semi-structured focus groups will be conducted with intervention group participants to inform program improvement.\n\nIf successful, this study will provide the evidence base required to proceed to a larger randomized controlled trial (ORBIT Phase III).",[32],[60,61,62,63,64,65,66,67,68,69],"migraine","self-hypnosis","clinical hypnosis","chronic pain","non-pharmacological intervention","telehealth","pain self-efficacy","pilot study","proof of concept","group intervention","NOT_YET_RECRUITING","2026-06-08",{"date":73,"type":37},"2026-06-12",{"date":75,"type":21},"2026-06-01",{"date":77,"type":21},"2027-09-30",{"name":79,"class":44},"Ciusss de L'Est de l'Île de Montréal",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":45},"100643788","evaluation-of-the-migraceutics-phase-specific-dietary-supplement-regimen-on-quality-of-life-work-productivity-and-biomarkers-in-adult-migraineurs-the-migraceutics-start-study-100643788","NCT07634146","Evaluation of the Migraceutics® Phase-Specific Dietary Supplement Regimen on Quality of Life, Work Productivity, and Biomarkers in Adult Migraineurs: The Migraceutics® START Study","A Randomized, Sham Supplement- and Care-as-Usual-Controlled Study to Evaluate Migraceutics® Phase-Specific Dietary Supplement Regimen on Quality of Life, Work Productivity, and Biomarkers in Adult Migraineurs: The Migraceutics® START Study","Inclusion Criteria:\n\n* Self-reported history of migraine, based on the International Headache Society (IHS) International Classification of Headache Disorders, 3rd edition (ICHD-3) diagnostic criteria for migraine.\n* Being able to take oral supplements.\n* Agreeing to maintain their regular lifestyle.\n* Access to internet and telephone.\n\nExclusion Criteria:\n\n* Pregnancy or lactation.\n* Presence of any active medical condition or diagnosis other than episodic migraine, including liver or kidney disease or condition.\n* Use of overlapping supplements or interacting medications.\n* Known allergies to study ingredients.\n* Daily use of alcohol, tobacco, or recreational drugs.\n* Participation in any other clinical or interventional study within 30 days prior to baseline or concurrently.",{"count":88,"type":21},920,[24],"The purpose of this study is to evaluate the impact of the Migraceutics® phase-specific dietary supplement regimen on quality of life, work productivity, and biomarkers in adult migraineurs.",[92,93,32,28,94,30,95,96],"Migraine","Migraine Disease","Migraine Disability","Menstrual Migraine","Menstrual Migraine (MM) Headaches",[98,99,100,101,102,60,103,104,105],"quality of life","productivity","disability","CGRP","headache","nutraceuticals","dietary supplement","migraceuticals","2026-06-03",{"date":71,"type":37},{"date":109,"type":21},"2026-07-08",{"date":111,"type":21},"2028-06-30",{"name":113,"class":44},"Miracle Wellness LLC",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":121,"minAge":17,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":126,"conditions":127,"keywords":138,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":45},"100571149","aerobic-exercise-and-its-impact-on-sensory-musculoskeletal-and-psychosocial-aspects-in-migraine-100571149","NCT06716489","Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine","Influence of Aerobic Exercise on Sensory Perception, Musculoskeletal and Psychosocial Alterations in Patients With Migraine","Inclusion Criteria:\n\n* Women aged between 18 and 48 years.\n* Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD).\n* Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment.\n\nExclusion Criteria:\n\n* Presence of any other type of concurrent headache.\n* Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others.\n* Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions.\n* Premature ovarian failure.\n* Regular physical exercise in the past year.\n* Body Mass Index (BMI) above 30.0.\n* Smokers or individuals using drugs that interfere with sensitivity and cardiac modulation (e.g., beta-blockers).\n* Abuse of abortive medications.","FEMALE","48 Years",{"count":124,"type":21},100,[24],"Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.\n\nThis randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session of pain neuroscience education, or a control group, which will receive recommendations for unsupervised physical activity at home.\n\nOutcomes related to migraine-related disability, self-reported symptoms, sensory sensitivity, and musculoskeletal function will be assessed at baseline and after the intervention period. Questionnaires will also be collected at a 6-month follow-up. The results of this study may contribute to the development of accessible and low-risk non-pharmacological treatment strategies for people with migraine.",[92,93,32,128,129,130,131,132,133,134,135,136,137],"Migraine Disorders, Brain","Headache","Headache (Migraine)","Headache Disorders","Headache Disorders, Primary","Aerobic Exercise","Pain Management","Sensory Disorders","Psychosocial Factors","Quality of Life",[60,139,140,141,102,100,142,98,143,144,145,136,146,147,148,149,150,151,152,153,154],"aerobic exercise","sensory perception","exercise","musculoeskeletal alterations","neck pain","cervical pain","Sensory Thresholds","Physical Fitness","Exercise Intervention","Central Sensitization","Physical Therapy","Migraine Management","Non-pharmacological Treatment","Clinical Trial","Headache Relief","sensitization","2026-04-27",{"date":157,"type":37},"2026-04-28",{"date":159,"type":37},"2026-03-03",{"date":161,"type":21},"2028-11-30",{"name":163,"class":44},"University of Sao Paulo",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":178,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100625694","sleep-hygiene-education-to-improve-sleep-in-chronic-migraine-and-back-pain-100625694","NCT07425964","Sleep Hygiene Education to Improve Sleep in Chronic Migraine and Back Pain","Kan Uddannelse i søvnhygiejne Forbedre søvnkvalitet for Patienter Med Kroniske Smerter?","Inclusion Criteria:\n\n* Chronic back pain (average pain VAS ≥ 3) AND\u002FOR Migraine (migraine or tension headaches ≥15 days per month with ≥8 days being migraine)\n* Lasting ≥3 months\n* Adults ≥18 years old\n* Read, speak, and understand Danish\n* Willing to implement sleep hygiene for four weeks\n* Digital competencies (sufficient to answer questionnaires online)\n\nExclusion Criteria:\n\n* Pregnancy\n* Drug addiction, defined as the use of cannabis, opioids, or other drugs\n* Malignant comorbidity (e.g., cancer)\n* Neurological conditions affecting cognition (e.g., multiple sclerosis, epilepsy, dementia, previous stroke\u002Ftransient cerebral ischemia)\n* Intake of acute headache medication on ≥15 days\u002Fmonth for simple analgesics\u002FNSAIDs or ≥10 days\u002Fmonth for triptans, ergotamine, opioids, or combinations thereof over 3 months.\n* Use of unstable sleep-modulating pharmacological treatment (e.g., melatonin, tricyclic antidepressants)\n* Diagnosed sleep disorder (e.g., insomnia, narcolepsy, sleep apnoea)\n* Night-shift work\n* Initiation of any new therapy during the study period\n* The subject is assessed as unable to engage in the necessary cooperation required by the study",{"count":124,"type":21},[24],"The goal of this clinical trial is to learn whether sleep hygiene education can improve sleep quality and reduce pain in adults with migraine and\u002For chronic lower back pain. Poor sleep is common in people with chronic pain and may worsen symptoms. Improving sleep may help break this cycle.\n\nThe main questions this study aims to answer are:\n\n1. Does a four-week sleep hygiene education program improve sleep quality?\n2. Does improved sleep lead to reduced pain intensity and changes in pain sensitivity?\n\nThis study does not include a comparison group. Each participant serves as their own comparison by completing the same tests before and after the sleep hygiene program.\n\nParticipants will:\n\n* Attend two study visits lasting 30-60 minutes, one at the beginning and one after four weeks\n* Complete questionnaires about sleep, pain, mood, and quality of life at both visits\n* Undergo pain sensitivity testing using light pinprick stimulations on the forearm\n* Receive individual sleep hygiene education and written materials to use at home for four weeks\n* Complete a short weekly online check-in about sleep habits and pain\n* Complete a three-month follow-up questionnaire about sleep habits, sleep quality, and pain",[32,175,176,177],"Low Back Pain","Chronic Pain","Sleep Disorder (Disorder)",[179,180,181],"Sleep Quality","Sleep Hygiene","Pain Sensitivity","2026-02-16",{"date":184,"type":37},"2026-02-23",{"date":186,"type":21},"2026-02",{"date":188,"type":21},"2028-12",{"name":190,"class":44},"Aalborg University",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":121,"minAge":17,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":203,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":45},"100590476","effectiveness-of-tai-chi-and-acupuncture-on-migraine-attack-prevention-and-brain-white-matter-changes-a-non-inferiority-rct-100590476","NCT06967909","Effectiveness of Tai Chi and Acupuncture on Migraine Attack Prevention and Brain White Matter Changes: A Non-Inferiority RCT","Effectiveness of Tai Chi and Acupuncture in the Prophylaxes of Episodic Migraine in Hong Kong Chinese Women and the Analysis of Microstructural White Matter Alterations: a Non-inferiority Single-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Chinese women aged 18 years and above;\n* Diagnosed with episodic migraines, with or without aura, according to the International Classification of Headache Disorders, 3rd edition (ICHD-3);\n* Migraine attack frequency ranging from 2 to 14 days per month (≥15 days\u002Fmonth is classified as chronic migraine and is not included in this study);\n* Assessed by a sports specialist as capable of engaging in moderate physical activity;\n* Residing in Hong Kong.\n\nExclusion Criteria:\n\n* Unable to engage in moderate physical activity;\n* Comorbid with other neurological disorders;\n* Experiencing non-migraine headaches for more than 5 days per month;\n* Previous practice of Tai Chi or other mind-body exercises (such as yoga, biofeedback, meditation, etc.);\n* Received alternative treatments for migraines (such as acupuncture or Chinese medicine) during the recruitment period or within the past 12 weeks;\n* Undergoing preventive medication treatment for migraines during the recruitment period or within the past 12 weeks;\n* Excessive use of medication, taking antipsychotic or antidepressant drugs, or using analgesics for other chronic pain conditions for more than 3 days per month within the past 12 weeks;\n* Diagnosed with epilepsy or having a mental illness;\n* Pregnant, breastfeeding, or currently taking contraceptive medication.",{"count":199,"type":21},132,[24],"The goal of this clinical trial is to determine the effectiveness of Tai Chi training and acupuncture on the migraine attacks and structural brain changes in women with episodic migraine.\n\nResearchers will compare Tai Chi training to acupuncture treatment in a randomized controlled trial with 132 female participants. Participants will:\n\n* Be randomly assigned to either the Tai Chi group or the acupuncture group.\n* Undergo a 24-week intervention, with structured sessions for Tai Chi or scheduled acupuncture treatments.\n* Complete assessments through migraine diaries, questionnaires, physical measurements, MRI and TCD scans at various time points.\n\nThe study ensures participant safety through close monitoring, with medical support available in case of discomfort. Data confidentiality will be maintained, with encrypted storage and restricted access for research purposes.",[92,32],[92,204,205,206,207],"Tai Chi","Acupuncture","Women","Prophylaxis","2025-05-05",{"date":210,"type":37},"2025-05-13",{"date":212,"type":21},"2025-06-01",{"date":214,"type":21},"2026-09-01",{"name":216,"class":44},"The Hong Kong Polytechnic University",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":228,"phases":4,"briefSummary":229,"conditions":230,"keywords":232,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":45},"100583883","neurophysiological-and-biomolecular-effects-of-atogepant-in-episodic-migraine-100583883","NCT06882122","Neurophysiological and Biomolecular Effects of Atogepant in Episodic Migraine","Neurophysiological and Biomolecular Effects of Atogepant in High Frequency Episodic Migraine (ATOM Project)","ATOM","Inclusion Criteria:\n\n* Individuals aged between 18 and 70;\n* Diagnosis of episodic migraine according to ICHD-3 criteria;\n* Monthly migraine days between 8 and 14 (high-frequency episodic migraine pattern) in the 3 months before screening;\n* Individuals naïve to CGRP-targeted treatments;\n* No more than one ongoing migraine preventive treatment with a stable dose for at least 3 months.\n\nExclusion Criteria:\n\n* Contraindications to atogepant;\n* History of serious psychiatric conditions;\n* Diagnosis of other primary or secondary headaches (only sporadic tension-type headache is allowed);\n* Medical conditions considered clinically significant by the investigator;\n* Chronic pain conditions that need chronic treatment;\n* Abuse of alcohol and\u002For drugs;\n* Pregnancy or breastfeeding.","70 Years",{"count":227,"type":21},30,"OBSERVATIONAL","The investigators aim to assess and compare neurophysiological and biochemical changes induced by a 3-month treatment with atogepant (60 mg daily) in patients with high-frequency episodic migraine (8-14 monthly migraine days). Evaluations will include neurophysiological assessments (High-Density EEG, nociceptive reflexes, and visual evoked potentials) and biomolecular profiling (gene expression of endocannabinoid catabolizing enzymes, CGRP and PACAP plasma levels, and headache-specific microRNAs). Outputs will contribute to defining predictors of atogepant response, elucidating its effects on brain connectivity, excitability, and CGRP\u002Fendocannabinoid pathways, and identifying alternative therapeutic targets for non-responders.",[32,231],"Episodic Migraine",[92,233,234,235,236,237,238],"Gepants","endocannabinoid system","MicroRNAs","Habituation deficit","Central sensitization","Functional Connectivity","2025-03-11",{"date":241,"type":37},"2025-03-18",{"date":243,"type":37},"2024-12-01",{"date":245,"type":21},"2026-04",{"name":247,"class":44},"IRCCS National Neurological Institute \"C. Mondino\" Foundation"]