[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"migraine-in-adolescence\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:migraine-in-adolescence":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100632436","headache-education-and-awareness-vs-daily-mindfulness-strategies---understanding-pain-100632436",false,"NCT07513662","Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain","Feasibility Trial of a Remotely-Delivered Mindfulness-Based Intervention for Adolescents With Migraine","HEADS-UP","Inclusion Criteria:\n\n* Age 12 to 17 years old\n* Diagnosed with migraine by medical provider using criteria from the International Classification of Headache Disorders, Third Edition\n* Patient report of at least 6 headache days per month\n* At least mild headache-related disability, as assessed by PedMIDAS score \\> 10\n* Stable dose (≥4 weeks) of prophylactic migraine medication or no current prophylactic medication at enrollment\n* Adolescent participant fluent in English for the intervention content\n\nExclusion Criteria:\n\n* Currently engaged in, or previously received 4 or more sessions of behavioral interventions for pain management (e.g., mindfulness or cognitive-behavioral therapy) in the past 6 months\n* Current psychiatric crisis (e.g., active suicidal ideation)\n* Cognitive impairments or developmental delays that interfere with their ability to participate in the study\n* Inability to provide consent\u002Fassent","ALL","12 Years","17 Years",{"count":21,"type":22},72,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study (supported by and included in the NIH HEAL Initiative: https:\u002F\u002Fheal.nih.gov\u002F) is to learn if a fully virtual study comparing two telehealth group interventions for adolescents with migraine is feasible and acceptable:\n\n1. Telehealth group mindfulness-based intervention\n2. Telehealth group headache education",[28,29],"Migraine","Migraine in Adolescence",[31,32,33,28,34,35,36],"Adolescent","Mindfulness","Mindfulness Intervention","Headache","Headache Education","Randomized controlled trial","NOT_YET_RECRUITING","2026-03-30",{"date":40,"type":41},"2026-04-07","ACTUAL",{"date":43,"type":22},"2026-09",{"date":45,"type":22},"2028-08",{"name":47,"class":48},"University of Colorado, Denver","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":49},"100537379","nvns-for-the-prevention-and-treatment-of-primary-headache-100537379","NCT06277063","nVNS for the Prevention and Treatment of Primary Headache","Noninvasive Vagus Nerve Stimulation for the Prevention and Treatment of Primary Headache: a Single-arm Single-center Clinical Trial.","Inclusion Criteria:\n\n1. Patients with migraine, cluster headache and tension-type headache were diagnosed according to Chinese Guidelines for the diagnosis and Treatment of Migraine (2022 edition) and Chinese Guidelines for the diagnosis and treatment of cluster headache (2022 edition).\n2. Age \\>=7 years old, \\\u003C=20 years old;\n3. Patients have experienced headache on 3-15 days per month in the past;\n4. Maintain a stable dose and frequency of medication and do not take new drugs during the course of participating in the trial;\n5. They volunteered to participate in the trial and signed informed consent.\n\nExclusion Criteria:\n\n1. History of secondary headache, aneurysm, intracranial hemorrhage, brain tumor, severe head trauma, drug abuse, addiction, syncope, or seizures;\n2. prior migraine-preventive surgery, cervical vagotomy, or implantation of an electronic or neurostimulator device;\n3. Simultaneous use of other devices (e.g., TENS devices, muscle stimulators);\n4. An implantable medical device in use, such as a pacemaker, hearing aid, or any implantable electronic device;\n5. underwent head and neck nerve block within the past 2 months;\n6. Opioid use (more than 2 days per month); Use of analgesics alone or non-steroidal anti-inflammatory drugs (more than 15 days per month); Or tamoxifen, ergots or combination analgesics (more than 10 days per month);\n7. Patients who underwent cervical vagotomy (cervical vagotomy);\n8. Pediatric patients (under 6 years old); Pregnant women;\n9. Patients with clinically significant hypertension, hypotension, bradycardia or tachycardia;\n10. Patients with congenital heart disease;\n11. Mental\u002Fcognitive disorders, etc.","7 Years","20 Years",{"count":60,"type":22},15,[25],"This study is a single-center, single-arm study. All subjects will receive the same treatment.\n\nChildren and adolescents (7-20 years old) with migraine who met the inclusion criteria will be enrolled as subjects in the experimental group, and the changes in headache scores before and after the intervention will be compared. The intervention method is as follows: ictal intervention, in which subjects will be evaluated for headache improvement after a short intervention during an acute exacerbation. By wearing a vagus stimulator, the stimulating electrode will be located in the concha region rich in vagus nerve fiber endings, and the appropriate stimulation intensity will be adjusted for stimulation.\n\nTherefore, this study will verify the effect of nVNS on the acute treatment of primary headache in children and adolescents. Based on the electrocardiogram and electromyography indicators during the intervention process of nVNS, an objective evaluation system for the improvement of headache by nVNS is established, and the role of stimulation parameters on the effect is further explored to realize the optimization of parameters.",[64,29,65,66,67],"Primary Headache","Migraine in Children","Cluster Headache","Tension Headache",[69,70,71],"Primary headache","Adolescents","Noninvasive vagus nerve stimulation","RECRUITING","2025-08-06",{"date":75,"type":41},"2025-08-12",{"date":77,"type":41},"2024-12-05",{"date":79,"type":22},"2026-12-30",{"name":81,"class":48},"Nanfang Hospital, Southern Medical University"]