[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mild-to-moderate-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mild-to-moderate-depression":76},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643989","probiotics-for-depressive-symptomatology-and-neural-activity-100643989",false,"NCT07667530","Probiotics for Depressive Symptomatology and Neural Activity.","The Acute and Chronic Effects of Ecologic® Barrier on Depressive Symptoms and Neural Activation.","PRODAN","Inclusion Criteria:\n\n* Mild to moderate depression symptoms (BDI-II 12-28)\n* Males and females\n* Age range will be 25-40 years\n* Right-handed participants only (required for EEG)\n\nExclusion Criteria:\n\n* Taking antidepressants (up to 2 months prior to inclusion)\n* Undergoing psychological treatment in the form of counselling, therapy or similar (up to 1 month prior to inclusion)\n* Any diagnosed chronic medical condition (e.g. diabetes) or psychiatric illness.\n* Use of antibiotics or laxatives (up to 3 months prior to inclusion)\n* Use of probiotics and\u002For prebiotics (up to 1 month prior to inclusion)\n* Enrolled in any other clinical trial (up to 1 month prior to inclusion)\n* Following restrictive and\u002For unbalanced diets\n* Smoking\n* Continuous use of a weight-loss medication for more than one month prior to screening\n* Significant gastrointestinal conditions affecting absorption, including but not limited to: inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end-stage renal disease; active cancer or cancer treatment within the past three years","ALL","25 Years","40 Years",{"count":21,"type":22},76,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.",[28,29,30],"Mild-to-moderate Depression","Neural Activity","Executive Function (Cognition)",[28,32,33,34],"Probiotic Supplementation","Neural Activation","Executive Function","NOT_YET_RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-07-01",{"date":43,"type":22},"2027-03-01",{"name":45,"class":46},"University of Reading","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100573861","phase-2-cross-over-study-on-the-influence-of-fampridine-on-working-memory-in-mild-to-moderate-depression-100573861","NCT06751784","Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression","Randomized Placebo-controlled Phase II Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression","FamD_2025","Inclusion Criteria:\n\n* Male or female\n* Major depressive episode confirmed by the Mini-DIPS. Currently mild to moderate (MADRS: 7-30).\n* Normotensive (BP: 90\u002F60mmHg - 140\u002F90mmHg). Sufficiently treated hypertensive subjects will be included.\n* BMI: 19 - 34,9 kg\u002Fm2\n* Age: 18 - 55 years\n* Fluent in German\n* IC as documented by signature\n\nExclusion Criteria:\n\n* Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to 4-aminopyridine\n* Use of potassium channel blockers within the last 3 months\n* Treatment with OCT 2 inhibitors and -substrates (e.g. cimetidine, propranolol)\n* Treatment with antidepressants or antipsychotics within the last 3 months and throughout the study period\n* Current intake of psychoactive drugs (e.g. benzodiazepines, antidepressants, neuroleptics).\n* Other acute or chronic psychiatric disorder (e.g. psychosis, somatoform disorder, alcohol or drug abuse disorder)\n* Cognitive impairment (MoCA score \\\u003C 25)\n* MADRS item 10 \\> 1 (suicidal tendency)\n* Risk of lowered seizure threshold (due to e.g. sleep deprivation, withdrawal of alcohol after alcohol abuse, hyponatraemia)\n* History of seizures\n* Acute cerebrovascular condition\n* Acute renal failure or severe renal insufficiency (creatinine clearance \\\u003C 30 ml\u002Fmin per 1.73 m2)\n* Bradycardia \\\u003C 50\u002Fmin during clinical examination.\n* History of malignant cancers\n* Walking problems (e.g. due to dizziness)\n* Other clinically significant concomitant disease states (e.g. hepatic dysfunction, cardiovascular disease, diabetes, asthma)\n* Clinically significant laboratory or ECG abnormality that could be a safety issue in the study\n* Severe somatic or neurological comorbidities\n* Smoking including all nicotine containing smoking systems and devices (\\>10 cigarettes\u002Funits per day). Failure to withstand a test day without craving, due to regular consummation patterns.\n* Pregnancy or breast feeding. Intention to become pregnant during the study participation.\n* Known or suspected non-compliance\n* Inability to follow the procedures of the study, e.g. due to language or psychological problems of the participant\n* Participation in another study with an investigational drug within the 30 days preceding and during the present study\n* Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons","18 Years","55 Years",{"count":59,"type":22},38,[61],"PHASE2","Cognitive deficits, including working memory deficits, are often present in depression and there are currently no effective pharmacological treatments targeting working memory deficits. Papassotiropoulos et al. (2024) has recently demonstrated that fampridine, a potassium channel blocker, can enhance working memory in healthy individuals with lower baseline performance, suggesting it may hold potential for addressing cognitive deficits in clinical populations. The primary aim of this study is to evaluate whether fampridine improves working memory performance in mild to moderate depression",[64,65],"Working Memory","Mild to Moderate Depression","RECRUITING","2025-12-04",{"date":69,"type":39},"2025-12-12",{"date":71,"type":39},"2025-05-22",{"date":73,"type":22},"2026-07",{"name":75,"class":46},"University of Basel","Mild to Moderate Depression."]