[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"military-operations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:military-operations":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":41,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":5},"100471118","art-therapy-and-emotional-well-being-in-military-populations-with-posttraumatic-stress-symptoms-100471118",false,"NCT05414708","Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms","Inclusion Criteria:\n\n* DEERS Eligible\n* Active Duty or Veteran separated within the past 10 years\n* Significant posttraumatic stress symptoms (score of \\>\u002F=31 on the PCL-5)\n\nExclusion Criteria:\n\n* History of moderate, severe, or penetrating brain injury\n* History of psychotic disorder, bipolar disorder, or active suicidal or homicidal ideation\n* History of multiple sclerosis, Huntington's disease, or Alzheimer's disease\n* History of stroke or myocardial infarction\n* History of brain tumor\n* History of seizures\n* Contradictions for MRI (for example, participants will be excluded for pregnancy, metal implants or suspected shrapnel, aneurysm\u002Fintracranial clips, cardiac pacemakers or implanted programmable devices or pumps)\n* Unable to provide informed consent\n* History of previous exposure to art therapy\n* Active substance use disorder","ALL","18 Years","64 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members. This research hopes to learn about the effects of art therapy on emotional expression and regulation in service members as well as the neurological systems at work. If a participant chooses to be in this study, he or she will attend eleven sessions over a period of six to eight months. The first session will be an interview and self-assessment questionnaires to collect information on a variety of symptoms, experiences, and personality traits, and an MRI scan. During the MRI scan, participants will be asked to perform a task where they will be shown a series of neutral and negative images. The following eight sessions will be one-hour art therapy sessions with a certified art therapist. The tenth session will consist of the same self-assessment questionnaires and another MRI scan. The final session will consist of some of the same questionnaires from the tenth visit, as well as a qualitative interview done virtually three months after the tenth visit.",[26,27,28,29,30,31,32,33,34,35,36,37,38,39,40],"PTSD","Military Activity","Post-Traumatic Headache","Posttraumatic Stress Disorder","Posttraumatic Stress Disorder, Delayed Onset","Sleep Disturbance","Nightmare","Irritable Mood","Anger","Combat and Operational Stress Reaction","Combat Stress Disorders","Military Family","Military Operations","Emotional Regulation","Emotion Processing",[26,42,43],"Military","Art Therapy","RECRUITING","2026-01-06",{"date":47,"type":48},"2026-01-08","ACTUAL",{"date":50,"type":48},"2022-02-01",{"date":52,"type":20},"2027-12",{"name":54,"class":55},"Walter Reed National Military Medical Center","FED",{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":21,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":83},"100560734","phase-3-hyperbaric-oxygen-treatment-for-veterans-with-traumatic-brain-injury-100560734","NCT06581003","Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury","Inclusion Criteria:\n\n1. U.S. Service Members and Veterans, between 18 and 75 years of age\n2. Ability to read, write, and speak English.\n3. Ability to provide informed consent.\n4. History of TBI. Participants must have a minimum of 1 year post injury and a TBI classified as mild to moderate as determined by with the Ohio State University TBI Identification Method (Bogner, 2009).\n5. Experiencing chronic symptoms of TBI as determined by at least a NSI total score of ≥22 (based on previous work using this score; Harch et al., 2020.\n6. Able to tolerate the HBOT environment lying down for one hour.\n\nExclusion Criteria:\n\n1. Received HBOT within the last 3 months.\n2. Concurrently enrolled in another clinical trial.\n3. Pregnancy or plans to become pregnant during the study period.\n4. Lactating\n5. History of retinal repair\n6. Malignancy:\n\n   1. Active\n   2. Tumor-related chemotherapy within the prior 6 months\n   3. Therapeutic radiation to the central nervous system within the prior year\n7. Current diagnosis of bipolar disorder type I or schizophrenia as determined by responses to inquiry: Have you ever been diagnosed or prescribed medications for bipolar disorder or schizophrenia?\n8. Chronic use of supplemental oxygen or hypoxemia while breathing room air.\n9. Untreated asthma\u002FBronchial obstruction\u002Fpulmonary blebs, recent\u002Funtreated pneumothorax\n10. Congestive heart failure with ejection fraction \\\u003C 40%\n11. Any implanted devices not cleared for hyperbaric pressurization\\*.\n12. Epilepsy and\u002F or seizures\n13. Scuba diving within the previous month\n14. Current suicidal intent as measured by ≥ 3 on the Columbia-Suicide Severity Rating Scale Screener\n15. Trapped gas observed indicating Bronchospasm present Tension Pneumothorax\n16. Evidence of Noncompliant TM (Until corrected)\n17. Evidence of Pneumothorax\n18. Evidence of Upper Respiratory Tract Infections\n19. Signs and symptoms of viral infections, such as high fevers\n20. Emphysema with CO2 retention\n21. Optic Neuritis\n22. Congenital spherocytosis\n23. History of middle ear surgery \u002F disorders\n24. Pneumocephalus\n25. Optional stool samples will not be collected if someone has diarrhea, vomiting, and took antibiotics in the past 30 days.\n26. Antabuse because it predisposes to oxygen toxicity.\n27. Other medications that would predispose to oxygen toxicity or known to increase drug toxicity will also be excluded. These are: Disulfuram, Acetazolamide, Sulfamylon; bleomycin, cisplatin, and doxyrubicin.\n28. Inability to complete MRIs (e.g., claustrophobia, pacemaker, ferromagnetic implants)\\* Exclusion criteria for fMRI optional sub-study only","75 Years",{"count":64,"type":20},420,[66],"PHASE3","The goal of this blinded, adaptive, randomized, placebo-controlled clinical trial is to investigate the use of hyperbaric oxygen as a therapy to treat mild to moderate traumatic brain injury in Veterans and active military. The main questions it aims to answer are:\n\n* Does Hyperbaric Oxygen Therapy (HBOT) reduce neurobehavioral symptoms? (Aim 1)\n* How many HBOT sessions are needed to achieve a significant reduction in neurobehavioral symptoms? (Aim 2)\n* Does HBOT reduce posttraumatic stress disorder (PTSD) symptoms? (Aim 3)\n\nExploratory objectives will explore if there are changes in: 1.) cognitive functioning using neuropsychological tests and the National Institutes of Health (NIH) toolbox, 2.) inflammation biomarkers in blood, 3.) microbiome in stool samples, 4.) electroencephalogram (EEG), 5.) sleep characteristics, and 6.) fMRI.\n\nResearch will compare HBOT therapy to a placebo condition to see if HBOT works to treat neurobehavioral symptoms. The placebo condition is a chamber that remains unpressurized and has 21% oxygen.\n\nParticipants will:\n\n1. Complete baseline assessments to determine eligibility.\n2. Attend 40 sessions of HBOT or placebo (normal air) within 12 weeks.\n3. Complete questionnaires and interviews throughout the course of the study.\n4. Complete a 2-week post treatment visit",[69,38],"Traumatic Brain Injury",[71,72],"hyperbaric chamber","neuromodulation","2025-11-14",{"date":75,"type":48},"2025-11-19",{"date":77,"type":48},"2024-09-18",{"date":79,"type":20},"2029-08-15",{"name":81,"class":82},"University of South Florida","OTHER",1]