[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"milk-expression-breast\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:milk-expression-breast":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100587492","effect-of-prenatal-and-postnatal-intervention-strategies-on-breastfeeding-outcomes-in-women-with-excessive-weight-ready-set-nourish-study-100587492",false,"NCT06929091","Effect of Prenatal and Postnatal Intervention Strategies on Breastfeeding Outcomes in Women With Excessive Weight (Ready, Set, Nourish Study)","Ready, Set, Nourish Study","RSN","Inclusion Criteria\n\n* Age 18 or older\n* Less than 37 weeks of pregnant with singleton fetus\n* Pre-pregnancy excessive weight (Body Mass Index ≥ 25 kg\u002Fm2)\n* Interested in breastfeeding\n* Willing to express colostrum from around 37 weeks of pregnancy if randomized to the prenatal intervention group\n* Willing to express human milk for sample collection during a 24-hour period\n* Willing to adhere to a meal plan for 5.5 months post-partum if randomized to the postnatal intervention group\n* Able to engage in study procedures for the first 24 months postpartum\n* Reside in Central Arkansas region Exclusion Criteria\n* Pre-existing conditions (e.g. diabetes, hypertension, heart disease, thyroid disorders);\n* Use of recreational drugs, tobacco, or 2 or more servings of alcohol per month\n* Food allergies, intolerances, or preferences interfering with the meal plan\n* Medical history including any contraindication to breastfeeding (medications or supplements incompatible with breastfeeding, substance use)Multiparous pregnancy\n* History of breast surgery or radiation\n* Congenital defects\n* Preeclampsia","FEMALE","18 Years",{"count":20,"type":21},240,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is about preparing women with excessive weight to have better breastfeeding outcomes. By doing this study, the investigators hope to learn more about how hand expression of breast milk or colostrum during pregnancy can help prepare a mother to breastfeed after she has her baby and about how her diet affects the composition of her breast milk and her baby's growth and development.",[27,28,29],"Breastfeeding","Dietary Intervention","Milk Expression, Breast",[27,31,32,33],"Human Milk","Obesity","Health Diet","RECRUITING","2025-12-04",{"date":37,"type":38},"2025-12-10","ACTUAL",{"date":40,"type":38},"2025-11-07",{"date":42,"type":21},"2029-12-01",{"name":44,"class":45},"Arkansas Children's Hospital Research Institute","OTHER",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100530105","virtual-reality-distraction-for-maternal-milk-expression-pilot-100530105","NCT06182449","Virtual Reality Distraction for Maternal Milk Expression (PILOT)","Feasibility, Acceptability and Effects of Virtual Reality Distraction for Management of Stress in Mothers Expressing Their Maternal Milk (VR-MOM)","VR-MOM","Inclusion Criteria:\n\n1. speak and read French or English\n2. have given birth to a premature newborn at 29 weeks or less\n3. minimum 18 years old\n4. have chosen breastfeeding\n5. who are at least in their second week postpartum\n\nExclusion Criteria:\n\n1. Having a mental health problem or a significant cognitive disorder that prevents them from understanding the purpose of the study\n2. Having a diagnosis of epilepsy",{"count":56,"type":21},20,[24],"Background In neonatal intensive care units (NICUs), mothers are encouraged to express their milk using an electric breast pump. This practice is promoted by nurses and neonatologists due to its beneficial outcomes for newborns. Compared to newborns exclusively fed commercial infant formula, preterm newborns fed breast milk (BM) are less likely to suffer from necrotizing enterocolitis and late-onset sepsis. However, the discomfort associated with using an electrical pump may discourage its use, and almost all mothers start expressing their BM after a premature birth but many stop after a few weeks due to fatigue and stress. Therefore, virtual reality (VR), an immersive experience, seems to be an interesting option as it would provide a relaxing environment and distract mothers of newborns in NICU from the stress and discomfort experienced in order to promote breast milk expression.\n\nAim\n\nThe aim of this within-subject, pilot clinical trial is to assess the feasibility, acceptability, and preliminary effects of VR on stress, discomfort, and volume of expressed milk in mothers of preterm newborns.\n\nMethods\n\nDesign:\n\nWithin-subject, randomized pilot clinical trial in which participants are their own control.\n\nSetting and sample:\n\nLevel 3 neonatal intensive care unit (NICU) at a Montreal pediatric teaching university center. Newborns under 29 weeks of age were chose to ensure that newborns would be admitted and remain in the NICU. The objective is to recruit 20 mothers of premature newborns. This will correspond to a total sample of 40 participants as they will be their own control. There will be 50% more mothers recruited (10) to compensate for the usually high attrition or rejection rate for this population, thus a total sample of 30 mothers. Healthcare professionals (nurses and doctors) providing care to participating mothers will be asked to fill a questionnaire on the feasibility of the VR intervention.\n\nRandomization and exposure to the interventions:\n\nThe sequence of exposure to VR will be randomized, not the participants: sequence of 2 days with VR and 2 days without VR. The study will take place over the course of one week. Participating mothers will either be exposed to VR for a minimum of 2 sessions of 30 minutes\u002Fday for two days and the following two days to the control intervention or the opposite.",[60,29,61],"Anxiety","Breast Milk Collection","NOT_YET_RECRUITING","2025-08-18",{"date":65,"type":38},"2025-08-24",{"date":67,"type":21},"2026-01",{"date":69,"type":21},"2027-06",{"name":71,"class":45},"St. Justine's Hospital",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":72},"100396871","bern-birth-cohort--trajectory-of-microbiota-maturation-in-healthy-bern-infants---a-network-approach-100396871","NCT04447742","Bern Birth Cohort \u002F Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach","BeBiCo","Inclusion Criteria:\n\n* Signed informed consent.\n* Ability to understand and follow study procedures and understand informed consent\n* From week 20 of pregnancy until birth\n* General good health, i.e. absence of major severe medical\u002F surgical\u002F psychiatric condition requiring ongoing management. Minor well controlled conditions (e.g. medically controlled arterial hypertension, occupational asthma, gestational diabetes mellitus) may be present.\n* Absence of known severe embryonal pathology, expected normal pregnancy (e.g. minor conditions including twin\u002F triplet pregnancy, final pelvic position may be present)\n* Age 18-45 years.\n\nExclusion Criteria:\n\n• Participation in another clinical study interfering with study procedures.",true,"45 Years",{"count":83,"type":21},250,"OBSERVATIONAL","Background: Intestinal microbiota composition is fundamental to human health and undergoes critical changes within the first two years of life. Factors probably influencing the microbiota are the maternal microbiota and the general environment in Switzerland. However, the development of the intestinal microbiota is incompletely understood. Gaining knowledge of the trajectory of microbiota maturation is likely key to the understanding of the pathogenesis of many pathologies in childhood.\n\nAims: The investigators aim for a deep understanding of the maturation of the healthy infant intestinal microbiota regarding composition, diversity and metabolic activities. The investigators aim for identifying parameters affecting microbiota maturation and effects of the microbiota on infant outcome.\n\nMethods: The investigators will recruit 250 pregnant mothers who will be followed as mother-baby pairs until 10 years of age. Infants will be followed clinically to determine adequate growth and development as well as pathology including abdominal pain. Epidemiological parameter and infant nutrition will be assessed. The investigators will collect biological samples such as stool, maternal milk, vaginal swaps and skin swaps.\n\nSpecies composition and diversity will be assessed by 16S sequencing. Metagenomic shotgun sequencing and bacterial messenger ribonucleic acid (mRNA) analysis will inform about metabolic potential and metabolic activity of the microbiota. Mass spectrometry will assess the small molecule content of stool and maternal milk samples. Network analysis will be used to assess the complex relationships between bacteria metabolic activities and small molecular content.\n\nExpected results: The investigators expect an increase in complexity and metabolic potential and activity with age. Microbiota parameters will differ according to nutrition and might predict infant outcomes such as growth and abdominal pain. Systematic analysis of sequential maternal and infant bacteria samples from stool, skin and maternal milk will help characterizing bacterial transfer from mother to infant Conclusion: The investigators propose an observational study of healthy Bern mother baby pairs with clinical characterisation and biological sampling. Advanced analysis tools will be used to characterise the microbiota and address mechanistic questions.",[87,88,89,29,90],"Maturation of the Healthy Infant Intestinal Microbiota","Microbial Colonization","Nutrition Disorder, Infant","Mental Health Disorder","2024-11-11",{"date":93,"type":38},"2024-11-12",{"date":95,"type":38},"2020-05-07",{"date":97,"type":21},"2035-03-03",{"name":99,"class":45},"Insel Gruppe AG, University Hospital Bern"]