[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"minimal-invasive-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:minimal-invasive-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,78,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100641582","the-anorectal-function-and-qol-of-patients-receiving-transrectal-nose-via-rigid-tamis-platform-in-minimal-invasive-colon-surgery-100641582",false,"NCT07653607","The Anorectal Function and QoL of Patients Receiving Transrectal NOSE Via Rigid TAMIS Platform in Minimal Invasive Colon Surgery","A Prospective, Multi-Center, Single-Arm, Open-Label Study to Analyze Anorectal Function and Quality of Life in Patients Undergoing Minimally Invasive Colectomy With Transrectal Natural Orifice Specimen Extraction (NOSE) Using a Rigid Transanal Minimally Invasive Surgery (TAMIS) Platform","Inclusion Criteria:\n\n1. Male or female, aged above 18 years, inclusive.\n2. Patients scheduled for an elective laparoscopic or robotic-assisted colectomy above sigmoid colon.\n3. Deemed a suitable candidate for the Transrectal NOSE procedure by the treating surgical team, based on tumor size (generally, largest diameter \\\u003C 4 cm), tumor T stage(1-3), location, and patient anatomy.\n4. American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.\n5. Able to understand the purpose, procedures, potential risks, and benefits of the study and willing to provide written informed consent, as approved by the Institutional Review Board (IRB).\n6. Willing and able to comply with all scheduled follow-up visits and assessment procedures outlined in the protocol.\n\nExclusion Criteria:\n\n1. Pre-existing moderate-to-severe fecal incontinence, defined as a Wexner incontinence score \\> 8.\n2. History of any prior anal surgery (e.g., sphincteroplasty, artificial sphincter implantation, fistulotomy), major pelvic surgery (e.g., hysterectomy, radical prostatectomy), or pelvic radiation therapy.\n3. Confirmed diagnosis of Inflammatory Bowel Disease (Crohn's disease or ulcerative colitis).\n4. The planned surgical procedure requires a protective stoma.\n5. Uncorrectable coagulopathy identified on preoperative assessment.\n6. Known neurological condition affecting bowel control (e.g., spinal cord injury, multiple sclerosis, significant post-stroke deficits).\n7. Cognitive impairment, severe psychiatric illness, or other condition that would interfere with reliable completion of questionnaires or compliance with the protocol.\n8. Currently pregnant, breastfeeding, or planning to become pregnant during the study period.\n9. Concurrent participation in another interventional clinical trial that could potentially interfere with the study outcomes.\n10. Any other condition which, in the professional opinion of the investigator, makes the subject unsuitable for participation in this study.","ALL","18 Years",{"count":19,"type":20},57,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary objective of this study is to prospectively determine and precisely estimate the incidence of Internal Anal Sphincter (IAS) Injury at 12 months following colectomy with Transrectal NOSE.",[26,27],"Minimal Invasive Surgery","Colon Surgery","NOT_YET_RECRUITING","2026-06-15",{"date":31,"type":32},"2026-06-17","ACTUAL",{"date":34,"type":20},"2026-06-01",{"date":36,"type":20},"2029-07-31",{"name":38,"class":39},"Chang Gung Memorial Hospital","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100611609","minimally-invasive-prostate-interventions-registry-mist-study-100611609","NCT07242807","Minimally Invasive Prostate Interventions Registry (MIST Study)","Evaluation of Clinical and Functional Outcomes After Minimally Invasive Prostate Interventions: A Multicenter Prospective REDCap Registry (MIST Study)","MIST","Inclusion Criteria:\n\n* Male patients aged ≥40 years\n* Diagnosis of benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS) or benign prostatic obstruction (BPO)\n* Undergoing a minimally invasive prostate intervention (Rezum, UroLift, Aquablation, PAE, iTind, TPLA, TUNA, TUMT) as part of standard clinical care\n* Ability and willingness to attend scheduled follow-up visits\n* Prospective participants able to provide written informed consent\n* Retrospective cases eligible if data are fully de-identified and inclusion is approved by local ethics\u002FIRB authorities\n\nExclusion Criteria:\n\n* Active urinary tract infection at the time of treatment\n* ASA physical status ≥5\n* Prior pelvic radiotherapy resulting in severe bladder dysfunction\n* Severe cognitive impairment or inability to participate in follow-up\n* Missing essential baseline data (for retrospective entries)\n* Patients receiving experimental or investigational prostate devices or therapies outside routine clinical care","MALE","40 Years",{"count":51,"type":20},2000,"72 Months","OBSERVATIONAL","This study is a multicenter prospective patient registry designed to evaluate clinical, functional, and safety outcomes after minimally invasive prostate interventions (MIST) performed for benign prostatic obstruction (BPO) secondary to benign prostatic hyperplasia (BPH). The interventions included in this registry represent standard-of-care treatment options and may include Rezum water vapor therapy, UroLift prostatic urethral lift, Aquablation, prostatic artery embolization (PAE), iTind, transperineal laser ablation (TPLA), transurethral needle ablation (TUNA), and transurethral microwave therapy (TUMT).\n\nThe registry collects standardized data using a secure REDCap platform from participating international centers. Data elements include demographic characteristics, comorbidities, medication use, laboratory parameters, prostate volume assessments, uroflowmetry, post-void residual measurements, patient-reported symptom scores, sexual function assessments, intraoperative details, complications (classified using Clavien-Dindo), and postoperative recovery parameters. Follow-up visits occur at 1, 3, 6, 12, 24, and 36 months, with an optional extended follow-up at 72 months to assess long-term durability and reintervention-free survival.\n\nThe primary aim of the study is to evaluate improvements in urinary symptoms (IPSS), quality of life, maximum urinary flow rate (Qmax), and post-void residual volume (PVR) following MIST procedures. Secondary objectives include assessing perioperative safety, catheterization duration, predictors of treatment success or failure, need for reintervention, and long-term preservation of continence and sexual function.\n\nThis registry is observational and does not assign or modify any treatment. All procedures are performed based on local clinical practice and physician judgment. Prospective participants provide informed consent. Data collected will be used to generate real-world evidence to guide patient selection, optimize procedural outcomes, and compare clinical performance across different minimally invasive prostate interventions.",[56,26,57],"Benign Prostatic Hyperplasia (BPH)","LUTS",[46,59,60,61,62,63,64,65,66,67],"Minimally Invasive Surgical Therapy","Rezum","UroLift","Aquablation","Prostatic Artery Embolization","iTind","TPLA","Benign Prostatic Hyperplasia","Lower Urinary Tract Symptoms","2026-03-28",{"date":70,"type":32},"2026-03-31",{"date":72,"type":20},"2026-03-25",{"date":74,"type":20},"2031-12-30",{"name":76,"class":39},"Necmettin Erbakan University",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":77},"100619396","comparing-outcomes-using-1-versus-2-kirshner-wire-fixation-in-patients-with-severe-hallux-valgus-100619396","NCT07344077","Comparing Outcomes Using 1 Versus 2 Kirshner Wire Fixation in Patients With Severe Hallux Valgus","Comparison of Radiographic and Functional Outcomes of Minimal Invasive Distal Metatarsal Osteotomy Using 1 Versus 2 Kirshner Wire Fixation in Patients With Severe Hallux Valgus: A Randomized Controlled Trial","Inclusion Criteria:\n\n* age 18-60 year\n* pain along medial surface of first MTP joint\n* radiographic finding : medial deviation of first Metatarsal bone , and lateral deviation of Big toe\n* complete a follow up period of 1 year , filling questionaires and undergone radiographic examination every visit\n* radiographic finding : Hallux valgus angle \\>20 , Intermetatarsal angle \\> 10 degrees\n* failed conservative treatment for atleast 8 months , with persistent pain along medial eminence and having difficulty walking, bearing weight\n\nExclusion Criteria:\n\n* previous injury\u002Ffracture at big toe\n* deviation\u002F subluxation of 1st MTP joint from traumatic event\n* arthritic change of metatarsal bone, phalangeal bone of big toe\n* previous\u002Factive infection , open wound along first metatarsal and big toe\n* patient denied enrolling in study","60 Years",{"count":87,"type":20},50,[23],"Comparing the radiographic and functional outcomes by using a Minimal invasive procedure to treat Hallux Valgus ; Distal linear Metatarsal Osteotomy -\n\n1 Kirshner wire fixation versus two Kirshner wire fixation",[91,92,93,26],"Hallux Valgus Correction","Hallux Valgus","Hallux Valgus Deformity",[95,96,97],"DLMO","kirshner wire fixation","minimal invasive surgery","RECRUITING","2026-01-07",{"date":101,"type":32},"2026-01-15",{"date":103,"type":32},"2024-06-01",{"date":105,"type":20},"2026-05-01",{"name":107,"class":39},"Queen Savang Vadhana Memorial Hospital, Thailand",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100575324","high-versus-low-pneumoperitoneum-pressure-for-parenchymal-transection-in-minimally-invasive-major-liver-surgery-100575324","NCT06770803","High Versus Low Pneumoperitoneum PressUre for Parenchymal Transection in Minimally Invasive Major Liver Surgery","High Versus Low Pneumoperitoneum PressUre for Parenchymal Transection in Minimally Invasive Major Liver Surgery - a Non-inferiority, Multicenter, Randomized, Controlled Trial","PPULS","Inclusion Criteria:\n\n* age equal or older than 18 years and\n* capacity of consent and\n* planned elective conventional laparoscopic or da Vinci-assisted major liver resection or resections near the liver hilum or the hepatic venous vasculature. Major liver resections are defined as the resection of 3 liver segments or more (right and left partial hepatectomies, extended right and left hepatectomies, liver resections of 3 or more segments). Right posterior sectionectomies and mesohepatectomies of ≥2 liver segments are considered resections in proximity to the liver hilum or hepatic venous vasculature.\n\nExclusion Criteria:\n\n* the participation in another trial with interference of intervention and outcome of this study,\n* being a woman who is pregnant or breast-feeding or planning to become pregnant,\n* American Society of Anesthesiologists (AS) score \\>3,\n* language barrier,\n* any contraindication to a minimal invasive surgical approach or intolerance to pneumoperitoneum\n* a patent foramen ovale (PFO) or any other structural cardiac defect that facilitates paradoxical gas embolisms,\n* diagnosis of neuromuscular disease, heart failure NYHA \\> class II or chronic obstructive pulmonary disease (COPD)\n* being on oral anticoagulation therapy other than Aspirin 100mg daily or any other condition known to increase the risk of bleeding.",{"count":117,"type":20},132,[23],"Minimally invasive techniques in liver surgery gain popularity as they facilitate postoperative recovery while achieving comparable oncologic outcomes to the open approach. No consensus on the application of pneumoperitoneum pressure in minimal invasive liver resections (MILR) has been reached yet, as prospective clinical studies are scarce. The positive pressure of the CO2 pneumoperitoneum reduces intraoperative blood loss during MILR alongside the development of new transection devices and advancements in inflow control. Low-pressure pneumoperitoneum on the other hand has been shown to decrease postoperative pain scores and analgesic consumption in comparison to standard pneumoperitoneum, and international guidelines recommend the application of \"the lowest intra-abdominal pressure allowing adequate exposure of the operative field rather than a routine pressure\". Nevertheless, evidence for the application of low-pressure pneumoperitoneum is only moderate to low, requiring additional studies to better define its safety. To address this oxymoron, the investigators conduct a randomized non-inferiority trial to investigate the effect of low in comparison to high-pressure pneumoperitoneum during the transection phase of major MILR on intraoperative blood loss while also evaluating the risk of embolic complications.",[121,26,122],"Liver Surgery","Major Liver Resection",[124,125,126],"Pneumoperitoneum","minimal-invasive liver surgery","intraoperative blood loss","2025-01-07",{"date":129,"type":32},"2025-01-13",{"date":131,"type":20},"2025-01",{"date":133,"type":20},"2027-01",{"name":135,"class":39},"University Hospital Heidelberg"]