[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"minoca\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:minoca":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,82,106,130,153,174,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100607007","determinants-of-cardiorespiratory-fitness-and-effects-of-hiit-in-patients-with-anoca-obstructive-coronary-artery-diseaseanoca-100607007",false,"NCT07182955","Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)","Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)","Inclusion Criteria:\n\n* Age 18-85\n* ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)\n* Able to use the wearable and participate in a remote exercise program\n* Able to participate in intermittent high-intensity training.\n* Able to perform cardiopulmonary exercise testing (CPET)\n* Able to provide Health-related quality of life questionnaire (HRQOL)\n* Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English\n\nExclusion Criteria:\n\n* Systolic heart failure (LVEF \\\u003C50% or NYHA class III symptoms)\n* Prior myocardial infarction, coronary revascularization\n* Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment\n* Pregnancy (due to unknown effects on CPET exercise markers)\n* Inability to provide informed consent\n* Life expectancy \\\u003C1 year\n* Prisoners\n* Cognitively impaired\n* Non-English speaking","ALL","18 Years","85 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it.\n\nThis study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life.\n\nInvestigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.",[27,28,29],"MINOCA","Shortness of Breath","Atherosclerotic Heart Disease of Native Coronary Artery",[31,32,33,34],"ANOCA\u002FMINOCA","High Intensity Interval Training","CPET Phenotype","Cardiorespiratory Fitness","RECRUITING","2025-09-18",{"date":38,"type":39},"2025-09-19","ACTUAL",{"date":41,"type":39},"2025-08-11",{"date":43,"type":21},"2026-04-14",{"name":45,"class":46},"University of Virginia","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100600886","comprehensive-coronary-physiology-in-patients-with-angina-with-nonobstructive-coronary-arteries---czech-republic-100600886","NCT07103317","Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic","Comprehensive COROnary PHYSiology Assessment in Patients With Angina With Nonobstructive Coronary Arteries - CZECH Republic (CoroPhys-CZECH)","CoroPhys-CZ","Inclusion Criteria:\n\n* Adults of both sexes older than 18 years\n* Angina symptoms or angina equivalent\n* Referred to cath lab for evaluation of CAD\n* Invasive physiology testing performed (microcirculation testing +\u002F- vasospasm testing)\n\nExclusion Criteria:\n\n* Persons under the age of 18\n* Pregnant of nursing\n* No coronary physiology measurements were performed",{"count":57,"type":21},1000,"100 Years","OBSERVATIONAL","Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of microcirculation and vasospastic disorders in causing angina. The microvascular bed is composed of vessels smaller than 400 microns in diameter. Their network is significantly larger than that of the epicardial vessels and serves essential functions, including regulating myocardial blood flow and cellular metabolism.\n\nAngina pectoris, a most frequent symptom of CAD or myocardial ischemia, was assumed to be caused by significant stenosis of the epicardial coronary artery. However, it was found that in over 50% of cases, there was no obstructive CAD, which is described as angina with no obstructive coronary arteries (ANOCA) or ischemia with no obstructive coronary arteries (INOCA), according to the clinical setting.",[62,63,27,64,65,66,67],"ANOCA","ANOCA - Angina With Non-obstructive Coronary Arteries","Microvascular Dysfunction","Microvascular Angina","Vasospastic Angina","Acetylcholine",[62,69,27,70,65,66,71,72],"INOCA","Coronary Microvascular Dysfunction","Acetylcholine Testing","Coronary Termodilution","2025-08-01",{"date":75,"type":39},"2025-08-05",{"date":77,"type":39},"2023-04-20",{"date":79,"type":21},"2030-01-01",{"name":81,"class":46},"University Hospital, Motol",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":90,"targetDuration":92,"studyType":59,"phases":4,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100597181","retinal-octa-for-microvascular-dysfunction-evaluation-and-outcome-prediction-in-minoca-patients-100597181","NCT07055152","Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients","REVEAL","Inclusion Criteria:\n\n* Age: Patients aged \\> 18.\n\nDiagnosis:\n\nMINOCA Group: Patients diagnosed with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) confirmed by coronary angiography.\n\nACS Group: Patients with Acute Coronary Syndrome (ACS) with significant coronary artery stenosis which are matched with MINOCA patients for gender, age, LVEF at admission and chronic kidney disease stage.\n\nHealthy Controls: Age and gender-matched healthy individuals with no history of cardiovascular disease.\n\nConsent: Written informed consent obtained from all participants. Feasibility: Ability to undergo OCTA and other required imaging procedures.\n\nExclusion Criteria:\n\n* Ocular Conditions: Any significant ocular disease (e.g., glaucoma, diabetic retinopathy, macular degeneration) that could interfere with OCTA imaging quality.\n\nSevere Comorbidities: Presence of severe systemic diseases, such as advanced renal failure, active cancer, or severe liver disease, which might impact study participation.\n\nCoronary Artery Disease or Myocarditis: For the MINOCA group, patients with coronary artery stenosis \\> 50% or functionally significant (FFR \\\u003C0.8) or patients with Myocarditis detected through CMR will be excluded Pregnancy: Pregnant or breastfeeding women. Inability to Comply: Patients unable or unwilling to comply with study procedures, including follow-up visits.",true,{"count":91,"type":21},90,"24 Months","The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS patients. The study will compare the retinal microvascular parameters across these groups to determine differences in microvascular function in MINOCA patients. Additionally, in the MINOCA subgroup, the study will further evaluate the differences in microvascular dysfunction within specific subsets of patients (e.g., Takotsubo, vasospastic angina, microvascular angina, patients with evidence of plaque erosion) to understand the variability and potential mechanisms underlying each subgroup of MINOCA.",[27,95,96],"STEMI","Normal","2025-07-03",{"date":99,"type":39},"2025-07-08",{"date":101,"type":39},"2025-01-01",{"date":103,"type":21},"2027-01-01",{"name":105,"class":46},"University of Pisa",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":47},"100577898","role-of-spectral-ct-in-the-diagnosis-of-myocarditisminoca-in-patients-undergoing-cardioct-investigations-for-acute-chest-pain-100577898","NCT06804278","Role of Spectral CT in the Diagnosis of Myocarditis\u002FMINOCA in Patients Undergoing cardioCT Investigations for Acute Chest Pain","Inclusion Criteria:\n\n* Age greater than or equal to 18 years;\n* patients with acute chest pain and indication for triple-rule-out CT or coronary CT examination, i.e. low\u002Fintermediate probability of acute coronary artery disease, ECG and\u002For troponin not diagnostic or altered;\n* Obtaining informed consent\n\nExclusion Criteria:\n\n* Absolute contraindications to CT examination and\u002For iodinated mdc administration (i.e. pregnancy, severe renal impairment in non-dialysis patients with GFR \\\u003C 15-30 ml\u002Fmin\u002F1.73m2 );\n* CT examinations that do not allow diagnostic information to be provided because they are assessed as quality too scarce and not interpretable (affected by artifacts such as motion artifacts)",{"count":113,"type":21},200,"It is a spontaneous, observational cross-sectional and single-center imaging (CT and MRI) study, coupled with clinical-laboratory data. Patients with acute chest pain with low\u002Fintermediate probability of coronary artery disease, ECG and\u002For troponin not diagnostic or altered according to the current \"standards of care\" used in the ED\u002FDepartment (ESC Guidelines 2020), will be enrolled consecutively and will undergo CT examinations by means of \"Spectral\" CT technology. CT investigation will allow to identify any non-myocarditis causes of acute chest pain and by means of spectral analysis of CT images it will try to identify signs suggestive of damage myocardial (such as ECV, LIE, hyperemia and edema).",[116,117,118,119,120],"Cardiac Imaging Techniques","Cardiac Imaging","Myocardial Disease","Myocarditis Acute","Minoca","2025-01-29",{"date":123,"type":39},"2025-02-03",{"date":125,"type":39},"2024-11-18",{"date":127,"type":21},"2027-02",{"name":129,"class":46},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":27,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":136,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":152},"100464371","implantable-cardiac-monitor-to-detect-atrial-fibrillation-in-patients-with-minoca-100464371","NCT05326828","Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA","Inclusion Criteria ICM group\n\n1. ≥18 years of age\n2. Written informed consent\n3. Acute myocardial infarction (AMI) type 1 in accordance with the 4th universal definition of myocardial infarction\n4. Non-obstructive coronary arteries on angiography defined as the absence of coronary artery stenoses ≥50% in any potential infarct-related artery\n5. No clinically overt specific cause for the acute presentation\n6. Subendocardial or transmural late gadolinum enhancement (LGE) consistent with an ischemic etiology on cardiac magnetic resonance imaging (CMR)\n7. No clear underlying cause of MINOCA and therefore increased probability of atrial fibrillation\n\nExclusion Criteria ICM group:\n\n1. Known atrial fibrillation or atrial flutter\n2. History of atrial fibrillation or atrial flutter ablation\n3. Known coronary artery disease\n4. Previous MI\n5. Previous percutaneous coronary intervention (PCI)\n6. Previous coronary artery bypass grafting (CABG)\n7. Contraindications to CMR (i.e. non-MR-compatible implantable cardiac device, glomerular filtration rate (GFR) \\\u003C30 ml\u002Fmin)\n8. Contraindications to ICM implantation\n9. Clear underlying cause of MINOCA before ICM implantation\n\nInclusion Criteria non-ICM group:\n\n1. ≥18 years of age\n2. Written informed consent\n3. AMI type 1 in accordance with the 4th universal definition of myocardial infarction\n4. Non-obstructive coronary arteries on angiography defined as the absence of coronary artery stenoses ≥50% in any potential infarct-related artery\n5. No clinically overt specific cause for the acute presentation\n6. Subendocardial or transmural LGE consistent with an ischemic etiology on CMR\n\nExclusion Criteria non-ICM group:\n\n1. Known coronary artery disease\n2. Previous MI\n3. Previous PCI\n4. Previous CABG\n5. Contraindications to CMR (i.e. non-MR-compatible implantable cardiac device, GFR \\\u003C30 ml\u002Fmin)",{"count":137,"type":21},60,"Myocardial infarction with non-obstructive coronary arteries (MINOCA) (i.e.\\\u003C50% stenoses) on coronary angiography) is an underappreciated clinical entity concerning 5-6% of patients with acute myocardial infarction. Approximately 50% of these patients remain without appropriate diagnosis and treatment.\n\nThe MINOCA study aims at systematically assessing the frequency of underlying pathologies of MINOCA and outcomes with a multidisciplinary etiologic work-up and follow-up of 5 years including, for the first time, an implantable cardiac monitor (ICM) to assess the frequency of atrial fibrillation as underlying cause for MINOCA.",[27,140],"Atrial Fibrillation",[142],"Implantable cardiac monitor","2024-10-28",{"date":145,"type":39},"2024-10-30",{"date":147,"type":39},"2022-05-24",{"date":149,"type":21},"2031-05-15",{"name":151,"class":46},"Insel Gruppe AG, University Hospital Bern",2,{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":47},"100555417","myocardial-infarction-with-non-obstructive-coronary-arteries-italian-study-100555417","NCT06511817","Myocardial Infarction With Non-obstructive Coronary Arteries: Italian Study","Myocardial Infarction With Non-obstructive Coronary Arteries: Italian Observational","MINOCA-IT","Inclusion Criteria\n\n* Age ≥ 18 years;\n* Diagnosis of MINOCA;\n* Informed consent signed by the patient or parent\u002Fguardian\u002Flegal representative.\n\nExclusion criteria\n\n* Age \\\u003C18 years;\n* Refusal to sign written informed consent.",{"count":57,"type":21},"Acute coronary syndromes have been extensively studied in recent decades, focusing mainly on myocardial infarctions with obstructive coronary artery disease and early revascularisation strategies. However, the extensive use of highly sensitive troponin tests and coronary angiography has revealed a substantial group of patients with myocardial infarction without significant coronary stenosis (≥50%). This group is referred to as myocardial infarction with non-obstructive coronary arteries (MINOCA). MINOCA are defined by evidence of a myocardial infarction with normal or near-normal coronary arteries on angiography, in the absence of an alternative diagnosis specific to the clinical presentation (e.g. sepsis, myocarditis, pulmonary embolism). MINOCA may present with different aetiologies, including coronary plaque rupture\u002Ferosion, epicardial or microvascular spasm and coronary embolism. Therefore, the diagnosis of MINOCA must be considered a 'working diagnosis', which not only requires but warrants further investigation to determine the underlying cause. In fact, the investigation of MINOCA is conducted on two levels, first by excluding disorders that mimic myocardial infarction and then by identifying the cause responsible for MINOCA. In order to identify the various underlying causes of MINOCA, a cardiac MRI and\u002For coronary vascular imaging approach with OCT or intravascular ultrasound (IVUS) and a coronary functional assessment of microvascular function, as well as the provocation of coronary spasms by acetylcholine testing are recommended. Moreover, the clear definition of the aetiology is of great importance considering the role they play in the most appropriate therapeutic choice.\n\nTherefore, the creation of an Italian national database could implement not only the knowledge of this clinical condition but also its management and consequent prognosis.",[27],"NOT_YET_RECRUITING","2024-07-22",{"date":167,"type":39},"2024-07-23",{"date":169,"type":21},"2024-09-30",{"date":171,"type":21},"2032-12-30",{"name":173,"class":46},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":184,"conditions":185,"keywords":190,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":47},"100551742","influence-of-air-quality-on-the-development-and-progression-of-premature-coronary-artery-disease-100551742","NCT06464042","Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease","AIRHEART","CASES:\n\nInclusion Criteria:\n\n* Women and men between 18 and 40 years old with a diagnosis of coronary artery disease coded in their medical records in Galicia\n\nExclusion Criteria:\n\n* Not having a postal code and primary care center assigned in their medical records in Galicia\n\nCONTROL\n\nInclusion Criteria:\n\n* Women and men between 18 and 40 years old with no diagnosis or history of CAD or other coronary disease coded in their medical records\n\nExclusion Criteria:\n\n* Present with non-ischemic coronary diseas.\n* Have a serious condition that affects or decreases life expectancy.\n* Do not have a postal code or primary care center assigned in their medical records in Galicia","40 Years",{"count":183,"type":21},4272,"The new global guidelines from the World Health Organization on air quality provide evidence of the damage that air pollution inflicts on human health at even lower concentrations than previously thought. Different studies have shown an increase in the incidence of coronary artery disease (CAD) in young people in recent decades. The main objective of this project is to study the impact of environmental pollutants on the premature manifestation of CAD from different epidemiological approaches and their impact on the evolution of these patients with a gender perspective. It is a retrospective analytical case-control study nested in a cohort of patients ≤40 years old with a clinical history of CAD including: ST-segment elevation myocardial infarction, non-ST-segment elevation acute coronary syndrome, unstable angina, stable angina or silent angina according to the international classification of diseases.",[186,187,188,27,189],"Coronary Artery Disease Premature","Angina, Stable","Acute Coronary Syndrome","Myocardial Infarction",[191,192,186],"Air pollution","young","2024-06-12",{"date":195,"type":39},"2024-06-18",{"date":197,"type":39},"2024-05-23",{"date":199,"type":21},"2025-07-01",{"name":201,"class":46},"pablo Juan-Salvadores",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":211,"conditions":212,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":47},"100491648","plaque-burden-and-ischemia-in-minoca-100491648","NCT05681858","Plaque Burden and Ischemia in MINOCA","Coronary Artery Plaque, Perivascular Inflammation and Myocardial Ischemia in Patients With Myocardial Infraction and Non-obstructive Coronary Arteries","Inclusion Criteria:\n\n* Acute chest pain\n* Elevated troponin\n* Non-obstructive coronary arteries by coronary angiography\n\nExclusion Criteria:\n\n* Obstructive coronary artery disease\n* Contraindications against CT coronary angiography or stress \\[12N\\] NH3 PET-MR\n* Not able to give informed consent",{"count":210,"type":21},100,"The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery disease. The main question it aims to answer are:\n\n* Identify coronary artery anatomy, plaque burden, composition and high-risk plaque features by CT coronary angiography in MINOCA\n* Assess presence, extent and severity of myocardial ischemia in MINOCA\n\nParticipants will examined by CT coronary angiography and stress \\[12N\\] NH3 PET-MR.",[27],"2023-11-28",{"date":215,"type":39},"2023-12-04",{"date":217,"type":39},"2023-08-15",{"date":219,"type":21},"2027-08",{"name":221,"class":46},"University of Bergen"]