[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"minor-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:minor-stroke":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,77,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100638293","feasibility-study-of-a-digital-interactive-life-style-platform-for-individuals-after-rehabilitation-100638293",false,"NCT07597031","Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation","Feas Platf","Inclusion Criteria:\n\n* Adults (≥18 years)\n* 10 or less days before discharge from inpatient rehabilitation at the Bern Rehab Center in Heiligenschwendi or the Insel Hospital (both belonging to the Insel Group)\n* Belonging to one of the following clinical cohorts: acute coronary syndrome or ischemic heart failure; chronic obstructive pulmonary disease (COPD) - clinically diagnosed and confirmed by pulmonary specialist; fragility fracture - e.g., hip fracture or other low-energy fractures; minor stroke, clinically confirmed ischemic or hemorrhagic stroke with mild neurological deficits.\n* Able to provide informed consent.\n* Access to and ability to use a device that has internet access (e.g., tablet, smartphone, laptop, etc.).\n\nExclusion Criteria:\n\n* Cognitive or psychiatric condition interfering with consent or use of the app.\n* Physical disability preventing digital device use without support.\n* Heavy language production or comprehension impairments.","ALL","18 Years",{"count":19,"type":20},240,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to evaluate the feasibility and usability of a digital lifestyle platform designed to support patients after discharge from inpatient rehabilitation. It will also assess patient engagement and the potential of the platform to support long-term self-management and healthy lifestyle behaviors in an outpatient setting.\n\nThe main questions it aims to answer are:\n\nIs the platform feasible and acceptable for patients after rehabilitation? Do patients engage with and regularly use the platform over time? Can personalized digital recommendations support adherence to healthy behaviors and self-management?\n\nResearchers will evaluate a telemedicine platform that delivers individualized suggestions, including lifestyle applications, educational content, and advice from healthcare professionals. The content is tailored to patient needs and continuously adapted based on patient feedback.\n\nParticipants will:\n\nUse the digital platform after discharge from inpatient rehabilitation for a defined follow-up period Receive personalized recommendations through the platform Rate the usefulness of recommendations to enable continuous adaptation Attend study visits or remote assessments to evaluate usability, engagement, and outcomes Continue standard outpatient care alongside the intervention",[26,27,28,29],"Chronic Obstructive Pulmonary Disease (COPD)","Acute Coronary Syndrome","Fragility Fracture","Minor Stroke",[31,32,33],"Telemedicine","Phase III rehabilitation","Long-term non-communicable diseases","RECRUITING","2026-05-18",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":20},"2026-05-01",{"date":42,"type":20},"2027-02-01",{"name":44,"class":45},"Matthias Wilhelm, MD","OTHER",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100610669","phase-3-butylphthalide-for-long-term-efficacy-in-minor-stroke-study-100610669","NCT07230587","Butylphthalide for Long-term Efficacy in Minor Stroke Study","A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Long-Term Efficacy of Butylphthalide in Patients With Minor Acute Ischemic Stroke (BLESS)","BLESS","1.Inclusion Criteria:\n\n1. Age between 40 and 80 years old.\n2. NIHSS score 0-5 at the time of stroke diagnosis, with MRI-confirmed acute ischemic infarct.\n3. Time from stroke onset to enrollment ≤ 2 weeks.\n4. Pre-stroke mRS score ≤ 1.\n5. No prior diagnosis of cognitive impairment or dementia.\n6. Informed consent must be voluntarily signed by the patient or their legal representative.\n\nExclusion Criteria:\n\n1. Based on the TOAST classification, consider cardioembolic stroke, stroke of other determined etiology, or stroke of undetermined etiology.\n2. Intracranial hemorrhagic diseases on imaging: hemorrhagic stroke, epidural hematoma, subarachnoid hemorrhage, etc. (If hemorrhagic transformation is present, eligibility is at investigator's discretion.)\n3. Carotid artery stenosis \\> 50% requiring surgical intervention.\n4. Systemic diseases causing cognitive impairment (e.g., endocrine diseases, vitamin deficiency, systemic autoimmune diseases).\n5. Neurological disorders causing cognitive impairment, such as CNS infections, Creutzfeldt-Jakob disease, primary Parkinson's disease, traumatic brain injury, epilepsy, brain tumors.\n6. Pre-stroke diagnosis of severe psychiatric disorders, including but not limited to depression, non-vascular cognitive impairment, or dementia (e.g., Alzheimer's disease, Parkinson's disease dementia, Lewy body dementia, frontotemporal dementia, drug or alcohol-induced cognitive impairment).\n7. Severe hemiplegia and aphasia that significantly affect cognitive assessment.\n8. Use of cognitive-enhancing drugs within 4 weeks before screening, including cholinesterase inhibitors (donepezil, rivastigmine, galantamine), NMDA receptor antagonists (memantine), sodium oligomannate (GV-971), or monoclonal antibodies (lecanemab, donanemab, aducanumab).\n9. Severe liver disease (e.g., acute hepatitis, active chronic hepatitis, cirrhosis) or ALT\u002FAST \\> 2× ULN.\n10. Severe kidney disease or renal impairment (serum creatinine \\> 1.5× ULN).\n11. Coagulation disorders or thrombocytopenia (platelet count \\\u003C 100 × 10⁹\u002FL).\n12. Severe systemic diseases with an expected survival \\\u003C 1 year.\n13. Contraindications for MRI or inability to complete MRI scan.\n14. Allergy to butylphthalide.\n15. Pregnancy, lactation, or planned pregnancy.\n16. Participation in another clinical trial within 30 days before randomization.\n17. Deemed unsuitable for the study by the investigator.","40 Years","80 Years",{"count":58,"type":20},1200,[60],"PHASE3","This study is a multicenter, randomized, double-blind, placebo-controlled trial designed to evaluate the long-term efficacy and safety of butylphthalide in patients with minor acute ischemic stroke (BLESS Trial).\n\nA total of 1200 participants aged 40 to 80 years with a minor acute ischemic stroke confirmed by MRI will be enrolled. Participants will be randomly assigned in a 1:1 ratio to receive butylphthalide or placebo for 12 months.\n\nThe primary outcome is a hierarchical composite endpoint assessed at 12 months, including:\n\n1. All-cause mortality\n2. Stroke recurrence\n3. Modified Rankin Scale (mRS) score ≥2\n4. New MRI-confirmed infarcts\n5. Change in Montreal Cognitive Assessment (MoCA) score from baseline\n\nSecondary outcomes include additional functional, cognitive, and imaging-based assessments at 12 months.\n\nThis study aims to determine whether butylphthalide can improve long-term functional and cognitive outcomes in patients with minor ischemic stroke, contributing to better secondary stroke prevention strategies.",[63,29],"Ischemic Stroke",[65,66],"minor stroke","Butylphthalide","NOT_YET_RECRUITING","2025-11-13",{"date":70,"type":38},"2025-11-17",{"date":72,"type":20},"2025-12-01",{"date":74,"type":20},"2028-10-01",{"name":76,"class":45},"Peking Union Medical College Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":46},"100435051","stroke-school--including-physical-exercise-patient-education-and-individual-follow-up-sessions-100435051","NCT04945174","Stroke School -Including Physical Exercise, Patient Education and Individual Follow-up Sessions","Stroke School - Cross-sectorial Physical Exercise for Patients With Minor Stroke or Non-disabling Stroke","Inclusion Criteria:\n\n* Patients with a minor stroke or TIA without the need of rehabilitation after hospital discharge, but need physical activity in order to prevent cardiovascular diseases\n* Patients spending ≤ 5 hour of leisure time on high-intensity physical activity on weekly basis within the last 3 months\n* Able to speak and read Danish and to provide informed consent\n* Individuals ≥ 18 years of age\n\nExclusion Criteria:\n\n* Previous large-artery stroke or hemorrhagic stroke\n* Unstable cardiac condition, e.g. pacemaker\n* Uncontrolled hypertension (patients not responding adequately to antihypertensive medication when applying treatment according to guidelines)\n* Symptoms or comorbidities not allowing exercise on a stationary bicycle (e.g. claudication)\n* Dyspnoea caused by heart or pulmonary disease (e.g. COPD)\n* Aphasia, or dementia that interferer with understanding the protocol and\u002For physical examinations.\n* Patients diagnosed with dementia at hospital admission (a score ≤23\u002F30 on the Mini-Mental State Examination are not invited into the study)",{"count":85,"type":20},100,[23],"In a randomized controlled trial the effect of 12 weeks of cross-sectorial physical exercise combined with patient education and individual follow-up session is investigated in patients with minor stroke or non-disabling stroke.",[29,89,90],"Non-disabling Stroke","Transient Ischemic Attack",[92,93,94,95,96,97],"Minor stroke","Stroke prevention","Physical exercise","Patient education","Cardiorespiratory fitness","Non-disabling stroke","2025-04-29",{"date":100,"type":38},"2025-05-02",{"date":102,"type":38},"2022-06-01",{"date":104,"type":20},"2033-12",{"name":106,"class":45},"Herlev Hospital",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100539615","early-phase-telecare-programs-for-minor-stroke-100539615","NCT06306144","Early-phase Telecare Programs for Minor Stroke","Mild Cognitive Impairment After Minor Stroke: Evaluation of Early-phase Telecare Programs (Psychoeducation and Computerized Cognitive Stimulation)","COGaDOM","Inclusion Criteria:\n\n* Man or woman, aged between 18 and 65 years old\n* Hospitalization for a first stroke\n* Minor stroke: NIHSS score \\\u003C 5 on discharge from neurovascular unit\n* Post-stroke delay \\\u003C 8 weeks\n* Living at home (not institutionalized)\n* Affiliated with social security or benefiting from such a scheme\n* French language\n* Presence of a cognitive complaint (FACT-Cog \"perceived cognitive impairments\" subscale score \\\u003C 55) and absence of major cognitive impairment\n* Signature of informed consent\n\nExclusion Criteria:\n\n* History of stroke\n* Uncorrected hearing or visual impairment\n* Neurological pathology other than stroke or disabling psychiatric disorder\n* Unstabilized epilepsy\n* Undergoing cognitive rehabilitation in another context or having integrated a post-stroke therapeutic education program\n* Living in a white zone that does not allow for remote rehabilitation\n* Unable to connect to the Internet\n* Pregnant, parturient or breast-feeding women\\* (interview data)\n* Persons deprived of their liberty by judicial or administrative decision\n* Persons admitted to a health or social institution for purposes other than research\n* Adults under legal protection (guardianship, curatorship)\n* Taking part in other interventional research involving a period of exclusion still in progress at pre-inclusion","65 Years",{"count":117,"type":20},80,[23],"Minor strokes (few acute neurological symptoms ; NIHSS score \\\u003C5), represent almost 65% of cerebrovascular ischemic events. The increasing incidence of stroke in people under 65, together with advances in diagnostic and revascularization techniques, mean that post-stroke life expectancy is now in the order of decades. Most patients with minor stroke are rapidly discharged from hospital, with follow-up focused on secondary prevention and they are offered little or no rehabilitation.\n\nHowever, up to 70% of patients with minor stroke experience difficulties resuming their social or professional activities, which can lead to social and economic disruption (delayed\u002Fcompromised return to work) and an increased risk of depression. While some care recommendations exist for this population, in France there is no consensus nor identified care pathway for follow-up assessment or management of these patients. Furthermore, existing services are unevenly distributed across the country, and research into the effectiveness of rehabilitation is still scarce, leading to uncertainty as to which interventions should be prioritized to decrease difficulties related to cognitive impairment.\n\nSince there are currently no rehabilitation proposals in France for patients with mild cognitive impairment after mild stroke, in this trial the investigaror will investigate the effectiveness of two six-week telerehabilitation programs each consisting of a weekly session supervised by a therapist and a self-rehabilitation session. The aim of this multicenter randomized controlled trial is the evaluate the relevance and feasibility of early identification of patients eligible for a cognition-focused management proposal and the efficacy of two telecare programs, (a) psychoeducation and (b) computerized cognitive rehabilitation.",[29],[122,123,124,125],"cognitive complaint","computerized stimulation","psychoeducation","tele-rehabilitation","2025-04-15",{"date":128,"type":38},"2025-04-18",{"date":130,"type":20},"2025-05-01",{"date":132,"type":20},"2028-06-01",{"name":134,"class":45},"Hospices Civils de Lyon",3]