[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"minority-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:minority-stress":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,82,108,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100563338","minority-stress-counseling-for-lgbtq-individuals-100563338",false,"NCT06614868","Minority Stress Counseling for LGBTQ+ Individuals","MST","Inclusion Criteria:\n\n* Must identify as non-heterosexual\n\nExclusion Criteria:\n\nSuicide attempt within the past 12 months.\n\nCurrent eating disorder.\n\nNarcotics use within the past 3 months\n\nNon-suicidal self-injury within the past 6 months.\n\nCurrent\u002FHistory of psychosis",true,"ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Lesbian, gay, bisexual, transgender, and queer+ (LGBTQ+) individuals experience a breadth of mental health disparities. Reducing these disparities is an area of key psychological research. Minority stress is theorized to be an underlying source of the disparities (Meyer, 2003). Minority stress can be conceptualized as the internalized stigma that results from experiences of social marginalization. By reducing minority stress, it is hypothesized that generalized mental illness indicators might be reduced and indicators of wellbeing increased.",[27],"Minority Stress",[27,29],"Acceptance and Commitment Therapy","RECRUITING","2026-06-10",{"date":33,"type":34},"2026-06-12","ACTUAL",{"date":36,"type":34},"2025-01-15",{"date":38,"type":21},"2026-08-15",{"name":40,"class":41},"University of Alabama at Birmingham","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":67,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":42},"100604558","tag-team---trans-adolescent-group-therapy-100604558","NCT07151079","TAG TEAM - Trans Adolescent Group Therapy","Evaluation of Trans Adolescent Group ThErapy for Alleviating Minority Stress (TAG TEAM): a Randomised Controlled Trial","TAG TEAM","Participants will be enrolled into the RCT only if they meet all the inclusion criteria and none of the exclusion criteria.\n\nInclusion Criteria:\n\n* Identifies as trans, non-binary, or gender diverse\n* Is between the ages of 12 and 17 years inclusive\n* Has completed primary school at the time of enrolment into the study\n* Has current psychological stress symptomology as determined by a score of moderate or above on the DASS-Y\n* Provide informed consent: All participants and parent\u002Flegal guardians must be willing to give informed consent\n\nExclusion Criteria:\n\n* Has current acute suicidal symptomology as determined by a combination of clinical judgement and the results of the Ask Suicide-Screening Questions (ASQ) suicide screening tool (e.g., answer yes to question 5) to determine the risk of suicide (has an active plan and\u002For intent to suicide) at time of screening interview\n* Is actively having treatment with any other group psychological intervention at the time of enrolment into the study\n* Is not proficient in English (as the group Cognitive behaviour therapy (CBT) program will be delivered in English and funds aren't available for interpreters)\n* Previous participation in the feasibility trial\n* Is currently enrolled in tertiary study (e.g., undergraduate university)","12 Years","17 Years",{"count":54,"type":21},142,[24],"This project will study the effect of the TAG TEAM group CBT program on the mental health of trans and gender diverse adolescents. TAG TEAM was co-designed by researchers and clinicians with a group of trans and gender diverse young people to help trans and gender diverse adolescents understand and cope with minority stress. Minority stress includes experiences like discrimination and rejection. TAG TEAM focuses on learning and practicing skills to support mental health and wellbeing. It also includes group discussions and activities with other trans and gender diverse young people. TAG TEAM groups are run by a psychologist and a trans peer facilitator. A trans peer facilitator is a trans and gender diverse person who is there to share their experience of being trans and to support participants in the group sessions.",[27,58,59,60,61,62,63,64,65,66],"Acceptability","Psychological Distress","Anxiety","Depression in Adolescence","Coping","Wellbeing","Pride","Internalised Stigma","Community Connection",[68,69,70,63,71,72],"Adolescent","Trans and gender diverse","Minority stress","Group Therapy","CBT","2026-06-04",{"date":75,"type":34},"2026-06-05",{"date":77,"type":34},"2026-05-21",{"date":79,"type":21},"2027-03",{"name":81,"class":41},"Murdoch Childrens Research Institute",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":105,"locationsCount":42},"100626856","effect-of-ashwagandha-root-extract-on-stress-anxiety-and-sleep-quality-in-adults-experiencing-minority-stress-100626856","NCT07441070","Effect of Ashwagandha Root Extract on Stress, Anxiety, and Sleep Quality in Adults Experiencing Minority Stress","Efficacy and Safety of Ashwagandha (Withania Somnifera) Root Extract on Stress, Anxiety, and Sleep Quality in Adults Experiencing Minority Stress: A Randomized, Double-Blind, Placebo-Controlled Study","Inclusion Criteria:\n\n1. Self-identified as a sexual or gender minority (e.g., lesbian, gay, bisexual, transgender, queer, non-binary).\n2. Aged 18-45 years.\n3. Moderate to high perceived stress levels (PSS-10 total score \\>14).\n4. Willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Current psychiatric diagnosis (e.g., major depressive disorder, bipolar disorder, psychosis).\n2. Use of anti-anxiety or sleep medication (including sleep aids, cannabis or melatonin) in the last 3 months.\n3. Known allergy or intolerance to Ashwagandha.\n4. Any chronic illness that may confound the results (e.g., known liver illness, severe insomnia, or neurological disorders).","45 Years",{"count":20,"type":21},[24],"Sexual and gender minority adults often experience elevated levels of chronic stress due to stigma, discrimination, and social adversity, commonly referred to as minority stress. This persistent stress is associated with increased anxiety, mood disturbances, impaired sleep quality, and reduced quality of life. There is a need for safe, non-pharmacological interventions that can support mental well-being in this population.\n\nThis randomized, double-blind, placebo-controlled study is designed to evaluate the efficacy and safety of Ashwagandha (Withania somnifera) root extract in reducing stress and improving anxiety and sleep quality in adults experiencing minority stress. A total of 80 adults aged 18 to 45 years who self-identify as sexual or gender minorities and report moderate to high perceived stress will be enrolled.\n\nParticipants will be randomly assigned to receive either Ashwagandha root extract (300 mg capsules taken twice daily) or an identical placebo for 8 weeks. Efficacy will be assessed using validated psychological and quality-of-life questionnaires, including the Perceived Stress Scale, Depression Anxiety Stress Scale, Pittsburgh Sleep Quality Index, and other mood and minority stress measures. Salivary cortisol will be measured as a biological marker of stress. Safety will be evaluated through monitoring of adverse events throughout the study.",[27,94,60],"Psychological Stress",[96,97,98],"Ashwagandha","LGBTQ health","Withania somnifera","2026-04-22",{"date":101,"type":34},"2026-04-27",{"date":103,"type":21},"2026-04-29",{"date":38,"type":21},{"name":106,"class":107},"SF Research Institute, Inc.","NETWORK",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":17,"minAge":116,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":121,"conditions":122,"keywords":130,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":42},"100580635","phase-2-family-acceptance-project-online-pilot-rct-100580635","NCT06839859","Family Acceptance Project Online (Pilot RCT)","An Online Family-based Program to Reduce Inequity Among Sexual and Gender Minority Youth of Color (Pilot RCT)","FAP-O","Inclusion Criteria (youth):\n\n1. Identify as a sexual\u002Fgender minority (including youth questioning their sexual orientation and\u002For gender identity AND their identity must be known to their participating caregiver).\n2. Identify as a person of color\u002Fbelonging to a minority racial and\u002For ethnic group.\n3. Be between the ages of 14 and 25 years\n4. Read and speak English\n5. Live in the United States\n6. Report consistent access to a phone, tablet, and\u002For computer with high-speed internet access\n7. Report an ability to attend eight, two-hour online sessions at pre-determined times\n8. Report moderate to high levels of caregiver\u002Ffamily rejection\n9. Not be at high-risk for suicide\n10. Not be actively psychotic\n\nInclusion Criteria (caregivers):\n\n1. Be a caregiver (biological parent, stepparent, grandparent, aunt\u002Funcle, or another adult who provides care) to an SGMY of color between the ages of 14 to 25\n2. Be over the age of 18\n3. Read and speak English\n4. Live in the United States\n5. Report consistent access to a phone, tablet, and\u002For computer with high-speed internet access.\n6. Report an ability to attend nine, two-hour online sessions at pre-determined times.\n7. Be aware of the SGM youth's minority identity\n8. NOT identify as SGM\n9. Report spending time with participating youth at least 5 waking hours per week\n10. Not be at high-risk for suicide\n11. Not be actively psychotic","14 Years",{"count":118,"type":21},180,[120],"PHASE2","Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic). A major factor that leads to these challenges is family rejection (family behaviors and reactions that minimize, deny, ridicule and attempt to prevent or change a child's sexual orientation, gender identity and gender expression). Racial and ethnic minority youth experience the highest rates of family rejection and related health risks.\n\nThe Family Acceptance Project (FAP) is a research, education, and intervention initiative that was founded more than 20 years ago to help diverse families learn to support and affirm their SGMY. FAP's Family Support Model is grounded in the lived experiences of diverse SGMY and families and uses a culture-based family support framework that enables parents and caregivers to change rejecting behaviors that FAP's research has shown contribute to health risks and increase supportive and accepting behaviors that promote well-being for SGMY.\n\nThe overall goal of this research project is to evaluate a nine-week online version of FAP's Family Support Model (FAP-O). The investigators will specifically study how FAP-O:\n\n1. Promotes parent\u002Fcaregiver acceptance and support of their sexual and gender minority youth.\n2. Increases family bonding and communication.\n3. Increases SGMYs' feelings of pride in being LGBTQ+ and more hopeful about the future.\n4. Leads to reductions in mental health problems reported by SGMY who experience family rejection.\n\nBefore receiving FAP-O's family support services, racial and ethnic minority SGMY (ages 14 to 25) and their caregivers will complete an initial pre-test survey. After completing this initial (baseline) survey, half of the families will participate in program sessions. Following the first round of sessions, all participants will complete an immediate follow-up survey, with an additional survey conducted six months after this. These surveys help us learn if FAP-O impacts the project's goals above. After the final survey, the other half of the families will attend program sessions. The investigators will also ask SGMY and caregivers to share what they liked about the program and their guidance for enhancing it.",[123,124,125,27,126,60,127,128,129],"LGBTQ","Racial Disparities","Family Relationships","Depression","Drug Use","Teen Dating Violence","Sexual Risk Reduction",[123,131,132,133,134,135],"Family Support","Parents of LGBTQ Youth","Racial\u002FEthnic Minority","Health Equity","Family Acceptance","2026-02-08",{"date":138,"type":34},"2026-02-11",{"date":140,"type":34},"2025-04-24",{"date":142,"type":21},"2026-12",{"name":144,"class":41},"University of Michigan",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":17,"minAge":153,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":176},"100618063","lakota-family-acceptance-project-100618063","NCT07326748","Lakota Family Acceptance Project","Development and Evaluation of an Indigenized Family Acceptance Project for Lakota LGBTQ2S+ Youth","L-FAP","Youth Inclusion Criteria:\n\n* Identify as 2SLGBTQ+ (and their identity must be known to their participating caregiver)\n* Identify as Indigenous (multiracial youth who are also Indigenous are eligible)\n* Youth should be between the ages of 13 and 18 years\n* Read and speak English\n* Report moderate to high levels of caregiver\u002Ffamily rejection (as evidenced by agreement on items that assess the presence and frequency of specific family rejecting behaviors \\[includes ambivalent and moderately and highly rejecting caregivers\\]\n* Report an ability and commitment to attending eight sessions at two hours a week over eight weeks with their caregiver\n\nParticipating Caregiver Inclusion Criteria:\n\n* Caregivers are broadly defined and may include a biological parent, stepparent, grandparent, aunt\u002Funcle, or other adult who provides care to the Indigenous 2SLGBTQ+ youth\n* Must be over the age of 18\n* Read and speak English\n* Be aware of the SGM identity of their Indigenous 2SLGBTQ+ youth\n* report an ability and commitment to attending eight sessions at two hours a week over eight weeks with their teen\n\nExclusion Criteria:\n\n* We will exclude Indigenous 2SLGBTQ+ youth and caregivers at imminent risk for suicide and\u002For who are experiencing current psychosis symptoms as determined by results on the safety items screener.","13 Years",{"count":155,"type":21},28,[24],"The goal of this open pilot trial (OPT) is to develop a Lakota-adapted Family Acceptance Project (LFAP) for Indigenous 2SLGBTQ+ youth and their caregivers. The OPT is specifically focused on acceptability, feasibility, and safety of programming and research protocols. The investigators will also examine pre- to post- changes on outcomes for the sole purposes of making sure scores on measures are changing in the hypothesized direction (e.g., depression scores are going from moderate to minimal as opposed to no change or depression scores increasing). Once enrolled in the study, participants complete a baseline survey. Then participants will engage in LFAP which is an 8-session group intervention; sessions will be scheduled once a week for eight weeks (at 2 hours per session). Participants will complete survey instruments before and immediately after the program sessions, in addition to post-program surveys and an exit interview.",[123,124,125,27,126,60,127,128,129],[160,123,161,162,163,164,133,165,166,167],"family acceptance","2SLGBTQ+","youth","family support","parents of LGBTQ youth","health equity","Native American\u002FIndigenous","Two Spirit","2026-01-23",{"date":170,"type":34},"2026-01-26",{"date":172,"type":34},"2026-01-20",{"date":174,"type":21},"2027-01-31",{"name":144,"class":41},2]