[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"misophonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:misophonia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,76,99,124,148,171,195],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100589874","transcranial-magnetic-stimulation-in-misophonia-100589874",false,"NCT06960083","Transcranial Magnetic Stimulation in Misophonia","A Transcranial Magnetic Stimulation Approach to Treat Misophonia","Inclusion Criteria:\n\n* Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger\u002Foutbursts, or fear.\n* Must be between the ages of 18 - 55.\n* Must be fluent in English since the study's instructions, surveys, and tasks will be in English.\n\nExclusion Criteria:\n\n* Epilepsy or previous episode of convulsion or seizure.\n* Previous episode of fainting spell or syncope.\n* Head trauma.\n* Hearing problems.\n* Cochlear implant.\n* Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).\n* Implanted neurostimulator (e.g., DBS, epidural\u002Fsubdural, VNS).\n* Presence of cardiac pacemaker or intracardiac lines.\n* Presence of medication infusion device.\n* Use of pro-convulsant or epileptogenic medications.\n* Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.\n* Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.\n* Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.","ALL","18 Years","55 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.",[27],"Misophonia",[27,29,30,31,32],"Transcranial Magnetic Stimulation","Crossover trial","Single session","EEG","RECRUITING","2026-06-05",{"date":36,"type":37},"2026-06-08","ACTUAL",{"date":39,"type":37},"2025-09-02",{"date":41,"type":21},"2026-10-01",{"name":43,"class":44},"Icahn School of Medicine at Mount Sinai","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100633522","prevalence-of-misophonia-and-hyperacusis-among-teachers-100633522","NCT07527780","Prevalence of Misophonia and Hyperacusis Among Teachers","Could Hyperacusis and Misophonia Be Causes of Occupational Stress Among Teachers?","Inclusion Criteria:\n\n* Teachers actively working in preschool, elementary, middle, or high schools.\n* Age between 22 and 45 years.\n* Willingness to participate and provide informed consent.\n* No diagnosed hearing loss.\n* No chronic illnesses.\n* No diagnosed psychological or psychiatric disorders.\n\nExclusion Criteria:\n\n* Individuals with hearing loss.\n* Individuals with chronic illnesses.\n* Individuals with serious psychological or psychiatric diagnoses.\n* Individuals who are not actively teaching.\n* Participants unwilling to provide informed consent.",true,"22 Years","45 Years",{"count":57,"type":21},500,"OBSERVATIONAL","This study aims to determine the prevalence of hyperacusis and misophonia among teachers and to explore how these auditory sensitivities may relate to occupational stress. By examining teachers' sensory challenges in school environments, the study seeks to contribute to a better understanding of their impact on professional well-being and to inform strategies that can improve working conditions.",[27,61],"Hyperacusis",[63,27,61,64,65],"Teacher","AMISOS-R","Khalfa Hyperacusis Scale","2026-04-07",{"date":68,"type":37},"2026-04-14",{"date":70,"type":37},"2025-03-01",{"date":72,"type":21},"2026-05-01",{"name":74,"class":44},"Ondokuz Mayıs University",2,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":53,"sex":16,"minAge":83,"maxAge":17,"enrollmentInfo":84,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":75},"100629006","prevalence-of-misophonia-in-turkish-high-school-students-100629006","NCT07469033","Prevalence of Misophonia in Turkish High School Students","Prevalence of Misophonia in Turkish High School Students: A Sample From Kayseri and Samsun","Inclusion Criteria:\n\n* Students enrolled in grades 9 through 12\n* Students without diagnosed hearing loss\n* Students without chronic illness\n* Students without severe psychological disorders\n\nExclusion Criteria:\n\n* Students with diagnosed hearing loss\n* Students with any chronic illness\n* Students with severe psychological disorders\n* Students outside the defined age range\n* Students who are illiterate\n* Students with intellectual disabilities","15 Years",{"count":85,"type":21},600,"This cross-sectional study aims to determine the prevalence of misophonia among high school students in Kayseri and Samsun, Turkey. Data will be collected using a sociodemographic data form and the Amsterdam Misophonia Scale-Revised (AMISOS-R). The study will evaluate the frequency and severity of misophonia symptoms and examine their association with demographic variables.",[27],[64,89,90],"High school students","Prevalence","2026-03-12",{"date":93,"type":37},"2026-03-13",{"date":95,"type":37},"2025-01-25",{"date":97,"type":21},"2026-04-01",{"name":74,"class":44},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":45},"100613814","early-phase-1-propranolol-for-misophonia-100613814","NCT07271485","Propranolol for Misophonia","Randomized, Placebo-Controlled Pilot Study of Propranolol for Treating Misophonia","Inclusion Criteria:\n\n* Age 18-65.\n* Able to complete study visit(s) in Littleton, CO.\n* Able to give informed consent.\n* Participant reports clinically significant misophonia symptoms, as determined by answers on the standardized \"Misophonia Trigger Screening Questions for Participants\" form (described separately in the protocol). Specifically, participants must demonstrate relevant misophonia trigger responses that meet pre-specified minimum severity criteria detailed on this form.\n* A-MISO-S rating scale severity criterion: Participants must score at least a moderate (\"2\") or higher on question 2 and question 3 of the Amsterdam Misophonia Scale (A-MISO-S) at screening, since this indicates clinically meaningful misophonia severity for study eligibility.\n* Able to communicate misophonic distress in writing and reasonably participate in our outpatient clinical setting, meaning able to tolerate being in this outpatient clinical setting, follow the clinic rules for all patients and guests, and respond in an understandable fashion to questions administered to them.\n* Must agree to follow study clinician advice and seek additional care outside of this clinic if advised (e.g., if advised to seek help from emergency services for a potentially serious adverse reaction).\n* English fluency\n\nExclusion Criteria:\n\n* Current use of scheduled propranolol for any condition.\n* Any of the known contraindications for taking propranolol:\n* cardiogenic shock\n* sinus bradycardia (\\\u003C50 bpm)\n* greater than first degree heart block\n* BP below 90\u002F60\n* asthma \u002F bronchial asthma that requires treatment or medication, and\u002For has caused clinical concerns within the last 5 years\n* Other heart conditions that require ongoing medical treatment\n* Participants with any of the following relative contraindications for taking propranolol:\n* participants who have active anorexia, purging, or who are underweight (\\\u003C18.5 BMI)\n* Active drug or alcohol use within the last 48 hours prior to study participation, or active drug withdrawals\n* A history of untreated diabetes or other endocrine disorders that could be harmed by exposure to propranolol\n* history of cardiovascular disease or stroke, or symptomatic blood disorders such as anemia\n* history of any other severe physical or neurological conditions that may affect their ability to participate in the study\n* Participants with liver or kidney disease that would be affect or be affected by the study drug\n* Participants may, depending on the circumstances as decided by the study clinician, be excluded for any of the following conditions that may have adverse reactions to propranolol, including: Raynaud disease or other peripheral vascular disease, Pheochromocytoma, Psoriasis, Thyroid disease (untreated, and affected by propranolol), Unexplained dizziness, Oxygen level below 91%, Respirations below 12 or above 20\n* Participants taking any other medications that could interfere with the effects of propranolol, as determined by the study clinician (e.g. other beta blockers, alpha blockers,prazosin, clonidine, guanfacine, diuretics, calcium channel blockers, acute us of anti-anxiety medications; other medications that interfere with the adrenergic system; or medications that have a significant effect on propranolol's pharmacology that would normally affect dosing in clinical practice\n* Allergy or sensitivity to propranolol, placebo ingredients, and\u002For capsule ingredients.\n* Pregnant or nursing.\n* Any of the following in 30 days prior to enrollment: active psychosis, suicidal\u002F self-harming \u002F homicidal thoughts, bipolar mania, panic attacks, traumatic dissociation, Post-Traumatic Stress Disorder (PTSD) flashbacks, or psychiatric hospitalization.\n* Participant self-reports or clinical interview identifies any misophonia-triggered reactions within the past year that posed a significant risk to health or safety, including suicidal or homicidal ideation, or uncontrolled physical behaviors (e.g., self-injury, aggression toward others, throwing objects, screaming, or fleeing uncontrollably). This criterion is assessed via direct structured questioning during participant screening interviews and review of participant self-reports on standardized screening questionnaires.\n* Misophonia trigger symptoms are determined by a medical provider to be better explained by a condition other than Misophonia, such as hyperacusis or phonophobia.\n* Inability to hear routine sounds and communication (ie severe hearing impairment), only if it interferes with ability to hear the misophonia triggers on the video.\n* Participants who are triggered by the sound of water running or a car alarm (our control videos)","65 Years",{"count":108,"type":21},20,[110],"EARLY_PHASE1","The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia.\n\nThe secondary goals of this study are:\n\n1. Determine potential predictors of response to propranolol treatment, including demographic factors, baseline symptom severity, psychometric instrument item responses, and physiological characteristics.\n2. Evaluate the safety and tolerability of propranolol in individuals with misophonia.",[27,113,114],"Propanolol","Misophonia Treatment","2025-12-05",{"date":117,"type":37},"2025-12-09",{"date":119,"type":21},"2025-12-19",{"date":121,"type":21},"2026-12-19",{"name":123,"class":44},"Bloom Mental Health, LLC",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":136,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":45},"100609927","digital-intervention-for-adults-with-misophonia-a-randomized-controlled-trial-100609927","NCT07220941","Digital Intervention for Adults With Misophonia: A Randomized Controlled Trial","Efficacy and Feasibility of an Online Acceptance Based Intervention for Misophonia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Currently meet clinical impairment for misophonia.\n* At least 18 years old.\n* Fluent English speakers.\n* Currently live or reside in the United States\n\nExclusion Criteria:\n\n* Currently receiving alternative psychotherapy for misophonia.\n* Currently modifying or starting psychotropic medication (within 30 days of starting the study).\n* Any psychological and\u002For neurological impairments that would preclude someone from participating in the study (e.g.,active self-harm or psychosis)",{"count":132,"type":21},100,[24],"The goal of this clinical trial is to test an online intervention for adults with misophonia. The main questions it aims to answer are:\n\n1. Is the online intervention effective, compared to a waitlist control condition?\n2. Is the online intervention acceptable to use?\n\nParticipants will be randomized into either the online intervention or waitlist control condition:\n\n1. Participants in the intervention condition will be asked to complete an 8 module acceptance and commitment therapy (ACT) program for misophonia and 5 surveys over 4 months.\n2. Participants in the waitlist condition will be asked to complete 5 surveys over 4 months, and will receive access to the intervention once the study is complete.",[27],[137,138],"Acceptance and commitment therapy (ACT)","Digital mental health intervention (DMHI)","2025-10-21",{"date":141,"type":37},"2025-10-24",{"date":143,"type":21},"2025-10",{"date":145,"type":21},"2027-02",{"name":147,"class":44},"Utah State University",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":53,"sex":16,"minAge":155,"maxAge":17,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":45},"100554033","mindfulness-application-effects-on-mental-health-symptoms-in-children-with-severe-tinnitus-and-misophonia-100554033","NCT06493825","Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia","Effects of Immersive Virtual Reality Mindfulness Application on Quality of Life, Anxiety and Depression Symptoms in Children With Severe Tinnitus and Misophonia - A Pilot Study","Inclusion Criteria:\n\n* Children between the ages of 10 to 18 years\n* All genders and ethnicities\n* Patients who meet criteria for \"severe\" symptoms of tinnitus and misophonia as scored by TIF and A-MISO-S\n\nExclusion Criteria:\n\n* Severe developmental delay as not to understand verbal instructions necessary to complete the VR application\u002Fsham exposure.\n* Severe visual impairment (refractive disorders are acceptable)\n* Patients with unilateral or bilateral hearing loss of any type.\n* History of seizure disorder","10 Years",{"count":157,"type":21},30,[24],"Children with \"bothersome\" tinnitus and misophonia have elevated anxiety and depression symptoms. The mainstay therapy for adults and children with these disorders is cognitive behavioral therapy (CBT). CBT resources are expensive and scarce for the pediatric population. Immersive virtual reality (IVR) has been shown in the adult population to be a proxy for CBT for several mental health disorders. There is sufficient published evidence that IVR is useful in treating adults with anxiety and depression disorders. However, the evidence in children in treating either anxiety and depression symptoms or disorder is scant. Our group views IVR application as a promising medical device to decrease anxiety and depression scores in children with tinnitus and misophonia disorders.\n\nThis is a randomized placebo control (single-blinded to the study subjects) study in which there will be a 2:1 ratio between the experimental and placebo subjects, receiving either active IVR or placebo exposure. A total of 30 subjects with 20 experimental (10 tinnitus, 10 misophonia subjects) and 10 placebo (5 tinnitus and 5 misophonia subjects) will enroll in this randomized clinical trial. Assessment of change of quality of life, anxiety and depression symptoms will be based on 5 validated instruments.\n\nThe 5 validated instruments are: Tinnitus Functional Index (TFI), Amsterdam Misophonia Scale (A-MIS-S), Pediatric Quality of Life PEDQL), Screen for Child Anxiety Related Emotional Disorders (SCARED) and Short Mood and Feelings Questionnaire (SMFQ).",[161,27],"Tinnitus","2025-04-11",{"date":164,"type":37},"2025-04-16",{"date":166,"type":37},"2024-09-01",{"date":168,"type":21},"2025-12-15",{"name":170,"class":44},"University of Colorado, Denver",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":75},"100586884","study-of-auditory-perception-after-progressive-exposure-to-aversive-sounds-in-people-with-misophonia-100586884","NCT06921187","Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia","Etude de la Perception Auditive après Exposition PROgressive Aux Sons Aversifs Chez Des Personnes MISophonEs","PROMISE","Inclusion Criteria:\n\nFor all participants\n\n* Obtain oral consent from the participant after receiving information about the study,\n* Be 18 years or older on the day of inclusion,\n* Be fluent in French (spoken and written),\n* Have no known hearing loss, verified by pure tone audiometry.\n* Declare that they do not have tinnitus,\n* Declare that they do not have hyperacusis, verified by measuring discomfort thresholds.\n* Be affiliated to the social security or equivalent scheme.\n\nFor participants with misophonia:\n\n\\- Declare discomfort, reduced tolerance to specific sounds (mouth noises, throat clearing, breathing, etc.).\n\nExclusion Criteria:\n\n* Bear the after-effects of an ear infection and\u002For have a history of an ENT disease that permanently affects hearing or balance (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis),\n* Be under guardianship,\n* deprived of liberty by judicial or administrative decision, or subject to legal protection.",{"count":180,"type":21},110,[24],"The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.",[27],"NOT_YET_RECRUITING","2025-04-03",{"date":187,"type":37},"2025-04-10",{"date":189,"type":21},"2025-06",{"date":191,"type":21},"2026-03",{"name":193,"class":194},"Institut Pasteur","INDUSTRY",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":210,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":4},"100576465","the-efficacy-of-lavender-herbal-tea-in-misophonia-100576465","NCT06785649","The Efficacy of Lavender Herbal Tea in Misophonia","The Effect of Lavender Herbal Tea on the Mental Health of Individuals With Misophonia: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Reporting at least three trigger sounds\n* Assessed by a specialist psychiatric nurse and a psychiatrist as humophonia based on the diagnostic criteria for humophonia established by Schröder et al. (2013)\n* Individuals aged 18 and over\n\nExclusion Criteria:\n\n* Allergy to any herbal tea, food or medicine\n* Psychiatric illness or chronic illness\n* Taking psychiatric medication (such as anxiolytics, and antidepressants)\n* Regular use of medication (such as antihypertensive, antidiabetic)\n* Regular use of herbal teas or complementary medicines\n* Tinnitus and\u002For hyperacusis",{"count":20,"type":21},[24],"Misophonia is a disorder characterized by a high level of annoyance with certain sounds. Exposure to these sounds causes physical symptoms characterized by anger, aggression, helplessness, overwhelm, and stimulation of the sympathetic nervous system. These emotional and physical reactions can lead to a decline in family relationships, work and school productivity, withdrawal from social relationships, and even suicide. There is limited empirical evidence evaluating the efficacy of therapeutic approaches to misophonia. This limited empirical evidence consists of pharmacological agents such as selective serotonin reuptake inhibitors, stimulants, antipsychotics, and β-Blockers, as well as cognitive behavioral therapy, acceptance and commitment therapy, and dialectical behavior therapy. Complementary therapies are important because of their potential efficacy, tolerability, possible non-interference, and low cost. The fact that lavender has anxiolytic, antidepressant, neuroprotective, and anti-inflammatory properties may affect the emotional and physical responses elicited by misophonia. Therefore, within the scope of the study, misophonia individuals will be divided into two groups; one group will use lavender tea for 14 days and the other group will form a waiting list. The study data will be collected by 'Information Collection Form', 'Misophonia Scale', 'Beck Depression Inventory-II', 'Anxiety Rating Scale', and 'Trait Anger Scale'. SPSS 25.0 software will be used to analyze the data obtained from the research. Considering the limitations of therapeutic approaches for misophonia, testing the effectiveness of lavender in reducing misophonia symptoms will make an important contribution to the literature.",[27,114,206,207,208,209],"Anxiety","Depression","Anger","Complementary Medicine",[211,212,213,214,215],"misophonia","anxiety","depression","anger","lavender","2025-01-19",{"date":218,"type":37},"2025-01-21",{"date":220,"type":21},"2025-02-01",{"date":222,"type":21},"2025-02-28",{"name":224,"class":44},"Sakarya University"]