[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"missed-abortion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:missed-abortion":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,74,94],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100633390","phase-1-comparison-of-efficacy-and-safety-of-oral-versus-vaginal-misoprostol-in-missed-abortion-in-first-trimester-of-pregnancy-100633390",false,"NCT07526064","Comparison of Efficacy and Safety of Oral Versus Vaginal Misoprostol in Missed Abortion in First Trimester of Pregnancy","Inclusion Criteria:\n\n* Parity \\\u003C5\n* Presenting with missed abortion (defined as spontaneous loss of pregnancy, presence of lower abdomen cramps, ultrasound scan shows no fetal cardiac activity during 8-16 weeks of pregnancy)\n\nExclusion Criteria:\n\n* Pregnancy with any degree of cervical dilatation\n* Signs or symptoms of infection,\n* Twin gestation sac, molar pregnancy (on ultrasound),\n* Excessive uterine bleeding,\n* Blood pressure ≥160\u002F90 mmHg,\n* Maternal history of asthma or cardiac or cerebral disease","FEMALE","18 Years","40 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","Incomplete abortion has an eminent clinical diagnosis and is characterized by transvaginal bleeding associated with an open uterine cervix upon physical examination when the products of conception have not been wholly discharged. This is the most frequent clinical presentation of this condition. Currently, misoprostol (prostaglandin E2 analog), along with mifepristone, is the reference drug for medicated uterine emptying in cases of spontaneous or induced abortion, both in the first gestational trimester and at more advanced gestational ages.Misoprostol-only is a safe and effective option for females with missed abortion in the first trimester, although less effective than standard regimens that also contain mifepristone.Once the efficacy, safety, and acceptability of misoprostol in incomplete abortion are well established, future studies must be done in finding the ideal route of administration (oral, sublingual, or vaginal), perfect dosage, and intervals of administration when necessary.\n\nThe purpose of this study is to evaluate the safety and effectiveness of oral versus vaginal misoprostol in cases of missed abortions during the first trimester of pregnancy. Misoprostol is widely used for medical management of early pregnancy loss; however, the optimal route of administration remains uncertain. Comparing these two routes may help identify the most effective and safest method, thereby improving patient outcomes and guiding clinical practice. According to literature, misoprostol administered vaginally has better effectiveness and fewer side effects. However, conflicting evidence has been found in literature that indicates there is no difference between both route for misoprostol administration. In order to determine the best course of action with the fewest adverse effects for women who have missed an abortion, we wish to carry out this experiment. In order to apply the more appropriate route to the local community, adopt a more effective approach, and revise the criteria for doing so. This will enhance our expertise and methods as well as will improve patients' satisfaction will treatment.",[26],"Missed Abortion",[28,29,30],"Oral misoprostol","First Trimester","Vaginal misoprostol","NOT_YET_RECRUITING","2026-04-06",{"date":34,"type":35},"2026-04-13","ACTUAL",{"date":37,"type":20},"2026-05-01",{"date":39,"type":20},"2026-07-31",{"name":41,"class":42},"Hamna Khaliq","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100625267","effects-of-mandala-coloring-in-missed-abortion-100625267","NCT07420413","Effects of Mandala Coloring in Missed Abortion","The Effect of Mandala Coloring Activity on Stress, Anxiety, Pain and Physiological Parameters in Women Diagnosed With Missed Abortion: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Women aged 18 years and older\n* Hospitalized with a diagnosis of missed abortion\n\nGestational age of 10 weeks or less\n\nMentally healthy and able to communicate\n\nAble to read, understand, and speak Turkish\n\nLiterate\n\nWilling to participate and provide written informed consent\n\nExcluPhysical limitations preventing participation in the coloring activity\n\nHistory of previous pregnancy loss\n\nPresence of chronic medical disease\n\nDiagnosis of a psychiatric disordersion Criteria:",{"count":52,"type":20},126,[54],"NA","This randomized controlled study aims to evaluate the effects of mandala coloring activity on stress, anxiety, pain, and physiological parameters in women diagnosed with missed abortion. Participants will be randomly assigned to either a mandala coloring group or a control group receiving standard care. Outcomes will be measured at hospital admission and after completion of the mandala coloring session.",[26],[26,58,59,60,61,62],"Mandala Coloring","Pregnancy Loss","Stress","Pain","Anxiety","RECRUITING","2026-02-20",{"date":66,"type":35},"2026-02-24",{"date":68,"type":35},"2025-10-30",{"date":70,"type":20},"2026-05",{"name":72,"class":73},"Selcuk University","OTHER",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100625428","a-real-world-study-comparing-the-efficacy-of-different-treatment-regimens-for-early-missed-abortion-100625428","NCT07422506","A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion","Inclusion Criteria:\n\n* ①Age 18-40 years old; ②Early pregnancy missed abortion confirmed by imaging and laboratory tests; ③All indicators of routine examinations before treatment are within the normal range, and there are no serious systemic diseases; ④No indications for emergency curettage; ⑤Good compliance, follow-up observation as required (prospective study).\n\nExclusion Criteria:\n\n* ①Contraindications to medical abortion; ②Those who are allergic to estrogen and have contraindications to the use of estrogen; ③Those who cannot be followed up according to the follow-up plan; ④Thromboembolic diseases, known or suspected history of breast cancer, hormone-dependent tumors, etc.; ⑤Vaginal bleeding exceeds the usual menstrual volume; ⑥Those with severe heart, liver and kidney diseases; ⑦Accompanied by serious internal and surgical diseases, malignant tumors or mental illnesses, and cannot cooperate.",{"count":81,"type":20},580,[54],"At present, there is no unified standard for the treatment of missed abortion in clinical practice. This study intends to collect clinical data of this type of disease to compare the efficacy of different treatments, and on this basis, presuppose the synergistic effect of different doses of estrogen in the process of drug induction, conduct statistical analysis of the efficacy, evaluate whether the treatment plan can achieve the therapeutic effect while reducing the occurrence of complications, and provide an effective basis for the subsequent clinical treatment of missed abortion.\n\nThis study is divided into two parts. The first part is a retrospective analysis to explore the differences between missed abortion surgery and drug treatment, clinical efficacy and reproductive outcomes; the second part is a prospective study to explore the effects of different doses of estrogen combined with surgery or drug abortion on the efficacy of missed abortion in early pregnancy, and explore the best clinical treatment method for missed abortion.",[26,85],"Early Pregnancy Failure","2026-02-12",{"date":64,"type":35},{"date":89,"type":35},"2024-01-01",{"date":91,"type":20},"2035-01-01",{"name":93,"class":73},"The Third Xiangya Hospital of Central South University",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":102,"briefSummary":103,"conditions":104,"keywords":105,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100552139","oxytocin-effectiveness-in-first-trimester-dilatation-and-curettage-100552139","NCT06469203","Oxytocin Effectiveness in First Trimester Dilatation and Curettage","Inclusion Criteria:\n\n* All patients admitted to the OBGYN Assuta Ashdod Hospital for elective surgical termination of pregnancy due to missed miscarriages in the first trimester, with gestational age range of 6.0 to 11.6 weeks.\n\nPatients aged 18 years and older who are capable to provide informed consent.\n\nExclusion Criteria:\n\n* individual intolerance to oxytocin\n* mullerian anomalies\n* Fibroid uterus\n* thrombophilia or coagulation disorders\n* cardiovascular disease",{"count":101,"type":20},160,[54],"The aim of this study is to investigate the impact of oxytocin on perioperative blood loss during the D\\&C procedure, as well as to assess early and late complications associated with it's use.",[26],[106,107,108,109,110],"missed abortion","vaginal bleeding","dilation and curretage","pregnancy termination","oxytocin","2024-08-12",{"date":113,"type":35},"2024-08-13",{"date":115,"type":20},"2024-09-01",{"date":117,"type":20},"2026-06",{"name":119,"class":73},"Assuta Ashdod Hospital"]