[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"missing-toothteeth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:missing-toothteeth":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100599253","abutment-hydrophilicity-on-soft-tissue-morphogenesis-100599253",false,"NCT07082088","Abutment Hydrophilicity on Soft Tissue Morphogenesis","Effect of Abutment Hydrophilicity on Soft Tissue Morphogenesis: Histological CCT","Inclusion Criteria:\n\n* presence of at least 4 mm of keratinized mucosa around the implants\n* patients aged 18 years or older\n* medically healthy patients (ASA I), or patients with mild systemic disease (ASA II)\n* partially edentulous state\n* healthy periodontal condition (also including periodontal health on reduced periodontium) according to the referent case definition\n\nExclusion Criteria:\n\n* ASA physical status 3\n* severe smokers (\\> 10 cig\u002Fday)\n* patients undergoing bisphosphonate therapy\n* pregnant or lactating women\n* estrogen-related hormonal disorders or hormonal substitution therapy\n* untreated periodontitis (pocket depth 4mm with positive bleeding on probing)\n* multiple gingival recession\n* patients with a history of head and neck cancers and radiotherapy in this region.",true,"ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy.\n\nThe main questions it aims to answer are:\n\nDoes argon plasma treatment of healing abutments improve the quality and organization of peri-implant connective tissue compared to untreated abutments?\n\nDoes the treatment influence histological parameters such as epithelial regeneration, vascularization, inflammatory infiltrate, and keratin layer thickness?\n\nResearchers will compare plasma-treated healing abutments to untreated machined-surface abutments to determine whether the bioactivated surface improves soft tissue morphogenesis.\n\nParticipants will:\n\nUndergo implant placement with immediate connection of either a treated or untreated healing abutment.\n\nHave plaque and bleeding indices recorded at 3 months.\n\nUndergo a soft tissue biopsy at 3 months for histological analysis (including evaluation of inflammation, connective tissue, epithelial morphology, vascularization, and keratinization).",[27],"Missing Tooth\u002FTeeth","NOT_YET_RECRUITING","2025-07-15",{"date":31,"type":32},"2025-07-24","ACTUAL",{"date":34,"type":21},"2025-07-31",{"date":36,"type":21},"2025-10-30",{"name":38,"class":39},"Paolo Pesce","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":22,"phases":48,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":54,"completionDateStruct":55,"leadSponsor":56,"locationsCount":4},"100598264","effect-of-bio-activation-on-epithelial-and-connective-cell-adhesion-to-titanium-abutments-split-mouth-clinical-trial-100598264","NCT07069231","Effect of Bio-activation on Epithelial and Connective Cell Adhesion to Titanium Abutments: Split Mouth Clinical Trial","Inclusion Criteria:\n\n* presence of at least 4 mm of keratinized mucosa around the implants,\n* patients aged 18 years or older\n* medically healthy patients (ASA I), or patients with mild systemic disease (ASA II)\n* Total or partial edentulous state with space for at least 2 implants\n\nExclusion Criteria:\n\n* ASA physical status 3\n* severe smokers (\\> 10 cig\u002Fday)\n* patients undergoing bisphosphonate therapy\n* pregnant or lactating women\n* estrogen-related hormonal disorders or hormonal substitution therapy patients with a history of head and neck cancers and radiotherapy in this region",{"count":47,"type":21},20,[24],"The aim of this \"in vivo\" controlled trial is to assess soft tissue cell adhesion to titanium abutments subjected to different cleaning procedures - no treatment (as they come from the industry), and cleaning by plasma- at an early healing time.\n\nIn fact, the primary aim is Quantity and Quality of soft tissue adhesion at the microscopic level (e.g Fibronectin, Integrin-actin).\n\nThe secondary Aim - Clinical parameters and outcomes - BOP, PPD, MBL (Marginal Bone Level to check influence of plasmapp-treated abutments).\n\nThe null hypothesis of the study was that the cleaning procedure applied to implant abutments has no effect on soft tissue cell adhesion and MBL at an early healing time.",[27],"2025-07-05",{"date":53,"type":32},"2025-07-16",{"date":29,"type":21},{"date":36,"type":21},{"name":57,"class":39},"Universita degli Studi di Genova"]