[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mitochondrial-encephalomyopathies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mitochondrial-encephalomyopathies":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100532460","patterns-of-neurodevelopmental-disorders-100532460",false,"NCT06213090","Patterns of Neurodevelopmental Disorders","Patterns of Disease, Outcomes and Treatment Response in Children With Neurodevelopmental Disorders","Inclusion Criteria:\n\nNeurodevelopmental delays Clinical visit at an Rossignol Medical Center\n\nExclusion Criteria:\n\n\\-","ALL",{"count":18,"type":19},1000,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.",[23,24,25,26,27,28,29,30],"Neurodevelopmental Disorders","Autism Spectrum Disorder","Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection","Pediatric Acute-Onset Neuropsychiatric Syndrome","Down Syndrome","Epilepsy","Mitochondrial Encephalomyopathies","Cerebral Folate Deficiency","RECRUITING","2026-04-13",{"date":34,"type":35},"2026-04-16","ACTUAL",{"date":37,"type":35},"2024-02-01",{"date":39,"type":19},"2030-12-31",{"name":41,"class":42},"Richard Frye","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":53,"conditions":54,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100504435","natural-history-study-of-patients-with-hpdl-mutations-100504435","NCT05848271","Natural History Study of Patients with HPDL Mutations","A Patient Registry and Natural History Study of Patients with Biallelic HPDL Mutations","Inclusion Criteria:\n\n* Any individuals diagnosed with HPDL variants\n* Clinical diagnosis can include:\n\n  * HPDL-related hereditary spastic paraplegia (HSP)\n  * HPDL-related neonatal mitochondrial encephalopathy\n  * Spastic paraplegia -83 (SPG83)\n  * Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities (NEDSWMA)\n\nExclusion Criteria:\n\n* Any known genetic abnormality (other than HPDL mutation)\n* Any condition that, in the opinion of the Site Investigator, could put the participant at undue risk and\u002For would ultimately prevent the completion of study procedures",{"count":52,"type":19},50,"This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations",[29,55,56,57,58,59,60],"Hereditary Spastic Paraplegia","Spastic Paraplegia","White Matter Disease","Neonatal Encephalopathy","Mutation","Genetic Disease",[62,63,64,65,66],"HPDL","HPDL related neonatal mitochondrial encephalopathy","HPDL related hereditary spastic paraplegia","Spastic paraplegia-83","Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities","2025-03-25",{"date":69,"type":35},"2025-03-30",{"date":71,"type":35},"2023-05-18",{"date":73,"type":19},"2027-12-31",{"name":75,"class":42},"University of California, San Diego"]