[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mitochondrial-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mitochondrial-function":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100611763","probing-the-role-of-mitochondrial-oxidative-stress-in-impaired-vascular-function-among-young-adults-with-early-life-adversity-100611763",false,"NCT07244809","Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity","PROMISE","Inclusion Criteria:\n\n* 18-29 years\n* ACE score \\>=4\n\nExclusion Criteria:\n\n* Resting arterial blood pressure \\>140\u002F90 mmHg\n* BMI \\\u003C=17 or \\>= 35\n* Are on a weight-loss diet or involved in a formal weight-loss program or are not intentionally weight stable for 6 months (+\u002F- 5 kg) prior to the study.\n* Cardiovascular or metabolic prescription drug use\n* Vasoactive antidepressant drug use (SSRIs and clonidine)\n* Current heavy alcohol use, as defined as binge drinking on 5 or more days in the last month, or consuming more than 7 (women) or 14 (men) drinks per week in the last month (per NIAAA definition)\n* Current or recent (within the last 6 mo.) illicit drug use disorder as indicated by a score of 3 or greater on the Drug Abuse Screening Test (DAST-10)\n* Current tobacco or nicotine use\n* Vaping\n* Regular vigorous (\\>6 METs) aerobic exercise (\\>4 bouts\u002Fweek, \\>30 min\u002Fbout)\n* dietary supplementation with antioxidants or habitual use of NSAIDs\n* Currently pregnant or breastfeeding",true,"ALL","18 Years","29 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Greater exposure to ACEs are associated with greater increases in the risk of cardiovascular diseases and death. Our laboratory has previously observed that vascular function is disrupted in young adults with prior ACE exposure, even though these individuals appear to be healthy clinically (i.e., no classic clinical cardiovascular disease risk factors). There is a need to identify and understand the biological mechanisms underlying these vascular impairments to inform effective interventions to reduce cardiovascular risks the millions of individuals affected by ACEs.\n\nThe body's response to stress is coordinated across various systems, all of which depend on energy supplied by mitochondria (often referred to as the \"powerhouse of cells\"). Based on new evidence across multiple physiological systems from our team, our overarching hypothesis is that disruption of mitochondrial function contributes to cardiovascular impairments among young adults with ACEs. Here we propose the initial pilot work necessary to begin to understand these associations, which will directly inform identification of individuals who may be most vulnerable to stress-related cardiovascular risk and the development of interventions to promote cardiovascular-stress resilience.\n\nOur aims are to:\n\n1. Determine whether mitochondrial oxidative stress contributes to impaired vascular function among young adults who experienced early life adversity.\n2. Determine whether reducing mitochondrial oxidative stress improves the cellular stress and integrated cardiovascular response to laboratory-based psychosocial stress among young adults who experienced early life adversity.",[28,29,30,31,32,33],"Adverse Childhood Experience","Endothelial Function (FMD)","Endothelial Injury","Mitochondrial Function","Oxidative Stress","Psychosocial Influence on Cardiovascular Disease",[35,36,37,38,39],"flow mediated dilation","mitoquinone mesylate","placebo","early life adversity","trier social stress test","RECRUITING","2025-11-17",{"date":43,"type":44},"2025-11-24","ACTUAL",{"date":46,"type":44},"2025-10-13",{"date":48,"type":22},"2026-12-31",{"name":50,"class":51},"University of Iowa","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":52},"100567769","near-infrared-spectroscopy-nirs-as-a-method-for-measuring-oxidative-capacity-of-skeletal-muscle-mitochondria-in-breast-cancer-and-all-gynecological-cancer-patients-100567769","NCT06672497","Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients","Inclusion Criteria:\n\n* Patients diagnosed with breast cancer or gynecological cancer without distance metastasis\n* Able to perform exercise on a stationary cycle ergometer at moderate intensities for a maximum of 15 minutes\n* Hemoglobin values greater than 10 at baseline\n* ALT and AST values less than 2.5X the upper limit of normal by institutional standards\n* Godin-Shepard Leisure time Physical Activity Questionnaire (GLTEQ) score of 14 or greater will be included. A score of less than 14 is considered insufficiency active\u002Fsedentary\n\nExclusion Criteria:\n\n* Metastatic breast or gynecological cancer\n* Clinically advanced cardiovascular disease\n* Clinically advanced pulmonary disease\n* Disease requiring continuous oxygen supplementation\n* Greater than 2 centimeters or more of subcutaneous adipose tissue on the anterior thigh\n* Inability to walk or stand\n* Movement disorders\n* Spinal cord injuries\n* Autoimmune disorders\n* Pregnant or breastfeeding\n* Mini-Mental State Examination (MMSE) \\\u003C24","FEMALE","20 Years",{"count":62,"type":22},30,"OBSERVATIONAL","Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a measure of skeletal muscle health. Participants will ride a stationary bicycle and the quadriceps muscle will be non-invasively evaluated.",[66,67,31],"Breast Cancer","Gynecologic Cancers",[69,70,71,72,73,74],"nirs","mitochondrial oxidative capacity","muscle oxidative capacity","breast cancer","gynecological cancer","near infrared spectroscopy","2024-11-01",{"date":77,"type":44},"2024-11-04",{"date":79,"type":44},"2021-09-07",{"date":81,"type":22},"2026-03",{"name":83,"class":51},"University of South Carolina"]