[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mixed-hemorrhoids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mixed-hemorrhoids":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100631005","low-excision-and-high-suspension-hemorrhoidectomy-versus-conventional-milligan-morgan-hemorrhoidectomy-for-grade-iii-iv-mixed-hemorrhoids-100631005",false,"NCT07495046","Low Excision and High Suspension Hemorrhoidectomy Versus Conventional Milligan-Morgan Hemorrhoidectomy for Grade III-IV Mixed Hemorrhoids","Low Excision and High Suspension Hemorrhoidectomy Versus Conventional Milligan-Morgan Hemorrhoidectomy for Patients With Goligher Grade III-IV Mixed Hemorrhoids","LEHS","Inclusion Criteria:• Age 18-70 years, male or female;\n\n* Diagnosed with Goligher grade III-IV mixed hemorrhoids via anorectal examination;\n* Failed conservative treatment for at least 3 months;\n* Voluntarily participated in the study and agreed to complete the 12-month follow-up.\n\nExclusion Criteria:• Combined with acute perianal abscess, anal fistula, anal fissure, inflammatory bowel disease, rectal prolapse, or anorectal malignancy;\n\n* History of previous anorectal surgery;\n* Severe coagulation dysfunction, cardiopulmonary insufficiency, hepatic\u002Frenal failure, or mental disorders;\n* Pregnancy or lactation;\n* Inability to cooperate with postoperative follow-up and evaluation.","ALL","18 Years","70 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","Low Excision and High Suspension Hemorrhoidectomy versus Conventional Milligan-Morgan Hemorrhoidectomy for Mixed Hemorrhoids",[28],"Mixed Hemorrhoids",[28,30,31],"low excision and high suspension hemorrhoidectomy","Milligan-Morgan hemorrhoidectomy;","NOT_YET_RECRUITING","2026-03-21",{"date":35,"type":36},"2026-03-27","ACTUAL",{"date":38,"type":22},"2026-04-01",{"date":40,"type":22},"2026-07-01",{"name":42,"class":43},"The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100618547","helo-trial-energy-based-therapies-vs-conventional-hemorrhoidectomy-for-grade-iii-hemorrhoids-100618547","NCT07333040","HELO Trial: Energy-Based Therapies vs. Conventional Hemorrhoidectomy for Grade III Hemorrhoids","Hemorrhoidectomy, Energy-Based, and Laser Outcomes in Grade III Hemorrhoids: A Prospective, Multicenter, Preference-Based Comparative Study","HELO","Inclusion Criteria:\n\n* Diagnosed with Goligher Grade III internal hemorrhoids.\n* Symptomatic with HDSS score \\>= 5.\n* Age 18-75 years.\n* Fit for general anesthesia or sedation.\n* Able to provide informed consent.\n* Agree to pre-operative photo documentation.\n\nExclusion Criteria:\n\n* Other anorectal diseases (fistula, abscess, IBD, malignancy).\n* Prior anorectal surgery within 6 months.\n* Pregnancy or lactation.\n* Contraindications to anesthesia.","75 Years",{"count":54,"type":22},60,[25],"This prospective, multicenter study compares the efficacy and functional outcomes of three surgical treatments for symptomatic Goligher Grade III internal hemorrhoids: Laser Hemorrhoidoplasty (LHP), Hemorrhoid Energy Therapy (HET), and conventional closed hemorrhoidectomy (Ferguson technique). Due to strong patient preferences in hemorrhoidal surgery, this study utilizes a pragmatic, preference-tolerant design. Eligible patients will undergo standardized counseling and select their preferred treatment arm. The study aims to evaluate whether minimally invasive energy-based therapies offer superior postoperative pain relief and faster functional recovery compared to conventional hemorrhoidectomy",[58,59,28],"Hemorrhoids Third Degree","Internal Hemorrhoids",[61,62,63,64,65],"Laser Hemorrhoidoplasty","Hemorrhoid Energy Therapy","Postoperative Pain","Minimally Invasive Surgery","Hemorrhoidectomy","2026-01-01",{"date":68,"type":36},"2026-01-12",{"date":70,"type":22},"2026-03-01",{"date":72,"type":22},"2028-03-01",{"name":74,"class":43},"Chang Gung Memorial Hospital",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":75},"100605614","phase-4-efficacy-of-methylene-blue-plus-ropivacaine-for-post-hemorrhoidectomy-pain-100605614","NCT07164807","Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain.","Comparative Efficacy of Varying Concentrations of Methylene Blue Combined With Ropivacaine for Postoperative Analgesia Following Milligan-Morgan Hemorrhoidectomy: A Single-Center, Prospective, Open-Label, Randomized, Parallel-Controlled Trial","Inclusion Criteria:\n\n1. Aged between 18 and 75 years.\n2. Diagnosed with Grade III-IV hemorrhoids according to the Goligher classification.\n3. Scheduled to undergo standard Milligan-Morgan hemorrhoidectomy.\n4. Procedure performed under spinal anesthesia alone.\n\nExclusion Criteria:\n\n1. Pregnancy or lactation.\n2. Current immunotherapy or coagulopathies.\n3. Contraindications to any protocol-specified agents (e.g., history of severe allergic reactions to methylene blue or ropivacaine).\n4. Concurrent anorectal pathologies (e.g., perianal abscess, anal fistula, fecal incontinence).\n5. Comorbid systemic conditions (e.g., cardiac\u002Fhepatic\u002Frenal insufficiency, diabetes mellitus, coagulopathy, peptic ulcer disease).\n6. Incomplete perioperative documentation.\n7. Inability to comply with follow-up protocols.",{"count":84,"type":22},177,[86],"PHASE4","Revised Translation (Academic English):\n\nAs one of the most prevalent anorectal disorders, mixed hemorrhoids continue to rely on the Milligan-Morgan hemorrhoidectomy as the gold-standard surgical approach. While this technique demonstrates well-established efficacy, managing acute postoperative pain-particularly during the critical 24-72-hour peak pain window-remains a persistent clinical challenge. Recent advancements in multimodal analgesia have highlighted the potential of local nerve blockers, with methylene blue (MB) gaining scientific interest due to its prolonged analgesic properties. This randomized controlled study systematically evaluates the synergistic analgesic effects of gradient concentrations of MB combined with ropivacaine (ROP) following Milligan-Morgan procedures. Therapeutic safety profiles were validated through dual-dimensional monitoring of Visual Analog Scale (VAS) scores and complication rates, aiming to establish evidence-based optimal dosing protocols and refine perioperative pain management strategies.",[28,89,90],"Milligan-Morgan Hemorrhoidectomy","Methylene Blue","2025-09-08",{"date":93,"type":36},"2025-09-10",{"date":95,"type":22},"2025-08-30",{"date":97,"type":22},"2026-12",{"name":99,"class":43},"The Affiliated Hospital of Putian University"]