[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mixed-reality\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mixed-reality":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,81,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100637436","validity-and-reliability-of-a-mixed-reality-based-6-minute-walk-test-100637436",false,"NCT07601009","Validity and Reliability of a Mixed Reality-Based 6-Minute Walk Test","Validity and Reliability of a Mixed Reality-Based Adaptation of the 6-Minute Walk Test in Asymptomatic Adults","Inclusion Criteria:\n\n* Aged between 18 and 65 years,\n* Asymptomatic, with no known or active cardiopulmonary, neurological, or musculoskeletal disease-related symptoms,\n* Ability to ambulate independently without the use of an assistive device,\n* Visual, auditory, and vestibular functions sufficient to tolerate mixed reality applications,\n* Cognitive ability sufficient to understand and follow test instructions,\n* Ability to read, understand, and follow instructions in Turkish,\n* Willingness to participate voluntarily in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* Inability to safely complete walking tests due to serious musculoskeletal conditions (e.g., recent fracture, severe arthritis, advanced osteoarthritis, significant muscle or tendon injury),\n* Presence of severe cardiopulmonary disease or any medical condition that may pose a risk during exercise testing (e.g., uncontrolled hypertension, heart failure, severe arrhythmia history, chronic obstructive pulmonary disease),\n* High risk of balance loss or spatial disorientation in the mixed reality environment due to vestibular, visual, or auditory impairments,\n* History of epilepsy or neurological conditions contraindicating mixed reality or head-mounted device use,\n* Severe migraine, significant motion sickness history, or high risk of dizziness\u002Fnausea during mixed reality applications,\n* Cognitive impairment or severe psychiatric conditions preventing understanding or completion of test procedures,\n* Insufficient motivation or cooperation that may interfere with safe participation in the study.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","The 6-Minute Walk Test (6MWT) is a widely used field test for assessing functional exercise capacity, walking endurance, and submaximal performance related to activities of daily living. However, in conventional applications, environmental conditions, observer-related differences, and standardization issues may lead to variability in measurement outcomes. In addition, evaluating only the total walking distance may not adequately reflect clinically important changes such as performance decline and walking-related motor fatigue occurring during the test.\n\nFor this reason, recent studies have recommended analyzing 6MWT data by dividing the test into minute-by-minute segments and using performance change metrics such as the Distance Walked Index (DWI). These approaches allow a more detailed evaluation of changes in walking performance throughout the test duration.\n\nWith advances in measurement technologies, mixed reality (MR)-based applications have attracted attention as a means of enabling more objective, standardized, and reproducible implementation of conventional clinical tests. MR technology allows users to maintain interaction with the real environment while receiving digital guidance and feedback, thereby providing a safe and standardized assessment setting. Nevertheless, evidence regarding the validity and reliability of mixed reality-based adaptations of the 6MWT, particularly in asymptomatic adults, remains limited.\n\nThe aim of this study is to evaluate the criterion validity and test-retest reliability of a mixed reality-based 6-Minute Walk Test (MR-6MWT) developed using the Meta Quest 3 and Unity platform. In addition, convergent validity will be examined by analyzing the relationships between total walking distance, minute-by-minute performance changes, fatigue effect (%), and outcomes of the 4-Meter Walk Test, Timed Up and Go Test, and knee extensor muscle strength.\n\nThe findings of this study are expected to contribute to the development of a more objective, standardized, and digitally based mixed reality adaptation of the 6MWT. Furthermore, the results may provide a scientific foundation for future remote assessment and digital monitoring applications.",[26,27],"Mixed Reality","Asymptomatic",[29,26,30,31,32,33,34,35,36,37],"6-Minute Walk Test","Functional Exercise Capacity","Walking Endurance","Validity","Reliability","Asymptomatic Adults","Distance Walked Index","Fatigue Effect","Digital Assessment","RECRUITING","2026-05-15",{"date":41,"type":42},"2026-05-22","ACTUAL",{"date":44,"type":42},"2026-02-01",{"date":46,"type":22},"2027-01-01",{"name":48,"class":49},"Selcuk University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100637058","apple-vision-pro-assisted-vascular-identification-in-lung-surgery-100637058","NCT07573748","Apple Vision Pro-Assisted Vascular Identification in Lung Surgery","Apple Vision Pro-Assisted Vascular Identification in Lung Surgery: A Prospective Interventional Study","AVP-Lung","Inclusion Criteria:\n\nPatients aged 18 years or older. Diagnosed with lung nodules or early-stage lung cancer requiring surgical resection (lobectomy or segmentectomy).\n\nScheduled for elective lung surgery at Huai'an Second People's Hospital. American Society of Anesthesiologists (ASA) Physical Status Classification I-III.\n\nAbility to understand and sign the informed consent form. Willingness to undergo surgery with the Apple Vision Pro navigation assistance.\n\nExclusion Criteria:\n\nPatients under 18 years of age. Pregnant or breastfeeding women. Patients with severe cardiopulmonary dysfunction (e.g., severe COPD, unstable angina, recent myocardial infarction) that would contraindicate surgery.\n\nParticipation in another interventional clinical trial within the past 30 days. Inability to cooperate with the surgical team or follow study procedures.","85 Years",{"count":61,"type":22},20,"INTERVENTIONAL",[64],"NA","This study is testing whether a new mixed-reality head-mounted display (Apple Vision Pro) can help surgeons see blood vessels more clearly during lung surgery.\n\nDuring the operation, doctors usually need to identify and protect important blood vessels to avoid bleeding. In this study, surgeons will wear the Apple Vision Pro device, which shows 3D images of the lungs and blood vessels. This may help them find vessels more accurately and make surgery safer.\n\nParticipants scheduled for lung surgery at Huai'an Second People's Hospital will be invited to join. Before the operation, participants will have a CT scan. During surgery, doctors will use the device while performing the procedure.\n\nThe study does not change the standard surgical steps, and there are no extra risks for participants. The main goal is to see if this new technology makes surgery easier and safer.\n\nParticipation is voluntary, and all personal information will be kept confidential.",[67,26],"Lung Neoplasms",[67,69,70,71],"Mixed reality","Intraoperative Navigation","Three-Dimensional Imaging","NOT_YET_RECRUITING","2026-05-01",{"date":75,"type":42},"2026-05-07",{"date":73,"type":22},{"date":78,"type":22},"2026-07-01",{"name":80,"class":49},"The Second People's Hospital of Huai'an",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":62,"phases":90,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":50},"100628835","resection-and-defect-repair-of-oral-cancer-aided-by-mixed-reality-technology-100628835","NCT07466810","Resection and Defect Repair of Oral Cancer Aided by Mixed Reality Technology","Prospective Clinical Study in Resection and Defect Repair of Oral Cancer Aided by Mixed Reality Technology Based on UE5 Engine","Inclusion Criteria:\n\n1. Definite pathological diagnosis of oral cancer before surgery;\n2. Defects suitable for free flap reconstruction;\n3. Patients have signed the informed consent form and are willing to cooperate with postoperative follow-up.\n\nExclusion Criteria:\n\n\\- Poor general condition, evaluated as unable to tolerate surgical treatment.\n\n-Exclusion Criteria (After Enrollment)\n\nSubjects who have been enrolled in this trial will be excluded if they meet any of the following conditions:\n\n1. Violation of important inclusion criteria;\n2. Subjects did not receive surgical treatment;\n3. No observation data after randomization. Withdrawal Criteria Withdrawal of subjects from the trial refers to cases where enrolled subjects are determined by the investigator to withdraw from the trial due to conditions that make it inappropriate to continue the trial. In accordance with the informed consent form, subjects have the right to withdraw from the trial midway. Subjects who do not explicitly propose to withdraw but stop receiving treatment and tests and are lost to follow-up are also considered \"withdrawn\" (or \"lost to follow-up\"). The reason for withdrawal should be understood and recorded as much as possible, such as: poor subjective curative effect; inability to tolerate certain adverse reactions; inability to continue participating in the clinical study due to personal reasons; economic factors; or lost to follow-up without stating the reason.\n\n(1) Aggravation or deterioration of the condition during the trial that requires emergency measures; (2) Occurrence of certain comorbidities, complications or special physiological changes in subjects during the trial, making it inappropriate to continue participating in the trial; (3) Voluntary withdrawal by the subject.\n\nData Handling of Withdrawn Subjects\n\nRegardless of the reason, the complete clinical data of subjects who withdraw from the trial shall be retained. For all withdrawn subjects, the trial conclusion form and the reason for withdrawal shall be filled in the case report form (CRF). Generally, there are 6 types of reasons: occurrence of adverse events (including adverse drug reactions and allergic reactions), lack of efficacy (deterioration of condition or occurrence of complications), violation of the trial protocol (including poor compliance), lost to follow-up (including voluntary withdrawal by the patient), termination by the sponsor, or others.",{"count":89,"type":22},30,[64],"The objective of this exploratory clinical trial is to apply Unreal Engine 5 (UE5)-based Mixed Reality (MR) technology to achieve real-time stereoscopic visualization of surgical planning, personalized free flap harvest and defect reconstruction, accurate oral cancer resection, and precise morphological and volumetric matching of the reconstructed free flap to the defect site.\n\nResearchers adopted a parallel controlled design, with participants randomized into three groups: Experimental Group 1 (undergoing Mixed Reality \\[MR\\] technology-assisted surgery), Experimental Group 2 (undergoing virtual surgical guide-assisted surgery), and Control Group (undergoing conventional surgery). A total of 30 participants will be recruited, with 10 cases in each group.\n\nThe primary purpose is to confirm the effectiveness of MR technology in assisting oral cancer resection, free flap design, harvest, and defect reconstruction. Allocation concealment will be implemented via the sealed envelope method.",[93,26,94,95,96],"Tongue Squamous Cell Carcinoma","Virtual Surgical Planning","Free Flap","Oral Cancer",[26,98,99,100,101,95,94,96],"tongue reconstruction","Unreal Engine 5","Glossectomy","Surgical guide","2026-03-18",{"date":104,"type":42},"2026-03-20",{"date":106,"type":22},"2026-04-01",{"date":108,"type":22},"2027-10-01",{"name":110,"class":49},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":50},"100620772","validity-and-reliability-of-mixed-reality-based-mobility-tests-in-multiple-sclerosis-100620772","NCT07361965","Validity and Reliability of Mixed Reality-Based Mobility Tests in Multiple Sclerosis","Validity and Reliability of the Mixed Reality-Based Adaptation of the Timed Up and Go, Five-Repetition Sit-to-Stand, and 25-Foot Walk Tests in Individuals With Multiple Sclerosis","Inclusion Criteria:\n\n* A confirmed diagnosis of multiple sclerosis (MS) established by a neurologist,\n* Not being in a relapse phase and having no MS relapse within the past 6 months,\n* Aged between 18 and 60 years,\n* Disease severity within an Expanded Disability Status Scale (EDSS) range of 1-5 (mild to moderate functional impairment),\n* Visual, auditory, and vestibular functions sufficient to tolerate mixed reality-based applications,\n* Adequate cognitive capacity to actively participate in the study (e.g., Mini-Mental State Examination score ≥ 24),\n* Ability to read, understand, and follow instructions in Turkish,\n* Willingness to participate voluntarily in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* Having experienced a multiple sclerosis relapse or undergone a change in MS-related treatment within the past 6 months,\n* Presence of severe musculoskeletal disorders (e.g., fracture, arthritis, advanced osteoarthritis, muscle tear) that may interfere with test performance,\n* Presence of severe cardiopulmonary disease (e.g., uncontrolled hypertension, heart failure, chronic obstructive pulmonary disease) or any medical condition that may pose a risk during exercise testing,\n* Risk of loss of balance or spatial disorientation in the mixed reality environment due to visual, vestibular, or auditory impairments,\n* Inability to perform functional tests due to severe spasticity, contractures, or orthopedic deformities,\n* History of epilepsy, migraine, or other neurological conditions that contraindicate the use of mixed reality or virtual reality devices,\n* Inability to understand test instructions due to cognitive impairment or severe mental health disorders (e.g., dementia, major depression, psychotic disorders),\n* Experiencing dizziness, nausea, or virtual reality-related symptoms (VR sickness) during testing,\n* Insufficient motivation or poor compliance that may hinder participation in the study.","60 Years",{"count":120,"type":22},75,"Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system, with common symptoms including muscle weakness, balance impairments, gait difficulties, and fatigue. These symptoms significantly affect individuals' functional mobility, independence, and quality of life. In individuals with MS, reduced lower extremity muscle strength leads to decreased walking speed and loss of balance, resulting in substantial limitations in activities of daily living.\n\nConventional clinical assessment tools, such as the Timed Up and Go (TUG), Five-Repetition Sit-to-Stand Test (5xSTS), and the Timed 25-Foot Walk (T25FW), have been widely used for many years to evaluate functional mobility in individuals with MS. However, these tests typically rely on unidimensional measurement parameters and may demonstrate subjective variability depending on the testing environment and the examiner's experience. Advances in measurement technologies now allow these clinical tests to be transformed into more objective, standardized, and interactive assessment tools.\n\nVirtual reality (VR) provides a new perspective for the assessment of motor performance by enabling three-dimensional and interactive simulations of real-world scenarios. VR-based applications allow for the simultaneous evaluation of both motor and cognitive components while also increasing individuals' motivation and engagement. Previous studies have demonstrated that VR technology is effective in neurological rehabilitation, particularly in improving balance, walking speed, and functional mobility in the MS population. In contrast to VR, mixed reality (MR) is a technology that allows individuals to maintain interaction with the real environment while integrating virtual objects into the physical space.\n\nThe existing literature reveals a notable gap in research focusing on the validity and reliability of VR or MR-based functional tests in individuals with multiple sclerosis. However, no studies to date have investigated the adaptation of lower extremity functional tests (TUG, 5xSTS, and T25FW) to a mixed reality environment. Therefore, the primary rationale of this study is to evaluate the digital applicability of commonly used functional tests in individuals with MS on the Meta Quest 3 virtual reality platform and to determine the validity and reliability of these tests. Additionally, this study aims to examine the relationships between data obtained from the virtual tests and fatigue (Modified Fatigue Impact Scale, MFIS), walking performance (12-Item Multiple Sclerosis Walking Scale: MSWS-12), and knee extensor muscle strength in order to establish the convergent validity of this novel approach.\n\nThe findings of this study are expected to contribute to the development of an objective, standardized, safe, and innovative digital assessment tool for functional evaluation in individuals with multiple sclerosis. Furthermore, the results will strengthen the scientific foundation for remote monitoring of the rehabilitation process and for the development of personalized treatment programs.",[123,26],"Multiple Sclerosis",[123,26,125,32,33,37],"Functional Mobility","2026-01-15",{"date":128,"type":42},"2026-01-23",{"date":130,"type":22},"2026-02-02",{"date":132,"type":22},"2026-07-30",{"name":48,"class":49}]