[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mobility-limitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mobility-limitation":35},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,77,108,139,165,189,218,248,273,302,334,362,400,454,474,508,537,571,600,635,657,686,715,749,774],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100619218","brain-stimulation-effects-on-orientation-and-mobility-skills-in-adults-with-vision-impairment-100619218",false,"NCT07341763","Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment","A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate Non-invasive Brain Stimulation Effects on Orientation and Mobility Performance in Adults With Visual Impairments","Inclusion Criteria:\n\n* Are healthy, capacitated adults with binocular constricted visual field loss (due to either retinitis pigmentosa (RP), rod-cone dystrophy, or advanced glaucoma) resulting in functional vision losses. These individuals with visual impairments can be those who have been previously trained by an Orientation and Mobility (O\\&M) specialist to independently travel with the long white cane daily (since the length of the white cane and tip at the base are based on personal preference, they should be willing to use their own white cane for the study), and those who do not necessarily use a cane for travelling.\n* Have binocular visual acuity or best corrected binocular visual acuity no worse than 6\u002F12 or 20\u002F40 or +0.30 logMAR (inclusive) with no eccentric viewing and binocular visual fields no better than 50 degrees in total in each eye as given by the Humphrey Field analyzer and no better than 50 degrees binocularly as given by arc perimeter test. The Humphrey Field Analyzer measures static visual field test, whereas the Arc perimeter test measures kinetic visual field test. Measuring kinetic and static visual field would promote a greater understanding of the individual's daily performance.\n* Are over the age of 18 (inclusive) and has full legal capacity to provide informed consent.\n* Have read and fully comprehends the information in the consent letter.\n* Are willing and capable of adhering to instructions and maintaining the outlined appointment schedule.\n\nExclusion Criteria:\n\n* Are involved in other recent eye-related studies, either clinical or research-related. To be eligible they would have to wait at least one week for studies not involving brain stimulation, and four weeks for studies in which they receive brain stimulation before they could participate in this study.\n* Have been diagnosed with dementia or self-reported dementia with no formal diagnosis.\n* Have been diagnosed with a cognitive impairment or self-reported cognitive impairment with no formal diagnosis.\n* Have been diagnosed with physical or motor impairments resulting in walking and\u002For balancing issues or self-reported physical or motor impairments resulting in walking and\u002For balancing issues with no formal diagnosis.\n* Have been diagnosed with vestibular disorders or dysfunctions which affects one's balance and\u002For mobility or self-reported vestibular disorders or dysfunctions which affects one's balance and\u002For mobility with no formal diagnosis.\n* Are unable to follow the researcher's instructions.\n* Are anticipating treatment (including ocular surgery) for any eye disease within the duration of the study.\n* Have any ocular pathology in addition to retinitis pigmentosa (RP), rod-cone dystrophy, or advanced glaucoma, which can diminish their visual acuity and\u002For their visual field, however wearing glasses or contact lenses, as well as mild cataract of grade 2 or below is acceptable.\n* Have severe hearing impairment.\n* Are pregnant or trying to get pregnant.\n* Fit any of the typical contraindicators for brain stimulation. See contraindicator section below.\n\nFor all participants the contraindications for brain stimulation are:\n\n* Diagnosed with epilepsy or have previously experienced an epileptic seizure.\n* Implanted medication pump or implanted electronic device, including defibrillator or pacemaker.\n* Any metal implants in the head (excluding tooth fillings).\n* Active electric implants anywhere in the body (especially the head region).\n* On psychoactive medication for any psychiatric or neurological conditions including but not limited to depression and schizophrenia.\n* Areas of sensitive skin located on the face or head, or a skin condition on the face, or regularly use medication to alleviate skin irritation on the face.\n* Recurring headaches.\n* Previous head injury or skull fracture or head\u002Fbrain surgery.\n* Heart disease, neurological condition, or a history of cardiac or neurological surgery.\n* Current or historical cancerous or noncancerous brain tumor, or other abnormalities in brain structure.","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot clinical trial evaluates whether non-invasive brain stimulation improves the orientation and mobility (O\\&M) skills of individuals with constricted visual fields in both eyes. The study is composed of three visits. The first visit is meant to confirm eligibility by performing a few clinical tests. Eligible participants will then complete two additional visits, one in which the participants receive active stimulation, and one in which the participants receive placebo (sham) stimulation. Stimulation will be administered in a randomized, double-blind order. To evaluate improvement, various measures of O\\&M performance will be assessed on a standardized obstacle course featuring static natural and artificial obstacles at defined intervals after the intervention. We hypothesize that the application of hf-tRNS to V1 will improve the orientation and mobility skills of individuals with constricted visual fields immediately following stimulation as a results of enhanced periphery through modulation of the mechanisms responsible for crowding, thereby reducing crowding effects and improving contrast for individuals with rod-cone dystrophy and RP (genetic conditions), whereas for individuals with glaucoma (a neurogenerative condition), any improvement noted would be attributed to be enhanced processing of visual signal in the affected periphery. The results will inform the design of a future, larger-scale study.",[27,28,29,30,31,32,33,34,35,36,37],"Retinitis Pigmentosa (RP)","Rod Cone Dystrophy","Visually Impaired Persons","Peripheral Visual Field Defect of Both Eyes","Low Vision, Both Eyes","Vision Loss Partial","Orientation","Mobility Difficulty","Mobility Limitation","Mobility and Independence","Glaucoma",[27,39,40,29,30,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64],"Rod Cone dystrophy","Advanced Glaucoma","Low Vision, Both eyes","Brain stimulation","tES","tRNS","hf-tRNS","transcranial electrical stimulation","transcranial random noise stimulation","high-frequency transcranial random noise stimulation","Long white cane","white cane","mobility cane","walking","orientation and mobility","orientation","mobility","low vision","vision loss partial","occipital pole","primary visual cortex","V1","neuroplasticity","mobility difficulty","mobility limitation","mobility and independence","RECRUITING","2026-06-30",{"date":68,"type":69},"2026-07-01","ACTUAL",{"date":68,"type":21},{"date":72,"type":21},"2027-08-31",{"name":74,"class":75},"University of Waterloo","OTHER",1,{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":76},"100584783","influence-of-the-culture-care-program-on-patient-mobility-after-thoracic-or-abdominal-surgery-a-mixed-methods-study-100584783","NCT06893848","Influence of the Culture Care Program on Patient Mobility After Thoracic or Abdominal Surgery: a Mixed-methods Study","Culture Care Program: a Mixed-methods Study Evaluating the Effect of an Innovative In-hospital Experience on Patient Mobility After Thoracic or Abdominal Surgery","CULTURECARE","Inclusion Criteria:\n\n* Admission to Surgical Units in the Surgical Department of the Hôpital de Neuchâtel implementing the Culture Care program.\n* Elective thoracic or abdominal surgery with an expected hospital stay of at least 2 days (i.e. discharge on postoperative day 3).\n* Neurocognitive and physical ability to complete questionnaires and individual participation in the Culture Care program.\n* Full capacity of discernment and signed informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Outpatient surgery.\n* Emergency surgery.\n* Mobility severely impaired prior to surgery: patients with 1 or 2 lower-limb amputations, patients with wheelchair mobility only, neurodegenerative diseases.\n* Bed restiction between POD 1 and POD 5 for medical reasons, i.e. surgery, post-operative complications or other pre-existing cardiorespiratory, neurological or orthopedic reasons.\n* Transfer to ICU\n* Only during the Culture Care phase, an unplanned transfer to another unit that does not have the Culture Care program (e.g. Medicine units).\n* Technical problem with the accelerometer (e.g. disfunctioning battery).\n* Allergic reaction to any dressing used to attach the accelerometer.\n* End-of-life patients.",true,{"count":87,"type":21},204,[24],"A sedentary behavior in the postoperative phase has a negative impact on recovery from various types of surgery (e.g. abdominal, pulmonary, cardiac or esophageal). In fact, sedentary behavior in the days following surgery is associated with an increased risk of postoperative complications, longer hospital stays and, consequently, higher healthcare costs. Stimulating early mobilization and increasing the level of physical activity after surgery therefore remains a relevant current challenge. The Culture Care program will propose a new experience of the hospital towards an attractive and stimulating intrahospital environment, including art and culture. The hypothesis is that the innovative, positive hospital experience offered by the Culture Care program could contribute to increasing patients' mobility in the postoperative phase and thus reduce the sedentary behaviour compared with a control group included before the implementation of the program.\n\nThe aim of this study is to explore the effect of the Culture Care program (Control group versus Culture Care group) on the mobility of patients hospitalized after thoracic or abdominal surgery, by determining the level of prediction in relation to the influencing covariates reported in the literature.\n\nThe first quantitative part of this research project will compare the mobility of patients hospitalized after surgery, before (control group) and after the implementation of the Culture Care program (Culture Care group). Patients will be asked to wear an accelerometer for the first five post-operative days, and to complete three questionnaires (psychological well-being, physical recovery, perception of their mobility).\n\nHealthcare workers will be asked to complete a survey on their readiness to stimulate patients' mobility before and after the Culture Care program.\n\nThe second part will be qualitative including individual semi-structured interviews with patients and healthcare workers during the Culture Care program, to gather their experiences.",[91,92,93,35],"Thoracic Surgery","Abdominal Surgery Patients","Hospital Mobility",[95,96,97,98],"Physical activity","Postoperative recovery","Accelerometer","Early mobilization","2026-06-23",{"date":101,"type":69},"2026-06-24",{"date":103,"type":69},"2025-03-10",{"date":105,"type":21},"2027-12",{"name":107,"class":75},"Haute Ecole ARC Sante",{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":85,"sex":17,"minAge":18,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":125,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":135,"leadSponsor":137,"locationsCount":76},"100641589","effects-of-a-powered-lower-limb-exoskeleton-on-walking-performance-in-older-adults-100641589","NCT07633093","Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Older Adults","Acute Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Community-Dwelling Older Adults: A Randomized Crossover Trial","E-WALK","Inclusion Criteria:\n\n* Older adults aged 65 to 75 years who are community-dwelling, independently ambulatory, able to walk independently on level ground, able to maintain standing balance without personal assistance, and able to understand study instructions.\n* Young-adult reference participants aged 18 to 22 years who are healthy university students without known conditions affecting walking or balance.\n\nExclusion Criteria:\n\n* Self-reported neurological disease affecting gait or balance.\n* Major musculoskeletal injury or surgery affecting walking within the previous 6 months.\n* Uncontrolled cardiopulmonary disease.\n* Severe visual or vestibular impairment affecting safe walking.\n* Current lower-limb pain that limits walking.\n* Cognitive impairment that prevents informed consent or protocol adherence.\n* Any condition judged by the study team to make participation unsafe.","75 Years",{"count":118,"type":21},40,[24],"The goal of this clinical trial is to learn whether a powered wearable lower-limb exoskeleton can improve walking performance in independently ambulatory older adults aged 65 to 75 years.\n\nThe main questions it aims to answer are:\n\n* Does use of a powered lower-limb exoskeleton increase comfortable walking speed over 10 meters?\n* Does use of a powered lower-limb exoskeleton increase average walking speed during a 400-meter walk?\n\nResearchers will compare walking performance in older adults during walking with the powered exoskeleton and walking without the device to determine whether the exoskeleton improves mobility. Young-adult reference participants will also complete walking assessments to provide reference values for walking performance.\n\nParticipants will:\n\n* Attend a screening and familiarization visit.\n* Complete walking assessments with and without the powered exoskeleton in randomized order (older adults only).\n* Perform a 10-meter walk test, a 400-meter walk test, and other physical performance assessments.\n* Complete questionnaires about balance confidence, fear of falling, and device usability.\n* Be monitored for safety events during testing.",[122,123,124,35],"Aging","Walking","Physical Function",[126,127,128,129,130],"Exoskeleton","Wearable Robotics","Gait Speed","Assistive Technology","Mobility Assistance","2026-06-18",{"date":133,"type":69},"2026-06-22",{"date":68,"type":21},{"date":136,"type":21},"2026-10-01",{"name":138,"class":75},"Hunan Normal University",{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100495034","assisted-ambulation-to-improve-health-outcomes-for-older-medical-inpatients-100495034","NCT05725928","Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients","Randomized Trial of Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients","Inclusion Criteria:\n\nParticipants must meet all of the inclusion criteria listed below to participate in this study:\n\n1. ≥65 years of age\n2. Admitted to a medical service\n3. Complete history and physical examination on file\n4. 6-Clicks score of 16-23\n5. Insurance with Traditional Medicare or Medicare Advantage\n\nExclusion Criteria:\n\nAny patient meeting any of the exclusion criteria listed below at baseline will be excluded from study participation:\n\n1. Significant language barrier that requires a translator (other than Spanish at Baystate site only)\n2. Discharge planned for that day or the following day\n3. Observation status\n4. Surgical procedure planned\n5. Patients diagnosed with unstable angina or other medical conditions precluding participation in exercise\u002Fambulation\n6. Permanent residence in a skilled nursing facility\n7. Comfort care measures only\n8. \\>48 hours since admission\n9. Active infection with COVID-19\n10. Other active infection requiring contact or droplet precautions\n11. Order for bedrest","65 Years",{"count":148,"type":21},3000,[24],"The investigator proposes to conduct a randomized trial of supervised ambulation delivered by mobility technician (MT) up to three times daily, including weekends, to hospitalized medical patients. The aims of the study are to compare the short and intermediate-term outcomes of patients randomized to the intervention versus those patients randomized to receive usual care, to identify patients who are most likely to benefit from the intervention and to assess whether the intervention increases or decreases overall costs of an episode of care, including the cost of the MTs, the index hospitalization and the first 30 days post enrollment.",[35,152,153,154],"Frailty","Hospital Acquired Condition","Weakness, Muscle","2026-06-05",{"date":157,"type":69},"2026-06-08",{"date":159,"type":69},"2023-05-15",{"date":161,"type":21},"2026-12-01",{"name":163,"class":75},"The Cleveland Clinic",5,{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":188},"100503106","up-2-study-cognitively-engaging-walking-exercise-and-neuromodulation-to-enhance-brain-function-in-older-adults-100503106","NCT05830942","Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults","Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults","Inclusion Criteria:\n\n* Age 65+\n* Objective executive function decline, based on standardized cognitive assessments.\n* Subjective cognitive decline, based on the question: \"During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?\"\n* Ability to walking independently for 6 minutes (use of cane permitted)\n\nExclusion Criteria:\n\n* Major cognitive disorder that interferes with independence\n* Percentile score less than 10th percentile on standardized cognitive assessments\n* Medications that are thought to influence tDCS neuroplasticity.\n* Contraindications to tDCS or MRI.",{"count":173,"type":21},120,[24],"Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.",[177,35,178],"Cognitive Dysfunction","Frail Elderly","2026-06-02",{"date":181,"type":69},"2026-06-03",{"date":183,"type":69},"2024-04-15",{"date":185,"type":21},"2027-04-30",{"name":187,"class":75},"University of Florida",2,{"id":190,"slug":191,"hasResults":12,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":12,"sex":17,"minAge":116,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":199,"phases":4,"briefSummary":200,"conditions":201,"keywords":205,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":76},"100640901","validation-of-the-french-version-of-the-new-mobility-score-nms-100640901","NCT07622095","Validation of the French Version of the New Mobility Score (NMS)","Validation of the French Version of the New Mobility Score (NMS) in Hospitalized Patients With Hip Fracture","MOB-SCORE","Inclusion Criteria:\n\n* Patients aged 75 years and older admitted to a hospital department following a hip fracture and treated surgically (osteosynthesis or arthroplasty).\n* Type of fracture: pertrochanteric fracture or femoral neck fracture.\n* Sufficient proficiency in French to complete the questionnaires.\n* Patients affiliated with a health insurance scheme.\n* No objection to participate from the patient or the caregiver in case of cognitive impairment.\n\nExclusion Criteria: no exclusion criteria",{"count":198,"type":21},100,"OBSERVATIONAL","The incidence of hip fractures in France is 50,000 cases per year among women and 16,000 among men, with a 1-year mortality rate of 20-24%. After a fracture, 10-30% of patients become functionally dependent. The increasing aging of the population and the rise in dependency are likely to worsen the situation of older patients in hospital settings.\n\nSeveral tools are available to assess functional independence, including the New Mobility Score (NMS), which evaluates mobility through three domains: mobility indoors, mobility outdoors, and shopping activities. The NMS has shown good performance in predicting patient mortality and functional recovery, and its use is recommended in clinical practice. However, the French version of the NMS has not yet been validated.\n\nThe French validation of the NMS is important to facilitate its implementation in clinical practice and research, particularly because of its simplicity and the need for rapid assessment tools for healthcare professionals. A French version of the NMS has been translated, and the MOB-SCORE study aims to assess its reliability and validity among healthcare professionals caring for patients with hip fractures.",[202,35,203,204],"Hip Fractures","Independence","Autonomy",[206,207,208],"New Mobility Score","Validation","Inter-rater reliability","NOT_YET_RECRUITING","2026-05-28",{"date":179,"type":69},{"date":213,"type":21},"2026-07",{"date":215,"type":21},"2028-02",{"name":217,"class":75},"Hospices Civils de Lyon",{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":12,"sex":17,"minAge":226,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":233,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":76},"100636090","feasibility-of-a-co-designed-mobility-intervention-after-hip-fracture-surgery-100636090","NCT07561164","Feasibility of a Co-designed Mobility Intervention After Hip Fracture Surgery","Feasibility, Fidelity, and Acceptability of a Co-designed Intervention to Promote Mobility in Patients After Hip Fracture Surgery","HIP-ME-UP","Inclusion Criteria:\n\n* Age ≥ 60 years.\n* Admitted to one of the two acute orthopedic wards at Copenhagen University Hospital Hvidovre (CUHH) following hip fracture surgery.\n* Pre-fracture Cumulated Ambulation Score (CAS) (by recall) ≥ 3 points, indicating independence or assisted independence in basic mobility activities such as bed transfer, chair transfer, and indoor walking.\n* Participants may be included if they are able to provide informed consent independently or if informed consent is obtained from a legally authorized proxy (e.g., caregiver or close relative) in cases of cognitive impairment. This applies to both Danish- and non-Danish speaking patients. Non-Danish speakers may be included with support from translated study materials and assistance from relatives or interpreters, where appropriate.\n* Inclusion the latest on postoperative day three.\n\nExclusion Criteria:\n\n* Non-ambulatory before the fracture, e.g. permanently bedbound or wheelchair-dependent.\n* Terminal illness with limited expected survival.\n* Post-operative weight-bearing restrictions precluding mobility activities.\n* Multiple fractures or suspected pathological fractures (e.g. related to malignancy).\n* Clinically unstable or presenting conditions in which early mobilization is contraindicated.\n* Patients who previously participated in HIP-ME-UP Study 4, ensuring that recipients in Study 6 have not been prior HIP-ME-UP study participants or patient partners.","60 Years",{"count":7,"type":21},[24],"This clinical study examines whether a co-designed mobility intervention can be delivered in routine hospital care after hip fracture surgery.\n\nHip fracture is a common and serious condition among older adults and is associated with loss of independence, complications, and increased mortality. During hospitalization, many patients remain inactive, even though early and frequent mobility is considered important for recovery.\n\nThe HIP-ME-UP intervention was developed in collaboration with healthcare professionals, patients, caregivers, and hospital management. It aims to support early mobilization, independence in basic mobility activities such as getting in and out of bed and increased physical activity during hospitalization.\n\nThe study will investigate whether the intervention is feasible to deliver in routine clinical practice, whether it is delivered as intended, and whether it is acceptable to patients and healthcare professionals.\n\nParticipants admitted after a hip fracture surgery will receive the intervention during hospitalization. Researchers will collect information on recruitment, retention, fidelity, acceptability, and mobility-related outcomes. Approximately 25 participants will be included.\n\nThe results will help determine whether a larger effectiveness study should be conducted.",[231,35,232],"Hip Fracture Surgery","Postoperative Rehabilitation",[234,95,235,236,237,238],"Early mobility","Feasibility study","Frequent mobility","hospitalization","Fidelity","2026-05-27",{"date":241,"type":69},"2026-05-29",{"date":243,"type":69},"2026-05-11",{"date":245,"type":21},"2027-06-30",{"name":247,"class":75},"Hvidovre University Hospital",{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":85,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":22,"phases":257,"briefSummary":258,"conditions":259,"keywords":261,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":76},"100618876","evaluating-stairway-designs-for-individuals-with-vision-impairment-100618876","NCT07337317","Evaluating Stairway Designs for Individuals With Vision Impairment","Frequency of Contrast Enhancement on Stairways","Inclusion Criteria:\n\n1. ≥ Contrast sensitivity log 1.6 or greater\n2. travels independently in the community, including stairways \\> two times\u002Fweek\n3. comfortable ascending and descending a stairway with rest time provided\n\n   Exclusion Criteria:\n4. severe rheumatologic and or orthopedic diseases (e.g., awaiting joint replacement, active inflammatory disease)\n5. lower-limb injuries and\u002For recent joint replacements (e.g., hip fracture, hip, or knee replacement within six months of study enrollment)",{"count":256,"type":21},65,[24],"The goal of this study is to learn if contrast frequency on step tread-edges influences foot clearance measures, a marker of fall risk, in older adults with and without visual impairments.\n\nThe main questions that aim to be answered are how foot clearance measures change across different frequencies of stair contrast, and how experiences and perceptions of different stair contrast frequencies are evaluated.\n\nResearchers will compare individuals with and without visual impairments to see if contrast frequency on step tread-edges changes.\n\nParticipants will attend one visit during which their vision will be measured, and they will be asked to ascend and descend laboratory stairs at different contrast frequencies.\n\nAn optional second visit will entail a focus group meeting to better understand how contrast affects mobility in their home and everyday life.",[260,35],"Vision, Low",[262,263],"older adults","impaired contrast sensivity","2026-04-27",{"date":266,"type":69},"2026-05-01",{"date":268,"type":69},"2026-01-22",{"date":270,"type":21},"2027-07",{"name":272,"class":75},"The University of Alabama in Huntsville",{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":76},"100632447","implementation-of-routine-walking-speed-measurements-in-older-veterans-100632447","NCT07513805","Implementation of Routine Walking Speed Measurements in Older Veterans","Walking Speed as a Vital Sign: Enhancing Function in Older Veterans","Inclusion Criteria:\n\nSite Inclusion Criteria:\n\n* VHA primary care clinics\n\nVHA Personnel Inclusion Criteria:\n\n* Providers working in a VHA primary care clinic where FASTER is implemented\n* Nursing staff working in a VHA primary care clinic where FASTER is implemented\n\nVeteran Inclusion Criteria:\n\n* Veterans 60 years and older receiving care in a VHA primary care clinic where FASTER is implemented\n\nExclusion Criteria:\n\n* None",{"count":281,"type":21},10500,[24],"Walking speed is a powerful predictor of mortality and adverse health consequences (e.g. fall or hospitalization) in older adults. Knowledge of individuals' walking speed can provide unique insight into current physical function and need for healthcare services. Furthermore, walking speed is a modifiable risk factor such that early recognition of physical function decline allows for appropriate and timely intervention prior to the occurrence of adverse health events. Therefore, this proposal seeks to implement routine measures of walking speed into VHA primary care as a 'vital sign' to routinely monitor Veteran physical function and help guide provider referrals.",[122,285,35],"Fall Risk",[287,288,289,290,291],"Screening","Preventative Care","Implementation Science","RE-AIM","PRISM","2026-03-30",{"date":294,"type":69},"2026-04-07",{"date":296,"type":21},"2027-04-01",{"date":298,"type":21},"2030-06-30",{"name":300,"class":301},"VA Office of Research and Development","FED",{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":85,"sex":17,"minAge":18,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":312,"briefSummary":313,"conditions":314,"keywords":319,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":4},"100614595","bedside-bike-early-mobilization-program-for-inpatients-100614595","NCT07281638","Bedside Bike Early Mobilization Program for Inpatients","BB-STEP","Inclusion Criteria:\n\n* Age 18 years or older\n* Admitted to participating hospital unit within 24 hours or less\n* Expected hospital stay of at least 3 days\n* Able to follow one-step commands\n* Anti-gravity leg strength\n* Informed consent obtained from patient or legally authorized representative\n\nExclusion Criteria:\n\n* Hemodynamic instability requiring vasopressor support with systolic blood pressure \\\u003C90 mmHg\n* Requiring fraction of inspired oxygen (FiO₂) \\>0.6 or positive end-expiratory pressure (PEEP) \\>8 cm H₂O\n* Uncontrolled cardiac arrhythmia\n* Open lower extremity wounds within the pedal arc area\n* Lower limb fracture requiring traction or immobilization\n* Active deep vein thrombosis (DVT) without therapeutic anticoagulation\n* Body mass index (BMI) \\>45 kg\u002Fm² (exceeds device reach limit)\n* Current pregnancy\n* Concurrent enrollment in another interventional clinical trial that would conflict with study procedures or outcomes","110 Years",{"count":311,"type":21},80,[24],"Hospital immobility leads to serious complications including muscle loss, weakness, delirium, pressure ulcers, and blood clots. Despite being medically stable, hospitalized patients spend over 90% of their time in bed due to staffing shortages, fall risks, and limited physical therapy availability. Within one week of admission, patients can lose approximately 2% of thigh muscle mass per day, and nearly half develop clinically significant hospital-acquired weakness.The Bedside Bike is a portable, low-resistance exercise device that clamps securely to hospital beds, allowing patients to perform leg and arm cycling exercises safely without leaving their bed. This study will evaluate whether hospitalized patients at Indiana University Health facilities can feasibly and safely use the Bedside Bike to maintain mobility during their hospital stay.This quality improvement study will enroll 80 adult inpatients expected to stay at least 3 days. All participants will receive the Bedside Bike in addition to usual care (standard physical therapy and medical treatment). The study will measure how often patients use the device, whether it is safe (tracking any device-related problems), and whether it may help improve outcomes such as hospital length of stay, functional mobility scores, discharge to home, and rates of hospital-acquired weakness. Participants will have functional assessments at admission and discharge, use the Bedside Bike throughout their hospitalization (targeting at least 15 minutes daily), and be followed for 60 days after discharge to track readmissions, falls, living arrangements, and mortality.",[315,316,317,153,318,35],"Immobility Syndrome","Deep Venous Thrombosis","Delirium","Fall",[320,321,322,323,324],"Immobility Harm","Hospital-Acquired Disability","Falls","Deconditioning","In-bed exercise","2026-03-24",{"date":327,"type":69},"2026-03-27",{"date":329,"type":21},"2026-07-05",{"date":331,"type":21},"2026-12-31",{"name":333,"class":75},"Indiana University",{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":146,"enrollmentInfo":341,"targetDuration":4,"studyType":22,"phases":343,"briefSummary":344,"conditions":345,"keywords":349,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":76},"100606393","innovative-approaches-to-enhance-balance-and-neuroplasticity-in-multiple-sclerosis-100606393","NCT07174973","Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis","Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis: Evaluating the Combined Effects of Transcutaneous Spinal Cord Stimulation, Functional Electrical Stimulation, and Visual Feedback Balance Training","Participants will be eligible if they meet the following conditions:\n\n* Confirmed diagnosis of Multiple Sclerosis (MS) according to the revised McDonald criteria\n* Age ≤ 65 years\n* Ability to walk at least 100 meters, with or without an assistive device, and without requiring rest\n* Self-reported perception of impaired balance during standing or walking in daily activities\n\nExclusion Criteria:\n\n* Participants will be excluded if they present with any of the following:\n* Uncorrected visual problems\n* Cognitive impairment affecting comprehension of instructions or completion of self-administered outcome measures\n* Ongoing MS exacerbation or paroxysmal vertigo\n* Concurrent neurological or orthopedic conditions affecting balance\n* Recent participation in rehabilitation therapies (physical therapy, occupational therapy, or vestibular therapy) within one month prior to recruitment\n* Planned or recent injection of botulinum toxin to the legs during the intervention period\n* Peripheral nerve damage affecting the legs\n* Contraindications to electrical stimulation, including:implanted electronic device, active cancer or radiation treatment within the past 6 months, uncontrolled epilepsy, skin rash or open wound at electrode site, pregnancy, active deep vein thrombosis",{"count":342,"type":21},24,[24],"This study will evaluate the effects of combining balance training with electrical stimulation techniques in individuals with Multiple Sclerosis (MS). MS commonly impairs leg strength, coordination, and balance, increasing the risk of falls and reducing independence. The interventions include:Balance training only, Balance training with Functional Electrical Stimulation (FES), and Balance training with FES and Transcutaneous Spinal Cord Stimulation (TSCS). FES delivers small electrical pulses to leg muscles, while TSCS delivers electrical signals through the skin to stimulate the spinal cord and enhance motor control.\n\nThe study will enroll up to 24 participants over a 3-year period. This trial is funded by MS Canada. Participants will be randomly assigned to one of three groups: (1) balance training only, (2) balance training with FES, or (3) balance training with FES and TSCS. All participants will complete 12 supervised training sessions over 6 weeks. During each session, participants will engage in interactive balance games while standing in a safety harness.Outcome assessments will be conducted at three time points: baseline (prior to training), post-intervention (after 6 weeks), and follow-up (8 weeks after training).\n\nAssessments will include:\n\n* Clinical tests of mobility and balance (Timed Up and Go:TUG, 10-Meter Walk Test:10MWT, Berg Balance Scale:BBS)\n* Computerized balance testing using a force plate\n* Questionnaires on walking ability, fear of falling, and balance confidence\n* Neurophysiological measures of brain-spinal cord-muscle communication before and after training",[346,35,347,348],"Multiple Sclerosis","Balance; Distorted","Gait",[350,351,61,352,55],"balance","neuromodulation","multiple sclerosis","2026-03-12",{"date":355,"type":69},"2026-03-16",{"date":357,"type":69},"2025-12-30",{"date":359,"type":21},"2028-12-30",{"name":361,"class":75},"University Health Network, Toronto",{"id":363,"slug":364,"hasResults":12,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":12,"sex":17,"minAge":370,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":22,"phases":373,"briefSummary":374,"conditions":375,"keywords":384,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":76},"100598260","feasibility-of-choose-to-move-replacement-ready-100598260","NCT07069179","Feasibility of Choose to Move Replacement Ready","Choose to Move Replacement Ready: A Feasibility Trial of a Virtual Health-promoting Intervention for People Awaiting Total Hip or Knee Replacement Surgery","CTM-RR","Inclusion Criteria:\n\n1. Activity coach hired by the Active Aging Society (activity coaches must speak English to participate in the evaluation);\n2. English-speaking older adults (aged \\>=50 years) who participate in CTM-RR will be invited to participate in the evaluation\n3. Referral partner (People who work in a healthcare setting who refer patients into the program)\n\nExclusion Criteria:\n\n1. non-English speaking activity coach\n2. non-English speaking referral partner","50 Years",{"count":372,"type":21},60,[24],"Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \\>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR\u002FTHR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people with hip and\u002For knee osteoarthritis who are on surgical waitlists for TKR\u002FTHR.\n\nParticipants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.",[376,377,378,379,35,380,381,289,382,383],"Osteoarthritis","Osteoarthritis (OA) of the Knee","Osteoarthritis, Hip","Total Knee Arthroplasty; Total Hip Arthroplasty","Social Isolation or Loneliness","Pain","Physical Inactivity","Sedentary Behaviors",[376,385,386,95,387,388,381,389,390,391,238],"Implementation science","Social isolation","Mobility","Loneliness","Joint replacement","Feasibility","Acceptability","2026-03-10",{"date":353,"type":69},{"date":395,"type":69},"2025-07-14",{"date":397,"type":21},"2028-03",{"name":399,"class":75},"University of British Columbia",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":116,"enrollmentInfo":407,"targetDuration":4,"studyType":22,"phases":408,"briefSummary":409,"conditions":410,"keywords":421,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":452,"locationsCount":76},"100612195","development-and-efficacy-of-a-novel-cost-effective-gait-training-device-utilized-at-home-for-stroke-survivors-100612195","NCT07250425","Development and Efficacy of a Novel, Cost-Effective Gait Training Device Utilized at Home for Stroke Survivors","Development of a Novel, Cost-Effective Gait Training Device Utilized at Home for the Neurological Patient Population","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* First-ever ischemic or hemorrhagic stroke confirmed by medical record.\n* 3 months to 5 years post-stroke at time of enrollment.\n* Presence of lower-extremity motor impairment limiting walking function.\n* Able to stand for at least 30 minutes with no more than minimal assistance (with or without a device).\n* Medically stable and cleared by a physician to participate in moderate-intensity ambulation exercise.\n* Living in a home environment that can safely accommodate device installation (e.g., adequate space, appropriate flooring, and power access) as determined by the study team.\n* Able to understand study procedures and provide informed consent (or have a legally authorized representative), with sufficient cognitive and communication skills to follow simple instructions.\n* If assistance is required for transfers or device set-up, availability of a caregiver or assistant willing to participate in training and device use.\n\nExclusion Criteria:\n\n* Unstable cardiovascular, respiratory, or other medical conditions that contraindicate moderate- to high-intensity walking exercise (e.g., unstable angina, decompensated heart failure, uncontrolled arrhythmias).\n* Severe musculoskeletal or orthopedic conditions limiting safe participation in supported stepping (e.g., unstable fractures, severe contractures preventing positioning in the device).\n* Severe spasticity or movement disorders that would preclude safe use of the device, based on investigator judgment.\n* Severe cognitive impairment, aphasia, or behavioral disturbance that would prevent informed consent or safe participation.\n* Progressive neurological conditions (e.g., progressive neurodegenerative disease) expected to significantly worsen over the 12-week study period.\n* Current participation in another interventional trial targeting gait or lower-extremity function.\n* Any other condition that, in the opinion of the investigators, would make participation unsafe or interfere with study adherence or outcome interpretation.",{"count":20,"type":21},[24],"This pilot, parallel-group randomized controlled trial will evaluate the feasibility, safety, usability, and preliminary efficacy of the Rise\\&Walk InHome (RWH), a novel robotic gait training device designed for home use after stroke. Twenty adults with lower-extremity motor impairment following a first-ever stroke (3 months to 5 years post-event) will be randomized 1:1 to either (1) RWH-assisted home walking plus usual care or (2) usual care alone for 12 weeks. Participants in the intervention group will receive an in-home RWH device, complete a structured device training program, and be instructed to perform 30-minute RWH walking sessions four times per week (48 sessions total). All participants will undergo standardized outcome assessments at baseline, weeks 4, 8, and 12, including the 6-Minute Walk Test (primary outcome), 10-Meter Walk Test, daily step count via wearable activity tracker, and health-related quality of life (SF-36). Additional feasibility and usability outcomes include device use and adherence, patient satisfaction and motivation, ease of use, perceived exertion, and adverse events. Findings will inform the feasibility of in-home deployment of the RWH device and provide preliminary effect-size estimates to guide the design of a larger efficacy trial.",[411,412,413,414,415,416,417,418,419,420,35],"Stroke","Neurological Diseases or Conditions","Hemiparesis;Poststroke\u002FCVA","Gait Disorders, Neurologic","Post Stroke Fatigue","Motor Recovery","Walking Difficulty","Balance Impairment","Falls Prevention","Hemiparesis",[422,423,424,425,426,427,428,429,430,431,432,433,434,435,436,437,438,439,440,441,442,443,444,445],"in-home rehabilitation","Robotic-Assisted Gait Training","gait training device","stroke recovery","functional mobility","rehabilitation technology","remote monitoring","rehabilitation robotics","Fitbit Step Tracking","Self-Directed Gait Training","high-intensity gait training","Neurorehabilitation Research","Lower Limb Rehabilitation","Motor Function Recovery","Physical Therapy","Walking Endurance","task specific walking practice","neurological recovery","stroke rehabilitation","home exercise program","Rise&Walk InHome","daily step count","6-minute walk test","10-meter walk test","2026-03-06",{"date":448,"type":69},"2026-03-09",{"date":450,"type":21},"2026-08",{"date":450,"type":21},{"name":453,"class":75},"Healing Innovations",{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":461,"targetDuration":4,"studyType":22,"phases":463,"briefSummary":464,"conditions":465,"keywords":4,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":472,"locationsCount":4},"100514206","comparison-of-two-park-based-activities-on-emotional-well-being-in-adults-with-mobility-impairments-100514206","NCT05975476","Comparison of Two Park-Based Activities on Emotional Well-Being in Adults With Mobility Impairments","Comparison of Two Park-Based Activities to Improve Emotional Well-Being and Reduce Stress of Adults With Mobility Impairments","Inclusion Criteria:\n\n* (1) ages between 18 and 60 years\n* (2) non-progressive mobility impairment who use a manual wheelchair (e.g., SCI, transverse myelitis, amputation, spina bifida)\n* (3) able to propel a manual wheelchair outdoors on even terrain independently\n* (4) commit to complete the 5-week park visit program in both Fall and Spring seasons.\n\nExclusion Criteria:\n\n* (1) bald or not willing to donate a hair sample\n* (2) weekly park visit to an urban park during the last 3 months\n* (3) weekly moderate intensity exercise regimen during the last 3 months\n* (4) having an endocrine disorder (that can affect cortisol levels\n* (5) taking oral corticosteroids\n* (6) receiving hormonal therapy\n* (7) unstable medical condition that prevents outdoor moderate intensity activity\n* (8) inadequate comprehension and verbal communication in English (i.e., inability to express basic needs, participate in measurement of outcomes, or provide consent to participate in the study)\n* (9) visual impairment that cannot be corrected using assistive devices",{"count":462,"type":21},10,[24],"This study will examine the impact of a 10-week crossover urban park intervention on the emotional well-being of people with mobility impairments. Outcomes between 5 weeks of sensory engagement activity (i.e., enjoy sights, sounds; primarily sedentary) and 5 weeks of physical activity (i.e., wheeling\u002Fwalking on trail) while in the park will be compared.",[35,466],"Physical Disability",{"date":468,"type":69},"2026-01-23",{"date":470,"type":21},"2026-09",{"date":105,"type":21},{"name":473,"class":75},"University of Alabama at Birmingham",{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":480,"eligibilityCriteria":481,"healthyVolunteers":12,"sex":17,"minAge":482,"maxAge":4,"enrollmentInfo":483,"targetDuration":4,"studyType":22,"phases":485,"briefSummary":486,"conditions":487,"keywords":492,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":506,"locationsCount":76},"100490050","non-invasive-brain-stimulation-for-cognitive-and-motor-dysfunction-in-dementia-100490050","NCT05661084","Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia","Multifocal Transcranial Current Stimulation for Cognitive and Motor Dysfunction in Dementia","ACDCStim","Inclusion Criteria:\n\nParticipants (Ps)\n\n* willing and capable to give informed consent for the participation in the study after it has been thoroughly explained\n* able and willing to comply with all study requirements\n* an informed consent form was signed\n* able to read, write, and communicate in English\n\nCaregiver\u002FAdministrators (As)\n\n* at least 18 years of age\n* able to read, write, and communicate in English\n* self-reported computer proficiency and willingness to learn how to use tES as defined by \"yes\" answers to the questions \"Do you feel comfortable using a computer?\" and \"Are you willing to be the primary caregiver for a participant and learn how to administer tES?\"\n* stated availability during weekdays throughout the study period to administer tES to the Ps\n\nExclusion Criteria:\n\nParticipants (Ps)\n\n* major psychiatric co-morbidity including major depressive disorder, schizophrenia or psychosis\n* blindness or other disabilities that prevent task performance\n* contraindications to tES, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuroactive drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, etc.)\n* the presence of any active dermatological condition, such as eczema, on the scalp a score of 18 or less on the Montreal Cognitive Assessment (MoCA) during the in-person screen\n* an inability to understand study procedures following review of the Informed Consent form\n* Understanding will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the \"Assessment of Protocol Understanding\" form. Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator\n\nCaregiver\u002FAdministrators (As)\n\n* mild cognitive impairment defined by a MoCA score ≤26 during the in-person screen\n* insufficient understanding of study procedures following review of the Informed Consent form\n* Understanding will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the \"Assessment of Protocol Understanding\" form. Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator.\n* poor eyesight, severe arthritis in the hands, pain, deformity or other condition that interferes with successful administration of tES","55 Years",{"count":484,"type":21},144,[24],"This project aims to examine the efficacy of remote, caregiver-led tES\u002Fbrain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.",[488,489,490,491,35],"Dementia","Memory Loss","Alzheimer Disease","Executive Dysfunction",[493,488,494,495,496,497,498,499],"Alzheimer's Disease","Memory","Brain Stimulation","transcranial alternating current stimulation (tACS)","transcranial direct current stimulation (tDCS)","Executive function","instrumental activities of daily living (IADL)","2026-01-08",{"date":502,"type":69},"2026-01-12",{"date":504,"type":69},"2023-01-24",{"date":72,"type":21},{"name":507,"class":75},"Hebrew SeniorLife",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":516,"enrollmentInfo":517,"targetDuration":4,"studyType":22,"phases":518,"briefSummary":521,"conditions":522,"keywords":524,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":188},"100602581","phase-1-living-independence-through-functional-training-100602581","NCT07125378","Living Independence Through Functional Training","Living Independence Through Functional Training (LIFT): Feasibility of Hybrid Task-Oriented Resistance Exercise Following Home Health Discharge","LIFT","Inclusion Criteria:\n\n* between the ages of 65 and 90 years\n* community-dwelling\n* live within a 50-mile radius of the study site with wireless connectivity in the area\n* mobility limitations as indicated by self-reported of using a mobility aid or having unsteady gait or walking slower than before\n* cognitive decline as indicated by a score \\\u003C 12 on Mini MoCA Version 2.1\n* a care partner or adult family member living in the home or nearby\n* willing to wear an activity tracker during the study period\n\nExclusion Criteria:\n\n* plan to receive skilled rehabilitation services\n* plan to move away outside the study area in two months\n* reside in an assisted living or long-term care facility or plan to relocate to such a facility in the next three months\n* severe vision or hearing loss that impedes activity performance or communication\n* unable to stand or walk even with a mobility aid\n* unable to follow a one-step command or carry on a conversation over the phone\n* unable to commit to the six-week exercise program\n* contradictions to resistance exercise, such as the end-stage heart failure\n* a terminal disease or on hospice care\n* a neurological condition affecting motor skills\n* not able to provide consent.","90 Years",{"count":462,"type":21},[519,520],"PHASE1","PHASE2","The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.",[35,523],"Cognitive Impairment",[525,526,527,528,387,529],"Home-based intervention","Exercise","Older adults","Activities of daily living","Cognition","2026-01-07",{"date":500,"type":69},{"date":533,"type":69},"2026-01-06",{"date":535,"type":21},"2026-07-31",{"name":187,"class":75},{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":543,"eligibilityCriteria":544,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":545,"targetDuration":4,"studyType":22,"phases":546,"briefSummary":547,"conditions":548,"keywords":552,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":567,"leadSponsor":569,"locationsCount":4},"100619164","comprehensive-geriatric-assessment-in-primary-care-100619164","NCT07341061","Comprehensive Geriatric Assessment in Primary Care","Comprehensive Geriatric Assessment in Primary Care for Older Adults Across Levels of Frailty","PC-CGA","Inclusion Criteria:\n\n* Older adult patients receiving care at the Dalhousie Family Medicine Clinic and scheduled to undergo an eCGA as part of routine primary care.\n* Fluent in English and able to respond to interview and questionnaire items.\n* Able to provide informed consent; or, if judged unable to consent, able to provide assent AND has a substitute decision maker (SDM) who is willing to provide informed consent on their behalf.\n* (PAHA sub-study) Enrolled in the main eCGA study, willing to participate in a personalized physical activity- program, and available for follow-up contact.\n\nExclusion Criteria:\n\n* Not scheduled for, or not receiving, an eCGA at the investigator's family medicine clinic.\n* Unable to communicate in English, such that questionnaires and interviews cannot be completed.\n* Unable to provide informed consent and no SDM available or willing to consent on the patient's behalf.\n* (PAHA sub-study) Deemed unsuitable for the physical activity intervention by the treating family physician (e.g., medical or functional condition that, in the physician's judgment, makes participation in light-moderate exercise unsafe).",{"count":173,"type":21},[24],"This study evaluates the feasibility and acceptability of implementing the electronic Comprehensive Geriatric Assessment (eCGA) in primary care for adults aged 65 years and older. The study examines how frailty changes over 12 months, how patient self-assessments compare with physician assessments, and how patients perceive the value of the eCGA when used as part of routine care.\n\nThe study also includes an interventional randomized sub-study (PAHA), in which eligible participants receive a personalized physical activity program developed by a Clinical Exercise Physiologist. Participants are randomized to either an immediate-start or delayed-start exercise group, allowing assessment of the effects of a tailored activity intervention on frailty, physical activity participation, and goal attainment.\n\nFindings will inform how eCGA tools and personalized activity interventions can be integrated into primary care to support healthy aging and frailty management.",[152,122,549,35,550,551],"Geriatric Syndromes","Functional Decline","Sedentary Lifestyle",[152,553,554,555,556,557,558,559,560,561,562],"eCGA","electronic Comprehensive Geriatric Assessment","Primary Care","Frailty Index","Clinical Frailty Scale","Older Adults","Healthy Aging","Physical Activity Intervention","Exercise Intervention","Geriatric Assessment","2026-01-05",{"date":565,"type":69},"2026-01-14",{"date":502,"type":21},{"date":568,"type":21},"2029-01-12",{"name":570,"class":75},"Nova Scotia Health Authority",{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":577,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":579,"minAge":18,"maxAge":370,"enrollmentInfo":580,"targetDuration":4,"studyType":199,"phases":4,"briefSummary":582,"conditions":583,"keywords":589,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":598,"locationsCount":76},"100499146","endometriosis---mri-100499146","NCT05779462","ENDOMETRIOSIS - MRI","Study of Pelvic Organ Mobility by Dynamic MRI in Pelvic Endometriosis","ENDO-MRI","Inclusion Criteria:\n\n* Patient referred for suspected pelvic endometriosis requiring pelvic MRI\n* Female, nulliparous,\n* patient with signed written consent, patient with health insurance,\n* patient willing to comply with all study procedures and duration\n\nExclusion Criteria:\n\n* BMI \\> 35,\n* history of hereditary collagen and elastic tissue disease,\n* history of pelviperitonitis,\n* history of major pelvic surgery,\n* inability to receive informed information,\n* inability to participate in the entire study,\n* lack of social security coverage,\n* refusal to sign consent","FEMALE",{"count":581,"type":21},52,"Endometriosis is a frequent pathology with an estimated prevalence of 10% of women of childbearing age. There is no exact correspondence between the symptoms described by the patients and the severity of the lesions, which makes clinical diagnosis difficult. It therefore seems important to improve the complementary examinations available to make the diagnosis more precise and to better study the effectiveness of the treatments implemented. The clinical examination and per-surgical findings of patients with deep pelvic endometriosis show a clear decrease in the mobility of the pelvic organs in relation to each other, but few studies have looked at this mobility, which could however have an implication in explaining the pathophysiology of the disease and the symptomatology of the patients, as well as in the detection of lesions preoperatively. The persistence of hypo-mobility could also help to understand treatment failures.",[584,35,585,586,587,588],"Endometriosis","Magnetic Resonance Imaging","Diagnosis","Pelvis","Comparative Study",[590,35,591,587,588],"Endometriosis ;","Magnetic Resonance Imaging, Cine","2025-12-18",{"date":594,"type":69},"2025-12-26",{"date":596,"type":69},"2023-05-23",{"date":213,"type":21},{"name":599,"class":75},"University Hospital, Lille",{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":606,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":608,"targetDuration":4,"studyType":22,"phases":610,"briefSummary":612,"conditions":613,"keywords":618,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":634},"100568814","phase-3-improving-mobility-after-revascularization-in-peripheral-artery-disease-100568814","NCT06686121","Improving Mobility After Revascularization in Peripheral Artery Disease","IMProving Mobility After revasCularizaTion in Peripheral Artery Disease: The IMPACT PAD Trial","IMPACT PAD","Inclusion Criteria:\n\nSuccessful lower extremity revascularization for disabling PAD performed at least 30 days before baseline testing and between 30 and 100 days before randomization.\n\nExclusion Criteria:\n\n1. History of leg amputation, not including toe and partial foot amputation\n2. Active gangrene\n3. Active limb threatening ischemia\n4. Already exercising at a level consistent with exercise intervention, using investigator discretion.\n5. Unstable angina\n6. Unwilling to drink study beverages\n7. Unwilling to adhere to the interventions and complete follow-up testing\n8. Currently taking sildenafil, tadalafil, or related drugs.\n9. Unwilling to accept randomization into either group (home-based exercise or attention control)\n10. Currently consuming beetroot juice, oral nitrate or nitrite, or a beetroot supplement and\u002For unwilling to avoid beetroot juice during the study. Participants will be asked to discontinue these items for 30 days before baseline testing and throughout the clinical trial. If the potential participant is unwilling to refrain from taking these items, they will not be eligible for the clinical trial.\n11. History of kidney stones that requires minimized intake of oxalate. Potential participants who need to minimize oxalate intake will be excluded from the trial.\n12. Baseline blood pressure \\\u003C100\u002F45.\n13. Wheelchair confinement or requiring a walker to ambulate\n14. Walking is limited by a condition other than PAD\n15. Current foot ulcer\n16. Planned major surgery, coronary revascularization, or lower extremity revascularization during the next 12 months\n17. Major medical illness including lung disease requiring oxygen, Parkinson's disease, or a life-threatening illness with life expectancy less than six months.\n18. Allergy to beetroot juice\n19. Currently consuming one cup or more of beets daily. Participants will be asked to decrease beet consumption to less than one cup of beets per day for 14 days before baseline testing and throughout the clinical trial. If the potential participant is unwilling to refrain from daily beet consumption of one cup or more for 30 days before the trial and during the trial, they will not be eligible for the clinical trial.\n20. Participation in or completion of a clinical trial in the previous three months, using investigator discretion for trials that may not impact study participation or outcome measures of the IMPACT PAD Trial.\n21. Visual impairment that limits walking ability.\n22. Unable to communicate in English, unless the participant communicates in Spanish and is enrolled at a site that can deliver the intervention in Spanish. All sites with a Spanish speaking coordinator and interventionist will be able to enroll Spanish-speaking participants. While investigators aim to be as inclusive as possible, resources are not available to allow inclusion of people speaking languages that are not Spanish or English.\n23. Using a mouthwash containing chlorhexidine or cetylpyridinium chloride or a mouthwash determined to be bactericidal and unwilling to discontinue.\n24. Planning to begin a supervised treadmill exercise program in the next 12 months.\n25. Heart attack or stroke in previous three months prior to baseline testing.\n26. In addition to the above criteria, investigator discretion will be used to determine if the trial is unsafe or not a good fit for the potential participant.",{"count":609,"type":21},386,[611],"PHASE3","Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia. However, supervised exercise is inaccessible or burdensome for most PAD patients. Investigators hypothesize that home-based exercise combined with lower extremity revascularization will significantly improve walking performance compared to revascularization alone in patients with PAD undergoing revascularization for disabling PAD.\n\nInvestigators further hypothesize that inorganic nitrate, a major source of nitric oxide (NO) abundant in beetroot juice, will improve walking performance after lower extremity revascularization, compared to placebo. In preclinical models, NO inhibits inflammation, neointimal hyperplasia, thrombosis, and vascular smooth muscle cell migration at sites of revascularization. NO increases angiogenesis and perfusion, repairs skeletal muscle damaged by ischemia, and stimulates mitochondrial activity.\n\nIn a randomized clinical trial with a 2 x 2 factorial design, the trial will test the following two primary hypotheses in 386 patients randomized within three months of a successful lower extremity revascularization for disabling PAD: First, that home-based exercise combined with lower extremity revascularization will improve six-minute walk distance more than revascularization alone at 6-month follow-up (Primary Aim #1). Second, that nitrate-rich beetroot juice combined with lower extremity revascularization will improve six-minute walk, compared to placebo combined with revascularization at 6-month follow-up (Primary Aim #2).",[614,615,616,35,617],"Peripheral Artery Disease","Intermittent Claudication","Peripheral Vascular Disease","Revascularization",[619,620,387,617,621,622,623,624],"Behavior Change","Patient Reported Outcome Measures","Peripheral artery disease","Intermittent claudication","6-minute walk","Oxidative stress","2025-08-23",{"date":627,"type":69},"2025-08-26",{"date":629,"type":69},"2025-08-04",{"date":631,"type":21},"2032-08-01",{"name":633,"class":75},"Northwestern University",7,{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":639,"acronym":640,"eligibilityCriteria":641,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":642,"targetDuration":4,"studyType":22,"phases":644,"briefSummary":645,"conditions":646,"keywords":647,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":188},"100546538","phase-2-impact-of-brief-daily-functional-resistance-training-on-lower-extremity-physical-performance-100546538","NCT06396247","Impact of Brief Daily Functional Resistance Training on Lower Extremity Physical Performance","FASTNIA","Inclusion Criteria:\n\n* Self-reported difficulty or inability to walk ¼ mile\n\nExclusion Criteria:\n\n* Chest pain on the PAR-Q",{"count":643,"type":21},360,[520,611],"In this study, we will randomly assign 360 older adults to 12 months of 5 minutes per day of functional resistance training or to a delayed treatment control condition, and measure the impact of the training on measures of lower extremity performance and walking ability.",[35],[262,52,55],"2025-07-11",{"date":650,"type":69},"2025-07-16",{"date":652,"type":69},"2025-04-09",{"date":654,"type":21},"2028-09",{"name":656,"class":75},"Milton S. Hershey Medical Center",{"id":658,"slug":659,"hasResults":12,"nctId":660,"briefTitle":661,"officialTitle":662,"acronym":663,"eligibilityCriteria":664,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":665,"targetDuration":4,"studyType":22,"phases":667,"briefSummary":668,"conditions":669,"keywords":673,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":680,"completionDateStruct":682,"leadSponsor":684,"locationsCount":76},"100585623","effect-of-shoulder-sling-use-on-balance-and-mobility-in-subacute-stroke-patients-100585623","NCT06904768","Effect of Shoulder Sling Use on Balance and Mobility in Subacute Stroke Patients","A Cross-Over Study on the Effect of Shoulder Sling Use on Balance and Functional Mobility in Patients With Hemiplegia During the Subacute Phase of Stroke Rehabilitation","SLS-Stroke","Inclusion Criteria:\n\n* Clinical diagnosis of stroke in the subacute phase (up to 6 months post-onset)\n* Hemiplegia affecting one upper limb\n* Brunnstrom stage \\\u003C 4 for the affected upper limb\n* Functional Ambulation Category (FAC) score \\> 3\n* Age between 40 and 80 years\n* Ability to follow simple instructions\n* Medically stable to participate in balance and mobility testing\n* Signed informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment (e.g. MMSE \\\u003C 23)\n* Visual or vestibular disorders affecting balance\n* Significant orthopedic or musculoskeletal conditions of the lower limbs\n* Uncontrolled cardiovascular or pulmonary disease\n* Use of assistive devices that prevent sling application\n* Severe aphasia interfering with understanding or communication\n* Skin lesions or injuries at the shoulder region preventing sling use",{"count":666,"type":21},17,[24],"This study examines whether wearing a shoulder sling can improve balance and mobility in people who are recovering from a stroke. Participants will perform simple movement and balance tests twice-once with the sling and once without. The goal is to find out if using the sling helps patients feel more stable and safe during walking and everyday activities.",[670,671,35,672,411],"Hemiplegia","Balance Disorders","Shoulder Subluxation",[411,670,55,674,350,675,676],"dynamic balance","shoulder brace","arm sling","2025-03-29",{"date":679,"type":69},"2025-04-01",{"date":681,"type":69},"2025-03-13",{"date":683,"type":21},"2025-04",{"name":685,"class":75},"Arnaoutis Stylianos",{"id":687,"slug":688,"hasResults":12,"nctId":689,"briefTitle":690,"officialTitle":690,"acronym":4,"eligibilityCriteria":691,"healthyVolunteers":12,"sex":17,"minAge":226,"maxAge":4,"enrollmentInfo":692,"targetDuration":4,"studyType":22,"phases":693,"briefSummary":694,"conditions":695,"keywords":700,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":707,"startDateStruct":709,"completionDateStruct":711,"leadSponsor":713,"locationsCount":76},"100536402","developing-a-nonpharmacological-pain-intervention-for-community-dwelling-older-adults-with-dementia-100536402","NCT06264362","Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia","Inclusion Criteria for people living with dementia:\n\n* Age 60 or older\n* Speaks English\n* Mild\u002FVery Mild dementia\n* Knee pain lasting ≥ 3 months, potentially related to arthritis\n* Knee pain is at least 2 out of 10 on average.\n\nExclusion Criteria for people living with dementia:\n\n* Reside in long term care facility\n* Unable or unwilling to consent\n* Has a condition with a life expectancy of less than 1-year\n* No care partner who is also willing to participate\n* Recent changes to pain or psychotropic medications in the last 60 days\n* Recent knee surgery in the last 1-year\n* Has a condition that contraindicates exercise (Phase 2 only)\n* Currently receiving rehab services (Phase 2 only)\n\nFor care partners:\n\n* No sex, gender, or age criteria\n* Has known person living with dementia ≥ 1 year\n* Speaks English\n* Able and willing to consent, including being recorded\n\nFor clinicians:\n\n* No sex, gender, or age criteria\n* Speaks English\n* Has ≥ 2 years of experience working with community-dwelling people with dementia and pain\n* Able and willing to consent, including being recorded",{"count":118,"type":21},[24],"The purpose of this study is to develop an exercise treatment program for knee osteoarthritis that works well for people with memory problems. This study will include two parts. Participants can choose to participate in either or both parts.\n\nIn Part 1 (not a clinical trial) - The investigators are inviting the following people to participate in an interview:\n\n1. Individuals aged 60 years or older who do not live in a nursing home and have both memory issues and knee pain.\n2. Care partners of people with knee pain and memory issues. A care partner can be a family member or friend who helps regularly.\n3. Clinicians (exercise physiologists or rehabilitation therapists like physical and occupational therapists) who have worked with older adults with memory issues and knee pain.\n\nThe goal of these interviews is to learn from the experiences of people with memory issues and knee pain and those who care for them. From these interviews, the investigators hope to design a non-drug, tailored physical activity program that will be interesting and helpful in managing knee pain for older adults with memory problems.\n\nFor people with memory problems and knee pain and their care partners: The investigators will ask some questions to determine eligibility to participate in the study.\n\nThose who qualify for the study will be invited to participate in an interview that could be completed online or in person (Philadelphia, PA). The interview could last up to 90 minutes (1 and a half hours) and can be completed as one or multiple sessions.\n\nFor clinicians: Participants will engage in a 90-minute focus group with other clinicians where lunch will be served if in person. Those participating in an online focus group will receive a gift card equal to the value of lunch.\n\nIn Part 2 (a clinical trial) - The program developed in Part 1 will be tested. The program will be physical activity-based. Specific program details for part 2 will be provided as they emerge. Participants can choose to sign up for either or both parts. Signing up for Part 1 does not mean participants have to sign up for Part 2.\n\nPlease contact us for any questions.",[696,697,35,466,698,699],"Pain, Chronic","Dementia, Mild","Osteo Arthritis Knee","Mild Cognitive Impairment",[701,702,703,704,705,706],"pain","dementia","cognitive impairment","osteoarthritis","knee pain","memory",{"date":708,"type":69},"2025-03-11",{"date":710,"type":21},"2025-06-02",{"date":712,"type":21},"2027-05-01",{"name":714,"class":75},"Drexel University",{"id":716,"slug":717,"hasResults":12,"nctId":718,"briefTitle":719,"officialTitle":720,"acronym":721,"eligibilityCriteria":722,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":723,"enrollmentInfo":724,"targetDuration":4,"studyType":22,"phases":725,"briefSummary":726,"conditions":727,"keywords":731,"overallStatus":209,"whyStopped":4,"lastUpdateSubmitDate":740,"lastUpdatePostDateStruct":741,"startDateStruct":743,"completionDateStruct":745,"leadSponsor":747,"locationsCount":76},"100578698","interactive-exergaming-with-otago-exercise-program-on-mobility-in-community-dwelling-older-adults-100578698","NCT06814678","Interactive Exergaming With Otago Exercise Program on Mobility in Community-Dwelling Older Adults","Effectiveness of Interactive Exergaming Combined With the Otago Exercise Program on Mobility in Older Individuals Living in Communities: A Cluster-Randomized Controlled Study","GAME-OEP","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Abnormal mobility based on ICOPE screening (Five-time chair stand test \\> 12 seconds)\n* Able to stand holding handrail for \\> 30 seconds\n\nExclusion Criteria:\n\n* Severe visual impairment\n* Lower limb fracture\n* Acute serious illness\n* Moderate to severe cognitive impairment (SPMSQ \\> 5 errors)\n* Diagnosed psychiatric disorders","99 Years",{"count":198,"type":21},[24],"This clinical trial aims to evaluate the effectiveness of interactive exergaming combined with Otago Exercise Program on mobility among community-dwelling older adults aged 65 and above. The main research questions are:\n\nDoes this combined exercise intervention improve elderly mobility? Does this program enhance muscle strength and psychological well-being?\n\nResearchers will compare two groups: one group will do the combined exercise program for 12 weeks, while the other group will continue their usual activities.\n\nParticipants will:\n\n* Have their health checked three times: at the start, after 12 weeks, and 3 months later\n* If in the exercise group, attend exercise sessions twice a week for 12 weeks\n* Complete tests about their physical abilities and how they feel emotionally\n\nWho can take part:\n\n* Adults age 65 or older\n* People who need more than 12 seconds to stand up and sit down 5 times\n* People who can stand for at least 30 seconds with support\n\nPeople cannot take part if they have serious vision problems, recent leg injuries, major illnesses, significant memory problems, or mental health conditions.",[728,729,730,35,122],"Physical Functional Performance","Psychological Health","Physical Fitness",[732,733,734,735,736,737,738,739],"Otago Exercise Program","Interactive exergaming","Mobility decline","Community-dwelling older adults","Physical performance","Intrinsic capacity","Psychological health","Muscle strength","2025-02-02",{"date":742,"type":69},"2025-02-07",{"date":744,"type":21},"2025-02-11",{"date":746,"type":21},"2026-03-31",{"name":748,"class":75},"National Taiwan University",{"id":750,"slug":751,"hasResults":12,"nctId":752,"briefTitle":753,"officialTitle":753,"acronym":4,"eligibilityCriteria":754,"healthyVolunteers":85,"sex":17,"minAge":755,"maxAge":226,"enrollmentInfo":756,"targetDuration":758,"studyType":199,"phases":4,"briefSummary":759,"conditions":760,"keywords":762,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":765,"lastUpdatePostDateStruct":766,"startDateStruct":768,"completionDateStruct":770,"leadSponsor":772,"locationsCount":76},"100577278","validity-and-reliability-of-the-arabic-version-of-de-morton-mobility-index-after-abdominal-surgeries-100577278","NCT06796218","Validity and Reliability of the Arabic Version of De Morton Mobility Index After Abdominal Surgeries","Inclusion Criteria:\n\n1. Patients after abdominal surgeries.\n2. Patients aged between 40 and 60 years.\n3. All patients are able to read and write in Arabic language.\n4. All patients can understand items of the scale.\n5. All patients will follow the given instructions during the assessment\n\nExclusion Criteria:\n\n1. Patients with mental disabilities .\n2. Patients with communication, vision and hearing disorders\n3. Patients who are not co-operative .\n4. patients who are contraindicated to mobilize due to medical reasons.\n5. patients who are isolated due to infection.","40 Years",{"count":757,"type":21},103,"2 Days","PURPOSE: To determine validity and reliability of translated Arabic version of the De Morton Mobility index for mobility assessment in patients after abdominal surgeries.\n\nBACKGROUND:\n\nMajor abdominal surgery has a high morbidity and Mortality rate, and the risk of surgical complications is higher than for equivalent elective operations. those receiving emergency laparotomy are in a condition of physiological derangement driven by inflammation that has already occurred prior to surgery, in contrast to those undergoing elective abdominal operations. early mobility and exercise play an important role in postoperative treatment following abdominal surgery and are related with reduced postoperative fitness loss and fewer postoperative complications in individuals undergoing elective surgery. reduced mobility is a primary factor of lower quality of life and decreased social participation. reduced mobility is particularly common in older hospitalized patients, and it leads to an increased risk of falls, longer hospitalizations, more severe impairment and morbidity, and higher mortality rates. To manage elderly patients' mobility function, a reliable and valid mobility assessment tool is required. Performance-based examinations are commonly used to measure the mobility of elderly individuals. The De Morton Mobility Index (DEMMI) was established and validated exclusively for older patients hospitalized in the ward. The DEMMI provides clinicians and researchers with a valid interval-level method for accurately measuring and monitoring mobility levels of acute medical patients. It has been validated also in sub acute hospital and community settings. A DEMMI score of \\\u003C40 indicates an independent risk of serious postoperative complications. A low DEMMI score suggested impaired mobilization, and prior research of patients following abdominal surgery discovered that delayed mobilization was related with postoperative pulmonary complications.\n\nHYPOTHESES: It will be hypothesized that: Arabic version of the De Morton Mobility Index may be valid and reliable in patients after abdominal surgeries.\n\nRESEARCH QUESTION: Is The Arabic version of the De Morton Mobility index valid and reliable for mobility assessment in patients after abdominal surgeries?",[761,35,34,92],"Abdominal Surgeries",[63,62,763,764],"abdominal surgeries","abdominal surgical approaches","2025-01-26",{"date":767,"type":69},"2025-01-28",{"date":769,"type":69},"2024-09-01",{"date":771,"type":21},"2025-01-30",{"name":773,"class":75},"Cairo University",{"id":775,"slug":776,"hasResults":12,"nctId":777,"briefTitle":778,"officialTitle":779,"acronym":4,"eligibilityCriteria":780,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":781,"targetDuration":4,"studyType":22,"phases":783,"briefSummary":784,"conditions":785,"keywords":786,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":791,"lastUpdatePostDateStruct":792,"startDateStruct":794,"completionDateStruct":796,"leadSponsor":798,"locationsCount":800},"100534923","time-at-home-randomized-controlled-trial-100534923","NCT06245135","TIME™ at Home Randomized Controlled Trial","Short-term Effects of a Virtual, Community-based, Task-oriented Group Exercise Program Compared to a Waitlist Control in Increasing Function Among Adults With Balance and Mobility Limitations: The TIME™ at Home Randomized Controlled Trial","Inclusion Criteria:\n\n1. adult defined as age 18 years or older;\n2. mobility limitations (eg, need to use a walking aid, difficulty stepping onto curbs, ramps, stairs, or walk on uneven surfaces);\n3. living independently in the community (in own home or assisted living settings);\n4. able to walk a minimum of 10 metres independently (with walking aids if used) without assistance and\u002For supervision from another person;\n5. able to stand up from and sit down onto a chair independently, without supervision;\n6. able to maintain balance while exercising in standing (e.g., marching on the spot) holding onto the back of a chair or a sturdy countertop;\n7. has a study partner (e.g., caregiver, family member or friend) willing to be present, at minimum, during the first evaluation in the home via Zoom;\n8. able to speak and read English to understand informed consent and follow instructions for study procedures and exercises;\n\nExclusion Criteria:\n\n1. involvement in another formal exercise or rehabilitation program in the next 2 months;\n2. previous participation in the TIME at Home exercise program;\n3. health conditions or symptoms preventing participation in exercise;\n4. cognitive impairment, defined as a score of \\\u003C11\u002F15 on the 5-minute Montreal Cognitive Assessment (MoCA);\n5. severe visual impairment;\n6. severe hearing impairment\n\nCaregivers\n\nInclusion criteria:\n\n1. caregiver defined as an individual who helps the exercise participant to live at home by providing support and assistance with at least one basic (e.g., self-care) and\u002For instrumental activity of daily living (e.g., doing groceries, cleaning, managing finances, making meals, doing laundry, etc.) at least once a week;\n2. able to speak and read English.\n\nExclusion criteria:\n\n1\\. Is a paid personal support worker.",{"count":782,"type":21},200,[24],"The goal of this randomized controlled trial is to compare the short-term effects of a virtual, community-based, task-oriented group exercise program (TIME™ at Home) with a waitlist control in community-dwelling adults with balance and mobility limitations.\n\nThe main questions the trial aims to answer are:\n\n1. Will there be improvements in physical and mental health outcomes, and caregiver mood and assistance, following participation in the TIME™ at Home exercise program that are greater than in the waitlist control group?\n2. Will level of mobility limitation, sex, or gender influence the experiences of people in the exercise program?\n3. What will be the costs of the TIME™ at Home exercise program for the organization delivering the program, and the people who are in the exercise program?\n\nParticipants and their caregivers will be asked to complete 3 evaluations using Zoom at study entry and 2 and 5 months later.\n\n* Participants will complete tests of balance and walking and questionnaires.\n* Caregivers will only complete questionnaires.\n\nAfter the first evaluation, participants will be randomly assigned to either participate in:\n\n* the 8-week TIME™ at Home exercise program from their homes using Zoom, or\n* to wait 5 months (waitlist control group) before beginning the 8-week TIME™ at Home exercise program",[35],[787,788,387,789,790],"Virtual Exercise","Community-based Exercise","Balance","Randomized Controlled Trial","2024-12-24",{"date":793,"type":69},"2024-12-30",{"date":795,"type":69},"2024-07-19",{"date":797,"type":21},"2026-03",{"name":799,"class":75},"University of Toronto",4]