[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mobilization-of-hematopoietic-stem-cells-hsc-to-peripheral-blood-pb\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mobilization-of-hematopoietic-stem-cells-hsc-to-peripheral-blood-pb":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100620837","phase-2-g-csf-combined-with-il-11-on-hematopoietic-reconstitution-after-autologous-hematopoietic-stem-cell-transplantation-100620837",false,"NCT07362810","G-CSF Combined With IL-11 on Hematopoietic Reconstitution After Autologous Hematopoietic Stem Cell Transplantation","The Impact of G-CSF Combined With IL-11 on Hematopoietic Reconstitution After Autologous Hematopoietic Stem Cell Transplantation","Inclusion Criteria:\n\n* Adults (≥18 years) with newly diagnosed multiple myeloma or lymphoma\n* Suitable candidates for autologous hematopoietic stem cell transplantation (auto-HSCT)\n* Zubrod (ECOG) performance status \\\u003C 4\n* Left ventricular ejection fraction (LVEF) \\> 40%\n* No uncontrolled arrhythmia or unstable cardiac disease\n* Corrected QT interval (QTc) \\\u003C 470 ms\n* No symptomatic pulmonary disease, with acceptable pulmonary function tests\n* Serum alanine aminotransferase (ALT) \\\u003C 4 × upper limit of normal (ULN)\n* Total bilirubin \\\u003C 2 × upper limit of normal (ULN)\n\nExclusion Criteria:\n\n* Intolerance to auto-HSCT\n* Prior exposure to other stem cell mobilizing agents\n* Pregnancy or lactation\n* Psychiatric disorders precluding participation\n* Positive serology for HIV (HIV-1\u002F2), hepatitis B, or hepatitis C","ALL","18 Years","70 Years",{"count":20,"type":21},224,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in treating hematologic malignancies. Mobilization and collection of peripheral blood stem\u002Fprogenitor cells is the key to successful autologous hematopoietic stem cell transplantation. Currently mobilization regimens are not enough in increasing the yield of megakaryocytic or erythroid stem\u002Fprogenitor cells, resulting in a delay of hematopoietic reconstitution of platelets and erythrocytes. IL-11 and G-CSF have a synergistic role in mobilizing peripheral blood stem cells towards megakaryocytic or erythroid stem\u002Fprogenitor cells in a preclinical study. Furthermore, a single-center, small cohort, prospective clinical study that has been completed in China(ChiCTR2500100054), which showed that after five days of mobilization, the combination of G-CSF and IL-11 significantly increased the number and proportion of functional megakaryocytic\u002Ferythroid progenitor cells in the peripheral blood mononuclear cells of patients, and also significantly shortened the time for platelet engraftment after transplantation, and also reduced the demand for red blood cell and platelet transfusions compared to G-CSF alone. A multi-center, prospective random clinical study is essential to compare the efficacy and safety of novel mobilization regimen with IL-11 plus G-CSF to G-CSF alone.",[27,28,29],"Mobilization of Hematopoietic Stem Cells (HSC) to Peripheral Blood (PB)","Hematopoetic Stem Cell Transplantation","Hemato-oncologic Patients",[31,32,33],"IL-11","mobilization","hematopoetic stem cell transplantation","RECRUITING","2026-01-22",{"date":37,"type":38},"2026-01-23","ACTUAL",{"date":40,"type":21},"2026-01-01",{"date":42,"type":21},"2026-12-30",{"name":44,"class":45},"Fudan University","OTHER",3]