[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mody\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mody":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100536407","phenotypic-and-genotypic-characterization-of-patients-with-dysmetabolism-in-greenland-100536407",false,"NCT06264427","Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland","Inclusion Criteria:\n\n* Type 2 diabetes and\u002For morbid obesity (BMI \\>40)\n* Over 18 years old\n\nExclusion Criteria:\n\n* Does not speak either English, Danish or Greenlandic","ALL","18 Years",{"count":18,"type":19},1000,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland.\n\nThe main questions it aims to answer are:\n\n* Are monogenetic diabetes variants associated with the same risk of developing late diabetic complications as other types of diabetes?\n* Can genotyping and thereby personalized medicine be implemented in Greenland, and can personalized medicine lead to improved treatment?\n* What is the prevalence of sleep apnea among high-risk individuals in Greenland?\n* Is it possible to develop and implement a simple algorithm for the identification of sleep apnea in Greenland that can ensure treatment of severe sleep apnea?\n\nParticipants will:\n\n* Answer WHO-5 and FOSQ-10 questionnaires regarding quality of life and functional outcomes of sleepiness\n* Perform VAGUS examinations for Cardiovasculare Autonomic Neuropathy\n* Clinical examination of height, weight, circumference of hip, waist and neck, Friedman tonsil and tongue score, nasal air flow, nasal septal deviation\n* Blood samples for full genome sequencing",[25,26,27,28,29,30],"Diabetes Mellitus, Type 2","Obesity, Morbid","Obstructive Sleep Apnea","MODY","Diabetic Retinopathy","Diabetic Neuropathies","RECRUITING","2024-02-15",{"date":34,"type":35},"2024-02-20","ACTUAL",{"date":37,"type":35},"2022-07-15",{"date":39,"type":19},"2026-12-31",{"name":41,"class":42},"Steno Diabetes Center Greenland","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100484327","identifying-maturity-onset-diabetes-of-the-young-in-emirati-patients-100484327","NCT05586594","Identifying Maturity-onset Diabetes of the Young in Emirati Patients","Identifying Maturity-onset Diabetes of the Young in Susceptible Emirati Patients Who Are Currently Treated as Type 1 or Type 2 Diabetes Mellitus","Inclusion Criteria:\n\n* Age \\> 11; both male or female, Emirati patients only\n* Diagnosed to have Type 1 or Type 2 Diabetes Mellitus diagnosed before the age of 40 and after the age of 6 months.\n* Attended Tawam hospital during the last 1 year.\n* All previous antibodies testing being negative.\n* Absence of ketoacidosis \u002F significant ketosis in the past medical records\n\nExclusion Criteria:\n\n* BMI of 40 or above (class 3 \u002F severe obesity)\n* History of Secondary diabetes (e.g. Diabetes following pancreatitis)\n* Absent\u002FDecreased C-peptide activity suggestive of Type 1 Diabetes","12 Years","45 Years",{"count":54,"type":19},150,[22],"Diabetes Mellitus is a disease that affects nearly 1 in 5 people in United Arab Emirates and is one of leading causes of death and disability. The main reason for this condition is either relative or near complete deficiency of essential hormone made by our pancreas called \"insulin\", which is required to utilize blood sugar (glucose), and insulin shortage leads to increased blood glucose. The common types of this condition include type 2 Diabetes Mellitus (the most common with almost 90% of all diabetes patients having this condition), which is related to mismatch of body requirements and production of essential hormone called insulin (relative deficiency) and type 1 diabetes, in which body's own defense system causes of destruction of insulin producing cells in the pancreas (near complete deficiency of insulin). However, in younger age group (below the age of 35) there is another type of diabetes which affects nearly 1 out 1000 people and is Maturity onset diabetes of the young (MODY). MODY is a condition passed by parents in 50% of the kids due to an affected single gene and most common forms of MODY do not require any Insulin treatment. However as type 1 Diabetes is generally identified in younger age group, 80% of patient who have MODY cannot be diagnosed and are labelled with other forms of diabetes instead, and may receive unnecessary insulin injections. Although, there has been a lot of research done in the west on prevalence of MODY in white\u002FCaucasian population, the studies in Middle East are minimal. Also, in the white\u002FCaucasian population, a reliable risk calculator has been developed that predicts the risk of having MODY, which if found to be high, is then confirmed by genetic testing for MODY. There is no study available on presence of MODY or on the reliability of the MODY risk calculator among young Emirati population. There is also no data on MODY being misdiagnosed as other forms of diabetes in Emirati population.\n\nThis study proposal aims to address this gap of knowledge and assess the reliability of MODY calculator in young Emirati patients with diabetes and to see if any MODY patient exist in Diabetes clinics of Tawam hospital Abu Dhabi, who may have been misdiagnosed as type 1 or type 2.",[58,59,28],"Maturity-onset Diabetes of the Young","Monogenic Diabetes",[61,62,63,64],"Maturity-onset Diabetes of the Young (MODY)","Diabetes Mellitus","Diagnosis","Precision Medicine","NOT_YET_RECRUITING","2024-01-10",{"date":68,"type":35},"2024-01-11",{"date":70,"type":19},"2024-03",{"date":72,"type":19},"2026-06",{"name":74,"class":42},"United Arab Emirates University"]