[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"molar-incisor-hypomineralization-mih\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:molar-incisor-hypomineralization-mih":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100640792","evaluation-of-occlusal-force-and-masticatory-function-in-children-with-molar-incisor-hypomineralization-100640792",false,"NCT07589179","Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization","Evaluation of Occlusal Force Distribution and Masticatory Function Before and After Restorative Treatment in Children With Molar-Incisor Hypomineralization","Inclusion Criteria:\n\n* Children aged 7 to 12 years\n* Presence of bilateral molar-incisor hypomineralization (MIH) affecting first permanent molars\n* Need for restorative treatment in MIH-affected molars\n* Cooperative children with sufficient cognitive ability to complete functional assessments\n* Presence of healthy control participants without MIH for comparison\n* Mixed dentition period\n* Signed informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Temporomandibular disorders or orofacial pain\n* Systemic diseases or regular medication use affecting mastication\n* History of orthodontic treatment or parafunctional habits\n* Craniofacial anomalies or developmental dental anomalies\n* Extensive prosthetic restorations affecting chewing function\n* Uncooperative children unable to complete examination procedures\n* Acute dental infection or pain requiring emergency treatment",true,"ALL","7 Years","13 Years",{"count":21,"type":22},68,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate right-left chewing balance and masticatory function in children with Molar-Incisor Hypomineralization (MIH) before and after restorative treatment. MIH is a developmental enamel defect that may cause tooth sensitivity, discomfort during chewing, and functional asymmetry.\n\nChildren aged 7 to 12 years with bilateral MIH affecting the first permanent molars will receive glass hybrid restorative treatment. Right-left occlusal force distribution will be assessed using a digital occlusal analysis system. In addition, chewing side preference and chewing balance will be evaluated using a standardized chewing gum protocol. These two assessment methods will be used together to provide complementary information about masticatory function.\n\nMeasurements will be performed before treatment and during follow-up visits after treatment. The findings obtained from children with MIH will also be compared with healthy children without MIH. The study aims to determine whether restorative treatment improves chewing balance and functional oral performance in children with MIH.",[28,29,30,31],"Molar-Incisor Hypomineralization (MIH)","Masticatory Performance","Occlusal Analysis","Chewing Function","NOT_YET_RECRUITING","2026-06-02",{"date":35,"type":36},"2026-06-04","ACTUAL",{"date":38,"type":22},"2026-05-11",{"date":40,"type":22},"2026-12-20",{"name":42,"class":43},"Marmara University","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100626469","color-change-and-desensitization-of-molar-incisor-hypomineralization-affected-enamel-using-biomimetic-nano-hydroxyapatite-toothpaste-100626469","NCT07436039","Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste","Inclusion Criteria:\n\n\\- Children aged 6-12 years.\n\n* Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first permanent molar or hypomineralization of a second primary molar (HSPM).\n* Presence of white, creamy, yellow, or brown demarcated opacities\n* Indexed teeth include permanent first molars and permanent maxillary incisors.\n\nExclusion Criteria:\n\n* • Decayed permanent molars.\n\n  * Diabetes, hypertension, sleeping disorders, or allergic reactions to medications.\n  * Children on medication\n  * Presence of other enamel defects (e.g., fluorosis, amelogenesis imperfecta, enamel hypoplasia, or white spot lesions).\n  * Previous treatment with liquid enamel or other remineralizing agents on affected teeth.","6 Years","12 Years",{"count":53,"type":22},60,[25],"This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are:\n\n* Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity?\n* How does Nano-HA compare to fluoridated toothpaste in terms of outcomes?\n\nParticipants will:\n\n* Use Nano-HA or fluoridated toothpaste daily for 12 months.\n* Visit the clinic for checkups and evaluations every 1 to 3 months.\n* Record symptoms, brushing compliance, and sensitivity.\n\nThe study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .",[28],"RECRUITING","2026-02-21",{"date":60,"type":36},"2026-02-27",{"date":62,"type":36},"2025-10-01",{"date":64,"type":22},"2027-07-01",{"name":66,"class":43},"King Abdulaziz University",1]