[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"molar-incisor-hypomineralization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:molar-incisor-hypomineralization":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,48,75,105,133,157,183,208,231,253,274,297,319,344],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100641661","effect-of-enamel-cleaning-on-a-remineralizing-paste-for-hypomineralizated-lesions-100641661",false,"NCT07653373","Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions","The Effect Of Deproteinization On The Performance Of CPP-ACPF On Hypomineralized Enamel: A Clinical Evaluation","ECLIPSE","Inclusion Criteria:\n\n* Children must have at least one permanent molar without MIH, at least two permanent molars with mild MIH lesions (demarcated opacities without structural loss), with or without sensitivity, that are cream-white or yellowish in color and at least 2 mm in diameter. The teeth with lesions may or may not be on the same dental arch.\n\nExclusion Criteria:\n\n* Children with visible bacterial biofilm, enamel malformations associated with syndromes, amelogenesis imperfecta, or fluorosis, and children who are allergic to milk proteins (casein) will not be eligible to participate in the study.",true,"ALL","7 Years","9 Years",{"count":22,"type":23},54,"ESTIMATED","INTERVENTIONAL",[26],"NA","Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments. Various agents have been used to remove proteins from hypomineralized enamel, such as sodium hypochlorite (NaOCl). Sodium hypochlorite is an antimicrobial irrigant capable of dissolving tissues. CPP-ACPF is used as a remineralizing agent for MIH lesions, it is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, maintaining them in an amorphous form. Therefore, the objective of this study is to evaluate the clinical performance of amorphous calcium fluoride casein phosphate phosphopeptide (CPP-ACPF) dental mousse on deproteinized hypomineralized enamel.",[29],"Molar Incisor Hypomineralization",[31,32,33,34],"molar hypomineralization","dental enamel","spectrophotometry","dental remineralization","NOT_YET_RECRUITING","2026-06-11",{"date":38,"type":39},"2026-06-17","ACTUAL",{"date":41,"type":23},"2026-08",{"date":43,"type":23},"2028-04",{"name":45,"class":46},"Universidade Ceuma","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100513355","effect-of-silver-diamine-fluoride-on-local-anesthesia-in-hypomineralized-molars-100513355","NCT05964387","Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars","Effect of Silver Diamine Fluoride on Local Anesthesia Efficacy in Molar Incisor Hypomineralization-affected Molars in Children: A Randomized Clinical Trial","Inclusion Criteria:\n\n* At least one hypomineralized first permanent molar with a primary cavitated caries lesion(s) or a cavitated tooth defect requiring restorative dental care with local anesthesia\n* American Society of Anesthesiologists (ASA) Physical Status Classification I or II (healthy children or those with mild systemic disease)\n* English speaking\n* Subjects for which basic behavior guidance (non-pharmacological or nitrous oxide\u002Foxygen) is indicated\n\nExclusion Criteria:\n\n* Teeth with irreversible pulpitis and pulp necrosis\n* Patients requiring advanced behavior management such as moderate sedation, general anesthesia, and\u002For active or passive restraint\n* Inability of the child to cooperate due to special needs or other conditions\n* Allergy to SDF, local anesthetic or other material component\n* Subjects with ulcerative gingivitis or stomatitis\n* Subjects with known sensitivity to silver or other heavy-metal ions\n* Subjects showing abnormal skin sensitization in daily circumstances","6 Years","11 Years",{"count":58,"type":23},50,[26],"The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia (MIH). The goal is to determine if pre-operative application of SDF results in improved local anesthesia and decrease in procedural pain in MIH affected teeth, thereby addressing an important challenge in routine clinical practice and contributing to the development of a treatment protocol for MIH affected molars.",[29,62],"Anesthesia, Local",[64],"Silver diamine fluoride","RECRUITING","2026-02-09",{"date":68,"type":39},"2026-02-12",{"date":70,"type":39},"2023-06-12",{"date":72,"type":23},"2027-12-31",{"name":74,"class":46},"University of Michigan",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":17,"sex":18,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100622863","salivary-cortisol-levels-in-children-with-molar-incisor-hypomineralization-100622863","NCT07389148","Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization","Evaluation of Salivary Cortisol Levels and Physiological Stress Parameters in Children With Molar Incisor Hypomineralization: A Comparative Observational Study","Inclusion Criteria:\n\n* Children aged between 8 and 12 years.\n* Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH.\n* Ability to cooperate sufficiently to complete the clinical dental examination and study procedures.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Presence of systemic, hormonal, or metabolic diseases.\n* Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers).\n* History of systemic conditions that may influence stress response.\n* Refusal of participation by the child or parent\u002Flegal guardian.","8 Years","12 Years",{"count":85,"type":23},90,"OBSERVATIONAL","Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment. These problems can increase dental anxiety and lead to physiological stress responses during dental visits.\n\nThe purpose of this observational study is to evaluate physiological stress responses in children with MIH by measuring salivary cortisol levels, heart rate, and oxygen saturation, and to compare these findings with those of children without MIH. A total of 90 children aged 8 to 12 years will participate in the study, including 45 children diagnosed with MIH and 45 healthy control participants.\n\nParticipation involves no treatment or intervention beyond a routine clinical dental examination. Heart rate and oxygen saturation will be measured during the dental visit, and saliva samples will be collected immediately after the examination using a non-invasive method to assess cortisol levels. The results of this study may contribute to a better understanding of stress responses in children with MIH and support the development of more individualized and anxiety-sensitive dental care approaches.",[29],[90,91,92,93,94,95],"Molar incisor hypomineralization","Salivary cortisol","Dental anxiety","Physiological stress","Children","Pediatric dentistry","2026-02-06",{"date":66,"type":39},{"date":99,"type":23},"2026-01-26",{"date":101,"type":23},"2026-04-26",{"name":103,"class":104},"Lokman Hekim University","OTHER_GOV",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":83,"enrollmentInfo":113,"targetDuration":4,"studyType":24,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":47},"100620068","intraosseous-vs-infiltration-anesthesia-in-molar-incisor-hypomineralization-mih-children-100620068","NCT07352813","Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children","A Comparative Evaluation of the Clinical Effectiveness of Computer-Assisted Intraosseous and Infiltration Anesthesia Techniques in Children With Molar-Incisor Hypomineralization","MIH","Inclusion Criteria:\n\n* Individuals applying to the Department of Pedodontics, Ankara Yıldırım Beyazıt University Faculty of Dentistry,\n* Systemically healthy individuals,\n* Individuals without any known allergies,\n* Children between the ages of 6 and 12 years,\n* Scoring 3-4 according to the Frankl Behavior Rating Scale,\n* Children and their legal guardians who, after reading and listening to the informed consent form, fully understand its content and voluntarily provide both verbal and written consent,\n* Children with contralateral and homologous maxillary first permanent molars affected by molar-incisor hypomineralization (MIH) and scoring 3-4 according to the MIH Treatment Need Index criteria,\n* Children with no emergency treatment needs, such as dental pain,\n* Both male and female volunteers.\n\nExclusion Criteria:\n\n\\-",{"count":114,"type":23},30,[26],"This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of permanent first molars affected by Molar-Incisor Hypomineralization (MIH) in children. Clinical effectiveness will be evaluated based on the Visual Analogue Scale (VAS), behavioral pain response, pulse rate , salivary chromogranin A levels, and the need for additional anesthesia.",[29,118],"Hypersensitivity",[120,121,122,123],"caries","dental anxiety","dental pain","molar incisor hypomineralization","2026-01-13",{"date":126,"type":39},"2026-01-20",{"date":128,"type":39},"2025-11-07",{"date":130,"type":23},"2026-12-01",{"name":132,"class":46},"Ankara Yildirim Beyazıt University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":83,"enrollmentInfo":140,"targetDuration":4,"studyType":24,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":156},"100618024","effects-of-silver-diamine-fluoride-and-intraoral-cryotherapy-on-local-anesthesia-in-mih-affected-molars-100618024","NCT07326241","Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars","Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia Efficacy in Permanent Molars With Molar-Incisor Hypomineralization","Inclusion Criteria:\n\n* Children aged between 6 and 12 years.\n* Systemically healthy children with no medical conditions that could interfere with dental treatment.\n* Presence of at least one permanent first molar affected by molar-incisor hypomineralization (MIH), diagnosed according to the European Academy of Paediatric Dentistry (EAPD) criteria.\n* Teeth with caries lesions classified as ICDAS II codes 2, 3, 4, 5, or 6.\n* Children with an adequate level of cooperation to allow completion of dental treatment under clinical conditions.\n* Children and their parents\u002Flegal guardians who have read, understood, and signed the informed consent form and agreed to participate in the study.\n\nExclusion Criteria:\n\n* Teeth that are not restorable.\n* Children with a known allergy or hypersensitivity to any materials used in the study, including local anesthetics, silver diamine fluoride, or restorative materials.\n* Presence of spontaneous pain, percussion sensitivity, or other signs\u002Fsymptoms of pulpal pathology in the study tooth.\n* Children with systemic diseases or conditions that could affect pain perception, healing, or cooperation during dental treatment.\n* Children who are unable or unwilling to complete the clinical procedure.",{"count":141,"type":23},75,[26],"Molar-incisor hypomineralization (MIH) is a developmental enamel defect of unclear etiology that affects permanent first molars and often permanent incisors, leading to increased porosity, hypersensitivity, and poor prognosis. The porous structure of MIH-affected enamel facilitates bacterial penetration, which may cause subclinical pulpal inflammation and reduce the effectiveness of local anesthesia during dental procedures. Achieving adequate anesthesia in children with MIH can be challenging, resulting in increased discomfort, anxiety, and behavioral management difficulties.\n\nCryotherapy has been shown to reduce pain by decreasing local inflammation and slowing nerve conduction, while silver diamine fluoride (SDF) has demonstrated efficacy in reducing dentin hypersensitivity through tubule occlusion, antibacterial activity, and remineralization. This study aims to evaluate the effects of intraoral cryotherapy and silver diamine fluoride application on pain perception and the efficacy of local anesthesia during operative dental procedures in MIH-affected permanent first molars.",[111,145,146],"Molar-Incisor Hypomineralization","Caries Assessment","2025-12-24",{"date":149,"type":39},"2026-01-08",{"date":151,"type":23},"2026-02-01",{"date":153,"type":23},"2026-04-01",{"name":155,"class":46},"Çanakkale Onsekiz Mart University",2,{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":83,"enrollmentInfo":164,"targetDuration":4,"studyType":24,"phases":165,"briefSummary":166,"conditions":167,"keywords":168,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":47},"100596941","pain-perception-and-anxiety-with-virtual-reality-vs-tell-show-do-in-children-with-mih-100596941","NCT07052019","Pain Perception and Anxiety With Virtual Reality vs Tell-Show-Do in Children With MIH","Pain Perception and Anxiety With Virtual Reality Distraction Versus Tell-Show-Do Technique in Restorative Treatment for Children With Molar Incisor Hypomineralization: A Pilot Crossover Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged between 6-12 years.\n* Patients with two First Permanent molars diagnosed with MIH indicated for class I cavities.\n* A cooperative and compliant patient\u002F parent.\n* Patients not allergic to medicaments necessary to complete the procedure.\n* Patients with no history of chronic systemic diseases.\n\nExclusion Criteria:\n\n* MIH-affected molars require apexogenesis, apexification, regeneration or RCT.\n* Non-restorable tooth.\n* Previous restorative treatment.\n* Periodontally affected.\n* Children having systemic disease, an emotional behavioural or learning disorder.",{"count":58,"type":23},[26],"This pilot crossover randomized clinical trial aims to compare the effect of distraction using Virtual Reality (VR) versus the Tell-Show-Do (TSD) technique on pain perception and anxiety in children aged 6-12 with Molar Incisor Hypomineralization (MIH) undergoing restorative dental treatment.",[29],[169,111,170,171,172,173],"Molar Incisor hypomineralization","virtual reality","behavioral","pain","anxiety","2025-06-26",{"date":176,"type":39},"2025-07-04",{"date":178,"type":23},"2025-08-01",{"date":180,"type":23},"2025-12-01",{"name":182,"class":46},"Cairo University",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":24,"phases":193,"briefSummary":194,"conditions":195,"keywords":196,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":47},"100586989","clinical-performance-of-giomer-preceded-by-etching-versus-resin-based-sealants-applied-on-permanent-molars-affected-by-molar-incisor-hypo-mineralization-100586989","NCT06922552","Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralization","Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralization: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy children aged 6-14 years who are diagnosed with mild (MIH) according to European Academy of Pediatric Dentistry (EAPD) criteria which includes demarcated enamel opacities (white, creamy, or yellow to brownish), that may induce sensitivity to external stimuli without enamel breakdown.\n\n  * Cooperative children.\n  * Presenting at least one first permanent molar (FPMs) that were fully erupted and indicated for non-invasive fissure sealant.\n  * Medically fit Children (ASA I).\n\nExclusion Criteria:\n\n* Children have hypomineralized (FPMs) with post-eruptive breakdown, cavitated and non-cavitated carious lesions, restorations, or fixed orthodontic appliances.\n* Enamel defects due to a condition other than (MIH).\n* Parents are not willing to join.\n* Molars that cannot be isolated using rubber dam.\n* Uncooperative children.\n* Medically unfit children (other than ASA I).","14 Years",{"count":192,"type":23},56,[26],"The goal of the study is to evaluate the clinical performance of giomer sealant preceded by etching versus resin-based sealants applied on first permanent molars affected by molar incisor hypomineralization (MIH)\n\nThe main question it aims to answer is :\n\nWill the use of Giomer (Beautisealant, Shofu, Kyoto, Japan) Preceded by Etching result in similar clinical performance as Resin-Based Sealants(UltraSeal XT™ Plus™ by Ultradent) Applied on Permanent Molars Affected by Molar-Incisor Hypomineralization?",[29],[111,197,169,198,199],"Giomer based sealants","Sealants","Rein based sealants","2025-04-11",{"date":202,"type":39},"2025-04-16",{"date":204,"type":23},"2025-06",{"date":206,"type":23},"2026-06",{"name":182,"class":46},{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":20,"enrollmentInfo":214,"targetDuration":4,"studyType":24,"phases":216,"briefSummary":217,"conditions":218,"keywords":219,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":229,"locationsCount":47},"100577689","evaluation-of-preventive-effect-of-sealants-and-laser-therapy-on-dental-caries-and-posteruptive-breakdown-on-molars-affected-with-molar-incisor-hypomineralisation-randomized-clinical-trial-100577689","NCT06801561","EVALUATION of PREVENTIVE EFFECT of SEALANTS and LASER THERAPY on DENTAL CARIES and POSTERUPTIVE BREAKDOWN on MOLARS AFFECTED with MOLAR INCISOR HYPOMINERALISATION (RANDOMIZED CLINICAL TRIAL)","Inclusion Criteria:\n\n* 6-9 years old children (29)\n* One tooth with MIH with no PEB according to evaluation criteria proposed by Ghanim (2017) (APPENDIX I) (30) and ICDAS scores 0, 1 and 2 (APPENDIX II) (31)\n* Good overall health (ASA I) (APPENDIX III) (32)\n\nExclusion Criteria:\n\n* First permanent molars with active carious lesions with ICDAS scores 5 and 6 (Appendix II) or defective restorations (31)\n* Sufficient dentin loss that requires restorative therapy\n* Any clinical signs of failure (abscess, fistula)",{"count":215,"type":23},134,[26],"Background: Molar Incisor Hypomineralisation (MIH) is a qualitative defect of enamel that shows asymmetrical involvement of one to four permanent first molars (PFM) with or without incisor teeth involvement. MIH molars are prone to post-eruptive breakdown (PEB) and to the development of atypical caries lesions.\n\nAim of the study: To evaluate and compare the preventive effect of glass ionomer sealant and laser therapy (LT) against dental caries and PEB on molars affected by molar incisor hypomineralisation (MIH) Materials and Method: This study is a two-arm, parallel group, randomized clinical trial. A sample of children (n=134) with an age range of 6-9 years old, having a first permanent molar erupted with MIH without PEB or carious lesion, will be selected from the outpatient clinic of Pediatric Dentistry and Public Health Department, Faculty of Dentistry, Alexandria University after securing necessary consents. All selected 134 first permanent molars will be randomly and equally allocated into two groups. Group 1(n=67): LT and Group 2 (n=67): Glass ionomer sealant (Fuji triage). Dental caries, PEB, retention of sealant and child-self-reported discomfort will be clinically evaluated after 6, 12 and 18months. Associations between dental caries and PEB with independent variables will be evaluated using logistic regression analysis (p \\\u003C 0.05).",[29],[220,221,222],"Molar Incisor Hypomineralisation","laser","sealant","2025-01-25",{"date":225,"type":39},"2025-01-30",{"date":227,"type":39},"2024-03-01",{"date":206,"type":23},{"name":230,"class":46},"Alexandria University",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":83,"enrollmentInfo":238,"targetDuration":4,"studyType":24,"phases":240,"briefSummary":241,"conditions":242,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":47},"100575760","clinical-evaluation-of-two-different-pit-and-fissure-sealants-100575760","NCT06776471","Clinical Evaluation of Two Different Pit and Fissure Sealants","Clinical Evaluation of Two Different Pit and Fissure Sealants Used in Teeth Affected by Molar Incisor Hypomineralization","Inclusion Criteria:\n\n* Healthy children aged 6-12 years with at least two fully erupted permanent first molars diagnosed with molar ıncisor hypomineralization according to the European Academy of Paediatric Dentistry criteria.\n* Hypomineralized first molars with enamel defects according to early lesions\n\nExclusion Criteria:\n\n* Ongoing orthodontic treatment\n* Uncooperative child during dental treatment\n* Teeth with advanced lesions, existing restorations, fluorosis, or enamel malformation due to syndromic causes\n* Presence of pulpal symptoms",{"count":239,"type":23},126,[26],"It is planned to include girls and boys between the ages of 6-12 who apply to Başkent University Faculty of Dentistry, Pediatric Dentistry Clinic for routine dental examination. Informed and written consent will be obtained from the parents of each participating child. In teeth planned to undergo treatment, molar ıncisor hypomineralization diagnosis will be made primarily in the presence of limited opacities\u002Fenamel fracture after eruption in at least one first permanent molar according to European Academy of Paediatric Dentistry criteria. In teeth diagnosed with molar ıncisor hypominerlization, tooth surfaces will be cleaned with a slow-speed rotary brush and dried with air before the evaluations to be made using the ICDAS II index. Early enamel caries lesions will be assessed by visual examination.\n\nThe decayed, missing, filled teeth of the patients will be assessed according to the World Health Organization assessment criteria. The groups will be double-blind randomized as conventional fissure sealant (n=63) and self-adhesive flowable composite (n=63): Group I (acid+resin-based fissure sealant) will be etched with 37% phosphoric acid for 30 seconds, the surface will be rinsed and air dried until an opaque appearance is achieved on the enamel. Low-viscosity fluoride containing resin based fissure sealant will be applied to the etched enamel surface. Group II (self-adhesive flowable composite); self adhesive flowable composite will be applied in one step. All applied fissure sealants will be polymerized using a light device. Finally, occlusion control will be performed on fissure sealants with articulation paper.The Schiff Cold Air Sensitivity Scale will be used to assess the presence of hypersensitivity in the affected teeth by applying the air-water spray perpendicular to the occlusal surface of the tooth from a distance of 1 cm for 1 second. Clinical evaluation of fissure sealants will be performed at 1, 3, 6 and 12 months using modified . Sealants that receive \"Alpha\" or \"Bravo\" scores for all criteria (anatomical form, marginal adaptation, surface texture, marginal color change, retention and secondary caries) will be classified as successful; while \"Charlie\" scores received from one or more of the United States Public Health Service criteria will be evaluated as failure.",[243,29],"Pit and Fissure Sealants","2025-01-15",{"date":246,"type":39},"2025-01-17",{"date":248,"type":39},"2024-11-18",{"date":250,"type":23},"2025-12-18",{"name":252,"class":46},"Baskent University",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":83,"enrollmentInfo":260,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":262,"conditions":263,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":4},"100571998","prevalence-of-hypomineralized-second-primary-molars-and-its-association-with-molar-incisor-hypomineralization-100571998","NCT06727539","Prevalence of Hypomineralized Second Primary Molars and Its Association with Molar-Incisor Hypomineralization.","Prevalence of Hypomineralized Second Primary Molars in a Group of Egyptian Children and Its Association with Molar-Incisor Hypomineralization: a Cross-Sectional Study.","Inclusion Criteria:\n\n1. Both genders will be included\n2. Children and adolescents with age group from 6-12 years\n3. Participants who agreed to sign rhe informed consent\n\nExclusion Criteria:\n\n1. Patients having enamel defects like fluorosis, amelogenesis imperfecta and dentinogenesis imperfecta\n2. Special health care needs\n3. Non-Egyptian children",{"count":261,"type":23},825,"The aim for thid study is to detect the prevalence of HSPM and the possible association between MIH and HSPM in a group of Egyptian children aged from 6-12 years. The study will also observe the possible etiological factors that might predispose hypomineralization of primary teeth.\n\nTo our knowledge, there are no relevant studies that considered the prevalence of HSPM and its possible etiology in Egypt or its association with MIH. So, this study will address this knowledge gap. The possible relationship between HSPM and MIH is highly significant in pediatric dentistry, since the early diagnosis of HSPM as soon as second primary molars erupt makes it possible to initiate more intensive supervision and preventive measures, as these patients are otherwise prone to developing MIH in permanent teeth within a few years.",[220,29,264,265],"Hypomineralization Molar Incisor","Hypomineralization of Enamel","2024-12-11",{"date":268,"type":39},"2024-12-16",{"date":270,"type":23},"2025-01-01",{"date":272,"type":23},"2026-02",{"name":182,"class":46},{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":17,"sex":18,"minAge":281,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":47},"100570000","prevalence-of-mih-in-young-adults-at-cairo-university-dental-hospital-and-its-link-to-dental-cavities-a-cross-sectional-study-100570000","NCT06701552","Prevalence of MIH in Young Adults At Cairo University Dental Hospital and Its Link to Dental Cavities: a Cross-Sectional Study","MIH Prevalence Among Early Adulthood Patients Attending Cairo University Dental Educational Hospital and Its Correlation to Dental Caries Experience: a Cross-Sectional Study","Inclusion Criteria:\n\n* patients whose age between 18 and 30 years old provide informed consent Egyptian patients from both sexes\n\nExclusion Criteria:\n\n* patients under or over this age group patients undergoing orthodontic treatment patients who refuse to participate","18 Years","30 Years",{"count":284,"type":23},266,"We are conducting a study to understand how often MIH (Molar Incisor Hypomineralization) occurs and whether it is linked to a higher chance of dental cavities (caries).\n\nMIH is a condition where the enamel (the hard outer surface) of the first permanent molars and incisors (front teeth) doesn't develop properly, making these teeth more prone to damage and decay. We are looking at whether patients with MIH have more cavities in their teeth compared to patients without MIH.\n\nThis study aims to help us learn more about the connection between MIH and dental health, so we can improve care and prevention strategies for kids at risk of cavities.",[29,287],"Dental Caries",[111],"2024-11-20",{"date":291,"type":39},"2024-11-22",{"date":293,"type":23},"2024-11",{"date":295,"type":23},"2025-02",{"name":182,"class":46},{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":11,"sex":18,"minAge":82,"maxAge":190,"enrollmentInfo":304,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":306,"conditions":307,"keywords":308,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":4},"100542378","prevalence-and-severity-of-molar-incisor-hypomineralization-among-a-group-of-children-with-type-i-diabetes-milletus-100542378","NCT06342089","Prevalence And Severity Of Molar Incisor Hypomineralization Among A Group Of Children With Type I Diabetes Milletus.","Prevalence And Severity Of Molar Incisor Hypomineralization Among A Group Of Children With Type I Diabetes Milletus:A Cross Sectional Study.","Inclusion Criteria:\n\n* Patient aged 8 to 14 years and diagnosed with types I diabetes milletus.\n* Eruption of all 4 first permanent molars.\n* Acceptance to participate.\n\nExclusion Criteria:\n\n* Presence of orthodontic appliance.\n* Patient with any other type of enamel defect.\n* Patients with any other systemic conditions rather than types I diabetes milletus that may affect tooth development.",{"count":305,"type":23},238,"* Determine the prevalence of molar incisor hypomineralization among a group of children with type I diabetes millutes, its severity and treatment need via clinical examination of children with type I diabetes millutes .\n* Teeth will be cleaned gently using gauze and wet with saliva during examination. A disposable diagnostic set (mirror, probe) will be used for each patient where mirrors will be used for proper visualization especially for maxillary teeth.\n* Blunt explorers will be used to aid in tactile sensation if needed, as during the differentiation between rough and smooth enamel edges and\u002For during the inspection of the caries extent if it exists. No diagnostic radiographs will be taken.\n* The severity and treatment needs of each case with MIH will be recorded in patient's chart.\n* The results of the study will be regularly monitored by the supervisors who will have full access to these results.",[29],[309,310],"Molar Incisor Hypomineralization (MIH)","Type I diabetes milletus(TIDM)","2024-07-12",{"date":313,"type":39},"2024-07-16",{"date":315,"type":23},"2024-09",{"date":317,"type":23},"2025-05",{"name":182,"class":46},{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":4,"eligibilityCriteria":325,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":329,"conditions":330,"keywords":331,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":47},"100501218","use-of-a-glass-ionomer-sealant-in-molar-incisor-hypomineralization-100501218","NCT05806398","Use of a Glass Ionomer Sealant in Molar Incisor Hypomineralization","Use of a Glass Ionomer Sealant in First Permanent Molars Affected by Molar Incisor Hypomineralization","Inclusion Criteria:\n\n1. FPMs of children aged between 6 and 10 years;\n2. Erupted MIH affected FPMs presenting lesions on the occlusal surface;\n3. Good general health conditions;\n4. Sufficient cooperative behaviour;\n5. Signature of the informed consent to the study by patients' parents or by their legal guardians\n\nExclusion Criteria:\n\n1. FPMs presenting fluorosis, amelogenesis imperfecta, white spots, or other enamel defects that are in differential diagnosis with MIH;\n2. FPMs presenting the occlusal surface already sealed or restored;\n3. FPMs presenting occlusal cavitated caries (ICDAS Pit and Fissures ≥ 3)\n4. FPMs presenting severe PEB involving the dentin;\n5. Children with orthodontic devices hiding FPMs.","10 Years",{"count":328,"type":23},15,"Molar Incisor Hypomineralization (MIH) is a worldwide widespread qualitative developmental defect of the dental enamel with a multifactorial aetiology defined in 2001 as an \"hypomineralization of systemic origin affecting one or more permanent molars, usually first permanent molars (FPMs), with or without the involvement of one or more affected permanent incisors\". Clinically MIH lesions appear as demarcated opacities with a creamy-white to yellow-brown colour depending on the severity of the defect that is classified as mild or severe (levels of severity) according to the European Academy of Pediatric Dentistry (EAPD) severity criteria. The distribution of the lesions is asymmetrical and their severity varies from a patient to another and also within the mouth of the same patient. Due to its porous structure with an altered prism organization and an increased content of proteins, the hypomineralized enamel has reduced mechanical properties and a lower refractive index if compared to the sound enamel. MIH is associated to a large number of objective and subjective problems as an altered aesthetics, an increased risk of plaque accumulation, caries, post-eruptive breakdown (PEB), reduced retention rates of adhesive materials, hypersensitivity and difficulty in anesthetizing the affected teeth making its management a challenging condition. Among preventive measures, pit-and-fissure sealants are a valuable and effective treatment to prevent occlusal caries in FPMs when they are still intact. However, since their efficacy is closely related to the sealant retention, they have to be monitored over time. When the molar to be sealed is fully erupted and isolation is adequate, resin-based sealants are indicated while if the moisture control is inadequate and\u002For the tooth is hypersensitive and patient is not sufficiently cooperative, low-viscous glass ionomer cements (GICs) are suggested as a temporary measure until the eruption is completed and both symptoms and cooperation are improved. To date, the scientific knowledge regarding the use of different type of sealants in MIH affected molars is insufficient to draw exhaustive conclusions and further studies are needed to deepen the knowledge on this topic. The aim of this study is to assess, by clinical examination, the survival rate of a glass ionomer sealant in MIH affected FPMs at 12 months of follow-up.",[29],[332,333,334],"Molar Incisor Hypomineralization (MIH) Molars","Glass ionomer sealant","Prevention","2024-06-13",{"date":337,"type":39},"2024-06-14",{"date":339,"type":39},"2022-06-01",{"date":341,"type":23},"2026-01-15",{"name":343,"class":46},"IRCCS Burlo Garofolo",{"id":345,"slug":346,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":17,"sex":18,"minAge":82,"maxAge":326,"enrollmentInfo":351,"targetDuration":4,"studyType":24,"phases":353,"briefSummary":355,"conditions":356,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":361,"leadSponsor":362,"locationsCount":4},"100480951","phase-3-comparative-evaluation-of-giomer-varnish-vs-fluoride-varnish-as-desensitizing-agents-in-teeth-with-mih-100480951","NCT05542667","Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIH","Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents Among a Group of Children With Molar Incisor Hypomineralization : A Controlled Clinical Trial","Inclusion Criteria:\n\n* Children :\n\n  1. Patients aged between 8 and 10 years old with MIH affected teeth according to European Academy of Pediatric Dentistry diagnostic criteria (Lygidakis et al., 2022)\n  2. Systemically healthy.\n  3. Cooperative patients who will comply with follow-up visits.\n* Teeth:\n\n  1. At least one first molar or one incisor erupted in the oral cavity exhibiting molar incisor hypomineralization.\n  2. Teeth representing molar incisor hypomineralization are sensitive.\n\n     \\-\n\n     Exclusion Criteria:\n     * • Children:\n\n  \u003C!-- -->\n\n  1. Undergoing desensitizing treatments in the last 3 months\n  2. Occlusal problems such as bruxism.\n  3. Cognition problems.\n  4. Who used any type of analgesics before treatment.\n  5. Undergoing orthodontic treatment.\n* Teeth:\n\n  1. Enamel defects as enamel hypoplasia, amelogenesis imperfecta, and dental fluorosis.\n  2. Carious teeth.",{"count":352,"type":23},24,[354],"PHASE3","this clinical trial's aim is to compare two desensitizing agents available in the market to prove which one is more efficient in children with molar incisor hypomineralization complaining from hypersensitivity",[29],"2023-08-31",{"date":359,"type":39},"2023-09-01",{"date":295,"type":23},{"date":41,"type":23},{"name":182,"class":46}]