[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"monitored-anesthesia-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:monitored-anesthesia-care":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100594707","the-million-anesthesia-cases-study-macs---a-cohort-study-of-preoperative-fasting-and-perioperative-outcomes-100594707",false,"NCT07022951","The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes","The Million Anesthesia Cases Study (MACS) - Retrospective and Prospective Characterization of Perioperative Fasting Practices and Their Effects on Clinical Outcomes","MACS","Inclusion Criteria:\n\n* Diagnostic or therapeutic procedure with anesthesia care (general anesthesia, regional anesthesia, sedation, or a combination of the above)\n\nExclusion Criteria:\n\n* Not receiving anesthesia care\n* Lack of medical record data in Epic electronic medical record system","ALL",{"count":19,"type":20},1200000,"ESTIMATED","OBSERVATIONAL","Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes through possible effects on patient well-being (anxiety, hunger, thirst), physiology (hypovolemia, hypotension), perioperative aspiration, etc. The research team hypothesized that in addition to known adverse effects on patients' well-being, prolonged preoperative fasting adversely affects circulating blood volume-related (hypotension, decreased urine output etc.) and glucose metabolism-related (e.g., hypo\u002Fhyperglycemia) perioperative physiology. The investigators will also test for an association between the duration of preoperative fasting and the risk of perioperative pulmonary aspiration.\n\nAdditional knowledge on the potential adverse effects of preoperative fasting will inform preoperative fasting policies and research interventions that are relevant to hundreds of millions of patients subjected to preoperative\u002Fpreprocedural fasting worldwide each year.",[24,25,26,27,28,29,30,31,32],"Anesthesia","Sedation","Monitored Anesthesia Care","Procedure","Surgery, Day","Surgery","Surgery Scheduled","Fasting Before Operation","Aspiration; Gastric Contents, Anesthesia",[34,35,36,37,38,39,40,41,42,43],"preoperative fasting","perioperative pulmonary aspiration","perioperative complications","postoperative nausea and vomiting","perioperative hypoglycemia","perioperative hyperglycemia","perioperative hypotension","myocardial injury after noncardiac surgery","perioperative acute kidney injury","clear liquid fasting","RECRUITING","2026-04-02",{"date":47,"type":48},"2026-04-08","ACTUAL",{"date":50,"type":48},"2016-01-01",{"date":52,"type":20},"2030-12-31",{"name":54,"class":55},"Massachusetts General Hospital","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":4,"enrollmentInfo":66,"targetDuration":68,"studyType":21,"phases":4,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":56},"100624762","qnox-response-to-nociceptive-motor-events-during-procedural-sedation-100624762","NCT07413848","qNOX Response to Nociceptive Motor Events During Procedural Sedation","Performance of the CONOX Monitor Without Neuromuscular Blockade: qCON and qNOX Responses to Nociceptive Motor Events During Procedural Sedation","MO-NOX","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective diagnostic or therapeutic urological procedures (cystoscopy, ureteroscopy, prostate biopsy, intradetrusor botulinum toxin injection) under monitored anesthesia care\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Known central neurological disease (epilepsy, Alzheimer's disease, Parkinson's disease, stroke) or history of brain surgery\n* Body Mass Index (BMI) ≥35 kg\u002Fm²\n* Known allergy to anesthetic agents used in the study (propofol, fentanyl, lidocaine)","18 Years",{"count":67,"type":20},120,"1 Day","The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures. The main questions it aims to answer are:\n\nDoes the qNOX index respond to pain-related motor responses during urological procedural sedation? Does the qNOX index show greater responsiveness to painful episodes compared to blood pressure and heart rate? Participants undergoing urological procedures (such as cystoscopy) under sedation as part of their regular medical care will have continuous brain activity monitoring with the CONOX device. All monitoring displays (CONOX monitor, vital signs monitor, and target-controlled infusion pump) will be video-recorded throughout the procedure to capture synchronized data including qCON, qNOX, EMG, heart rate, blood pressure, oxygen saturation, and drug concentrations. Researchers will analyze the relationship between these indices and spontaneous movements triggered by painful stimulation to evaluate the monitor's performance compared to traditional vital signs.",[71,72,26],"Monitoring Noxious Events Using EEG-Derived Pain Indices","Procedural Sedation and Analgesia",[74,75,76,77,78,79,80],"EEG Monitoring","CONOX Monitor","qNOX Index","qCON Index","Target Controlled Infusion","Procedural Sedation","Propofol","2026-02-15",{"date":83,"type":48},"2026-02-18",{"date":85,"type":48},"2026-01-14",{"date":87,"type":20},"2026-05-30",{"name":89,"class":55},"Ankara University"]