[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"monochorionic-twins\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:monochorionic-twins":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,73,99,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100643915","modi-twin-placental-imaging-100643915",false,"NCT07667647","MoDi Twin Placental Imaging","Healthy Monochorionic Diamniotic Twin Microvasculature and Placental Imaging","Inclusion Criteria:\n\n1. Subject is 18 to 45 years of age at screening\n2. Non-anomalous, monochorionic, diamniotic (MoDi) or monochorionic, monoamniotic (MoMo) twin gestation without suspected genetic disorders\n3. Low-risk aneuploidy screening, if performed\n4. Intention to deliver at Carilion Roanoke Memorial Hospital (CRMH) or Carilion New River Valley Medical Center (CNRVMC)\n5. Anatomical survey has been performed\n6. 18 - 26 weeks gestational age\n\n8\\. Subject willing and able to provide\u002Fre-provide informed consent\n\nExclusion Criteria:\n\n1. Suspected fetal genetic disorder(s)\n2. Suspected fetal infection(s), twin-twin transfusion syndrome (TTTS), twin reversed arterial perfusion sequence (TRAPS), or maternal vascular disease\n3. Non-English reading and speaking\n4. Unstable housing or transportation\n5. Any other criterion which, in the clinical judgement of the investigator, would make the subject unsuitable for study enrollment","FEMALE","18 Years","45 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or Mono-Mono) twins, arising from division on day 8-13 GA.\n\nIn monochorionic twin pregnancies sharing a single placenta often unevenly, anastomoses \\[connections\\] artery to artery (AA), vein to vein (VV), and artery to vein (AV) can occur.\n\nAV anastomoses usually flow unilaterally, shunting blood unevenly towards one twin and away from the other. This can lead to fluid overload and polyhydramnios along with many other pathologies in one twin while the other twin suffers from inadequate blood flow and oligohydramnios, along with secondary pathologies arising from these conditions.\n\nTTTS will affect approximately 8-10% of MoDi twins while 6% of MoMo twins will suffer with this condition.\n\nTreatment for TTTS is necessary, with the donor or 'pump' twin having around an 80% chance of death without medical intervention.\n\nThe aim of this single arm, unblinded, feasibility study of the Verasonics Vantage 256 device is to leverage the devices ultrafast power Doppler imaging (uPDI) to perform microvascular mapping of the placenta in healthy, non-anomalous, 18-26 week gestational age (GA), monochorionic, diamniotic (MoDi) or monochorionic, monoamniotic (MoMo\u002FMonoMono) pregnancies without TTTS, twin reversed arterial perfusion sequence (TRAP), or maternal vascular disease.\n\nParticipants will be recruited in the Maternal Fetal Medicine department of Carilion Clinic, which specializes in high risk or complicated pregnancies. Pregnant subjects carrying monochorionic twins and scheduled for appointments at the clinic, who meet study eligibility criteria, will be approached between weeks 18 and 26 for study enrollment.\n\nThose providing informed consent will undergo a single, transabdominal ultrasound examination by a licensed ultrasonographer or obstetrician with the Verasonics Vantage 256 ultrasound machine, with imaging focused on mapping the vasculature of the placenta with ultrafast power Doppler imaging (uPDI). The ultrasound exam will last about 15 minutes and occur immediately after the subject's standard-of-care appointment at the clinic so as not to inconvenience subjects more than necessary. Similar to commercially marketable ultrasounds in the US, the Verasonics ultrasound will use the principle of 'As Low As Reasonably Achievable (ALARA) to output the lowest acoustic waves possible to achieve the ultrasound imaging.\n\nAfter the single ultrasound scan, subjects' electronic medical records will be used to source demographic, medical, obstetric, and other historical datapoints to better characterize the 10-subject study population and their babies.\n\nNo follow-up contact with subjects is expected after the single research ultrasound visit.",[27,28,29,30,31,32,33,34],"Monochorionic Diamniotic Placenta","Monochorial Monoamniotic Placenta","Monochorionic Twins","Ultrasound Doppler","Ultrasound","Pregnancy","Twin Pregnancy, Monochorionic","Twin Twin Transfusion Syndrome",[36,37,38,39,40,32,41,42,43,44,45,46,47,48,49,50,34,51,52,53,54,55,56,57,31,58,59,60],"Carilion Clinic","Maternal Fetal Medicine","Obstetrics","OB","OBGYN","Twin Pregnancy","Whitham","Monochorionic","Monochorionic Diamniotic","MoDi","MoMo","Monochorionic Monoamniotic","Twin","TTTS","Twin-Twin Transfusion Syndrome","uPDI","ultrafast power Doppler Imagine","Quantitative Ultrasound","QUS","Fetoscopic laser photocoagulation","FLP","Verasonic","Doppler","Doppler Imaging","Prenatal Care","NOT_YET_RECRUITING","2026-06-19",{"date":64,"type":65},"2026-06-25","ACTUAL",{"date":67,"type":21},"2026-07-01",{"date":69,"type":21},"2029-07-01",{"name":36,"class":71},"OTHER",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":72},"100587979","role-of-cerebroplacental-ratio-discordance-at-16-20-weeks-in-predicting-monochorionic-twin-pregnancies-specific-complications-100587979","NCT06935422","Role of Cerebroplacental Ratio Discordance at 16-20 Weeks in Predicting Monochorionic Twin Pregnancies' Specific Complications","Role of Cerebroplacental Ratio Discordance at 16-20 Weeks in Predicting Monochorionic Twin Pregnancies' Specific Complications : a Prospective Cohort Study","CPR","Inclusion Criteria:\n\n* Aged 18 years or more and able to consent.\n* Monochorionic Diamniotic twin pregnancy.\n* Discordant inter-twin cerebroplacental ratio at 16-20 weeks of gestation.\n\nExclusion Criteria:\n\n* Fetal structural malformations or chromosomal abnormalities in any of the twins as detected by anomaly scan antenatally or neonatal examination postnatally (chromosomal abnormalities and some congenital malformations can interfere with normal fetal growth).\n* Identified infectious etiologies detected during immediate postnatal examination or during pregnancy (fetal infections can cause FGR ,usually symmetric type particularly if they occur in early gestation).\n* Referral after development of Twin to twin transfusion syndrome, twin anemia polycythemia sequence or selective fetal growth restriction.\n* Single fetal demise at the time enrollment in the study.\n* Conjoint twins.",{"count":82,"type":21},55,"OBSERVATIONAL","The purpose of this study is to evaluate the predictive value of CPR discordance at 16-20 weeks in MCDA twin pregnancies in predicting monochorionic-specific complications such as TTTS, TAPS, sFGR and IUFD of one or both fetuses",[29,86],"Cerebroplacental Ratio",[88],"Monochorionic twins","RECRUITING","2025-08-29",{"date":92,"type":65},"2025-09-05",{"date":94,"type":65},"2025-03-01",{"date":96,"type":21},"2026-09-15",{"name":98,"class":71},"Ain Shams Maternity Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":72},"100602500","placental-characteristics-within-monochorionic-twin-pregnancies-100602500","NCT07124312","Placental Characteristics Within Monochorionic Twin Pregnancies","Placental Characteristics Within Monochorionic Twin Pregnancies: a Prospective Cohort Study.","Inclusion Criteria:\n\n• All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis.\n\nExclusion Criteria:\n\n* Singleton, dichorionic and higher order pregnancies (e.g. triplet).\n* Fetus with known major congenital anomalies or aneuploidy",true,{"count":108,"type":21},65,"This prospective study aims to collate a comprehensive database of all main monochorionic twin groups to enable comparisons to be made within each twin group and additionally between each group with regards to several placental characteristics, whilst understanding their impact on several fetal outcomes. This study aims to provide new insights in to how the placental architecture influences pregnancy care within the UK pregnancy cohort. Results of this study may impact how clinicians conduct antenatal surveillance for these anatomical placental factors.\n\nPatients of both uncomplicated and complication monochorionic twin groups will be consented at a single site and recruited during the antenatal period. Following delivery the placenta will then be analysed macroscopically and assessed for several anatomical features. This will be compared with the antenatal complications and perinatal outcomes for the respective twin.",[111,29,112],"Placenta","Anatomy","2025-08-08",{"date":115,"type":65},"2025-08-15",{"date":117,"type":65},"2024-12-12",{"date":119,"type":21},"2027-02-01",{"name":121,"class":122},"Birmingham Women's NHS Foundation Trust","OTHER_GOV",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":72},"100287687","unequal-placental-sharing-in-monochorionic-diamniotic-twins-an-observational-study-100287687","NCT03024918","Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study","Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study to Investigate Prediction and Outcome: the TWINSHARE Study","TWINSHARE","Inclusion Criteria:\n\n* MCDA cohort\n\n  * Ongoing monochorionic diamniotic twin pregnancy between 11 and 14 weeks, as determined by the crown rump length of the larger twin in spontaneous conceptions and by the date of insemination or embryonic age at replacement in pregnancies resulting from subfertility treatment\n  * Women aged 18 years or more, who are able to consent\n  * Written informed consent to participate in this study, forms being approved by the Ethical Committees\n* TTTS cohort\n\n  * Monochorionic diamniotic twin pregnancy, with gestational age defined in the first trimester as mentioned above\n  * Complicated by TTTS according to the definition used in the Quintero staging of TTTS (DVP of donor \\\u003C 2 cm and DVP of receptor \\> 8 cm before 20 weeks or \\> 10 cm after 20 weeks\n  * Undergoing laser surgery for TTTS\n  * Women aged 18 years or more, who are able to consent\n  * Written informed consent to participate in this study, forms being approved by the Ethical Committees\n* sIUGR cohort\n\n  * Monochorionic diamniotic twin pregnancy, with gestational age defined in the first trimester as mentioned above\n  * Complicated by sIUGR defined as a discordance in EFW of ≥ 20%, with the percentage of discordance being calculated as (EFW larger twin - EFW smaller twin)\u002FEFW larger twin x 100.\n  * Women aged 18 years or more, who are able to consent\n  * Written informed consent to participate in this study, forms being approved by the Ethical Committees\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Inability to consent",{"count":132,"type":21},393,"This is an observational study in 3 cohorts of monochorionic diamniotic (MCDA) twins. The aim of the study is to assess whether unequal placental sharing can be predicted in pregnancy and whether it is predictive of pregnancy outcome.",[29],[136,137],"monochorionic","placental sharing","2024-07-09",{"date":140,"type":65},"2024-07-10",{"date":142,"type":65},"2016-04",{"date":144,"type":21},"2025-12",{"name":146,"class":71},"Universitaire Ziekenhuizen KU Leuven"]