[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mood-disturbance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mood-disturbance":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100609695","neurofeedback-and-well-being-among-people-with-co-occurring-obsessive-compulsive-disorder-and-post-traumatic-stress-symptoms-100609695",false,"NCT07217925","Neurofeedback and Well-Being Among People With Co-Occurring Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms","Exploring the Influence of Neurofeedback on the Well-Being of People With Symptoms of Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms","Inclusion Criteria:\n\n1. being a client placed on the clinic waitlist to receive exposure-response prevention for OCD symptoms at the Anxiety and OCD Treatment Center of Ann Arbor, in Ann Arbor, MI.\n2. having self-reported symptoms of OCD;\n3. having post-traumatic stress symptoms as indicated by a score of 3 or higher on the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) screening measure;\n4. being age 18+.\n5. being a citizen of the United States of America -\n\nExclusion Criteria:\n\n1. a lifetime history of significant untreated mental illness (not currently treated schizophrenia, schizoaffective disorder, bipolar disorder, or substance use disorder) or neurological or pervasive developmental disorder;\n2. a documented history of epilepsy;\n3. lifetime history of any head injury with loss of consciousness;\n4. current exposure domestic or intimate partner violence or otherwise state that their current living conditions are unsafe;\n5. current experiences of psychosis or suicidality within the last six months;\n6. currently taking, or in the past month has taken benzodiazepines, narcotic drugs, or cannabis;\n7. currently pregnant\n8. engagement in self-harming behaviors in the last 3 months that required medical attention;\n9. lack of competence to understand or consent to the study procedures;\n10. lack of fluency in written and spoken English. -","ALL","18 Years","90 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The proposed study will collect novel data evaluating the feasibility of a neurofeedback training program delivered to prospective clients with a history of clinically concerning trauma-related mental health symptoms who are on a wait list to receive obsessive compulsive disorder-specific psychotherapy at an outpatient mental health clinic. This study will evaluate the influence of neurofeedback training on participant's overall sense of well-being, and additionally, whether any enhanced well-being is subsequently associated with positive changes in symptoms of obsessive compulsive disorder, post-traumatic stress, dissociation and other trauma-related mental health symptoms, emotional regulation, etc.",[27,28,29,30,31],"Well-Being, Psychological","Mood Disturbance","Emotional Regulation","Dissociation","Post Traumatic Stress Symptoms","NOT_YET_RECRUITING","2025-11-10",{"date":35,"type":36},"2025-11-12","ACTUAL",{"date":38,"type":21},"2025-11",{"date":40,"type":21},"2029-01",{"name":42,"class":43},"Wayne State University","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100556957","early-phase-1-curcumin-and-egcg-supplementation-to-improve-serum-bdnf-and-mood-disturbance-100556957","NCT06531863","Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance","A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin Gallate Supplementation on Serum Brain Derived Neurotrophic Factor and Mood Disturbance in Adults","Inclusion Criteria:\n\n* Adults age 18-50\n* Depression subscale score of \\>9\u002F21 on the DASS-21\n* No change in medications or supplements over the past 3 months\n* Can read and speak English\n\nExclusion Criteria:\n\n* Currently consume curcumin or green tea daily\n* Currently, pregnant, nursing, or trying to become pregnant\n* Currently diagnosed with a perimenopausal disorder",true,"50 Years",{"count":54,"type":21},64,[56],"EARLY_PHASE1","The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores \\>9. The main questions it aims to answer are:\n\nDoes curcumin and EGCG supplementation improve mood disturbance symptomology? Does curcumin and EGCG supplementation increase serum BDNF? Researchers will compare intervention versus placebo.\n\nParticipants will consume an 8-week supplement of both:\n\n* 1,330mg\u002Fday curcumin\n* 350mg\u002Fday epigallocatechin gallate (EGCG)",[28],"RECRUITING","2025-02-13",{"date":62,"type":36},"2025-02-14",{"date":64,"type":36},"2024-09-30",{"date":66,"type":21},"2025-08-01",{"name":68,"class":43},"Auburn University",1]