[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"morphine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:morphine":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100592243","comparison-of-the-analgesic-effect-of-oliceridine-versus-morphine-or-sufentanil-for-postoperative-analgesia-in-lumbar-surgeries-a-randomized-control-trial-100592243",false,"NCT06990893","Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial","Inclusion Criteria:\n\n* Lumbar spine surgery with ASA grades I-III\n* Aged 18-65 years\n* Ethically, the patient voluntarily accepted this trial and signed the informed consent form\n\nExclusion Criteria:\n\n* Severe respiratory and circulatory system diseases\n* Nervous system disease\n* Mental and psychological disorders\n* Abnormal liver and kidney functions\n* Participated in another drug clinical research within the past 30 days","ALL","18 Years","65 Years",{"count":19,"type":20},90,"ESTIMATED","INTERVENTIONAL",[23],"NA","Objective: This study aimed to compare the efficacy and safety of oliceridine versus morphine and sufentanil for postoperative analgesia following elective lumbar spine surgery.\n\nMethods: In this randomized, controlled trial, 90 patients scheduled for lumbar spine surgery were allocated in a 1:1:1 ratio to receive postoperative intravenous patient-controlled analgesia (PCIA) with either oliceridine (Group O，1.5mg oliceridine for loading dose， 0.5mg\u002Fkg oliceridine for PICA), morphine (Group M，4mg morphine for loading dose，1.5mg\u002Fkg morphine for PICA), or sufentanil (Group S，4ug sufentanil for loading dose，1.5ug\u002Fkg sufentanil for PICA). The primary outcome was the movement Visual Analogue Scale (VAS) score at 6 hours postoperatively. Secondary outcomes included resting and movement VAS scores, ramsay sation score at 0.5, 2, 6, 12, 24, and 48 hours postoperatively (excluding the motor VAS score at 6 hours postoperatively); number of PCIA demands and rescue analgesic requirements within 48 hours; hemodynamic parameters at 5, 10, 15, 30, and 60 minutes after administration of the initial loading dose. The incidence of adverse events within 48 hours postoperatively, such as nausea and vomiting, somnolence, respiratory depression, or pruritus.",[26,27,28,29,30],"Sufentanil","Morphine","Validity","Safety","Oliceridine",[26,29,27,32],"oliceridine","RECRUITING","2026-05-28",{"date":36,"type":37},"2026-06-01","ACTUAL",{"date":39,"type":37},"2025-06-01",{"date":41,"type":20},"2026-10-01",{"name":43,"class":44},"Anqing Municipal Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":16,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100594749","determining-the-optimal-dose-of-intrathecal-morphine-for-post-cesarean-analgesia-100594749","NCT07023497","Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia","Determination of the Optimal Dose of Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Using the Up-and-Down Sequential Allocation Method","Inclusion Criteria:\n\n* term parturient\n* single pregnancy\n* elective cesarean delivery\n* adult parturient\n* ASA II\n\nExclusion Criteria:\n\n* participants under the age of 18\n* extreme somatometric characteristics\n* lack of patient consent\n* absolute contraindications for spinal anesthesia\n* urgent cesarean section\n* presence of known fetal anomalies\n* onset of labor prior to administration of the block\n* history of chronic pain\n* use of opioids (systemic or otherwise) for any reason (e.g., chronic malignant pain)\n* communication difficulties (e.g., language barriers, cognitive impairments)\n* allergy or hypersensitivity to morphine\n* severe arrhythmia or other serious cardiovascular conditions\n* severe hepatic or renal insufficiency",true,"FEMALE","50 Years",{"count":57,"type":20},100,[23],"Using spinal or epidural anesthesia (known as neuraxial blocks) is the gold standard for pain control during childbirth, especially in cesarean sections (C-sections). However, many women experience moderate to severe pain after a C-section, which can affect both their physical and emotional well-being, and even impact their ability to care for their newborn. Unfortunately, this pain is often not treated effectively, which can lead to increased sensitivity to pain or even chronic postoperative pain.\n\nOne effective way to manage this pain is by giving opioids directly into the spinal fluid (subarachnoid space). This method allows doctors to use much smaller doses than would be needed if the same medication were given through a vein, which also helps avoid many of the common side effects of opioids like respiratory depression, nausea, pruritus, and constipation.\n\nCommon opioids used in this setting include fentanyl, sufentanil, and morphine. These drugs behave differently depending on their chemical properties. For example, drugs that are more fat-soluble work faster, while those that are less fat-soluble tend to last longer. Morphine, which is less fat-soluble than the others, provides strong and long-lasting pain relief. When injected spinally, its effect can last 18-24 hours, with the pain relief starting 1-2 hours after the injection. Its performance is comparable to that of epidural anesthesia or nerve blocks.\n\nResearchers have studied a wide range of spinal morphine doses (from 20 to 500 micrograms) to find the most effective and safest dose. Most of these studies are small or use set doses without clear reasoning. Recently, a method called sequential allocation has become popular for finding the best dose more accurately.\n\nAbout the Study This research aims to find the ideal dose of spinal morphine when it's given with a fixed amount of fentanyl and varying doses of ropivacaine (a local anesthetic) during spinal anesthesia for C-section in healthy full-term parturients. The goal is to find the dose that provides adequate analgesia (pain score under 3 out of 10) for at least 12 hours after surgery.\n\nThis is a prospective, non-randomized, double-blind study. The study follows ethical standards and all participants sign an informed consent form. Two anesthesiologists are involved in each case: one handles the spinal injection and dose decision (based on the previous patient's response), while the other monitors the patient and collects the data without knowing the dose used.\n\nAnesthetic Technique Spinal anesthesia is done using standard procedures. A very fine needle (25 or 27 gauge) is used to inject a mixture of fentanyl (15 mcg), a variable dose of ropivacaine (based on somatometrics), and a variable dose of morphine (based on the algorithm). The mixture is injected slowly (1 ml every 10 seconds), with the needle facing toward the head. After surgery, all women receive additional pain medications like paracetamol and NSAIDs as part of a multimodal pain relief approach.\n\nHow the Morphine Dose is Decided\n\nThe dose of morphine changes based on whether the previous participant had effective pain relief. Pain relief is considered successful if the pain score stays at or below 3 (on a 0-10 scale) for at least 12 hours after the spinal injection. For the first woman in the study, the starting dose is chosen based on published research. Then:\n\n* If the previous participant had good pain control (NRS ≤3 for 12 hours), the dose for the next woman is reduced by 20 micrograms.\n* If pain control was poor (NRS \\>3 within the first 12 hours), the dose is increased by 40 micrograms.\n\nThis up-and-down adjustment continues for each new participant.",[27,61,62,63,64],"Cesarean Section","Postoperative Pain, Acute","Spinal Analgesia","Postoperative Pain","2026-05-01",{"date":67,"type":37},"2026-05-07",{"date":69,"type":37},"2023-07-04",{"date":71,"type":20},"2026-09-01",{"name":73,"class":44},"University of Ioannina",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":45},"100530079","intraoperative-administration-of-intravenous-morphine-in-patients-undergoing-laparoscopic-cholecystectomy-100530079","NCT06182111","Intraoperative Administration of Intravenous Morphine in Patients Undergoing Laparoscopic Cholecystectomy","Intraoperative Administration of Intravenous Morphine in Patients Undergoing Laparoscopic Cholecystectomy - a Retrospective, Observational, Quality-improvement Study","MORPHLAPCHOL","Inclusion Criteria:\n\n* patients who have had elective laparoscopic cholecystectomy\u002Fplanned gall-bladder removal surgery\n\nExclusion Criteria:\n\n* age limit as above\n* patients unable to give consent to anesthesia\n* patients unable to participate in pain scoring\n* patients with chronic pain syndromes, characterized by patients receiving regular analgesic treatment and patients with active or previous contact to pain clinic)\n* patients with active or previous substance abuse\n* emergency surgery","21 Years",{"count":84,"type":20},300,"OBSERVATIONAL","The goal of this observational, quality improvement study is to compare the effect of a dose of morphine given during gall-bladder removal surgery. The main questions to answer are:\n\n* Do participants, who are given given a dose of morphine during gall-bladder removal surgery, experience less pain after surgery?\n* Does a dose of morphine during gall-bladder removal surgery cause more side effects? The investigators will compare the effects of two types of anesthesia: a) anesthesia without morphine during surgery, and b) anesthesia with morphine during surgery.",[64,27,88],"Laparoscopic Cholecystectomy",[90],"Intraoperative morphine for laparoscopic cholecystectomy","2024-08-27",{"date":93,"type":37},"2024-08-28",{"date":95,"type":37},"2024-06-01",{"date":97,"type":20},"2025-10-31",{"name":99,"class":44},"Esbjerg Hospital - University Hospital of Southern Denmark"]