[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mortality\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mortality":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,27,0,25,[9,57,121,149,178,211,245,270,291,335,364,409,440,472,498,526,561,592,626,660,686,713,733,764,800],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100602123","icu-background-early-awareness-for-critical-deterioration-100602123",false,"NCT07119411","ICU Background Early Awareness for Critical deterioratiON","ICU Background Early Awareness for Critical deterioratiON (BEACON)","BEACON","Inclusion Criteria:\n\n* admission to intensive care unit\n\nExclusion Criteria:\n\n* age \\\u003C 18 years\n* presence of documented refused general consent form (at database closure)\n* admission for the sole purpose of dying\u002Forgan donation or evaluation of such",true,"ALL","18 Years",{"count":22,"type":23},1962,"ESTIMATED","OBSERVATIONAL","The study will compare ICU sub-units, those with additional support of a clinician awareness system, ICU Beacon, and those receiving the standard of care. The win-ratio composite outcome will be assessed by comparing patients by study group and stratified by APACHE score at admission.",[27,28,29,30,31],"Respiratory Failure","Circulatory Failure","Mortality","Organ Dysfunction","Organ Failure, Multiple",[33,34,35,36,37,38,39,40,41,42,43],"icu","respiratory failure","circulatory failure","early warning system","prevention","prediction","risk prediction","organ failure","multi-organ failure","win-ratio","ICU Beacon","RECRUITING","2026-06-12",{"date":47,"type":48},"2026-06-15","ACTUAL",{"date":50,"type":48},"2025-12-01",{"date":52,"type":23},"2027-11-01",{"name":54,"class":55},"ETH Zurich","OTHER",1,{"id":58,"slug":59,"hasResults":12,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":67,"conditions":68,"keywords":87,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":56},"100641995","human-observatory-study-100641995","NCT07646782","Human Observatory Study","The Human Observatory: A Prospective Individual and Population-Level Study of Aging, Health, and Longevity","HOS","Inclusion Criteria:\n\n* Enrolled in the 100-Year Human Aging Study at any fixed or mobile clinical site; OR completion of online health screener with provision of geographic anchor data and consent.\n\nExclusion Criteria:\n\n* Age under 18 years (current protocol; pediatric amendment planned).",{"count":66,"type":23},1000000,"The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a continuously-ingested ecological data infrastructure spanning environmental exposures, social determinants, genealogical and family history records, mortality data, and population health databases at geographic resolutions from home address to global scale and beyond. The resulting model generates individual screening recommendations informed by population-level causal estimates, and population-level causal forecasts anchored by present-timepoint individual clinical biology. Thus creating a feedback architecture designed to improve both simultaneously.",[69,29,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86],"Aging","All-cause Mortality","Life Expectancy","Cardiovascular Diseases","Neoplasms","Cognitive Dysfunction","Metabolic Syndrome","Frailty","Musculoskeletal Disease","Neurodegenerative Disease","Dementia","Activities of Daily Living","Health Related Quality of Life","Disability Physical","Environmental Exposure","Occupational Diseases","Health Equity","Social Determinants of Health",[88,89,90,91,92,93,94,95,96,97,98,99,100,85,101,102,103,104,105,106,107,108,109,110,111],"longevity","biological aging","causal inference","life expectancy","exposome","Environmental Health","Social Determinants","Genealogy","Family History","Human Family Tree","Population Health","Neighborhood Health","Geographic Health Disparities","Mortality Prediction","Biomarker Validation","Cardiopulmonary Exercise Testing","Body Composition","Preventive Medicine","Healthspan","Functional Decline","Centenarian","Space Medicine","Aerospace Medicine","World Model","2026-06-09",{"date":47,"type":48},{"date":115,"type":48},"2026-04-25",{"date":117,"type":23},"2099-12-31",{"name":119,"class":120},"Longevity Metrics, Inc.","INDUSTRY",{"id":122,"slug":123,"hasResults":12,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":129,"conditions":130,"keywords":136,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":148,"locationsCount":56},"100636291","100-year-human-aging-study-100636291","NCT07563777","100-Year Human Aging Study","100-Year Human Aging Study: Prospective Longitudinal Validation of Multi-System Health Measurements Against Mortality and Aging Outcomes","Inclusion Criteria:\n\n* Age 18 years or older\n* Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative\n* Willing to participate in longitudinal follow-up\n\nExclusion Criteria:\n\n* Age under 18 years",{"count":66,"type":23},"The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed and mobile clinical sites to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.",[69,131,132,29,75,72,74,133,73,76,80,134,82,135,79],"Aging Well","All-Cause Mortality","Musculoskeletal Diseases","Health-Related Quality of Life","Neuro-Degenerative Disease",[137,103,104,105,138,101,107,106,71,139,140,141,102,142,98,108],"Longevity","Surrogate Endpoint Validation","Biological Aging","Preventive Screening","Longitudinal Cohort","Human Performance",{"date":144,"type":48},"2026-06-11",{"date":146,"type":48},"2025-02-09",{"date":117,"type":23},{"name":119,"class":120},{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":160,"conditions":161,"keywords":166,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":56},"100612143","factor-associated-with-mortality-in-the-icu-100612143","NCT07249749","Factor Associated With Mortality in the ICU","Factors Associated With Mortality in the Intensive Care Unit From the Orinoco Region. An Observational Trial","ICUMortal","Inclusion Criteria:\n\n* All adult patients older than 18 admitted to the intensive care unit during the study period.\n\nExclusion Criteria:\n\n* Patients admitted for intermediate care (low therapeutic intervention with a TISS \\[Therapeutic Intervention Scoring System\\] - 28 score below 20 points). Patients derived to other institutions.","100 Years",{"count":159,"type":23},1000,"ICU mortality indicates the severity of disease, healthcare quality, and the efficacy of interventions. The severity scores are tools to predict the risk of mortality in the ICU, and the APACHE II score is frequently used for this purpose. However, studies validating the score in Colombia are limited. There is uncertainty about the precision and discrimination capacity of the APACHE II score in a population that varies from the original, with varying diseases, and in a different timeline. The investigators determined to evaluate: 1. Evaluate the rate of mortality in the ICU by type of disease and type of admission. 2. The factors associated with mortality. 3. Validate the performance of the APACHE II score as a predictor of mortality.",[162,163,164,29,101,165],"Critically Ill","Intensive Care (ICU)","Intensive Care Medicine","Mortality in Intensive Care Units",[162,167,29,168],"Intensive Care Unit","Colombia","2026-05-25",{"date":171,"type":48},"2026-05-27",{"date":173,"type":48},"2026-01-10",{"date":175,"type":23},"2028-12-21",{"name":177,"class":55},"Hospital Departamental de Villavicencio",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":186,"targetDuration":188,"studyType":24,"phases":4,"briefSummary":189,"conditions":190,"keywords":194,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":56},"100639232","adding-a-gastrointestinal-subscore-to-sofa2-for-mortality-risk-assessment-in-the-icu-the-sofa2-gis-study-100639232","NCT07586254","Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS Study","Development and Validation of the SOFA2-GIS Score: Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in Critically Ill Patients - A Multicenter Prospective Observational Cohort Study","SOFA2-GIS","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Admission to a participating intensive care unit\n* Expected ICU length of stay of at least 24 hours\n* Availability of clinical and laboratory data required to calculate the SOFA2 score and the AGI grade within the first 24 hours of ICU admission\n* Written informed consent obtained from the patient or, when not feasible due to the patient's clinical condition, from a legally authorized representative\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Pregnancy\n* ICU length of stay shorter than 24 hours (including patients who die or are discharged within the first 24 hours)\n* ICU readmission during the same hospital stay (only the index admission will be included)\n* Postoperative admission for routine monitoring without organ dysfunction (planned short-term observation following elective surgery)\n* Admission solely for end-of-life care or with treatment limitations (do-not-resuscitate or withdrawal of life-sustaining therapy decisions) made within the first 24 hours of admission\n* Patients with primary gastrointestinal pathology as the reason for ICU admission that would confound AGI grading (e.g., gastrointestinal surgery within the preceding 7 days, acute mesenteric ischemia as the primary diagnosis)\n* Patients with anatomical or functional conditions precluding standard AGI assessment (e.g., short bowel syndrome, permanent gastrostomy\u002Fjejunostomy with chronic feeding intolerance, chronic intestinal pseudo-obstruction)\n* Refusal of consent by the patient or legal representative\n* Participation in an interventional clinical trial that may affect outcome measures",{"count":187,"type":23},800,"3 Months","The goal of this observational study is to learn whether adding a gastrointestinal (GI) component to a widely used organ failure score improves the prediction of death risk in critically ill adults treated in the intensive care unit (ICU).\n\nThe Sequential Organ Failure Assessment 2 (SOFA2) score is used in ICUs to measure how severely a patient's organs are failing. The current version evaluates six organ systems but does not include the gastrointestinal system, even though gut dysfunction is common and serious in critically ill patients. Researchers in this study will add a GI subscore based on the European Society of Intensive Care Medicine (ESICM) Acute Gastrointestinal Injury (AGI) classification and create a new combined score called SOFA2-GIS.\n\nThe main questions this study aims to answer are:\n\nDoes adding a gastrointestinal subscore to the SOFA2 score improve the prediction of 28-day mortality in ICU patients? Does the new SOFA2-GIS score perform better than the standard SOFA2 score in identifying patients at higher risk of dying in the ICU or in the hospital?\n\nResearchers will compare the standard SOFA2 score with the new SOFA2-GIS score in the same patients to see which one better predicts patient outcomes.\n\nParticipants will:\n\nReceive their usual ICU care without any change, additional treatment, or extra tests Be evaluated using routinely collected clinical and laboratory information during the first 24 hours of ICU admission Be followed during their hospital stay to record outcomes such as length of stay, need for mechanical ventilation, need for dialysis, and survival\n\nThis is a multicenter, prospective, observational cohort study conducted in tertiary ICUs in Türkiye. No additional procedures, tests, or interventions will be performed for the purpose of this study.",[191,192,193,29],"Critical Illness","Multiple Organ Failure","Gastrointestinal Diseases",[195,196,197,184,198,199,200],"sofa2","sofa-2","Sequential Organ Failure Assessment","Organ dysfunction score","Prognostic score","ICU mortality","NOT_YET_RECRUITING","2026-05-20",{"date":204,"type":48},"2026-05-26",{"date":206,"type":23},"2026-07",{"date":208,"type":23},"2027-03",{"name":210,"class":55},"Ozkul Yilmaz Colak",{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":12,"sex":19,"minAge":219,"maxAge":157,"enrollmentInfo":220,"targetDuration":222,"studyType":24,"phases":4,"briefSummary":223,"conditions":224,"keywords":232,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":56},"100600102","rehabilitation-practices-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-in-the-intensive-care-unit-100600102","NCT07093125","Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.","An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)","REPOrt","Inclusion Criteria:\n\n* Patients admitted to a participating ICU\n* Adult patients (aged 16 years or older, depending on local regulations for the definition of \"adults\")\n* Patients who have received invasive ventilation for at least 48 hours\n* Patients who have obtained written informed consent from the patient or next of kin (if local legislation demands so)\n\nExclusion Criteria:\n\n• Patients admitted for withdrawn of life sustain therapy","16 Years",{"count":221,"type":23},2400,"28 Days","This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.\n\nThe primary objective is to provide an overview of current rehabilitation strategies used in ICUs globally.\n\nSecondary objectives include assessing the relationship between rehabilitation and key ICU outcomes such as ICU and hospital mortality, length of stay, duration of invasive ventilation, extubation failures, and long-term outcomes including quality of life and functional performance 28 days post-ICU discharge.\n\nThe study will also compare rehabilitation practices across different geographic and economic regions to identify potential disparities. The study is structured into three modules, with participation contingent on local resources and feasibility.\n\nThe BASIC Module (mandatory for all centers) gathers fundamental data on rehabilitation practices and their association with patient outcomes.\n\nThe EXTENDED Module (optional) collects more detailed information on the type, timing, duration, and safety of rehabilitation interventions, including passive exercises, active mobilization, respiratory therapies, dysphagia training, occupational therapy, and cognitive support.\n\nThe EXTENDED FOLLOW-UP Module (optional) evaluates the patient's quality of life and functional recovery 28 days after ICU discharge. By examining global rehabilitation practices and their impact on patient outcomes, this study aims to improve rehabilitation strategies in ICUs, contributing to better patient care, recovery, and long-term health outcomes.",[225,226,227,228,229,230,29,231],"Mechanical Ventilation","Pulmonary Rehabilitation","Intensive Care Units (ICUs)","Quality of Life (QOL)","Outcome Assessment","Extubation Failure","Critical Care",[233,225,234,235],"Pulmonary rehabilitation","Intensive Care Unit (ICU)","Rehabilitation Outcomes","2026-04-27",{"date":238,"type":48},"2026-05-04",{"date":240,"type":48},"2025-10-01",{"date":242,"type":23},"2029-10-01",{"name":244,"class":55},"Universita degli Studi di Genova",{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":12,"sex":19,"minAge":253,"maxAge":20,"enrollmentInfo":254,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":56},"100413512","national-non-interventional-study-of-invasive-pneumococcal-disease-in-children-and-newborns-100413512","NCT04664556","National, Non Interventional Study of Invasive Pneumococcal Disease in Children and Newborns","Population-based Nationwide Study on Invasive Pneumococcal Infections Among Children (0-18 Years) in France","IPD","Inclusion Criteria:\n\n* Isolate of Streptococcus pneumoniae from at least one blood culture, or pleural fluid, or joint fluid, or cerebrospinal fluid or other normally sterile body site, or if there is a positive blood polymerase chain reaction (PCR).\n\nExclusion Criteria:\n\n* Pneumococcal strain not transmetted to National Reference Center for Pneumococci or to Regional Pneumococci Observatory","1 Day",{"count":255,"type":23},2500,"After 7 then 13 valent pneumococcal conjugate vaccine (PCV) implementation in France in children, we will evaluate the impact of this vaccination on invasive pneumococcal disease (IPD). We will describe the clinical characteristics of IPD, pneumococcus serotyping, underlying conditions and vaccination status.",[258,259,260,29],"Pneumococcal Infections","Pneumococcal Conjugate Vaccine","Antibiotic Treatment","2026-04-23",{"date":263,"type":48},"2026-04-28",{"date":265,"type":48},"2010-12-13",{"date":267,"type":23},"2030-01-01",{"name":269,"class":55},"Association Clinique Thérapeutique Infantile du val de Marne",{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":18,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":4},"100632033","association-between-primary-care-supply-and-population-morbidity-and-mortality-in-france-at-the-territorial-level-100632033","NCT07508423","Association Between Primary Care Supply and Population Morbidity and Mortality in France at the Territorial Level","M-OSP","Inclusion Criteria:\n\nAll individuals affiliated with any French health insurance scheme and recorded in the Système National des Données de Santé (SNDS; French National Health Data System) through the Datamart de Consommation Inter-Régimes (DCIR; French national health insurance claims database) between January 1, 2009 and December 31, 2022",{"count":278,"type":23},7000000,"The M-OSP study investigates the association between the density of primary care professionals, including general practitioners (GPs), and population-level health outcomes across 2,850 life-health territories in France. Evidence from several OECD countries suggests higher GP density may reduce mortality, particularly cause-specific mortality such as cardiovascular deaths, but uncertainties remain regarding generalizability and other health outcomes.\n\nThis cross-sectional epidemiological study uses aggregated, territory-level data from 2009-2022, including: mortality rates (age- and sex-standardized), hospitalizations (MCO), emergency department visits, and the distribution of primary care professionals and facilities (GPs, nurses, physiotherapists, dentists, midwives, gynecologists, pediatricians, psychiatrists, and community pharmacies).",[29,281],"Morbidity","2026-03-30",{"date":284,"type":48},"2026-04-02",{"date":286,"type":23},"2026-06-01",{"date":288,"type":23},"2027-12-31",{"name":290,"class":55},"MSPU de Pins-Justaret",{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":300,"phases":301,"briefSummary":304,"conditions":305,"keywords":311,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":56},"100611166","phase-2-minocycline-in-stroke-study-at-maimonides-100611166","NCT07237048","Minocycline in Stroke Study at Maimonides","Effect of Oral Minocycline in Patients With Acute Stroke - a Randomized, Open Label, Prospective Trial","\\* Inclusion criteria\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Age \\>\u002F=18\n2. NIHSS 5-20 \\*National Institutes of Health Stroke Scale\\*\n3. Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO \\*(World Health Organization) \\* guidelines or acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed\n4. The onset of neurological symptoms less than 24 hours\n\n   * Exclusion criteria\n\nAn individual who meets any of the following criteria is excluded from participation in this study:\n\n1. Clinically stroke is not suspected\n2. Allergic to the Tetracycline group of medications or Intolerance to Minocycline\n3. Pregnancy or suspected pregnancy or breastfeeding\n4. Previous history of intolerance to Minocycline\n5. Acute or chronic renal failure (stage III with GFR \\*(Glomerular Filtration Rate) \\* or Creatinine threshold)\n6. Any patients with contraindications to undergo CT (Computed Tomography) \u002F MRI (Magnetic Resonance Imaging)\n7. Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission\n8. Pre-existing infectious disease requiring antibiotics\n9. Inability to tolerate enteral medications\u002Ffeeds\n10. Patient\u002F family refusal",{"count":299,"type":23},1164,"INTERVENTIONAL",[302,303],"PHASE2","PHASE3","The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.\n\nThe main questions it aims to answer are:\n\n1. Does Minocycline improve \\*National Institutes of Health Stroke Scale\\* (NIHSS) scores at hospital discharge and 90 days post-stroke?\n2. Does Minocycline reduce stroke-related disability, all-cause in hospital mortality (mRS -\\*Modified Rankin Scale\\* = 6) and at 90 days besides reducing brain bleeding complications compared to standard care?\n\nResearchers will compare patients receiving oral Minocycline plus standard care to those receiving standard care only to see if Minocycline leads to better neurological outcomes and lower mortality.\n\nParticipants will:\n\n1. Be randomly assigned by block to receive either:\n\n   Minocycline 200 mg orally once daily for five days within 24 hours from symptoms onset + Standard Care, or Standard Care only\n2. Undergo neurological assessments using NIHSS \\*National Institutes of Health Stroke Scale\\* and Modified Rankin Scale (mRS) at admission, discharge, 30 days post-stroke, 90 days post-stroke\n3. Be monitored for: a) hemorrhagic transformation of ischemic strokes; b) Adverse events and mortality outcomes; c) Safety and efficacy signals through interim analyses\n\nNIHSS: \\*National Institutes of Health Stroke Scale\\*, which is stroke severity scale,\n\nmRS: \\*Modified Rankin Scale\\*, which is stroke disability scale",[306,307,308,29,281,309,310],"Stroke","Ischemia Stroke","Hemorrhagic Strokes","Cerebrovascular Accident (Stroke)","Intracerebral Haemorrhage (ICH)",[312,313,314,315,316,317,318,319,320,321,281,29,322,323,324,325],"Minocycline","Acute Stroke","Neuroprotection","Ischemic Stroke","Hemorrhagic Stroke","NIH Stroke Scale","Modified Rankin Scale (mRS)","Stroke Recovery","Stroke Treatment","Stroke Outcomes","Intravenous Thrombolysis","Mechanical Thrombectomy","Hemorrhagic Transformation","Oral antibiotic","2026-03-18",{"date":328,"type":48},"2026-03-19",{"date":330,"type":48},"2026-02-02",{"date":332,"type":23},"2028-12",{"name":334,"class":55},"Joyce Chen",{"id":336,"slug":337,"hasResults":12,"nctId":338,"briefTitle":339,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":12,"sex":19,"minAge":341,"maxAge":4,"enrollmentInfo":342,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":344,"conditions":345,"keywords":4,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":361,"locationsCount":56},"100629258","home-based-acute-care-for-older-persons-initiated-by-the-emergency-medical-and-ambulance-services---a-retrospective-observation-of-effects-on-healthcare-utilisation-and-mortality-100629258","NCT07472335","Home-based Acute Care for Older Persons Initiated by the Emergency Medical and Ambulance Services - a Retrospective Observation of Effects on Healthcare Utilisation and Mortality","Inclusion Criteria:\n\n* Contact with the emergency number (112), followed by either a telephone assessment by the Emergency Medical Dispatch Centre or an in-home assessment by an ambulance nurse\n* Home-based acute care a weekday between 8 AM - 4 PM\n* Emergency-department care weeknight 4 PM - 8 AM or weekends\n* Registered residence in one of the municipalities of Gothenburg, Mölndal, Partille, or Härryda\n\nExclusion Criteria:\n\n* Immediate conditions requiring hospital care\n* Care at the emergency department or by a mobile primary care team occurring more than 24 hours after assessment by the Emergency Medical Dispatch Centre or ambulance services\n* Individuals who have already been assessed by a physician and\u002For have a written referral to the emergency department","75 Years",{"count":343,"type":23},5000,"This observational study aims to examine outcomes of home-based acute care delivered by a mobile healthcare team in persons aged 75 years and older following an episode of acute illness.\n\nThe study will assess whether home-based acute care initiated by the emergency medical dispatch centre or ambulance services is non-inferior to emergency department care with regard to care needs and mortality.",[346,347,348,349,350,351,352,353,29,354],"Aged","Home Care, Hospital-Based","Home Care Services","Emergency Medical Dispatch Centre","Emergency Medical Services","Ambulances","Emergency Service, Hospital","Acute Disease","Treatment Outcome","2026-03-10",{"date":357,"type":48},"2026-03-16",{"date":359,"type":23},"2026-04-01",{"date":288,"type":23},{"name":362,"class":363},"Vastra Gotaland Region","OTHER_GOV",{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":370,"eligibilityCriteria":371,"healthyVolunteers":12,"sex":19,"minAge":372,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":375,"conditions":376,"keywords":392,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":405,"leadSponsor":407,"locationsCount":56},"100625999","saudi-emergency-laparotomy-audit-100625999","NCT07429929","Saudi Emergency Laparotomy Audit","Saudi Emergency Laparotomy Audit (SELA): A National Multicenter Observational Audit of Outcomes Following Emergency Laparotomy in Saudi Arabia","SELA","Inclusion Criteria:\n\n* Age ≥14 years\n* Undergoing an emergency (E1-E4) laparotomy, laparoscopy, or laparoscopically-assisted abdominal operation\n* Procedures involving the stomach, small bowel, large bowel, or rectum for acute pathology (e.g., perforation, ischemia, abscess, bleeding, or obstruction)\n* Washout\u002Fevacuation of intra-peritoneal abscess or hematoma (excluding those secondary to appendicitis or cholecystitis)\n* Bowel resection or repair for obstructed\u002Fincarcerated hernias with acute presentation (incisional, umbilical, inguinal, femoral)\n* Adhesiolysis (open or laparoscopic)\n* Trauma-related emergency abdominal procedures\n* Inoperable pathology where a definitive operative procedure was intended (not purely diagnostic)\n* Return to theatre for major wound dehiscence (\"burst abdomen\")\n* Complications requiring general surgical intervention following interventional radiology procedures\n* Complications requiring general surgical intervention following gynecological oncology surgery\n* Complications following elective or non-elective general\u002Fupper GI surgery, where the above criteria are met\n\nExclusion Criteria:\n\n* Age \\\u003C14 years\n* Elective laparotomy or laparoscopy\n* Diagnostic-only laparotomy or laparoscopy (unless abandoned due to inoperable disease)\n* Appendicectomy or cholecystectomy (including their complications), unless incidental to a more major non-elective gastrointestinal procedure\n* Non-elective hernia repair without bowel resection or adhesiolysis\n* Minor wound dehiscence repair (unless bowel resection is required)\n* Stoma formation via trephine or laparoscopic approach (include only if midline laparotomy is the primary procedure)\n* Vascular, obstetric, gynecological (except gynecological oncology complications requiring general surgery input), transplant, hepatobiliary, urological, renal, pancreatic, or splenic procedures","14 Years",{"count":374,"type":23},10000,"The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia. The audit will collect standardized data on patient characteristics, comorbidities, perioperative processes, and postoperative outcomes through a retrospective baseline phase followed by a prospective registry phase. SELA aims to establish national benchmarks, assess applicability of international risk models, support development of a Saudi-specific risk prediction tool, and drive quality improvement through systematic feedback and benchmarking across participating hospitals.",[377,378,379,380,193,381,382,383,384,385,386,387,388,389,390,391,29],"Laparotomy","Laparotomy Surgery","Emergency Treatment","Abdominal Diseases","Intestinal Obstruction","Intestinal Obstruction and Ileus","Intestinal Perforation","Intestinal Ischemia","Peritonitis Infectious, Gastrointestinal Perforation, Surgical Infection, Postoperative Complications","Peritonitis Bacterial","Peritonitis Caused by Perforated Left-sided Colon Diverticulitis","Peritonitis Infectious","Sepsis","Postoperative Complications After Gastrointestinal Operations","Surgical Procedures, Operative",[393,394,395,396,29,281,397,398,399,400],"Emergency laparotomy","Surgical audit","Postoperative outcomes","Perioperative care","Quality improvement","Risk stratification","Retrospective audit","Saudi Arabia","2026-02-22",{"date":403,"type":48},"2026-02-24",{"date":286,"type":23},{"date":406,"type":23},"2028-12-31",{"name":408,"class":55},"King Faisal Specialist Hospital & Research Center",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":18,"sex":19,"minAge":416,"maxAge":4,"enrollmentInfo":417,"targetDuration":4,"studyType":300,"phases":419,"briefSummary":421,"conditions":422,"keywords":427,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":438,"locationsCount":56},"100622304","gel-aid-safe-and-effective-hydration-for-institutionalized-older-adults-100622304","NCT07381881","GEL-AID: Safe and Effective Hydration for Institutionalized Older Adults","Efficacy and Efficiency of GEL-AID Gelled Water for Hydration in Institutionalized Older People","Inclusion Criteria:\n\n* Age equal to or greater than 65 years.\n\nExclusion Criteria:\n\n* No exclusion criteria have been established.","65 Years",{"count":418,"type":23},156,[420],"NA","The objective of this clinical trial is to assess whether hydration with gelled water (GEL-AID) can improve fluid intake and reduce cases of dehydration, as well as the incidence of urinary and respiratory infections in institutionalized elderly individuals in nursing homes.\n\nThe main question this trial aims to answer is:\n\n• Do institutionalized elderly individuals hydrated with GEL-AID increase their daily fluid intake and reduce the incidence of dehydration, urinary infections, and respiratory infections?\n\nParticipants:\n\nThe control group will follow the center's usual hydration plan. Individuals with swallowing difficulties will receive thickened liquids and\u002For gelatin, while those without swallowing difficulties will be hydrated with unmodified liquids or gelatin.\n\nThe intervention group will receive hydration with GEL-AID. For participants with swallowing difficulties, thickened liquids and gelatin will be replaced by GEL-AID, with texture adapted to their needs. Those without swallowing difficulties will receive unmodified liquids and GEL-AID instead of gelatin.",[423,424,425,426,29],"Dehydration","Urinary Infections","Respiratory Infections","Daily Fluid Intake",[428,429,430,431,432],"dehydration","aged","nursing homes","fluid intake","gelled water","2026-01-27",{"date":330,"type":48},{"date":436,"type":23},"2026-02-23",{"date":288,"type":23},{"name":439,"class":55},"Universitat de Lleida",{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":300,"phases":451,"briefSummary":452,"conditions":453,"keywords":457,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":56},"100618229","steroid-treatment-to-prevent-thoracic-endovascular-aortic-repair-postimplantation-syndrome-100618229","NCT07328906","Steroid Treatment to Prevent Thoracic Endovascular Aortic Repair Postimplantation Syndrome","Steroid Treatment to Prevent Thoracic Endovascular Aortic Repair Postimplantation Syndrome (STOP TEVAR PIS): A Randomized, Double-Blind, Placebo-Controlled Trial","STOP TEVAR PIS","Inclusion Criteria:\n\n* Consecutive patients admitted due to endovascular treatment of aortic dissection type B or thoracoabdominal aortic aneurysm in whom elective, open repair is planned.\n* Patients capable of giving informed consent.\n* Patients who are estimated to be available for long-term follow-up.\n\nExclusion Criteria:\n\n* emergency procedures, the existence of severe renal insufficiency (serum creatinine \\>176 µmol\u002FL or estimated glomerular filtration rate \\\u003C 30 mL\u002Fmin\u002F1.73 m2), severe liver insufficiency (ALT value more than twice the upper limit or bilirubin levels more than twice the reference values), uncontrolled diabetes mellitus (fasting glycemia above 13.9 mmol\u002FL, i.e. the value glycosylated hemoglobin over 8.5%), existence of active infection or sepsis, autoimmune disease, chronic pain syndromes, proven allergy to methylprednisolone, existence of gastric or duodenal ulcer, immunosuppressive or chemotherapy in the previous three months, active malignant disease, genetic diseases of connective tissue, pregnancy, critical lower limb ischemia, previous endovascular procedure on the aorta, preoperative administration of corticosteroids for any reason, significantly impaired cognitive status or psychiatric illness, acute peri\u002Fmyocarditis, advanced heart failure, as well as voluntary refusal to participate in the study","90 Years",{"count":450,"type":23},174,[420],"Postimplantation syndrome (PIS) is a common and clinically important complication following thoracic endovascular aortic repair (TEVAR). PIS is characterized by a strong systemic inflammatory response to the stent-graft implantation and is manifested by flu-like symptoms, which include fever, increased white blood count, increased levels of acute phase proteins, and fatigue, but without a clear inflammatory and infective cause. Besides, it has been demonstrated that PIS is associated with prolonged hospital stay and increased risk for postoperative complications, including acute kidney injury, postoperative delirium, and increased postoperative pain scores. Recently, there has been increasing evidence that PIS is associated with an increased risk of major adverse cardiac events (MACE) and perioperative myocardial injury. Observational studies suggest that preoperative administration of glucocorticoids may decrease the incidence of PIS after TEVAR and EVAR procedures. However, to date, there are no randomised trials that have investigated whether preoperative administration of glucocorticoids can reduce the incidence of PIS and its associated poorer treatment outcomes following TEVAR. This randomized controlled trial was designed to investigate the effect of glucocorticoid administration on reducing the incidence and improving the outcome of patients who develop PIS after TEVAR.",[454,455,456,29],"Postimplantation Syndrome","Myocardial Injury","MACE",[458,459,460,461,456,462],"postimplantation syndrome","methylprednisolone","TEVAR","myocardial injury","mortality","2026-01-08",{"date":465,"type":48},"2026-01-12",{"date":467,"type":23},"2026-01",{"date":469,"type":23},"2029-01",{"name":471,"class":55},"University of Belgrade",{"id":473,"slug":474,"hasResults":12,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":478,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":480,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":482,"conditions":483,"keywords":485,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":56},"100614472","mortality-and-muscle-mass-loss-in-critically-ill-patients-100614472","NCT07280039","Mortality and Muscle Mass Loss in Critically Ill Patients.","Mortality and Muscle Mass Loss in Critically Ill Patients: A Prospective, Observational, Multicenter Study.","MUSIC 2","Inclusion Criteria:\n\n* age ≥18 years\n* mechanical ventilation expected for at least 48 hours\n\nExclusion Criteria:\n\n* Clinical Frailty Score above 7 prior admission\n* Neuromuscular disease in previous medical history\n* Amputated lower extremities\n* Trauma of lower extremities involving tights\n* Conditions affecting the nervous system with involvement of the thigh muscle\n* Inability to cooperate during ultrasound examination\n* Inability to perform ultrasound examination on day 7\n\n  9\\. Inability to perform ultrasound examination on day 7",{"count":481,"type":23},386,"The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasoud for measurement the rectus femoris cross sectional area.",[29,484],"Muscle Loss",[29,486,487,488,489],"Muscle loss","Muscle ultrasound","Critically ill","Rectus femoris cross area",{"date":491,"type":48},"2025-12-12",{"date":493,"type":23},"2025-12-15",{"date":495,"type":23},"2026-12-15",{"name":497,"class":55},"Brno University Hospital",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":506,"targetDuration":4,"studyType":300,"phases":508,"briefSummary":509,"conditions":510,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":525},"100563841","a-national-study-examining-the-most-effective-drainage-method-after-burr-hole-evacuation-of-chronic-subdural-hematoma-100563841","NCT06621407","A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma","Active 24 Hours Subperiostal vs. 24 Hours Passive Subdural Drainage Following Burr Hole Evacuation of Chronic Subdural Hematoma (the SUPERDURA Trial) - Protocol for a Nationwide Randomized Clinical Non-inferiority Trial","SUPERDURA","Inclusion Criteria:\n\n* Adult patients (≥ 18 years).\n* Patients with symptomatic CSDH confirmed on brain CT- or magnetic resonance imaging (MRI), admitted to a Danish neurosurgical department for surgical treatment.\n* Patients undergoing a single burr-hole evacuation.\n* Informed written and oral consent is taken prior to surgery.\n\nExclusion Criteria:\n\n* Patients who are mentally incapacitated\n* Patients with known abnormalities in their cerebrospinal fluid (protein and glucose levels, cell count, and type)\n* Patients with changes or abnormalities in their normal cerebrospinal fluid dynamics, e.g., obstructive hydrocephalus, normal pressure hydrocephalus, intracranial hypotension, and ventricular peritoneal shunt.\n* Patients with additional\u002Fpreviously intracranial pathology that requires\u002Fhas required neurosurgical treatment (e.g., brain tumor, vascular malformation, abscess).\n* Patients with recurrent CSDH or with previous craniotomy or other transcranial surgery (for any reason)\n* Patients unable to give consent prior to surgery",{"count":507,"type":23},354,[420],"Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage. However, consensus on the optimal drain placement site, and whether the drainage should be active or passive, is lacking.\n\nThe aim of the current study is to test the hypothesis that 24 hours active subperiosteal drainage is non-inferior to 24 hours passive subdural drainage after single burr hole evacuation of a unilateral CSDH.\n\nThe study is a multicenter randomized non-inferiority trial encompassing all neurosurgical units in Denmark.\n\nAdult patients with symptomatic CSDH admitted to a Danish neurosurgical unit for single burr hole evacuation will be screened for inclusion. Patients who are not able to give informed consent, and patients with recurrent CSDH, known cerebrospinal fluid abnormalities, and other known brain pathologies will be excluded. Patients with bilateral CSDH will be registered as one case and treated similarly on both sides.\n\nBefore surgical hematoma evacuation patients will be randomized to 24-hour passive subdural drainage or 24-hour active subperiosteal drainage.\n\nThe patients included and the two study statisticians will be blinded. The primary outcome is a composite outcome of 90-day mortality and symptomatic CSDH recurrence.\n\nSecondary outcomes are 90-day simplified modified Rankin score (smRSq), and complications related to surgery or occurring during admission, including intracerebral hemorrhage due to misplaced drains, acute subdural hematoma, tension pneumocephalus, wound infection, drain seepage, subperiosteal hematoma, thromboembolic events, infections and seizures.\n\nSample size simulations of non-inferiority with a threshold of 7% increased relative risk show that a total of 354 participants will be required to demonstrate a relative risk reduction of recurrent CSDH and mortality of 30% for the cohort receiving active subperiosteal drainage given a stable power above 80% with an alpha of 5%. The study inclusion period is estimated to last 2 years.\n\nEthics approval for inclusion of competent patients has been obtained (N-20240009).",[511,391,512,29,513,514,515],"Chronic Subdural Hematoma","Recurrence","Drainage","Drainage\u002FMethods","Drainage Procedure","2025-11-20",{"date":518,"type":48},"2025-11-25",{"date":520,"type":48},"2025-09-01",{"date":522,"type":23},"2027-11",{"name":524,"class":55},"Aalborg University Hospital",4,{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":530,"acronym":531,"eligibilityCriteria":532,"healthyVolunteers":18,"sex":19,"minAge":533,"maxAge":534,"enrollmentInfo":535,"targetDuration":4,"studyType":300,"phases":537,"briefSummary":538,"conditions":539,"keywords":541,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":560},"100584790","phase-3-limited-versus-extended-trophic-feeding-let-feed-trial-100584790","NCT06893939","Limited Versus Extended Trophic Feeding (LET-FEED) Trial","LET-FEED","Inclusion Criteria:\n\n* \\\u003C1500 gram birthweight\n* 25w0d-31w6d at birth\n* Consent to feed donor milk when parent's own milk is not available or of insufficient quantity\n\nExclusion Criteria:\n\n* \\\u003C5th percentile for weight at birth (Fenton growth curve)\n* Parent or legal guardian unable to provide consent within 36 hours after birth\n* Congenital anomaly affecting decisions on enteral feedings (e.g. gastroschisis, omphalocele, congenital diaphragmatic hernia, congenital heart disease, etc.)\n* Known genetic condition affecting growth, feeding, or mortality\n* Vasopressor use within first 24 hours after birth (not including hydrocortisone)\n* Considered terminally ill","0 Hours","36 Hours",{"count":536,"type":23},350,[303],"Study Hypothesis\u002FQuestion In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis (LOS) without increasing the risk of other adverse outcomes.\n\nStudy Design Type This is a multi-center, open-label, parallel-group, individual randomized controlled trial comparing two different trophic feeding regimens in preterm infants born between 25w0d and 31w6d. These infants will be randomly assigned to either the intervention group, receiving limited trophic feeding (20 to 25 mL\u002Fkg\u002Fday for one day) or the control group, receiving extended trophic feeding (20 to 25 mL\u002Fkg\u002Fday for three days) prior to advancing enteral feeds until full feeding volume (140 mL\u002Fkg\u002Fday) is achieved.\n\nEligibility Criteria Preterm infants with gestational ages between 25 0\u002F7 and 31 6\u002F7 weeks and a birthweight of \\\u003C1500 grams who are admitted to six participating neonatal units will be eligible for inclusion. Infants with \\\u003C5th percentile for weight at birth, vasopressor use within first 24 hours of life major congenital\u002Fgenetic anomalies affecting enteral feeding, growth, or mortality, and those with a terminal illness in which decisions to withhold or limit support have been made will be excluded. Infants of parents or legal guardians who are unable to provide consent within 36 hours of birth will also be excluded.\n\nStudy Intervention\u002FMethods Written parental informed consent will be obtained prenatally or within the first 36 hours of birth. Infants will be randomized to receive limited trophic feeds of 24 to 36 hours or extended trophic feeds for 72 hours prior to the advancement of enteral feeds. Infants will be fed parent's own milk (POM) with donor human milk as the alternative if POM is unavailable.\n\nPrimary Outcome Late-onset sepsis, defined as positive blood, urine, and\u002For cerebrospinal fluid (CSF) cultures in the presence of compatible clinical signs of sepsis, occurring after postnatal day 3 and before hospital discharge, and treated with antibiotics for 5 days or more.\n\nSecondary Outcome(s) The trial will assess various secondary outcomes including length of hospital stay, all-cause in-hospital mortality, duration of IV fluids and central line utilization, necrotizing enterocolitis (Bell's stage IIa or higher), severe intraventricular hemorrhage (grade III or IV either unilaterally or bilaterally), bronchopulmonary dysplasia (oxygen requirement or positive pressure ventilation at 36 weeks corrected gestational age), or retinopathy of prematurity requiring intervention. Additionally, growth metrics throughout hospitalization will be evaluated using change in weight, length, and head circumference z-scores from birth to 36 weeks' corrected gestational age between infants in the limited and extended trophic feeding groups.",[389,540,29],"Length of Stay",[542,543,544,545,546,547,548,549,550],"Feeding","Nutrition","Prematurity","Very preterm","Trophic","Trophic feeds","Trophic feeding","enteral feeds","sepsis","2025-07-23",{"date":553,"type":48},"2025-07-28",{"date":555,"type":48},"2025-07-03",{"date":557,"type":23},"2028-03-31",{"name":559,"class":55},"University of Washington",6,{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":18,"sex":19,"minAge":569,"maxAge":570,"enrollmentInfo":571,"targetDuration":4,"studyType":300,"phases":573,"briefSummary":575,"conditions":576,"keywords":578,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":56},"100543669","phase-4-azithromycin-for-child-survival-in-niger-ii-100543669","NCT06358872","Azithromycin for Child Survival in Niger II","Azithromycine Pour la Vie Des Enfants au Niger II","AVENIR II","Inclusion Criteria:\n\nCSI-level for mortality and AMR monitoring:\n\n* Located in a region participating in the program\n* Designated as rural by local study team\n* Selected for participation in monitoring activities\n* Safe and accessible for study teams\n* Verbal approval from community leaders\n\nIndividual level for mortality monitoring:\n\n* Residing in the catchment area of an eligible CSI\n* Selected for participation in monitoring activities\n* Female\n* Age between 12 and 55 years old\n* Verbal approval from participant\n\nIndividual-level for AMR monitoring:\n\n* Residing in the catchment area of an eligible CSI\n* Selected for participation in monitoring activities\n* Age between 1 and 59 months old\n* Verbal approval from a caregiver or guardian\n\nExclusion Criteria:\n\nAt the community-level:\n\n* Designated as urban by local study team\n* Inaccessible or unsafe for study team\n\nAt the individual-level:\n\n* Known allergy to macrolides","1 Month","59 Months",{"count":572,"type":23},3300000,[574],"PHASE4","Several randomized controlled trials have demonstrated that azithromycin mass drug administration (MDA) reduces child mortality, but increases antimicrobial resistance (AMR). The World Health Organization (WHO) guidelines for this intervention specify that implementation must be accompanied by continued monitoring of mortality and AMR. Niger is expanding the azithromycin MDA program nationwide. To establish monitoring of mortality and AMR as part of this program as well as to leverage the infrastructure to evaluate other child health interventions, AVENIR II is designed as an adaptive platform trial with monitoring and re-randomization every 2 years.",[29,577],"Antimicrobial Resistance",[579,580,581,577,582],"Mass Treatment","Azithromycin","Childhood Mortality Rate","Implementation and Cost Analysis","2025-06-18",{"date":585,"type":48},"2025-06-22",{"date":587,"type":48},"2024-04-29",{"date":589,"type":23},"2028-04-29",{"name":591,"class":55},"University of California, San Francisco",{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":602,"conditions":603,"keywords":611,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":617,"lastUpdatePostDateStruct":618,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":56},"100594226","prognosis-of-veno-venous-extracorporeal-membrane-oxygenation-in-emergency-thoracic-surgery-100594226","NCT07016685","Prognosis of Veno-Venous Extracorporeal Membrane Oxygenation in Emergency Thoracic Surgery","Prognostic Factors for 90-day Mortality in Patients Undergoing Veno-venous Extracorporeal Membrane Oxygenation for Emergency Thoracic Surgery","PECUR","Inclusion Criteria:\n\n* Adults ≥ 18 years\n* VV-ECMO initiated during or after emergency thoracic surgery\n* No opposition to data use\n\nExclusion Criteria:\n\n* Pregnant women\n* Veno-Arterial ECMO patients\n* Patients under legal protection",{"count":601,"type":23},380,"Veno-vneous extracorporeal membrane oxygenation (VV-ECMO) is an established support strategy for acute respiratory failure, but its role in the perioperative management of emergency thoracic surgery remains poorly defined. This retrospective, multicenter, observational study aims to assess the clinical outcomes and prognostic factors in this high-risk population. Patients undergoing emergency thoracic procedures requiring VV-ECMO will be compared to a control cohort of patients treated with VV-ECMO for medical respiratory failure. Data will be collected from two French academic centers (CHU Amiens-Picardie and CHU Dijon).",[604,605,606,607,608,609,29,610],"VV-ECMO","Thoracic Surgery","Emergency Surgery","ARDS","Retrospective Cohort","Propensity Score Matching","ECMO Outcomes",[612,604,613,607,614,615,462,616],"thoracic surgery","emergency surgery","retrospective cohort","propensity score matching","ECMO outcomes","2025-06-12",{"date":619,"type":48},"2025-06-13",{"date":621,"type":48},"2025-06-01",{"date":623,"type":23},"2026-04",{"name":625,"class":55},"Centre Hospitalier Universitaire, Amiens",{"id":627,"slug":628,"hasResults":12,"nctId":629,"briefTitle":630,"officialTitle":630,"acronym":631,"eligibilityCriteria":632,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":633,"targetDuration":4,"studyType":300,"phases":635,"briefSummary":636,"conditions":637,"keywords":647,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":654,"completionDateStruct":656,"leadSponsor":658,"locationsCount":4},"100590960","patient--and-family-centred-care-in-the-adult-intensive-care-unit-a-feasibility-study-100590960","NCT06974214","Patient- and Family-centred Care in the Adult Intensive Care Unit: a Feasibility Study","FAM-ICU","Patients are eligible if they are:\n\n* ≥18 years of age.\n* Expected to require ICU admission for at least 48 hours in a mixed surgical and medical ICU for adult critically ill patients.\n\nFamily members are eligible if they are:\n\n* ≥18 years of age.\n* a close family member to a patient-enrolled in the FAM-ICU. A family-member can be blood-related or not. It may be a spouse, relative, partner, or friend as determined by the patient as a close family member.",{"count":634,"type":23},60,[420],"Background: In the intensive care unit (ICU), delirium in patients and long-term mental health challenges in both patients and their family members are highly prevalent. To address these issues, patient- and family-centered care has been recommended to alleviate the burdens associated with critical illness and ICU admission. We have developed the patient- and FAMily-centered care in the adult ICU intervention (FAM-ICU intervention). This multi-component intervention comprises several concrete and manageable components and operationalizing patient- and family-centered care principles in clinical practice. In this protocol, we describe a study aiming to evaluate the feasibility and acceptability of the FAM-ICU intervention in the adult ICU setting, including the feasibility of collecting relevant patient- and family-member outcome data.\n\nReferenc: Bohart et al. 2024. Acta Anaesthesiol Scand\n\n. 2025 Jan;69(1):e14539. doi: 10.1111\u002Faas.14539. Epub 2024 Oct 24. Method: We will conduct a pre-\u002Fpost two-group study design. We plan to recruit 30 adult ICU patients and their close family members at Herlev University Hospital in Denmark. The pre-group (n = 15) will receive usual care and the post-group (n = 15) will receive the FAM-ICU intervention. The FAM-ICU intervention involves interdisciplinary training of the ICU team and a systematic approach to information sharing and consultations with the patients and their family. Feasibility outcomes will include recruitment and retention rates, intervention fidelity, and the feasibility of participant outcome data collection. Acceptability will be assessed through questionnaires and interviews with clinicians, patients, and family members. Data collection is scheduled to begin in January 2025.\n\nDiscussion: This study will assess the feasibility and acceptability when implementing the FAM-ICU intervention and the feasibility of conducting a main trial to investigate its effectiveness on delirium in patients and the mental health of patients and family members. The data from the feasibility study will be used to guide sample size calculations, trial design, and final data collection methods for a subsequent stepped-wedge randomized controlled trial.",[638,639,640,641,642,643,29,644,645,646],"Delirium","Anxiety","Post Intensive Care Unit Syndrome","Post Intensive Care Unit Syndrome Family","Depression","Posttraumatic Stress Disorder (PTSD)","Length of ICU Stay","Pain","Satisfaction Survey",[648,649,650],"Patient- and family-centerede care","Feasibility","ICU","2025-05-08",{"date":653,"type":48},"2025-05-15",{"date":655,"type":23},"2025-08-01",{"date":657,"type":23},"2026-08-01",{"name":659,"class":55},"Herlev Hospital",{"id":661,"slug":662,"hasResults":12,"nctId":663,"briefTitle":664,"officialTitle":665,"acronym":666,"eligibilityCriteria":667,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":668,"targetDuration":4,"studyType":300,"phases":670,"briefSummary":671,"conditions":672,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":676,"lastUpdatePostDateStruct":677,"startDateStruct":679,"completionDateStruct":681,"leadSponsor":683,"locationsCount":685},"100586158","effect-of-the-postoperative-trendelenburg-position-on-chronic-subdural-hematoma-recurrence-100586158","NCT06911736","Effect of the Postoperative Trendelenburg Position on Chronic Subdural Hematoma Recurrence","Effect of the Postoperative Trendelenburg Position on Chronic Subdural Hematoma Recurrence: a Clinical Trial","POTHeR","Inclusion Criteria:\n\n* The study included patients aged 18 years or older who required surgical management of symptomatic CSH confirmed by CT scan and whose informed consent was given by the patient or responsible family member to participate in the study\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding\n* Conditions in which the trendelenburg position might not be safe, such as intracranial hypertension without a drain to allow evacuation of the hematoma, cardiovascular instability (severe heart failure, unstable angina, cardiogenic pulmonary edema), acute respiratory distress syndrome without a secure airway, glaucoma, spinal cord trauma not stabilized with surgery, peripheral vascular disease,\n* History of ipsilateral chronic subdural hematoma drainage, intracranial hypotension syndrome, ventriculoperitoneal shunting\n* Simultaneous participation in any other clinical trial.",{"count":669,"type":23},254,[420],"Objective: Determine the effect of the postoperative trendelenburg position on the recurrence of chronic subdural hematoma (CSH) in patients undergoing surgery.\n\nMaterials and Methods: An open-label, randomized, controlled clinical trial was conducted in three hospitals in Medellín. Patients with CSH were enrolled and assigned to the trendelenburg position (30° leg elevation and 10° head tilt) or a flat bed for 24 hours postoperatively. CSH recurrence was measured at 3 months, along with functional outcome (modified Rankin scale), adverse events, and comfort (Likert scale).",[511,673,512,29,674,675],"Trendelenburg","Prognosis","Clinical Trials","2025-04-16",{"date":678,"type":48},"2025-04-22",{"date":680,"type":48},"2024-06-01",{"date":682,"type":23},"2027-04-30",{"name":684,"class":55},"Universidad de Antioquia",3,{"id":687,"slug":688,"hasResults":12,"nctId":689,"briefTitle":690,"officialTitle":691,"acronym":4,"eligibilityCriteria":692,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":693,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":695,"conditions":696,"keywords":701,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":704,"lastUpdatePostDateStruct":705,"startDateStruct":707,"completionDateStruct":709,"leadSponsor":711,"locationsCount":56},"100459360","analysis-of-the-evolution-of-mortality-in-an-intensive-care-unit-100459360","NCT05261607","Analysis of the Evolution of Mortality in an Intensive Care Unit","Epidemiological Analysis of the Evolution of the Case-mix and Mortality in the Intensive Care Unit of Hospital Universitario De Getafe (1991-2026)","Inclusion Criteria:\n\n• Patients admitted to intensive care unit\n\nExclusion Criteria:\n\n• None",{"count":694,"type":23},25000,"The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical and respectful of their autonomy. Intensive medicine is a cross-sectional specialty that encompasses a broad spectrum of pathologies in their most severe condition, and specifically has as its foundation the practice of comprehensive care of the patient with organ dysfunction and susceptible to recovery. Although critically ill patients are a heterogeneous population, they have in common the need for a high level of care, often requiring the use of high technology, specific procedures for the support of organ dysfunction and the collaboration of other medical and surgical specialties for their management and treatment.\n\nSince their origins in the late 1950s, intensive care units have been adapting to the changes arising from the best scientific evidence. In the late 1990s and early 2000s, there were some successful clinical trials published that had tested alternative management strategies in the ICU.\n\nMechanical ventilation is an intervention that defines the critical care specialty. Between 1970 and the 1990s, the management focused on normalizing arterial blood gas with aggressive mechanical ventilation. Over the ensuing decades, it became apparent that performing positive pressure ventilation worsened lung injury. The pivotal moment in the mechanical ventilation story would be the low versus high tidal volume trial. This trial shifted the focus away from normalizing gas exchange to reducing harm with mechanical ventilation. Further, it paved way for further trials testing ventilation interventions (PEEP strategy, prone position ventilation) and nonventilation interventions (neuromuscular blockade, corticosteroids, inhaled nitric oxide, extracorporeal gas exchange) in critically ill patients.\n\nThat evidence-based intensive care medicine has undoubtedly had an influence on the outcome of critically ill patients, in general, and, particularly, of patients requiring mechanical ventilation. Temporal changes in mortality over the time have been scarcely reported for patients admitted to intensive care unit.\n\nObjective of this study is to estimate the changes over the time in several outcomes in the patients admitted to an 18-beds medical-surgical intensive care unit from 1991 (year of start of activity) to 2026",[167,29,697,698,699,27,700],"Epidemiology","Respiration, Artificial","Sepsis Syndrome","Neurologic Disorder",[702,703,29],"Intensive care units","Outcome","2025-03-11",{"date":706,"type":48},"2025-03-13",{"date":708,"type":48},"1991-07-01",{"date":710,"type":23},"2026-10-31",{"name":712,"class":55},"Hospital Universitario Getafe",{"id":714,"slug":715,"hasResults":12,"nctId":716,"briefTitle":717,"officialTitle":718,"acronym":4,"eligibilityCriteria":719,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":416,"enrollmentInfo":720,"targetDuration":4,"studyType":300,"phases":721,"briefSummary":722,"conditions":723,"keywords":4,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":726,"lastUpdatePostDateStruct":727,"startDateStruct":728,"completionDateStruct":730,"leadSponsor":731,"locationsCount":56},"100582980","phase-3-role-of-non-selective-beta-adrenergic-blocker-in-severe-tbi-100582980","NCT06870370","Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI","Role of Non-Selective Beta-Adrenergic Blocker in Severe Traumatic Brain Injury","Inclusion Criteria:\n\n* Patients aged between 18and 65 years old\n* Patients who have Severe traumatic brain injury\n* Glascow outcome scale ≤ 8\n\nExclusion Criteria:\n\n* Patients have pre-existing heart disease.\n* If there are contraindications to β blocker.\n* penetrating traumatic brain injury.\n* pre-injury brain dysfunction.\n* β-blocker or α2-agonist use before trauma.",{"count":634,"type":23},[303],"The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury",[724,725,167,29],"Traumatic Brain Injury (TBI) Patients","Intracranial Pressure","2025-03-06",{"date":704,"type":48},{"date":729,"type":23},"2025-09-20",{"date":729,"type":23},{"name":732,"class":55},"Tanta University",{"id":734,"slug":735,"hasResults":12,"nctId":736,"briefTitle":737,"officialTitle":738,"acronym":739,"eligibilityCriteria":740,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":741,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":743,"conditions":744,"keywords":747,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":755,"lastUpdatePostDateStruct":756,"startDateStruct":758,"completionDateStruct":760,"leadSponsor":762,"locationsCount":56},"100574661","scores-in-critically-ill-patients-after-craniotomy-100574661","NCT06762184","Scores in Critically Ill Patients After Craniotomy","Comparison of the Predictive Value of APACHE II, SOFA, SAPS II, GCS and GCS-P Scores for In-hospital Mortality in Critically Ill Patients After Craniotomy","SCORES","Inclusion Criteria:\n\n* Patients admitted to the ICU wards between 2017 and 2020\n* Patients underwent craniotomy\n* Patientshad an ICU stay of more than 24 hours\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Patients enrolled in other clinical studies",{"count":742,"type":23},1600,"This study planned to review patients admitted to three ICU wards at Beijing Tiantan Hospital between 2017 and 2020. It focused on adult patients who had undergone craniotomy and stayed in the ICU for more than 24 hours. Researchers intended to collect patient information, surgery details, complications, and outcomes from medical records. They also planned to gather routine scoring data used at the hospital and double-check its accuracy. Patients would be divided into two groups based on whether they survived or not, and the ability of different scoring systems to predict outcomes would be analyzed. Additionally, the study aimed to group patients by the type of surgery and assess how well the scoring systems predicted outcomes for each group.",[745,191,29,746],"Post-craniotomy","Severity of Illness Scores",[748,749,750,751,752,753,754,462],"critical ill","post-craniotomy","APACHE II","SOFA","SAPS II","GCS","GCS-P","2025-02-08",{"date":757,"type":48},"2025-02-11",{"date":759,"type":48},"2024-11-01",{"date":761,"type":23},"2025-03-01",{"name":763,"class":55},"Beijing Tiantan Hospital",{"id":765,"slug":766,"hasResults":12,"nctId":767,"briefTitle":768,"officialTitle":769,"acronym":770,"eligibilityCriteria":771,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":772,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":774,"conditions":775,"keywords":781,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":791,"lastUpdatePostDateStruct":792,"startDateStruct":794,"completionDateStruct":796,"leadSponsor":798,"locationsCount":56},"100572802","national-emergency-bariatric-surgery-audit-100572802","NCT06738004","National Emergency Bariatric Surgery Audit","A National Multi-centre Prospective Audit of Unplanned Surgical and Endoscopic Interventions in Patients Who Have Undergone Bariatric Surgery in the UK or Abroad","NEBSA","Inclusion Criteria:\n\n* Admissions from i) the emergency department, clinic, urgent care or primary care to the bariatric surgical team as an emergency; ii) from an inpatient team as an urgent referral; iii) a return to theatre following an elective bariatric procedure; iv) another hospital via patient transfer to a specialised unit.\n* Participants undergoing any intervention or procedure to treat or diagnose bariatric complications, (e.g., OGDs, interventional radiology, surgery, supplemental enteral or parenteral nutrition).\n\nExclusion Criteria:\n\n* age \\\u003C18 years old\n* have a length of stay \\\u003C24 hrs.\n* initial diagnosis of BSE is changed or if their readmission is found to be unrelated to previous bariatric surgery.",{"count":773,"type":23},500,"The goal of this observational study is to investigate the incidence, management, and outcomes of complications following bariatric surgery in patients in the United Kingdom. The main questions it aims to answer are:\n\n* What is the prevalence of unplanned interventions due to complications following bariatric surgery in the UK?\n* What are the current practices for managing these complications, and how do they impact patient outcomes?\n\nParticipants will:\n\nBe identified from hospitals treating patients presenting with complications following bariatric surgery.\n\nHave their data collected regarding demographics, surgical history, complications, treatments, and outcomes.\n\nResearchers will compare different management strategies and their impact on patient outcomes, with the aim of identifying best practices to improve emergency bariatric care and factors leading to patients attending as an emergency.",[776,777,778,391,779,780,281,29],"Bariatric Surgery","Postoperative Complications","Emergencies","Outcome Assessment (Health Care)","Quality Improvement",[782,783,784,785,786,787,788,397,789,790],"Bariatric surgery","Emergency complications","National audit","Surgical outcomes","Management strategies","United Kingdom","Patient safety","Morbidity and mortality","Postoperative complications","2024-12-12",{"date":793,"type":48},"2024-12-17",{"date":795,"type":48},"2023-11-09",{"date":797,"type":23},"2025-12-09",{"name":799,"class":55},"Bedfordshire Hospitals NHS Foundation Trust",{"id":801,"slug":802,"hasResults":12,"nctId":803,"briefTitle":804,"officialTitle":805,"acronym":806,"eligibilityCriteria":807,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":808,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":810,"conditions":811,"keywords":815,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":821,"lastUpdatePostDateStruct":822,"startDateStruct":824,"completionDateStruct":826,"leadSponsor":828,"locationsCount":56},"100369752","burden-mortality-and-supply-costs-in-intensive-care-unit-patients-100369752","NCT04094428","Burden, Mortality and Supply Costs in Intensive Care Unit Patients","Burden, Mortality and Supply Costs in Intensive Care Unit Patients. Health Services Research.","PLV_Ulm","Inclusion Criteria:\n\n* All patients dying on the ICU and all patients staying for at least 72 hours on the ICU\n\nExclusion Criteria:\n\n* No",{"count":809,"type":23},700,"This study systematically observes in a pragmatic trail under real world conditions the association between strategies of therapy (maximal therapy, withhold, withdraw) and treatment success in three endpoint related initial risk groups (high, intermediate, low risk) regarding three endpoints (burden, mortality and supply costs).",[812,29,813,167,814,76,192],"Burden, Dependency","End-of-life Care","Critically Ill Patient",[816,462,817,818,819,820,192],"burden","end-of-life care","intensive care unit","critically ill patient","frailty","2024-01-16",{"date":823,"type":48},"2024-01-17",{"date":825,"type":48},"2019-10-21",{"date":827,"type":23},"2026-09-30",{"name":829,"class":55},"University of Ulm"]