[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"morton-neuroma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:morton-neuroma":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100610443","phase-2-nac-repair-for-post-surgical-pain-100610443",false,"NCT07227649","NAC-REPAIR for Post-surgical Pain","NAC-REPAIR: N-Acetylcysteine-facilitated Redox-Immune Modulation for Post-surgical Analgesia and Injury Recovery","Inclusion Criteria:\n\n* Elective outpatient hand\u002Fupper-extremity or foot\u002Fankle surgery (single site; same-day discharge)\n* Baseline visit feasible ≤14 days pre-op\n* Can complete surveys\u002Fblood draw\n* Provides informed consent\n* Willing to follow dosing schedule and avoid restricted supplements\u002Fmeds\n\nExclusion Criteria:\n\n* Allergy to NAC\u002Fcapsule components □ NAC or high-dose antioxidants in past 14 days (unwilling to stop)\n* Chronic daily opioids ≥3 months or OUD\u002Fmaintenance therapy □ Pregnant\u002Fbreastfeeding or no contraception as applicable\n* Daily nitrates (nitroglycerin\u002Fisosorbide) □ Planned \\>24h admission, multistage\u002Ftrauma case □ Other interventional study within 30 days\n* Unable to swallow capsules \u002F malabsorption surgery affecting oral meds","ALL","18 Years","75 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand\u002Ffoot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, adherence, follow-up), estimate NAC vs placebo effects on pain, function, and opioid consumption, and characterize inflammatory signatures that may predict response.\n\nMethods: a single-site, double-blind, 1:1 randomized trial (N≈80) comparing NAC 1,200 mg twice daily for 14 days (starting pre-op) vs matching placebo; daily e-diaries for POD0-14; standardized outcomes (PROMIS Pain Interference; QuickDASH or FAAM; PGIC; opioid MME); and small blood draws pre-surgery and at two follow-up visits for cytokine profiling.",[27,28,29,30,31,32,33,34,35],"Carpal Tunnel Surgery","Trigger Finger Disorder","De Quervain Syndrome","Guyon's Canal","Dupuytren Contracture","Morton Neuroma","Tarsal Tunnel Syndrome","Plantar Fasciopathy","Peroneal Nerve Entrapment","NOT_YET_RECRUITING","2025-11-12",{"date":39,"type":40},"2025-11-14","ACTUAL",{"date":42,"type":21},"2026-01-15",{"date":44,"type":21},"2027-07-15",{"name":46,"class":47},"University of Arizona","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100477768","comparative-effectiveness-of-cryoablation-versus-steroid-and-lidocaine-alone-for-treatment-of-mortons-neuroma-100477768","NCT05501262","Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma","Comparative Effectiveness of Cryoablation Using the ICE-Seed Cryoablation Needle With Steroid and Lidocaine Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma","Inclusion Criteria:\n\n* Age \\>18 years\n* Able to consent and complete questionnaires\n* Failure of a four-week trial of conservative therapy (includes orthotics, appropriate footwear, and\u002For metatarsal pads)\n* X-ray and ultrasound excluding other pathology and confirming the presence and location of a Morton's neuroma\n\nExclusion Criteria:\n\n* Inability to follow-up or to comply with the follow-up protocol\n* Contraindication to cryoablation and\u002For lidocaine\u002Fsteroid injection\n* Other pathology which could account for symptoms identified on imaging studies\n* Unwillingness to be randomized",true,"105 Years",{"count":59,"type":21},32,[61],"NA","Morton's neuroma is a benign thickening involving the plantar interdigital nerve, most common in middle aged women. Morton's neuroma is one of the most frequent diagnoses seen in the investigators podiatry clinic and is difficult to treat. These lesions cause a burning or shooting pain that can radiate to the toes, or an aching pain in the ball of the foot. The pain is exacerbated with activity and certain footwear greatly limits activity in the involved patient population. Morton's neuroma is first treated conservatively with orthotics. Patients may require further interventions such as steroid injections. The literature reports only a 30% long term resolution of pain with the steroid. Surgical resection has a reported 51-85% success rate with 14-21% rate of complication; recurrent pain, numbness\u002Floss of sensation, and subsequent stump neuromas.\n\nCryoablation is well known to be efficacious for neuropathic pain and has recently been shown in two small studies to be safe and efficacious for treatment of Morton's neuroma. The investigators study will compare outcomes of cryoablation to corticosteroid injection in short- and long-term for treatment of Morton's neuroma that have failed conservative therapy.",[32],"RECRUITING","2025-10-14",{"date":67,"type":40},"2025-10-16",{"date":69,"type":40},"2022-07-25",{"date":71,"type":21},"2027-12-31",{"name":73,"class":47},"Oregon Health and Science University"]