[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mother-infant-interaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mother-infant-interaction":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,78,106,140,165,189],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":21},"100614171","the-effect-of-the-cesarean-eras-protocol-on-mother-infant-and-father-infant-bonding-a-multicenter-randomized-controlled-clinical-trial-100614171",false,"NCT07276126","The Effect of the Cesarean ERAS Protocol on Mother-Infant and Father-Infant Bonding: a Multicenter, Randomized Controlled Clinical Trial.","ERAS-CS-BOND-1","IInclusion Criteria:\n\nPregnant women aged 18-60 years.\n\nSingleton, live fetus, and ≥37 weeks of gestation.\n\nUndergoing elective or medically indicated cesarean delivery.\n\nAbility to read and understand Turkish (for questionnaire validity).\n\nMothers and fathers willing and able to complete postpartum follow-up assessments (2 hours, 24 hours, day 4, day 7).\n\nProvision of written informed consent by mother and, if participating, by father\u002Fpartner.\n\nMaternal postpartum clinical stability (no condition precluding questionnaire completion).\n\n❌ Exclusion Criteria (Dışlanma Kriterleri)\n\nExclusion Criteria:\n\nPreterm birth (\\\u003C37 weeks) or multiple gestation (twins, triplets).\n\nStillbirth, early neonatal death, or major congenital anomaly.\n\nNewborn requiring prolonged NICU stay preventing bonding assessments.\n\nMaternal severe obstetric complications:\n\nMassive postpartum hemorrhage\n\nHysterectomy\n\nSevere preeclampsia or eclampsia\n\nSevere postpartum infection\n\nMaternal active psychiatric disorder or use of psychotropic medication.\n\nMaternal need for high-dose opioid analgesia or sedation interfering with bonding assessments.\n\nInability to read\u002Funderstand Turkish or cognitive impairment preventing questionnaire completion.\n\nFailure to complete follow-up visits (2 hours, 24 hours, day 4, day 7).\n\nWithdrawal of consent at any time.",true,"ALL","18 Years","60 Years",{"count":21,"type":22},1,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a multicenter, 1:1 parallel-group, randomized controlled trial designed to compare the effect of the Enhanced Recovery After Cesarean (ERAS) protocol versus standard perioperative care on mother-infant and father-infant bonding in women undergoing cesarean delivery. The study will initially be conducted as a single-center trial at Istanbul Okan University Hospital. Once adequate site preparation is completed, additional centers will be added to expand the study to a multicenter setting.\n\nPrimary Outcome:\n\nThe primary outcome is the total score on the Postpartum Bonding Questionnaire (PBQ) assessed on postpartum day 7, reflecting mother-infant bonding.\n\nSecondary Outcomes:\n\nSecondary outcomes include:\n\nMaternal\u002FParental Postnatal Attachment Scale (MIBS) score at 2 hours postpartum (mother)\n\nPBQ score at 24 hours postpartum (mother)\n\nPBQ score at day 4 postpartum (mother)\n\nPBQ score at day 7 postpartum (father-infant bonding)\n\nEdinburgh Postnatal Depression Scale (EPDS) scores for mothers at 2 hours and 7 days postpartum\n\nTime to initiation of breastfeeding\n\nRequirement for neonatal intensive care unit (NICU) admission\n\nSample Size:\n\nThe total multicenter target sample size is n=300, with 150 participants in the ERAS group and 150 in the standard care group. The initial single-center phase at Okan University Hospital will enroll a target of n=100 participants (50 per group).\n\nRandomization:\n\nParticipants will be randomized using a block and stratified randomization approach based on parity (primiparous vs multiparous) and planned type of anesthesia.\n\nBlinding (Masking):\n\nDue to the nature of the intervention, care providers cannot be blinded to group assignment. However, outcome assessors and data analysts will remain blinded to treatment allocation to minimize bias.\n\nStudy Timeline and Visits:\n\nParticipants will be evaluated at multiple time points following cesarean delivery: 2 hours postpartum, 24 hours postpartum, day 4 postpartum, and day 7 postpartum. All primary and secondary outcomes will be collected at the specified time points.\n\nSignificance and Rationale:\n\nThe ERAS protocol for cesarean delivery is designed to optimize perioperative care, enhance recovery, and potentially improve early parent-infant bonding. While previous studies have focused on maternal recovery and clinical outcomes, evidence regarding the impact of ERAS on both mother-infant and father-infant bonding remains limited. This trial aims to provide high-quality evidence on whether ERAS implementation can improve early bonding experiences, maternal mental health, breastfeeding initiation, and neonatal outcomes compared with standard perioperative care. The findings may guide future clinical practice and contribute to optimizing family-centered care in cesarean deliveries.\n\nKey Features:\n\nMulticenter, randomized controlled design\n\nParallel 1:1 allocation\n\nStratified randomization by parity and anesthesia type\n\nBlinded outcome assessment and data analysis\n\nMultiple postpartum evaluation points\n\nFocus on psychosocial and clinical outcomes\n\nExpected Contributions:\n\nThis study will provide comprehensive data on the feasibility and effectiveness of ERAS protocols in cesarean deliveries and their potential benefits for both maternal and paternal bonding with the newborn. The inclusion of both mother-infant and father-infant outcomes, as well as maternal mental health and breastfeeding indicators, ensures a holistic assessment of early family-centered outcomes.",[28,29,30,31,32,33],"Bonding","ERAS","Cesarean Section","Maternal Care","Father - Child Relations","Mother-Infant Interaction",[35,36,37,38,39],"eras","erac","cesarean","maternal bonding","paternal bonding","RECRUITING","2026-04-27",{"date":43,"type":44},"2026-04-28","ACTUAL",{"date":46,"type":44},"2025-12-13",{"date":48,"type":22},"2026-04-20",{"name":50,"class":51},"Okan University","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":21},"100514185","continuous-delivery-room-skin-to-skin-study-for-moderate-and-late-preterm-infants-100514185","NCT05975203","Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants","COSY","Inclusion Criteria:\n\n* preterm birth between gestational age of 32 0\u002F7 and 36 6\u002F7 weeks\n* vaginal delivery\n* singleton\n* informed consent before birth\n\nExclusion Criteria:\n\n* malformations or syndromes of the infant\n* resuscitation of the infant\n* maternal psychological or severe physical illness\n* lack of German language skills",{"count":60,"type":22},60,[25],"The goal of this randomized controlled trial is to compare the effect of direct skin-to-skin contact in moderate and late preterm infants. The main questions it aims to answer are:\n\n* does skin-to-skin contact in moderate and late preterm infants influence gene expression in the stress signaling pathway?\n* does skin-to-skin contact in moderate and late preterm infants improve the short- and long-term outcome?\n\nParticipants will either get immediate separation after vaginal birth or receive immediate skin-to-skin contact. Researchers will compare these two groups to answer the proposed questions.",[64,33,65],"Preterm Birth","Infant Development",[67,68],"preterm behavioral epigenetics","skin-to-skin contact","2026-02-18",{"date":71,"type":44},"2026-02-20",{"date":73,"type":44},"2023-08-04",{"date":75,"type":22},"2028-12-31",{"name":77,"class":51},"University of Cologne",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":21},"100534092","peking-university-birth-cohort-in-weifang-pkubc-wf-100534092","NCT06234332","Peking University Birth Cohort in Weifang (PKUBC-WF)","Peking University Birth Cohort in Weifang","Inclusion Criteria:\n\n* Pregnant woman\n\n  1. Pregnant women, 6-13\\^+6 gestational weeks\n  2. Resided in Weifang in the past half years and have no plan to move out after delivery\n  3. Pregnant women who plan to have antenatal care and delivery in Weifang maternal\\&Child Hospital.\n  4. Pregnant women who is willing to participate in this study with informed consent\n* Pregnant woman's husband\n\n  1. His wife was eligible for enrollment\n  2. He is the biological father of the child (his wife's current pregnancy)\n  3. Pregnant women's husband who is willing to participate in this study with informed consent\n* Offspring 4. Children born to pregnant women who met the inclusion criteria after enrolling in this study.\n\n  5\\. Before the age of 8 years, his\u002Fher mother provided written informed consent. 6. After 8 years old, he\u002Fshe agreed to continue this study and signed the informed consent.\n\nExclusion Criteria:\n\n* Participants who cannot communicate normally.",{"count":86,"type":22},2800,"OBSERVATIONAL","The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.",[90,91,92,93,64,94,33,95,96],"Health Problems in Pregnancy","Pregnancy Outcomes","Gestational Diabetes","Gestational Hypertension","Obesity","Child Development","Anemia","2025-11-18",{"date":99,"type":44},"2025-11-24",{"date":101,"type":44},"2024-02-01",{"date":103,"type":22},"2043-12-31",{"name":105,"class":51},"Peking University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":16,"sex":17,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":124,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":21},"100505449","combined-oral-motor-stimulation-and-language-on-preterm-infant-feeding-100505449","NCT05861531","Combined Oral Motor Stimulation and Language on Preterm Infant Feeding","The Combined Association of an Oral Motor Stimulation and Language Intervention on Preterm Infant Feeding","Inclusion Criteria:\n\n* 23-30 weeks\n* English and Spanish speaking\n\nExclusion Criteria:\n\n* Major congenital anomalies\n* Surgical necrotizing enterocolitis\n* Non-English and Non-Spanish speaking","23 Weeks","30 Weeks",{"count":116,"type":22},124,[25],"This is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings, linguistic feedback, and a language curriculum to improve the neonatal inpatient oral feeding and language outcomes for preterm infants.",[120,121,122,33,123],"Language Delay","Language Development","Feeding; Difficult, Newborn","Maternal Behavior",[125,126,127,128,129,130],"Neonatal feeding","Neonatal language","Oromotor stimulation","Newborn reading","Parent infant interaction","LENA","2025-09-10",{"date":133,"type":44},"2025-09-17",{"date":135,"type":44},"2025-07-01",{"date":137,"type":22},"2030-07-01",{"name":139,"class":51},"Women and Infants Hospital of Rhode Island",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":21},"100499272","investigating-baby-behavior-and-family-technology-use-study-100499272","NCT05781100","Investigating Baby Behavior and Family Technology Use Study","Maternal Technology Use During Feeding and Infant Self-Regulation and Growth","iBaby","Eligibility Criteria\n\nAt the time of recruitment, eligibility criteria for participants will include:\n\n* 18 years of age or older\n* In 3rd trimester of singleton pregnancy\n* History of healthy, low-risk pregnancy\n* Lives within 50 miles of the Cal Poly campus\n* Owns a mobile device\n\nAfter the child is born, eligibility criteria for participants will remain in the study will include:\n\n* Infant was born term (gestational age ≥37 weeks) Exclusion criteria include\n* Mother has an untreated medical or psychiatric condition (e.g. bipolar disorder) that could impede study participation or affect mother-infant interaction\n* Mother is participating in another interventional study that influences parenting, mother-infant interactions, feeding practices, or technology use\n* The mother is unwilling or unable to commit to longitudinal follow-ups of herself or her child\n* Infant was born preterm (gestational age \\\u003C37 weeks)\n* Infant diagnosed with fetal abnormality or medical condition that interferes with oral feeding (e.g., feeding disorder, milk protein allergy) or development\n* Infant diagnosed with developmental delay (e.g., Down's syndrome)",{"count":149,"type":22},345,[25],"Maternal sensitivity and contingent responsiveness to infant behavioral cues is an important contributor to infants' developing capacities to self-regulate. During early infancy, feeding interactions comprise a significant portion of mother-infant dyadic interactions and high-quality feeding interactions provide both nutritive and socioemotional benefits; recent data suggest that, for many dyads, mothers' sensitive responsiveness during feeding interactions is routinely impacted by the omnipresence of portable technology. The objective of the proposed research is to better understand the development and possible impacts of maternal technology use on infant feeding interactions, emotion and intake regulation, and sociobehavioral and growth outcomes.",[153,33,65,154,155],"Mobile Phone Use","Self-Regulation, Emotion","Self-Regulation","2025-02-21",{"date":158,"type":44},"2025-02-24",{"date":160,"type":44},"2023-01-16",{"date":162,"type":22},"2027-06-30",{"name":164,"class":51},"California Polytechnic State University-San Luis Obispo",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":179,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":21},"100558905","a-virtual-support-intervention-for-postnatal-well-being-100558905","NCT06557200","A Virtual Support Intervention for Postnatal Well-being","Empowering Early Parenthood: A Digital Psychoeducational Support Intervention for Postnatal Well-being","Inclusion Criteria:\n\n* Pakistani female aged 18-45 years\n* Recent childbirth (within 0-6 weeks)\n* Access to a smartphone or computer with internet connectivity\n* Able to understand and communicate in Urdu or English\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* Pre-existing severe mental illness (e.g., schizophrenia, bipolar disorder)\n* Current substance abuse or dependence\n* Limited or no access to the internet or smartphone\n* Inability to understand or communicate in Urdu or English\n* Pregnancy complications requiring intensive care\n* Infants with severe medical conditions requiring hospitalization","45 Years",{"count":174,"type":22},1400,[25],"Postnatal depression (PND) and anxiety are significant public health concerns affecting a substantial proportion of new mothers worldwide. These conditions can have profound consequences for both maternal and infant well-being, including increased risk of\n\n1. maternal morbidity\n2. impaired parent-infant bonding\n3. long-term developmental challenges for the child.",[178,33],"Postnatal Depression","NOT_YET_RECRUITING","2024-08-13",{"date":182,"type":44},"2024-08-16",{"date":184,"type":22},"2024-08-15",{"date":186,"type":22},"2025-08-10",{"name":188,"class":51},"Universiti Putra Malaysia",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":16,"sex":197,"minAge":198,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":204,"conditions":205,"keywords":209,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":21},"100431567","phase-4-measles-and-bcg-vaccines-for-mother-and-child-100431567","NCT04899765","Measles and BCG Vaccines for Mother and Child","Specific and Non-specific Effects of Measles and BCG Vaccines for Mother and Child","MATVAC","Inclusion Criteria:\n\n* Female women in the fertile age\n* Non-pregnant\n* HIV-negative\n* Living in the BHP HDSS study area\n* Delivered a child that has reached 12 months of age\n* Currently not using contraceptives.\n\nExclusion Criteria:\n\n* Positive pregnancy test\n* Positive HIV test\n* Tuberculosis (previous or current)\n* Immunodeficiency\n* Cancer within the last 2 years\n* Mid-upper-arm-circumference\\\u003C200\n* Acute ongoing infection","FEMALE","15 Years","35 Years",{"count":201,"type":22},2400,[203],"PHASE4","In Africa, the mortality from infectious diseases remains high. The investigators have discovered that live vaccines such as the BCG vaccine against tuberculosis and the measles vaccine can strengthen resistance to other infections: they have beneficial \"non-specific effects\". The investigators have now seen signs that these non-specific effects for children are stronger if their mother has been given the same vaccines.\n\nIn Africa, BCG vaccine is recommended at birth and measles vaccine at 9 months of age. They are not used beyond childhood.\n\nThe investigators will randomize 2400 women to BCG vaccine, measles vaccine, or placebo. The investigators will further randomize their children to an extra early measles vaccine or placebo. The investigators will assess which of the resulting six vaccination schedules are best for women's and children's protection against measles, for the child's immune system, and for general health.\n\nThe project will be the first in the world to investigate the importance of vaccinating women with live vaccines.",[206,207,33,208],"Vaccine Preventable Disease","Measles","BCG Vaccination Reaction",[210],"Non-specific effects of vaccines","2024-01-18",{"date":213,"type":44},"2024-01-19",{"date":215,"type":44},"2021-05-20",{"date":217,"type":22},"2027-12-31",{"name":219,"class":51},"Bandim Health Project"]