[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"motor-delay\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:motor-delay":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,87,119,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100546822","baker-gordon-syndrome-natural-history-study-100546822",false,"NCT06399952","Baker Gordon Syndrome Natural History Study","A Prospective, Longitudinal and Observational Natural History Study for Children and Adults With Baker Gordon Syndrome - Genetic Autism Alliance","BAGOS","Inclusion Criteria:\n\n* Genetically confirmed diagnosis of Baker Gordon syndrome.\n* 0-99 years\n* Ability to send medical records and diagnostic test results.\n* Ability to complete tests and questionnaires.\n\nExclusion Criteria:\n\n• The presence of another condition or co-morbidity unrelated to Baker Gordon syndrome, that affects neurodevelopment.\n\nIn this study, the primary caregivers\u002FLAR for each participant diagnosed Baker Gordon Syndrome will be also considered participants.\n\nCaregivers\u002FLAR will have to meet the following inclusion criteria:\n\n* \\>18 years.\n* Legal caregiver of the patient diagnosed with a Baker Gordon Syndrome.\n* Willingness to follow study procedures, as assessed by the research team.\n* Willingness to sign the consent form.\n* Ability to understand all the information regarding the study, as assessed by the research team.\n\nCaregivers\u002FLAR Exclusion Criteria:\n\n• Less than 18 years old.","ALL","0 Years","99 Years",{"count":21,"type":22},50,"ESTIMATED","OBSERVATIONAL","The goal of this study is to conduct a prospective, longitudinal assessment of the natural clinical progression of children and adults with Synaptotagmin1-Associated Neurodevelopmental Disorder also known as Baker Gordon Syndrome (BAGOS). This will be performed by acquiring baseline measurements and developing effective outcome measures and diagnostic tools for the disorder, to prepare the healthcare system for future clinical trials.",[26,27,28,29,30,31,32],"Rare Diseases","Autism or Autistic Traits","Development Delay","SYT-SSX Fusion Protein Expression","Sleep Disorder","Epilepsy, Generalized","Motor Delay",[34,15,35],"Baker Gordon Syndrome","Synaptotagmin 1-Associated Neurodevelopmental Disorder","RECRUITING","2026-06-01",{"date":39,"type":40},"2026-06-03","ACTUAL",{"date":42,"type":40},"2024-04-30",{"date":44,"type":22},"2027-05-05",{"name":46,"class":47},"University of Missouri-Columbia","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":48},"100612371","complex-rehabilitation-technology-enabled-physical-activity-for-children-with-motor-delays-via-telehealth-in-natural-environments-100612371","NCT07252713","Complex Rehabilitation Technology Enabled Physical Activity for Children With Motor Delays Via Telehealth in Natural Environments","CP-MOVES","Inclusion Criteria:\n\n* Child age 1-6 years with CP or other severe motor delay (GMFCS IV-V);\n* Unable to stand without external support;\n* Parent willing and able to participate;\n* Internet access for telehealth;\n* Live within 50 miles of lab or willing to travel to OSU for pre and post testing and stander provision\n* One parent is fluent in English.\n\nExclusion Criteria:\n\n* Inability to participate in telehealth\n* Parent\u002Fcaregiver unable to participate","1 Year","6 Years",{"count":59,"type":22},20,"INTERVENTIONAL",[62],"NA","The primary goal of CP-MOVES is to evaluate 1) the preliminary efficacy of a telehealth-delivered, parent coaching intervention in the use of adaptive standers, on physical activity, sleep, and endurance in young children with severe motor delays and 2) on physical activity, sedentary time, resting heart rate, and perceived stress in parents.\n\nThe main questions the study aims to answer include:\n\n1. Do measures of physiological fitness and sleep in children with severe motor delays (i.e., unable to stand without support) change after a therapist-directed, parent-delivered intervention using telehealth and adaptive standers?\n2. Do parents report any changes in their child's endurance, participation, or quality of life OR parent stress following intervention?\n\nChildren ages 1-6 years old with severe motor delay and one parent will:\n\n1. Complete three 30 minute sessions of standing in an adapted stander per week for 8 weeks. One session per week will be completed with a physical therapist, delivered through telehealth and two sessions per week will be completed as a home program with the parent and child (no therapist or telehealth).\n2. Wear activity tracker sensors on the wrist(s) and waist for one-week before and after treatment.\n3. Complete questionnaires about the child's endurance, participation, and quality of life and the parent's stress, before and after treatment.\n4. Complete an assessment of postural control before and after treatment.\n5. Complete an post-treatment interview",[65,66,32],"Cerebral Palsy (CP)","Motor Disability",[68,69,70,71,72,73,74,75,76,77],"Assistive Device","Stander","Physical Activity","Sedentary","Parent","Physical Therapy","Rehabilitation","Digital Health","Telehealth","Wearable Sensors","2026-05-06",{"date":80,"type":40},"2026-05-07",{"date":82,"type":40},"2026-02-19",{"date":84,"type":22},"2026-12",{"name":86,"class":47},"Ohio State University",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":60,"phases":98,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":48},"100631374","synchronous-vs-asynchronous-telerehabilitation-for-high-risk-infants-100631374","NCT07499843","Synchronous vs. Asynchronous Telerehabilitation for High-Risk Infants","Family-Centered Early Intervention Program Under Physiotherapist Coaching for High-Risk Infants: A Comparison of Synchronous and Asynchronous Telerehabilitation Models","Inclusion Criteria:\n\n* Gestational age ≤32 weeks and\u002For birth weight ≤1500 grams.\n* Corrected age between 6 and 9 months at the time of enrollment.\n* Referral to a pediatric neurology clinic and\u002For current follow-up by a pediatric neurologist due to developmental risk.\n* A total score of ≤73 on the Hammersmith Infant Neurological Examination (HINE) (Romeo et al., 2021; Novak et al., 2017).\n* A score ≤5th percentile on the Alberta Infant Motor Scale (AIMS) (Fuentefria et al., 2017).\n* Parental willingness to participate and signing of the \"Informed Consent Form.\"\n* Access to the minimum technological infrastructure required for telerehabilitation (smartphone, tablet, or computer with video calling capability and active internet access).\n\nExclusion Criteria:\n\n* Presence of diagnosed genetic syndromes or metabolic diseases known to directly affect neuro-motor development.\n* Major congenital malformations causing significant movement restriction or exercise intolerance.\n* History of symptomatic hypoglycemia associated with severe brain injury during the neonatal period.\n* Sensory impairments (bilateral blindness or severe bilateral hearing loss not correctable with hearing aids) that prevent participation in assessments and exercises based on visual and auditory stimuli.\n* Acute or unstable clinical conditions that preclude the safe conduct of the intervention (e.g., continuous mechanical ventilation, hemodynamic instability, uncontrolled seizures, or active acute infections).\n* Non-adherence to the study protocol, defined as missing more than 6 intervention sessions.","6 Months","9 Months",{"count":97,"type":22},48,[62],"Premature birth, low birth weight, and a history of neonatal intensive care history are significant risk factors associated with long-term neurodevelopmental adverse outcomes in infants. Family-centered early intervention programs play a critical role in minimizing the impact of these risks and optimizing developmental potential. Currently, telerehabilitation (TR) has emerged as a cost-effective solution that facilitates access to early intervention services. However, there is limited literature directly comparing the efficacy and feasibility of synchronous (real-time) and asynchronous (store-and-forward) parent coaching-based TR models specifically within the at-risk infant population.\n\nThe primary objective of this project is to comparatively examine the effects of synchronous and asynchronous TR programs on motor development levels, individualized goal attainment, and parental self-efficacy in infants aged 6-9 months (corrected age) at risk of developmental delay, against a standard home program (control group). Designed as a randomized controlled trial, the study will include 45 high-risk infants meeting the inclusion criteria, who will be randomly allocated into three groups: Synchronous TR, Asynchronous TR, and Control. In the Synchronous group, parents will receive real-time coaching via video conferencing for 12 weeks, whereas the Asynchronous group process will be managed through video analysis and delayed feedback mechanisms. The Control group will be provided with standard digital educational materials.\n\nThe primary outcome measures of the study include Goal Attainment Scaling (GAS) scores, the Parental Self-Efficacy Instrument, and the Parenting Stress Index. Secondary measures will include the Bayley Scales of Infant and Toddler Development (Bayley-IV), the Alberta Infant Motor Scale (AIMS), and the Hammersmith Infant Neurological Examination (HINE). Data will be collected at baseline (T0) and post-intervention (T1) by an assessor blinded to group allocation. The findings obtained from this study aim to demonstrate the clinical efficacy of different TR models, thereby providing guidance for the planning and dissemination of remote healthcare services for high-risk infants.",[101,102,32],"Risky Baby","Premature Birth of Newborn",[104,105,106,107,108],"At-risk infant","Early intervention","Telerehabilitation","Parent coaching","Motor development","NOT_YET_RECRUITING","2026-03-25",{"date":112,"type":40},"2026-03-30",{"date":114,"type":22},"2026-05-04",{"date":116,"type":22},"2027-07-04",{"name":118,"class":47},"Biruni University",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":130,"conditions":131,"keywords":136,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":48},"100578123","motor-voice-assessment-in-infants-mami-100578123","NCT06807203","Motor-voice Assessment in Infants (MAMI)","Spontaneous Motor-voice Assessment in Infants Using Video and Audio Recordings.","MAMI","Inclusion Criteria:\n\n* gestational age of 24 0\u002F7 - 41 6\u002F7,\n* admitted to the NICU,\n* medically stable by 40 weeks of gestation (including off ventilator support),\n* born to mothers 18 - 43 years old at the time of birth,\n* one parent fluent in English.\n\nExclusion Criteria:\n\n* diagnosis of a genetic syndrome (e.g. Trisomy 21),\n* musculoskeletal deformity,\n* failed hearing screen.","10 Days",{"count":129,"type":22},46,"The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are:\n\nIdentify voice factors among infants with newborn-detectable risk. Identify association between individual characteristics (Gestational age at birth, global function, motor-function) and voice factors.\n\nExamine unique features of voice production that are present in infants with high-risk for Cerebral Palsy (CP).\n\nParticipants will be asked to upload a 3-minute videos of their child at term-age, 3.5-, and 9-months of age.\n\nAt the 3.5-month and 9-month time point parents can choose to attend an optional in-person assessment with their child.",[132,133,32,134,135],"Cerebral Palsy Infantile","Pre-Term","Neurodevelopmental Disorders","Autism Spectrum Disorder",[137,138,139,140,141],"Digital health,","Motor assessment,","voice assessment,","cognition","neurodevelopment,","2026-03-24",{"date":144,"type":40},"2026-03-27",{"date":146,"type":40},"2025-10-22",{"date":148,"type":22},"2030-01-28",{"name":86,"class":47},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":157,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":60,"phases":161,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":177},"100482917","effects-of-a-physical-therapy-intervention-on-motor-delay-in-infants-admitted-to-a-neonatal-intensive-care-unit-100482917","NCT05568264","Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit","Early Detection and Therapeutic Improvement of Motor Delay in High Risk Infants: A Randomized, Controlled Trial","Inclusion Criteria:\n\nNICU admission and qualifies for Early Childhood Clinic (NICU high-risk follow up clinic) or Early Intervention due to:\n\n* BW \\\u003C1500 grams\n\nOR\n\n* Disorders of the central nervous system\n\n  * Brain injury (including but not limited to extra axial hemorrhage, any grade intraventricular or intraparenchymal hemorrhage, stroke, hypoxic ischemic encephalopathy (HIE), meningitis)\n\n    * HIE includes mild, moderate, severe exam on modified Sarnat exam, both cooled and non-cooled\n    * includes \"at risk for HIE\" with 10-minute Apgar \\\u003C7 plus pH\\\u003C7.15 or base deficit \\>\u002F=12.\n  * Brain developmental abnormalities (hydrocephalus, microcephaly, cortical dysgenesis)\n  * Cramped synchronous movements at term PMA\n\nOR\n\n* Bronchopulmonary dysplasia (BPD) defined as need for respiratory support at 36 weeks postmenstrual age in an infant born at \\\u003C32 weeks of gestation.\n\nAND\n\n* Medically stable AND able to start intervention between 34-48 weeks PMA.\n\nExclusion Criteria:\n\n(related to inability to complete intervention, sensor placement, or clinic assessments)\n\n* open wounds, skin condition precluding sensor placement\n* immune deficiencies requiring protective isolation\n* limb reduction defects\n* followed primarily in another clinic (including but not limited to meningomyelocele and related conditions\u002Ftrisomy 21)\n* bleeding disorders or ongoing need for anticoagulation\n* palliative or hospice care (for life limiting conditions including, but not limited to trisomy 18, 13)\n* known visual impairment at the time of enrollment\n* DCFS custody\n* no English-speaking caregivers\n* any other condition that would preclude participation in the study, as determined by the PI\n* previously enrolled in competing randomized trial with developmental outcome variables\n\nEach child's enrollment in the study will be approved by the child's neonatologist.","33 Weeks","48 Weeks",{"count":160,"type":22},222,[62],"Study Aims\n\nPilot study: Due to the large recruitment goal and length of the project, the study team\u002FPIs will evaluate the first cohort of 6-10 participants to refine study procedures and study-related materials. If no major modifications are made to the protocol as a result of this evaluation, data from these participants will be included for analysis.\n\nAim 1: Evaluate the efficacy of an early, evidence-based, clinical experience-based therapeutic intervention (from the NICU to 12-months corrected age) on improving motor function and reducing severity of motor delays in infants at 12-months corrected age.\n\nThe investigators hypothesize that the intervention group will demonstrate an average 8-point difference (0.5 standard deviation) compared to the standard of care group. \\[an 8-point difference is considered a clinically meaningful difference\\]\n\nAim 2: Evaluate the early effects (i.e., before 12 months) of a therapeutic intervention, provided from NICU to 12-months corrected age, on motor function and severity of motor delay.\n\nThe Investigators hypothesize that a statistically significant higher percentage of infants in the intervention group will demonstrate improved motor function and reduced severity of motor delays, compared to the standard of care group-assessed using sensors, the NSMDA and TIMP-as early as 3-months corrected age.\n\nAim 3: Evaluate whether an early intervention that focuses on caregiver engagement improves caregiver well-being.\n\nThe invetigators hypothesize that an intervention that focuses on supporting and addressing the individual needs of the caregiver will improve caregiver well-being. The investigators will evaluate these effects using the PedsQL (Family Impact Module).",[32,164,165,166,167],"Premature Birth","Intraventricular Hemorrhage","Hypoxic-Ischemic Encephalopathy","Bronchopulmonary Dysplasia","2025-05-19",{"date":170,"type":40},"2025-05-21",{"date":172,"type":40},"2022-10-01",{"date":174,"type":22},"2026-12-31",{"name":176,"class":47},"Shirley Ryan AbilityLab",3]