[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"motor-module-guided-rehabilitation-targeting-impaired-intermuscular-coordination-and-motor-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:motor-module-guided-rehabilitation-targeting-impaired-intermuscular-coordination-and-motor-recovery":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100633790","early-phase-1-neuro-intermuscular-coordination-enhancement-nice-rehabilitation-through-human-machine-interaction-in-chronic-stroke-100633790",false,"NCT07531264","Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction in Chronic Stroke","Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation","NICE","Inclusion criteria for individuals after stroke are:\n\n* Hemiparetic chronic stroke survivors more than 6 months after stroke onset\n* Adults aged 21-80 years, including both female and male participants\n* Individuals with a single unilateral ischemic or hemorrhagic stroke\n* Individuals with Upper Extremity Fugl-Meyer Assessment score between 10 and 59 out of 66\n* Individuals who have not received botulinum toxin injections in the upper extremity within the past 3 months\n* Individuals without severe spasticity, defined as Modified Ashworth Scale score ≤3 at the elbow and shoulder\n\nExclusion criteria for individuals after stroke are:\n\n* Individuals younger than 21 years of age or older than 80 years of age\n* Individuals with an orthopedic disorder involving the upper limbs\n* Individuals unable to produce voluntary upper-extremity muscle EMG activity;\n* Individuals with cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol, assessed using the Montreal Cognitive Assessment or other IRB-approved screening procedures.\n* Individuals whose stroke-affected arm has an intermuscular coordination pattern similarity score \\>0.80 relative to the non-affected arm\n\nInclusion criteria for healthy individuals are:\n\n* Healthy adults aged 21-80 years, including both female and male participants\n* Individuals with no known neurological or orthopedic injuries\n\nExclusion criteria for healthy individuals are:\n\n* Individuals younger than 21 years of age or older than 80 years of age\n* Individuals with known neurological disorders\n* Individuals with orthopedic injuries or conditions affecting upper-extremity movement\n* Individuals unable to provide informed consent",true,"ALL","21 Years","80 Years",{"count":22,"type":23},48,"ESTIMATED","INTERVENTIONAL",[26],"EARLY_PHASE1","The objective of this study is to develop Neuro-Intermuscular Coordination Enhancement (NICE) rehabilitation, a novel neuromuscular control signal-guided strategy that visually guides stroke patients to individually activate motor modules through human-machine interaction. Ultimately, the development will lead to better clinical motor recovery, better quality of life, and lowered healthcare costs associated with the impairment.",[29,30],"Chronic Stroke-related Upper-extremity Motor Impairment","Motor Module-guided Rehabilitation Targeting Impaired Intermuscular Coordination and Motor Recovery",[32,33,34,35,36],"Muscle Synergy","Non-invasive Rehabilitation","Intermuscular Coordination","Stroke","Motor module","NOT_YET_RECRUITING","2026-06-15",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":23},"2027-08",{"date":45,"type":23},"2032-08",{"name":47,"class":48},"University of Houston","OTHER"]