[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"motoric-cognitive-risk-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:motoric-cognitive-risk-syndrome":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,70,89,105,133,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100550807","personalized-exercise-treatments-for-older-veterans-with-motoric-cognitive-risk-syndrome-100550807",false,"NCT06451874","Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome","Motoric Cognitive Risk Syndrome: Refining Treatment Strategies and Testing Feasibility to Personalize Treatment for Older Veterans","Inclusion Criteria:\n\n1. Age 65\n2. Receiving VA primary care\n3. Community-dwelling\n4. Motoric Cognitive Risky Syndrome i. Slow gait speed ii. Subjective cognitive concerns\u002Fcomplaints\n\nExclusion Criteria:\n\n1. Non-English speaking\n2. Presence of a terminal disease\n3. Major medical problem\n4. Myocardial infarction or major surgery in the previous 3 months\n5. 3-point walking pattern\n6. Dementia diagnostic\n7. Mobility disability","ALL","65 Years",{"count":19,"type":20},54,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).",[26],"Motoric Cognitive Risk Syndrome",[28,29,30,31],"Veterans","Mobility","Cognition","Sequential Multiple Assignment Randomized Trial","RECRUITING","2026-06-30",{"date":35,"type":36},"2026-07-02","ACTUAL",{"date":38,"type":36},"2025-07-01",{"date":40,"type":20},"2029-12-31",{"name":42,"class":43},"VA Office of Research and Development","FED",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":44},"100639177","figure-of-8-walk-test-in-individuals-with-motoric-cognitive-risk-syndrome-100639177","NCT07586553","Figure-of-8 Walk Test in Individuals With Motoric Cognitive Risk Syndrome","Validity and Reliability of the Figure-of-8 Walk Test (8FWT) in Individuals With Motoric Cognitive Risk Syndrome","8FWT-MCR","Inclusion Criteria:\n\nAged 65 years or older Presence of subjective cognitive complaints Gait speed ≤ 0.8 m\u002Fs (4-meter walk test) Able to walk independently without assistive devices No clinical diagnosis of dementia Able to understand and follow test instructions\n\nExclusion Criteria:\n\nMini-Mental State Examination (MMSE) score \\\u003C 24 Neurological diseases affecting gait (e.g., stroke, Parkinson's disease, multiple sclerosis) Severe musculoskeletal conditions affecting walking Lower extremity surgery within the last 6 months Severe visual or hearing impairment that interferes with testing Dependence on assistive walking devices",{"count":54,"type":20},52,"OBSERVATIONAL","This observational study aims to investigate the validity and reliability of the Figure-of-8 Walk Test (8FWT) in individuals with Motoric Cognitive Risk Syndrome (MCRS). The study will evaluate test-retest reliability, measurement error (SEM, MDC), and construct validity by examining the relationship between 8FWT performance and functional mobility measures. The findings are expected to provide evidence for the clinical applicability of 8FWT in assessing dynamic balance, gait performance, and cognitive-motor interaction in older adults.",[26,58,59],"Gait","Balance","2026-05-07",{"date":62,"type":36},"2026-05-14",{"date":64,"type":36},"2026-04-07",{"date":66,"type":20},"2026-07-08",{"name":68,"class":69},"Balikesir University","OTHER",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":44},"100636998","dual-task-effects-on-gait-and-balance-in-mcrs-100636998","NCT07572968","Dual-Task Effects on Gait and Balance in MCRS","Effects of Cognitive Load on Gait and Balance Performance in Individuals With Motoric Cognitive Risk Syndrome: A Dual-Task Analysis","Inclusion Criteria:\n\nAge ≥ 65 years Subjective cognitive complaints Slow gait speed No dementia diagnosis\n\nExclusion Criteria:\n\nSevere visual\u002Fhearing impairment Neurological diseases (stroke, Parkinson) Acute orthopedic conditions affecting walking",{"count":78,"type":20},35,"This study aims to investigate the effects of cognitive load on gait and balance performance in individuals with Motoric Cognitive Risk Syndrome (MCRS). Participants will perform Timed Up and Go (TUG) and tandem walking tests under single-task and dual-task conditions. The study evaluates cognitive-motor interference and dual-task cost to better understand early markers of cognitive decline and fall risk.",[26,81,58,59],"Dual-Task Performance","2026-05-01",{"date":60,"type":36},{"date":85,"type":36},"2026-04-15",{"date":87,"type":20},"2026-07-15",{"name":68,"class":69},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":103,"leadSponsor":104,"locationsCount":44},"100636996","laser-based-map-tests-in-motoric-cognitive-risk-syndrome-100636996","NCT07572942","Laser-Based Map Tests in Motoric Cognitive Risk Syndrome","Validity and Reliability of Neuroscience-Based Visual Laser Feedback Map Tests in Individuals With Motoric Cognitive Risk Syndrome","Inclusion Criteria:\n\nAged ≥65 years Diagnosis of Motoric Cognitive Risk Syndrome (subjective cognitive complaint + slow gait) Living independently in the community Able to understand and perform test procedures\n\nExclusion Criteria:\n\nDiagnosed dementia Severe psychiatric disorders Advanced visual impairments (e.g., macular degeneration, severe cataract) Neurological disorders affecting motor control Severe tremor or ataxia interfering with task performance",{"count":78,"type":20},"This study aims to evaluate the validity and reliability of neuroscience-based visual laser feedback map tests in individuals with Motoric Cognitive Risk Syndrome (MCRS). The developed assessment protocol integrates visuospatial processing, reaction time, and upper extremity motor control within a single task. Construct validity will be examined through correlations with reaction time and proprioception measurements, and test-retest reliability will be assessed to determine measurement consistency.",[26,99,100],"Cognitive-Motor Interaction","Sensorimotor Performance",{"date":60,"type":36},{"date":85,"type":36},{"date":87,"type":20},{"name":68,"class":69},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":121,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":131,"locationsCount":44},"100596423","effect-of-exergaming-program-versus-neuromuscular-exercise-in-elderly-people-with-motor-cognitive-risk-syndrome-100596423","NCT07045259","Effect of Exergaming Program Versus Neuromuscular Exercise in Elderly People With Motor Cognitive Risk Syndrome","Effect of Exergaming Program Versus Neuromuscular Exercise on Locomotor and Cognitive Functions in Elderly People With Motor Cognitive Risk Syndrome","Inclusion Criteria:\n\n* Being over 65 years of age\n* Having a Barthel Daily Living Activities Index score of ≥ 90\n* Having a Mini Mental Status Score (MMSE) of ≥24\n* Having the ability to walk with or without a walking aid\n* Having a slow walking speed\n* Having subjective memory complaints\n\nExclusion Criteria:\n\n* Presence of Dementia\n* Major Depression\n* Generalized Anxiety Disorder and Delirium\n* Parkinson's Disease\n* Anemia\n* Thyroid Disease\n* Vitamin B12 Deficiency\n* Malnutrition\n* Terminal Illness\n* Hearing or Visual Impairment",{"count":113,"type":20},60,[23],"The primary aim of our study is to compare the effects of neuromuscular exercise training versus structured exergaming program on locomotor and cognitive functions in elderly individuals with Motor Cognitive Risk (MCR), which defines the transition state between typical aging and dementia and mild cognitive impairment. This study aims to present for the first time the effects of neuromuscular exercise training and exergaming program on locomotor and cognitive functions in elderly individuals with MCR with comparative results.",[26,117,118,119,120],"Elderly (People Aged 65 or More)","Geriatric Patient","Exergaming","Neuromuscular Exercise",[26,122,123,124],"Elderly","neuromuscular exercise","exergaming","2026-04-23",{"date":127,"type":36},"2026-04-24",{"date":129,"type":36},"2025-12-25",{"date":33,"type":20},{"name":132,"class":69},"Istanbul University - Cerrahpasa",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":139,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":148,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":44},"100635541","effect-of-episodic-future-thinking-on-promoting-physical-activity-among-older-adults-with-motoric-cognitive-risk-syndrome-a-randomized-controlled-trial-100635541","NCT07554027","Effect of Episodic Future Thinking on Promoting Physical Activity Among Older Adults With Motoric Cognitive Risk Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\nParticipants will be eligible for inclusion if they are 60 years of age or older and meet all of the following four criteria:\n\n* 1\\. Subjective Cognitive Decline (SCD) Assessed using the Chinese version of the Subjective Cognitive Decline Questionnaire-9 (SCD-9). A total score greater than 5 is considered indicative of SCD.\n* 2\\. Slow Gait Participants will walk 4 meters at their usual pace. Gait speed will be calculated using the recorded time, and gait speed \\\u003C1.0 m\u002Fs will be classified as slow gait.\n* 3\\. No Difficulty in Basic Activities of Daily Living (ADL) Participants must report no difficulty in the following six basic ADL domains: bathing, dressing, toileting, transferring, continence, and eating.\n* 4\\. No Dementia No self-reported history of dementia and a Mini-Mental State Examination (MMSE) score of ≥24, indicating the absence of dementia.\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following conditions:\n\n* 1\\. Severe visual or hearing impairment that interferes with communication or assessment.\n* 2\\. Primary psychiatric disorders, such as schizophrenia or bipolar disorder.\n* 3\\. Significant language or communication difficulties that prevent completion of assessments or participation in the intervention.\n* 4\\. Severe diseases of major organs or systems, such as advanced heart failure, end-stage renal disease, or active malignancy, that may affect safety or participation.\n* 5\\. Any other condition that, in the judgment of the research team, makes the participant unsuitable for the study.","60 Years",{"count":141,"type":20},166,[23],"Motor Cognitive Risk (MCR), a pre-dementia state characterized by the coexistence of subjective cognitive decline (SCD) and slow gait speed, has a high prevalence among community-dwelling older adults in China and is associated with significantly increased risks of progression to dementia and other adverse health outcomes. Physical activity is the most cost-effective non-pharmacological intervention for slowing cognitive decline and the modifiable factor with the greatest contribution to dementia prevention. However, older adults with cognitive impairment commonly face behavioral challenges such as insufficient physical activity and difficulty maintaining adherence. Episodic Future Thinking (EFT), a novel intervention strategy grounded in health psychology and behavioral economics, has been shown to promote healthy behaviors by reducing delay discounting rates and enhancing future orientation. The goal of this randomized controlled study is to test the effect of EFT intervention in promoting physical activity among older adults with MCR.",[145,26],"Physical Activities",[145,147,26],"Episodic Futhre Thinking","NOT_YET_RECRUITING","2026-04-21",{"date":151,"type":36},"2026-04-28",{"date":153,"type":20},"2026-05",{"date":155,"type":20},"2027-03",{"name":157,"class":69},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":21,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":148,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":4},"100560769","home-transcranial-direct-current-stimulation-for-motoric-cognitive-risk-syndrome-100560769","NCT06581458","Home Transcranial Direct-Current Stimulation for Motoric Cognitive Risk Syndrome","HometDCS","Inclusion Criteria:\n\n* Age 65-90\n* Cognitive complaints\n\n  * A positive answer to the question \"Do you feel you have more problems than most people?\"\n  * A negative answer to the question \"Is your thinking as clear and sharp as it was before?\"\n* Slow walking - one standard deviation below the average for age and gender (under age 75: men less than 101.9 cm\u002Fs, women less than 97.4 cm\u002Fs. Over or equal to age 75: men less than 85.3 s) m\u002Fs women less than 76.7 cm\u002Fs)\n* No significant disability\n\n  * There is the ability to walk without support on a walking carpet\n  * A result below 9 in the Functional Activities Questionnaire index\n* Identification as qualified\n* Identification as willing and able to operate a tDCS device or have a partner who is able to operate the device during home use. According to the criteria:\n\n  * Inclusion: selected by the patient, over the age of 21, with basic computer skills and available throughout the study period\n  * Exclusion: MOCA score lower than or equal to 26. Presents insufficient understanding, poor vision, severe joint problems in the hands, deformity pain or other conditions that may interfere with the successful operation of the tDCS\n* Has access to a reliable wireless internet network (WiFi) at the patient's home\n\nExclusion Criteria:\n\n* Less than eight years of study\n* dementia\n\n  * According to the clinical definition clinical dementia rationing (CDR) score 1 or higher\n  * Previous diagnosis\n  * Performance in the range indicating dementia in the neuropsychological test bettery (lower than 2 standard deviations below the age- and sex-matched average)\n* IQ is low or equal to 85 in the WTAR test. without a background of mental disability\n* Current diagnosis of major psychiatric disorders (schizophrenia, bipolar, major depression)\n* Evidence of moderate to severe symptoms of depression. A score high or equal to 9 on the 15 item geriatric depression scale\n* History of head injury that led to prolonged loss of consciousness\n* History of palpitations of unknown origin that may indicate convulsions\n* History of convulsions, diagnosis of epilepsy in the patient or in most of the first degree family. Except for a case of a single seizure of benign etiology determined by a neurologist\n* Hospitalization during the last three months following an acute illness or musculoskeletal injury with a significant impact on walking or stability\n* An unbalanced medical condition that can worsen following convulsive stimulation (cardiac malformation, cardiac arrhythmias, asthma, etc.)\n* Substance use disorders during the last six months\n* A wig or hair design that prevents contact of the electrodes with the scalp or interferes with the administration of the stimulation\n* Chronic vertigo\n* A cardiac event within the last six months\n* Active cancer treated with chemotherapy or radiation\n* blindness\n* Visual hallucinations (according to history or self-report)\n* There are contraindications for MRI or tDCS as defined by the International Federation for Clinical Neurophysiology\n\n  * Includes unprovoked convulsions during the last 2 years\n  * Danger of finding ferromagnetic objects in the body, self-reporting of medical implants in the body (DBS, deep brain stimulation, drug delivery pump, cochlear implant, pacemaker)\n  * Inventions active dermatological condition\n* History of behavior disorders in REM sleep, sometimes an early sign of Parkinson's disease\n* Medications and medical history will be examined by a clinician and a decision regarding entry into the study will be based on medical history, current medication dosage and medication change before or during the treatment as well as combination with other active CNS medications.","90 Years",{"count":167,"type":20},64,[23],"1. To examine the effect of a two-week tDCS intervention of 3 months of continued tDCS intervention versus 3 months of receiving a placebo treatment (dummy). On the costs of performing an action task (dual task cost) walking speed, cognitive measures and motor function.\n2. To examine whether the effects of tDCS build up over time by creating a delayed start mechanism in the intervention (delayed-start design)\n3. Examining mechanical and neuroplastic effects of tDCS intervention\n4. To examine the response to tDCS over time",[26],"2024-08-26",{"date":173,"type":36},"2024-09-03",{"date":175,"type":20},"2024-09",{"date":177,"type":20},"2026-09",{"name":179,"class":180},"Tel-Aviv Sourasky Medical Center","OTHER_GOV"]