[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mouthwash\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mouthwash":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100623904","phase-4-oral-health-outcomes-with-amphion-mouthwash-as-an-adjunct-to-non-surgical-periodontal-therapy-100623904",false,"NCT07402694","Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy","Inclusion Criteria:\n\n1. Aged between 18 and 65 years old.\n2. At least 20 natural teeth (excluding root remnants) present in the oral cavity.\n3. Diagnosed with Stage I-IV periodontitis according to the 2018 new classification of periodontal diseases.\n4. No impairment in vision, motor function, or cognitive ability, capable of understanding and cooperating with the study.\n5. Not undergoing any orthodontic treatment and not wearing removable partial dentures during the study period.\n6. Fully informed and voluntarily signed a written informed consent form.\n\nExclusion Criteria:\n\n1. Individuals allergic to any component used in the study.\n2. Pregnant or lactating women.\n3. Those who have undergone periodontal treatments such as scaling, root planing, or used antimicrobial mouthwash within the past 3 months.\n4. Those with a history of systemic hormone or antibiotic use within the past 3 months, or who are assessed as requiring adjunctive use of such medications during periodontal treatment.\n5. Individuals with underlying systemic diseases that may affect the evaluation of periodontal status, including but not limited to: abnormal liver function, renal insufficiency, hematological diseases, neurological or psychiatric disorders, systemic bone diseases, diabetes, coronary heart disease, malignant tumors, etc.\n6. Current or former smokers (including active or passive smoking), or users of other nicotine and tobacco products (such as e-cigarettes, chewing tobacco).","ALL","18 Years","65 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Periodontitis is a chronic inflammation caused by dental plaque that can destroy periodontal tissues. Current primary treatments include mechanical removal methods such as supragingival scaling and subgingival curettage. However, issues like microbial recolonization leading to inflammation recurrence exist, often necessitating the use of antimicrobial agents. Prolonged antibiotic use, however, can easily lead to bacterial resistance.\n\nAmphion oral rinse is a novel biomimetic material mouthwash. It inhibits plaque regrowth by forming a long-lasting physical barrier and avoids flora imbalance. Compared with traditional antibiotics, this product has shown unique advantages in the adjuvant treatment of periodontal diseases. This study aims to evaluate the efficacy of Amphion rinse combined with conventional periodontal therapy in patients with stage I-IV periodontitis, including plaque control and inflammation improvement. Additionally, it will analyze its impact on the oral microbiome and collect user experience feedback to provide a reference for its clinical application.",[26,27],"Periodontitis","Mouthwash","NOT_YET_RECRUITING","2026-02-04",{"date":31,"type":32},"2026-02-11","ACTUAL",{"date":34,"type":20},"2026-03-01",{"date":36,"type":20},"2027-12-31",{"name":38,"class":39},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":15,"minAge":16,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":40},"100623220","phase-3-evaluation-of-the-anti-plaque-effect-of-a-resveratrol-based-mouthwash-using-a-24-hour-plaque-re-growth-100623220","NCT07393802","Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth","Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Biofilm Re-Growth Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 30 years\n* Systemically healthy individuals\n* Presence of at least 20 natural teeth\n* Clinically healthy gingiva with no signs of gingivitis or periodontitis\n* No probing depth \\>3 mm\n* No clinical attachment loss\n\nExclusion Criteria:\n\n* Presence of gingivitis or periodontitis\n* Active dental caries requiring treatment\n* History of periodontal therapy within the previous 6 months\n* Use of antibiotics, anti-inflammatory drugs, or antiseptic mouthwashes within the previous 3 months\n* Smoking or tobacco use\n* Pregnancy or lactation\n* Known allergy to any mouthwash components",true,"25 Years",{"count":51,"type":20},20,[53],"PHASE3","Dental plaque is a biofilm that accumulates on tooth surfaces and is a primary factor in the development of gingival inflammation. While toothbrushing remains the main method for plaque control, the effectiveness of mechanical oral hygiene depends largely on individual compliance and technique. As a result, mouthwashes are commonly used as adjunctive chemical plaque control agents.\n\nChlorhexidine gluconate is an effective anti-plaque mouthwash, but its use is associated with undesirable effects that may limit patient acceptance. Resveratrol is a naturally derived compound with reported antimicrobial and anti-biofilm properties, suggesting its potential use as an alternative chemical plaque control agent.\n\nThis randomized, double-blind, placebo-controlled, three-period crossover clinical trial aims to evaluate the short-term anti-plaque effect of a resveratrol-based mouthwash by measuring supragingival plaque regrowth over a 24-hour period in periodontally healthy individuals. The effects of the resveratrol-based mouthwash will be compared with 0.12% chlorhexidine (CHX) and a placebo mouthwash under standardized conditions without mechanical oral hygiene",[27,56,57,58],"Chlorhexidine","Biofilm Formation","Periodontal Health",[60,61,62,63],"Resveratrol","mouthwash","anti-plaque","crossover","2026-01-30",{"date":66,"type":32},"2026-02-06",{"date":68,"type":20},"2026-03",{"date":70,"type":20},"2026-05",{"name":72,"class":39},"University of Baghdad",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100406709","phase-2-anticariogenic-effect-of-moringa-oleifera-mouthwash-compared-to-chlorhexidine-mouthwash-100406709","NCT04575948","Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash","Antibacterial, Antiplaque and Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Systemically free as reported by the patients\n* Minimum of 20 teeth present in the dentition (excluding wisdom teeth);\n* Clinically healthy gingiva (on intact periodontium)\n* Dental biofilm-induced gingivitis (plaque induced gingivitis) according to the criteria set by the American Academy of Periodontology for classification of periodontal diseases and conditions in 2017\n* Moderate to high caries risk patients\n\nExclusion Criteria:\n\n* Patients with periodontitis or requiring other immediate dental treatments (within the current 6 months)\n* Subjects on antibiotics within last 6 months\n* Periodontal therapy for the past 6 months\n* Pregnant women and lactating mothers\n* Medically compromised patients\n* Subjects with tobacco consumption in any form\n* Subjects wearing partial dentures or having clinically unacceptable restorations or bridges\n* Subjects wearing orthodontic appliances\n* History of allergy to chemical or any herbal products","50 Years",{"count":82,"type":20},90,[84,53],"PHASE2","Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their effectiveness might yield promising antibacterial, antiplaque and anticariogenic agents with minimal side effects.\n\nAim of the study:\n\nPart I: The aim of this in-vitro part of the study is to formulate a nontoxic mouthwash from MO leaves extract, having antimicrobial activity, to be used in part II of the study. Furthermore, stability and efficacy of the developed mouth wash will be evaluated.\n\nPart II: The aim of this randomized controlled trial is to evaluate the antibacterial, antiplaque and anticariogenic effect of MO mouthwash compared to chlorhexidine mouthwash.",[87,88,27,89],"Plaque, Dental","Antimicrobial","Cytotoxicity",[91,92,61,93,94,95,96],"Moringa Oleifera","antibacterial activity","chlorhexidine","antiplaque","herbal","translational research","2026-01-26",{"date":99,"type":32},"2026-01-27",{"date":101,"type":20},"2027-12",{"date":103,"type":20},"2028-12",{"name":105,"class":39},"Misr International University"]